Professor Ralph Martins AO

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Professor Ralph Martins AO

Chair in Aging & Alzheimers Disease

Staff Member Details
Telephone:	+61 8 6304 5456
Facsimile:	+61 8 6304 5851
Email:	r.martins@ecu.edu.au
Campus:	Joondalup
Room:	JO17.314

Ralph is the Foundation Chair in Aging and Alzheimer's Disease within the School of Medical and Health Sciences.

Background

Professor Ralph Martins, Foundation Chair in Aging and Alzheimer’s Disease at Edith Cowan University, was appointed the Director of the Centre. Ralph Martins graduated from University of Western Australia with a PhD in 1986. In 1987 he won a scholarship to Heidelberg University to work with Konrad Beyreuther. His collaborative seminal research involved isolating and characterising beta-amyloid and its precursor, the amyloid precursor protein (APP), which are now recognized as central to the pathogenesis of Alzheimer's disease.

He was the first to propose and demonstrate that the Alzheimer brain was under oxidative stress, which is now widely recognized by the Alzheimer research community. In 1989 he joined Professor Masters at Melbourne University where he was the first to isolate and characterize the molecular components of the neuropathological hallmarks of Alzheimer’s disease. This led to an international patent and formation of a spin-off company, Alzhyme Pty Ltd. In 2001 he won a Media Fellowship with the ABC and was the first Media Fellow to have his work on the Science Show. In 2002 he won a Biotechnology Innovation Fund grant, which was matched by commercial funding. He established the Sir James McCusker Alzheimer’s Research Unit at Hollywood Hospital, whose research is directed at the cause(s), and development of diagnostics and treatments. He received the UWA "Excellence in Teaching Award - Post Graduate Research" for 2002 and in 2003 was appointed Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease.

Edith Cowan University appointed him to the Inaugural Chair, Ageing and Alzheimer’s Disease in 2004. He has Adjunct Professorial positions and close ties with clinical academics with both the University of Western Australia and Thomas Jefferson University’s Farber Neurosciences Institute. He is instigator and director of the state government funded Centre of Excellence for Alzheimer’s Disease Research and Care composed of researchers from 4 universities, 3 hospitals and 2 healthcare providers.

2004-2006: Professor – Inaugural Chair, Ageing and Alzheimer’s Disease, Edith Cowan University, Western Australia
2004: Adjunct Professor School of Psychiatry & Clinical Neurosciences,University of Western Australia, Adjunct Professor, School of Biomedical Science
Curtin University of Technology
2001-2002: Associate Professor, Department of Psychiatry and Neurogenetics,University of Western Australia, Hollywood Private Hospital, Western Australia
2001-2004: Professor on Staff, Research Centre and Community Services,Universitas Peila Harapan, Karawaci, Tangerang, Indonesia
1998-2003: Adjunct Associate Professor, School of Biomedical Science,Curtin University
1997-2001: Senior Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
1997-1998:Adjunct Teaching Fellow, Curtin University, Western Australia
1990-1997: Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
1989: Senior Research Officer, Department of Pathology, University of Melbourne
1984-1988: Research Scientist, Department of Pathology, University of Western Australia
1983-1988: Permanent Part-time Clinical Biochemist, Department of Pathology, King Edward Memorial Hospital for Women
1980-1984: Tutor of 2nd and 3rd year medical students in Biochemistry at the University of Western Australia
1979-1983: Demonstrator of 2nd year Biochemistry

Professional Memberships

1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
1982-1997: Australian Society for Medical Research
1984-2002: Australian Neuroscience Society
1984-1991: Australian Nutrition Foundation
1991-2002: Surgical Research Society of Australasia
1991-2004: Australian Association of Gerontology (WA)
1992-2004: Alzheimer’s Association (WA)
1996-2004: Society of Neuroscience (USA)
2000-2004: The Australian Menopause Society
2002-2004: Human Genetics Society of Australia
2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)

Research Areas and Interests

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Qualifications

Doctor of Philosophy, The University of Western Australia, 1987.

Research Outputs

2024

Journal Articles

Dissanayaka, S., Jayasena, V., Rainey-Smith, S., Martins, R., Fernando, B. (2024). The Role of Diet and Gut Microbiota in Alzheimer’s Disease. Nutrients, 16(3), Article number 412. https://doi.org/https://doi.org/10.3390/nu16030412.
Yang, Y., Kim, WS., Michaelian, JC., Lewis, SJ., Phillips, CL., D'rozario, AL., Chatterjee, P., Martins, R., Grunstein, R., Halliday, GM., Naismith, SL. (2024). Predicting neurodegeneration from sleep related biofluid changes. Neurobiology of Disease, 190(2024), article number 106369. https://doi.org/10.1016/j.nbd.2023.106369.

2023

Journal Articles

Naismith, SL., Michaelian, JC., Santos, C., Mehrani, I., Robertson, J., Wallis, K., Lin, X., Ward, SA., Martins, R., Masters, CL., Breakspear, M., Ahern, S., Fripp, J., Schofield, PR., Sachdev, PS., Rowe, CC. (2023). Tackling Dementia Together via The Australian Dementia Network (ADNeT): A Summary of Initiatives, Progress and Plans. Journal of Alzheimer's Disease, 96(3), 913-925. https://doi.org/10.3233/JAD-230854.
McKay, N., Gordon, B., Hornbeck, R., Dincer, A., Flores, S., Keefe, S., Joseph-Mathurin, N., Jack, C., Koeppe, R., Millar, P., Ances, B., Chen, C., Daniels, A., Hobbs, D., Jackson, K., Koudelis, D., Massoumzadeh, P., McCullough, A., Nickels, M., Rahmani, F., Swisher, L., Wang, Q., Allegri, R., Berman, S., Brickman, A., Brooks, W., Cash, D., Chhatwal, J., Day, G., Farlow, M., La Fougère, C., Fox, N., Fulham, M., Ghetti, B., Graff-Radford, N., Ikeuchi, T., Klunk, W., Lee, J., Levin, J., Martins, R., Masters, C., McConathy, J., Mori, H., Noble, J., Reischl, G., Rowe, C., Salloway, S., Sanchez-Valle, R., Schofield, P., Shimada, H., Shoji, M., Su, Y., Suzuki, K., Vöglein, J., Yakushev, I., Cruchaga, C., Hassenstab, J., Karch, C., McDade, E., Perrin, R., Xiong, C., Morris, J., Bateman, R., Benzinger, T. (2023). Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN). Nature Neuroscience, 26(8), 1449-1460. https://doi.org/10.1038/s41593-023-01359-8.
Shirzadi, Z., Schultz, SA., Yau, WW., Joseph-Mathurin, N., Fitzpatrick, CD., Levin, R., Kantarci, K., Preboske, GM., Jack, CR., Farlow, MR., Hassenstab, J., Jucker, M., Morris, JC., Xiong, C., Karch, CM., Levey, AI., Gordon, BA., Schofield, PR., Salloway, SP., Perrin, RJ., McDade, E., Levin, J., Cruchaga, C., Allegri, RF., Fox, NC., Goate, A., Day, GS., Koeppe, R., Chui, HC., Berman, S., Mori, H., Sanchez-Valle, R., Lee, J., Rosa-Neto, P., Ruthirakuhan, M., Wu, C., Swardfager, W., Benzinger, TL., Sohrabi, H., Martins, R., Bateman, RJ., Johnson, KA., Sperling, RA., Greenberg, SM., Schultz, AP., Chhatwal, JP. (2023). Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. JAMA Neurology, 80(12), 1353-1363. https://doi.org/10.1001/jamaneurol.2023.3618.
Ramezani, M., Fernando, M., Eslick, S., Asih, PR., Shadfar, S., Bandara, E., Hillebrandt, H., Meghwar, S., Shahriari, M., Chatterjee, P., Thota, R., Dias, CB., Garg, ML., Martins, R. (2023). Ketone bodies mediate alterations in brain energy metabolism and biomarkers of Alzheimer’s disease. Frontiers in Neuroscience, 17(2023), article number 1297984. https://doi.org/10.3389/fnins.2023.1297984.
Blagojevic Castro, C., Costa, L., Dias, C., Chen, J., Hillebrandt, H., Kirby, S., Brown, B., Loo, R., Garg, M., Rainey-Smith, S., Martins, R., Sohrabi, H. (2023). Multi-Domain Interventions for Dementia Prevention–A Systematic Review. Journal of Nutrition, Health and Aging, 27(12), 1271-1280. https://doi.org/10.1007/s12603-023-2046-2.
Slee, MG., Rainey-Smith, S., Villemagne, V., Doecke, JD., Sohrabi, H., Taddei, K., Ames, D., Dore, V., Maruff, P., Laws, S., Masters, CL., Rowe, CC., Martins, R., Erickson, KI., Brown, B. (2023). Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults. Alzheimer's and Dementia, 2023(2023), TBD. https://doi.org/10.1002/alz.13556.
Schultz, S., Shirzadi, Z., Schultz, A., Liu, L., Fitzpatrick, C., McDade, E., Barthelemy, N., Renton, A., Esposito, B., Joseph-Mathurin, N., Cruchaga, C., Chen, C., Goate, A., Allegri, R., Benzinger, T., Berman, S., Chui, H., Fagan, A., Farlow, M., Fox, N., Gordon, B., Day, G., Graff-Radford, N., Hassenstab, J., Hanseeuw, B., Hofmann, A., Jack, C., Jucker, M., Karch, C., Koeppe, R., Lee, J., Levey, A., Levin, J., Martins, R., Mori, H., Morris, J., Noble, J., Perrin, R., Rosa-Neto, P., Salloway, S., Sanchez-Valle, R., Schofield, P., Xiong, C., Johnson, K., Bateman, R., Sperling, R., Chhatwal, J. (2023). Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell, 22(8), article number e13871. https://doi.org/10.1111/acel.13871.
Xia, Y., Maruff, P., Doré, V., Bourgeat, P., Laws, S., Fowler, C., Rainey-Smith, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Coulson, E., Fripp, J. (2023). Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease. Neurobiology of Aging, 132(2023), 120-130. https://doi.org/10.1016/j.neurobiolaging.2023.09.002.
Huang, X., Li, Y., Fowler, C., Doecke, J., Lim, Y., Drysdale, C., Zhang, V., Park, K., Trounson, B., Pertile, K., Rumble, R., Pickering, J., Rissman, R., Sarsoza, F., Abdel-Latif, S., Lin, Y., Doré, V., Villemagne, V., Rowe, C., Fripp, J., Martins, R., Wiley, J., Maruff, P., Mintzer, J., Masters, C., Gu, B. (2023). Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease. Alzheimer's and Dementia, 19(5), 2084-2094. https://doi.org/10.1002/alz.12813.
Tarawneh, H., Jayakody, D., Verma, S., Doré, V., Xia, Y., Mulders, W., Martins, R., Sohrabi, H. (2023). Auditory Event-Related Potentials in Older Adults with Subjective Memory Complaints. Journal of Alzheimer's Disease, 92(3), 1093-1109. https://doi.org/10.3233/JAD-221119.
Chatterjee, P., Dore, V., Pedrini, S., Krishnadas, N., Thota, R., Bourgeat, P., Ikonomovic, MD., Rainey-Smith, S., Burnham, SC., Fowler, C., Taddei, K., Mulligan, R., Ames, D., Masters, CL., Fripp, J., Rowe, CC., Martins, R., Villemagne, VL. (2023). Plasma Glial Fibrillary Acidic Protein Is Associated With 18F-Smbt-1 Pet: Two Putative Astrocyte Reactivity Biomarkers For Alzheimer'S Disease. Journal of Alzheimer's Disease, 92(2), 615-628. https://doi.org/10.3233/JAD-220908.
Castro, CB., Dias, CB., Hillebrandt, H., Sohrabi, HR., Chatterjee, P., Shah, TM., Fuller, SJ., Garg, ML., Martins, R. (2023). Medium-Chain Fatty Acids For The Prevention Or Treatment Of Alzheimer'S Disease: A Systematic Review And Meta-Analysis. Nutrition Reviews, 2023(article in press), TBD. https://doi.org/10.1093/nutrit/nuac104.
Chatterjee, P., Vermunt, L., Gordon, B., Pedrini, S., Boonkamp, L., Armstrong, N., Xiong, C., Singh, A., Li, Y., Sohrabi, H., Taddei, K., Molloy, M., Benzinger, T., Morris, J., Karch, C., Berman, S., Chhatwal, J., Cruchaga, C., Graff-Radford, N., Day, G., Farlow, M., Fox, N., Goate, A., Hassenstab, J., Lee, J., Levin, J., McDade, E., Mori, H., Perrin, R., Sanchez-Valle, R., Schofield, P., Levey, A., Jucker, M., Masters, C., Fagan, A., Bateman, R., Martins, R., Teunissen, C. (2023). Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's and Dementia, 19(7), 2790-2804. https://doi.org/10.1002/alz.12879.
Sewell, KR., Rainey-Smith, S., Peiffer, J., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, CL., Rowe, CC., Martins, R., Erickson, KI., Brown, B. (2023). The Relationship Between Objective Physical Activity And Change In Cognitive Function. Alzheimer's and Dementia, 19(7), 2984-2993. https://doi.org/10.1002/alz.12950.
Dawes, P., Reeves, D., Yeung, WK., Holland, F., Charalambous, AP., Cote, M., David, R., Helmer, C., Laforce, R., Martins, R., Politis, A., Pye, A., Russell, G., Sheikh, S., Sirois, M., Sohrabi, HR., Thodi, C., Gallant, K., Nasreddine, Z., Leroi, I. (2023). Development And Validation Of The Montreal Cognitive Assessment For People With Hearing Impairment (Moca-H). Journal of the American Geriatrics Society, 71(5), 1485-1494. https://doi.org/10.1111/jgs.18241.
O'Connor, A., Rice, H., Barnes, J., Ryan, N., Liu, K., Allegri, R., Berman, S., Ringman, J., Cruchaga, C., Farlow, M., Hassenstab, J., Lee, J., Perrin, R., Xiong, C., Gordon, B., Levey, A., Goate, A., Graff-Radford, N., Levin, J., Jucker, M., Benzinger, T., McDade, E., Mori, H., Noble, J., Schofield, P., Martins, R., Salloway, S., Chhatwal, J., Morris, J., Bateman, R., Howard, R., Reeves, S., Fox, N. (2023). First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: The Dominantly Inherited Alzheimer's Network Study. Journal of Neurology, Neurosurgery and Psychiatry, 94(5), 403-405. https://doi.org/10.1136/jnnp-2022-329843.
Vöglein, J., Franzmeier, N., Morris, J., Dieterich, M., McDade, E., Simons, M., Preische, O., Hofmann, A., Hassenstab, J., Benzinger, T., Fagan, A., Noble, J., Berman, S., Graff-Radford, N., Ghetti, B., Farlow, M., Chhatwal, J., Salloway, S., Xiong, C., Karch, C., Cairns, N., Perrin, R., Day, G., Martins, R., Sanchez-Valle, R., Mori, H., Shimada, H., Ikeuchi, T., Suzuki, K., Schofield, P., Masters, C., Goate, A., Buckles, V., Fox, N., Chrem, P., Allegri, R., Ringman, J., Yakushev, I., Laske, C., Jucker, M., Höglinger, G., Bateman, R., Danek, A., Levin, J. (2023). Patterns and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer's and Dementia, 19(2), 632-645. https://doi.org/10.1002/alz.12684.
Rajendra, A., Bondonno, N., Murray, K., Zhong, L., Rainey-Smith, S., Gardener, S., Blekkenhorst, L., Ames, D., Maruff, P., Martins, R., Hodgson, J., Bondonno, C. (2023). Habitual dietary nitrate intake and cognition in the Australian Imaging, Biomarkers and Lifestyle Study of ageing: A prospective cohort study. Clinical Nutrition, 42(8), 1251-1259. https://doi.org/10.1016/j.clnu.2023.05.022.
Chatterjee, P., Pedrini, S., Doecke, J., Thota, R., Villemagne, V., Doré, V., Singh, A., Wang, P., Rainey-Smith, S., Fowler, C., Taddei, K., Sohrabi, H., Molloy, M., Ames, D., Maruff, P., Rowe, C., Masters, C., Martins, R. (2023). Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort. Alzheimer's and Dementia, 19(4), 1117-1134. https://doi.org/10.1002/alz.12724.
Sewell, K., Rainey-Smith, S., Villemagne, V., Peiffer, J., Sohrabi, H., Taddei, K., Ames, D., Doré, V., Maruff, P., Laws, S., Masters, C., Rowe, C., Martins, R., Erickson, K., Brown, B. (2023). The interaction between physical activity and sleep on cognitive function and brain beta-amyloid in older adults. Behavioural Brain Research, 437(2 February 2023), Article number 114108. https://doi.org/10.1016/j.bbr.2022.114108.
Koemans, E., Chhatwal, J., Van Veluw, S., Van Etten, E., Van Osch, M., Van Walderveen, M., Sohrabi, H., Kozberg, M., Shirzadi, Z., Terwindt, G., Van Buchem, M., Smith, E., Werring, D., Martins, R., Wermer, M., Greenberg, S. (2023). Progression of cerebral amyloid angiopathy: a pathophysiological framework. Lancet Neurology, 22(7), 632-642. https://doi.org/10.1016/S1474-4422(23)00114-X.
Feizpour, A., Doré, V., Doecke, J., Saad, Z., Triana-Baltzer, G., Slemmon, R., Maruff, P., Krishnadas, N., Bourgeat, P., Huang, K., Fowler, C., Rainey-Smith, S., Bush, A., Ward, L., Robertson, J., Martins, R., Masters, C., Villemagne, V., Fripp, J., Kolb, H., Rowe, C. (2023). Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer’s Continuum. Journal of Prevention of Alzheimer's Disease, 2023(Article in press), -. https://doi.org/10.14283/jpad.2023.83.
Yuan, J., Pedrini, S., Thota, R., Doecke, J., Chatterjee, P., Sohrabi, H., Teunissen, CE., Verberk, IM., Stoops, E., Vanderstichele, H., Meloni, BP., Mitchell, C., Rainey-Smith, S., Goozee, K., Tai, AC., Ashton, N., Zetterberg, H., Blennow, K., Gao, J., Liu, D., Mastaglia, F., Inderjeeth, C., Zheng, M., Martins, R. (2023). Elevated Plasma Sclerostin Is Associated With High Brain Amyloid-Β Load In Cognitively Normal Older Adults. Npj Aging, 9(1), article number 17. https://doi.org/10.1038/s41514-023-00114-4.
Johnson, E., Bian, S., Haque, R., Carter, E., Watson, C., Gordon, B., Ping, L., Duong, D., Epstein, M., McDade, E., Barthélemy, N., Karch, C., Xiong, C., Cruchaga, C., Perrin, R., Wingo, A., Wingo, T., Chhatwal, J., Day, G., Noble, J., Berman, S., Martins, R., Graff-Radford, N., Schofield, P., Ikeuchi, T., Mori, H., Levin, J., Farlow, M., Lah, J., Haass, C., Jucker, M., Morris, J., Benzinger, T., Roberts, B., Bateman, R., Fagan, A., Seyfried, N. (2023). Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease. Nature Medicine, 29(8), 1979-1988. https://doi.org/10.1038/s41591-023-02476-4.
Fernando, MG., Silva, R., Fernando, B., De Silva, HA., Wickremasinghe, AR., Dissanayake, AS., Sohrabi, H., Martins, R., Williams, SS. (2023). Effect of Virgin Coconut Oil Supplementation on Cognition of Individuals with Mild-to-Moderate Alzheimer’s Disease in Sri Lanka (VCO-AD Study): A Randomized Placebo-Controlled Trial. Journal of Alzheimer's Disease, 96(3), 1195-1206. https://doi.org/10.3233/JAD-230670.

2022

Journal Articles

Tarawneh, H., Sohrabi, H., Mulders, W., Martins, R., Jayakody, D. (2022). Comparison of Auditory Steady-State Responses With Conventional Audiometry in Older Adults. Frontiers in Neurology, 13(2022), article number 924096. https://doi.org/10.3389/fneur.2022.924096.
Frost, N., Weinborn, M., Gignac, G., Xia, Y., Dore, V., Rainey-Smith, S., Markovic, S., Gordon, N., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., Brown, B. (2022). The effect of self-paced exercise intensity and cardiorespiratory fitness on frontal grey matter volume in cognitively normal older adults: A randomised controlled trial. Journal of the International Neuropsychological Society, 28(9), 902-915. https://doi.org/10.1017/S1355617721001132.
Morris, J., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P., Allegri, R., Benzinger, T., Berman, S., Cairns, N., Carrillo, M., Chui, H., Chhatwal, J., Cruchaga, C., Fagan, A., Farlow, M., Fox, N., Ghetti, B., Goate, A., Gordon, B., Graff-Radford, N., Day, G., Hassenstab, J., Ikeuchi, T., Jack, C., Jagust, W., Jucker, M., Levin, J., Massoumzadeh, P., Masters, C., Martins, R., McDade, E., Mori, H., Noble, J., Petersen, R., Ringman, J., Salloway, S., Saykin, A., Schofield, P., Shaw, L., Toga, A., Trojanowski, J., Vöglein, J., Weninger, S., Bateman, R., Buckles, V. (2022). Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology. Brain, 145(10), 3594-3607. https://doi.org/10.1093/brain/awac181.
Fowler, C., Stoops, E., Rainey-Smith, S., Vanmechelen, E., Vanbrabant, J., Dewit, N., Mauroo, K., Maruff, P., Rowe, C., Fripp, J., Li, Q., Bourgeat, P., Collins, S., Martins, R., Masters, C., Doecke, J. (2022). Plasma p-tau181/Aβ1-42 ratio predicts Aβ-PET status and correlates with CSF-p-tau181/Aβ1-42 and future cognitive decline. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), article number e12375. https://doi.org/10.1002/dad2.12375.
Dhiman, K., Villemagne, V., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Rowe, C., Masters, C., Ames, D., Blennow, K., Zetterberg, H., Martins, R., Gupta, V. (2022). Cerebrospinal fluid levels of fatty acid–binding protein 3 are associated with likelihood of amyloidopathy in cognitively healthy individuals. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), article number e12377. https://doi.org/10.1002/dad2.12377.
Laffoon, S., Doecke, J., Roberts, A., Vance, J., Reeves, B., Pertile, K., Rumble, R., Fowler, C., Trounson, B., Ames, D., Martins, R., Bush, A., Masters, C., Grieco, P., Dratz, E., Roberts, B. (2022). Analysis of plasma proteins using 2D gels and novel fluorescent probes: in search of blood based biomarkers for Alzheimer’s disease. Proteome Science, 20(1), article number 2. https://doi.org/10.1186/s12953-021-00185-9.
Drieu, A., Du, S., Storck, S., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., Harari, O., Karch, C., Bateman, R., Perrin, R., Farlow, M., Chhatwal, J., Brosch, J., Buck, J., Farlow, M., Ghetti, B., Adams, S., Barthelemy, N., Benzinger, T., Brandon, S., Buckles, V., Cash, L., Chen, C., Chua, J., Cruchaga, C., Denner, D., Dincer, A., Donahue, T., Fagan, A., Feldman, B., Flores, S., Franklin, E., Joseph-Mathurin, N., Gonzalez, A., Gordon, B., Gray, J., Gremminger, E., Groves, A., Hassenstab, J., Hellm, C., Herries, E., Hoechst-Swisher, L., Holtzman, D., Hornbeck, R., Jerome, G., Keefe, S., Koudelis, D., Li, Y., Marsh, J., Martinez, R., Mawuenyega, K., McCullough, A., McDade, E., Morris, J., Norton, J., Shady, K., Sigurdson, W., Smith, J., Wang, P., Wang, Q., Xiong, C., Xu, J., Xu, X., Allegri, R., Mendez, P., Egido, N., Araki, A., Ikeuchi, T., Ishii, K., Kasuga, K., Bechara, J., Brooks, W., Schofield, P., Berman, S., Goldberg, S., Ikonomovic, S., Klunk, W., Lopez, O., Mountz, J., Nadkarni, N., Patira, R., Smith, L., Snitz, B., Thompson, S., Weamer, E., Bodge, C., Salloway, S., Carter, K., Duong, D., Johnson, E., Levey, A., Ping, L., Seyfried, N., Fitzpatrick, C., Chui, H., Ringman, J., Day, G., Graff-Radford, N., Graham, M., Stephens, S., Cruz, C., Goldman, J., Mejia, A., Neimeyer, K., Noble, J., Diffenbacher, A., Yakushev, I., Levin, J., Vöglein, J., Douglas, J., Fox, N., Grilo, M., Mummery, C., O’connor, A., Esposito, B., Goate, A., Renton, A., Fujii, H., Senda, M., Shimada, H., Gardener, S., Martins, R., Sohrabi, H., Taddei, K., Gräber-Sultan, S., Häsler, L., Hofmann, A., Jucker, M., Käser, S., Kuder-Buletta, E., Laske, C., Preische, O., Haass, C., Morenas-Rodriguez, E., Nuscher, B., Ihara, R., Nagamatsu, A., Niimi, Y., Jack, C., Koeppe, R., Mason, N., Masters, C., Obermüller, U., Hu, S., Randolph, G., Smirnov, I., Kipnis, J. (2022). Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature, 611(7936), 585-593. https://doi.org/10.1038/s41586-022-05397-3.
Dharmaraj, G., Arigo, F., Young, K., Martins, R., Mancera, R., Bharadwaj, P. (2022). Novel Amylin Analogues Reduce Amyloid-β Cross-Seeding Aggregation and Neurotoxicity. Journal of Alzheimer's Disease, 87(1), 373-390. https://doi.org/10.3233/JAD-215339.
Thota, R., Chatterjee, P., Pedrini, S., Hone, E., Ferguson, J., Garg, M., Martins, R. (2022). Association of Plasma Neurofilament Light Chain With Glycaemic Control and Insulin Resistance in Middle-Aged Adults. Frontiers in Endocrinology, 13(2022), article number 915449. https://doi.org/10.3389/fendo.2022.915449.
Pedrini, S., Doecke, J., Hone, E., Wang, P., Thota, R., Bush, A., Rowe, C., Dore, V., Villemagne, V., Ames, D., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Taddei, K., Gandy, S., Masters, C., Chatterjee, P., Martins, R. (2022). Plasma high-density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume. Journal of Neurochemistry, 163(1), 53-67. https://doi.org/10.1111/jnc.15681.
Shirzadi, Z., Yau, W., Schultz, S., Schultz, A., Scott, M., Goubran, M., Mojiri-Forooshani, P., Joseph-Mathurin, N., Kantarci, K., Preboske, G., Wermer, M., Jack, C., Benzinger, T., Taddei, K., Sohrabi, H., Sperling, R., Johnson, K., Bateman, R., Martins, R., Greenberg, S., Chhatwal, J. (2022). Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy. Annals of Neurology, 92(3), 358-363. https://doi.org/10.1002/ana.26429.
Jayatunga, D., Hone, E., Fernando, B., Garg, , ML., Verdile, , G., Martins, R. (2022). A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease.. Frontiers in Aging Neuroscience, 14(16 February 2022), Article number 780602. https://doi.org/10.3389/fnagi.2022.780602.
Jayatunga, D., Hone, E., Fernando, B., Garg, , ML., Verdile, , G., Martins, R. (2022). Mitoprotective Effects of a Synergistic Nutraceutical Combination: Basis for a Prevention Strategy Against Alzheimer's Disease.. Frontiers in Aging Neuroscience, 13(21 February 2022), Article number 781468. https://doi.org/10.3389/fnagi.2021.781468.
Cadby, G., Giles, C., Melton, P., Huynh, K., Mellett, N., Duong, T., Nguyen, A., Cinel, M., Smith, A., Olshansky, G., Wang, T., Brozynska, M., Inouye, M., McCarthy, N., Ariff, A., Hung, J., Hui, J., Beilby, J., Dube, M., Watts, G., Shah, S., Wray, N., Lim, F., Chatterjee, P., Martins, I., Laws, S., Porter, T., Vacher, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Taddei, K., Arnold, M., Kastenmuller, G., Nho, K., Saykin, A., Han, X., Kaddurah-Daouk, R., Martins, R., Blangero, J., Meikle, P., Moses, E. (2022). Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease. Nature Communications, 13(1), Article number 3124. https://doi.org/10.1038/s41467-022-30875-7.
Li, Y., Schindler, S., Bollinger, J., Ovod, V., Mawuenyega, K., Weiner, M., Leslie, S., Masters, C., Fowler, C., Trojanowski, J., Korecka, M., Martins, R., Janelidze, S., Hansson, O., Bateman, R. (2022). Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques. Neurology, 98(7), e688-e699. https://doi.org/10.1212/WNL.0000000000013211.
Wang, T., Huynh, K., Giles, C., Mellett, N., Duong, T., Nguyen, A., Lim, F., Smith, A., Olshansky, G., Cadby, G., Hung, J., Hui, J., Beilby, J., Watts, G., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Taddei, K., Doré, V., Fripp, J., Arnold, M., Kastenmüller, G., Nho, K., Saykin, A., Baillie, R., Han, X., Martins, R., Moses, E., Kaddurah-Daouk, R., Meikle, P. (2022). APOE ε2 resilience for Alzheimer’s disease is mediated by plasma lipid species: Analysis of three independent cohort studies. Alzheimer's and Dementia, 18(11), 2151-2166. https://doi.org/10.1002/alz.12538.
Buckles, V., Xiong, C., Bateman, R., Hassenstab, J., Allegri, R., Berman, S., Chhatwal, J., Danek, A., Fagan, A., Ghetti, B., Goate, A., Graff-Radford, N., Jucker, M., Levin, J., Marcus, D., Masters, C., McCue, L., McDade, E., Mori, H., Moulder, K., Noble, J., Paumier, K., Preische, O., Ringman, J., Fox, N., Salloway, S., Schofield, P., Martins, R., Vöglein, J., Morris, J. (2022). Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease. Alzheimer's and Dementia, 18(10), 1754-1764. https://doi.org/10.1002/alz.12505.
Chatterjee, P., Pedrini, S., Ashton, N., Tegg, M., Goozee, K., Singh, A., Karikari, T., Simrén, J., Vanmechelen, E., Armstrong, N., Hone, E., Asih, P., Taddei, K., Doré, V., Villemagne, V., Sohrabi, H., Zetterberg, H., Masters, C., Blennow, K., Martins, R. (2022). Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease. Alzheimer's and Dementia, 18(6), 1141-1154. https://doi.org/10.1002/alz.12447.
Rosenich, E., Bransby, L., Yassi, N., Fripp, J., Laws, S., Martins, R., Fowler, C., Rainey-Smith, S., Rowe, C., Masters, C., Maruff, P., Lim, YY. (2022). Differential effects of APOE and modifiable risk factors on hippocampal volume loss and memory decline in Aβ− and Aβ+ older adults. Neurology, 98(17), e1704-e1715. https://doi.org/10.1212/WNL.0000000000200118.
Dhiman, K., Villemagne, V., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Bush, A., Rowe, C., Masters, C., Ames, D., Blennow, K., Zetterberg, H., Martins, R., Gupta, V. (2022). Cerebrospinal Fluid Neurofilament Light Predicts Risk of Dementia Onset in Cognitively Healthy Individuals and Rate of Cognitive Decline in Mild Cognitive Impairment: A Prospective Longitudinal Study. Biomedicines, 10(5), Article number 1045. https://doi.org/10.3390/biomedicines10051045.
Seneviratne, R., Weinborn, M., Badcock, D., Gavett, B., Laws, M., Taddei, K., Martins, R., Sohrabi, H. (2022). The Western Australia Olfactory Memory Test: Reliability and Validity in a Sample of Older Adults. Archives of Clinical Neuropsychology, 37(8), 1720-1734. https://doi.org/10.1093/arclin/acac048.
Tarawneh, H., Jayakody, D., Sohrabi, H., Martins, R., Mulders, W. (2022). Understanding the Relationship Between Age-Related Hearing Loss and Alzheimer's Disease: A Narrative Review. Journal of Alzheimer's Disease Reports, 6(1), 539-556. https://doi.org/10.3233/ADR-220035.
Cespedes, M., Jacobs, K., Maruff, P., Rembach, A., Fowler, C., Trounson, B., Pertile, K., Rumble, R., Rainey-Smith, S., Rowe, C., Villemagne, V., Bourgeat, P., Lim, C., Chatterjee, P., Martins, R., Ittner, A., Masters, C., Doecke, J., Guillemin, G., Lovejoy, D. (2022). Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β. Neurobiology of Disease, 171(September 2022), Article number 105783. https://doi.org/10.1016/j.nbd.2022.105783.
Pedrini, S., Chatterjee, P., Nakamura, A., Tegg, M., Hone, E., Rainey-Smith, S., Rowe, C., Dore, V., Villemagne, V., Ames, D., Kaneko, N., Kirby, S., Taddei, K., Fernando, B., Martins, I., Bharadwaj, P., Sohrabi, H., Masters, C., Brown, B., Martins, R. (2022). The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults. Frontiers in Aging Neuroscience, 14(2022), article number 771214. https://doi.org/10.3389/fnagi.2022.771214.
Woodfield, A., Porter, T., Gilani, I., Noordin, S., Li, Q., Collins, S., Martins, R., Maruff, P., Masters, C., Rowe, C., Villemagne, V., Dore, V., Newsholme, P., Laws, S., Verdile, G. (2022). Insulin resistance, cognition and Alzheimer’s disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of Aging, 114(June 2022), 38-48. https://doi.org/10.1016/j.neurobiolaging.2022.03.004.
Doré, V., Doecke, J., Saad, Z., Triana-Baltzer, G., Slemmon, R., Krishnadas, N., Bourgeat, P., Huang, K., Burnham, S., Fowler, C., Rainey-Smith, S., Bush, A., Ward, L., Robertson, J., Martins, R., Masters, C., Villemagne, V., Fripp, J., Kolb, H., Rowe, C. (2022). Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), article number e12307. https://doi.org/10.1002/dad2.12307.

2021

Journal Articles

Bondonno, C., Bondonno, N., Dalgaard, F., Murray, K., Kirby, S., Martins, R., Rainey-Smith, S., Cassidy, A., Lewis, J., Croft, K., Kyro, C., Gislason, G., Scalbert, A., Tjønneland, A., Overvad, K., Hodgson, J. (2021). Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 7(1), Article number e12175. https://doi.org/10.1002/trc2.12175.
Pedrini, S., Chatterjee, P., Hone, E., Martins, R. (2021). High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease. Journal of Neurochemistry, 159(2), 343-377. https://doi.org/10.1111/jnc.15170.
Rezaee, N., Fernando, B., Hone, E., Sohrabi, H., Johnson, S., Gunzburg, S., Martins, R. (2021). Potential of sorghum polyphenols to prevent and treat Alzheimer’s disease. Frontiers in Aging Neuroscience, 13(Oct 2021), Article number 729949. https://doi.org/10.3389/fnagi.2021.729949.
Fagan, A., Henson, R., Li, Y., Boerwinkle, A., Xiong, C., Bateman, R., Goate, A., Ances, B., Doran, E., Christian, B., Lai, F., Rosas, H., Schupf, N., Krinsky-McHale, S., Silverman, W., Lee, J., Klunk, W., Handen, B., Allegri, R., Chhatwal, J., Day, G., Graff-Radford, N., Jucker, M., Levin, J., Martins, R., Masters, C., Mori, H., Mummery, C., Niimi, Y., Ringman, J., Salloway, S., Schofield, P., Shoji, M., Lott, I. (2021). Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurology, 20(8), 615-626. https://doi.org/10.1016/S1474-4422(21)00139-3.
Keret, O., Staffaroni, A., Ringman, J., Cobigo, Y., Goh, S., Wolf, A., Allen, I., Salloway, S., Chhatwal, J., Brickman, A., Reyes-Dumeyer, D., Bateman, R., Benzinger, T., Morris, J., Ances, B., Joseph-Mathurin, N., Perrin, R., Gordon, B., Levin, J., Voglein, J., Jucker, M., Fougere, C., Martins, R., Sohrabi, H., Taddei, K., Villemagne, V., Schofield, P., Brooks, W., Fulham, M., Masters, C., Ghetti, B., Saykin, A., Jack, C., Graff-Radford, N., Weiner, M., Cash, D., Allegri, R., Chrem, P., Yi, S., Miller, B., Rabinovici, G., Rosen, H. (2021). Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article Number 12197. https://doi.org/10.1002/dad2.12197.
Doecke, J., Francois, C., Fowler, C., Stoops, E., Bourgeat, P., Rainey-Smith, S., Li, Q., Masters, C., Martins, R., Villemagne, V., Collins, S., Vanderstichele, H. (2021). Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods. Alzheimer's Research and Therapy, 13(December 2021), Article number 79. https://doi.org/10.1186/s13195-021-00812-9.
Kirby, S., Rainey-Smith, S., Villemagne, V., Fripp, J., Dore, V., Bourgeat, P., Taddei, K., Fowler, C., Masters, C., Maruff, P., Rowe, C., Ames, D., Martins, R. (2021). Higher coffee consumption is associated with slower cognitive decline and less cerebral Aβ-Amyloid accumulation over 126 months: Data from the Australian Imaging, Biomarkers, and Lifestyle Study. Frontiers in Aging Neuroscience, 13(19 November 2021), Article number 744872. https://doi.org/10.3389/fnagi.2021.744872.
Chatterjee, P., Tegg, M., Pedrini, S., Fagan, A., Xiong, C., Singh, A., Taddei, K., Gardener, S., Masters, C., Schofield, P., Multhaup, G., Benzinger, T., Morris, J., Bateman, R., Greenberg, S., Van Buchem, M., Stoops, E., Vanderstichele, H., Teunissen, C., Hankey, G., Wermer, M., Sohrabi, H., Martins, R. (2021). Plasma amyloid‐beta levels in a pre‐symptomatic dutch‐type hereditary cerebral amyloid angiopathy pedigree: A cross‐sectional and longitudinal investigation. International Journal of Molecular Sciences, 22(6), Article number 2931. https://doi.org/10.3390/ijms22062931.
Tan, S., Porter, T., Bucks, R., Weinborn, M., Milicic, L., Brown, A., Rainey-Smith, S., Taddei, K., Ames, D., Masters, C., Maruff, P., Savage, G., Rowe, C., Villemagne, V., Brown, B., Sohrabi, H., Laws, S., Martins, R. (2021). Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition. Hormones and Behaviour, 131(May 2021), Article number 104966. https://doi.org/10.1016/j.yhbeh.2021.104966.
Gardener, S., Rainey-Smith, S., Weinborn, M., Bondonno, C., Martins, R. (2021). Intake of Products Containing Anthocyanins, Flavanols, and Flavanones, and Cognitive Function: A Narrative Review. Frontiers in Aging Neuroscience, 13(3 September 2021), article number 640381. https://doi.org/10.3389/fnagi.2021.640381.
Tarawneh, H., Mulders, W., Sohrabi, H., Martins, R., Jayakody, D. (2021). Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies. Journal of Alzheimer's Disease, 84(1), 419-448. https://doi.org/10.3233/JAD-210556.
Chatterjee, P., Fagan, A., Xiong, C., McKay, M., Bhatnagar, A., Wu, Y., Singh, A., Taddei, K., Martins, I., Gardener, S., Molloy, M., Multhaup, G., Masters, C., Schofield, P., Benzinger, T., Morris, J., Bateman, R., Greenberg, S., Wermer, M., Van Buchem, M., Sohrabi, H., Martins, R. (2021). Presymptomatic Dutch-type hereditary cerebral amyloid angiopathy related blood metabolite alterations. Journal of Alzheimer's Disease, 79(2), 895-903. https://doi.org/10.3233/JAD-201267.
Jayatunga, P., Hone, E., Khaira, H., Lunelli, T., Singh, H., Guillemin, G., Fernando, B., Garg, M., Verdile, G., Martins, R. (2021). Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease. Nutrients, 13(11), article number 3744. https://doi.org/10.3390/nu13113744.
Parker, D., Bucks, R., Rainey-Smith, S., Hodgson, E., Fine, L., Sohrabi, H., Martins, R., Weinborn, M. (2021). Sleep Mediates Age-Related Executive Function for Older Adults with Limited Cognitive Reserve. Journal of the International Neuropsychological Society, 27(7), 711-721. https://doi.org/10.1017/S1355617720001186.
Ewers, M., Luan, Y., Frontzkowski, L., Neitzel, J., Rubinski, A., Dichgans, M., Hassenstab, J., Gordon, B., Chhatwal, J., Levin, J., Schofield, P., Benzinger, T., Morris, J., Goate, A., Karch, C., Fagan, A., McDade, E., Allegri, R., Berman, S., Chui, H., Cruchaga, C., Farlow, M., Graff-Radford, N., Jucker, M., Lee, J., Martins, R., Mori, H., Perrin, R., Xiong, C., Rossor, M., Fox, N., O'Connor, A., Salloway, S., Danek, A., Buerger, K., Bateman, R., Habeck, C., Stern, Y., Franzmeier, N. (2021). Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain: a journal of neurology, 144(7), 2176-2185. https://doi.org/10.1093/brain/awab112.
Frost, N., Weinborn, M., Gignac, G., Rainey-Smith, S., Markovic, S., Gordon, N., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., Brown, B. (2021). A Randomized Controlled Trial of High-Intensity Exercise and Executive Functioning in Cognitively Normal Older Adults. The American Journal of Geriatric Psychiatry, 29(2), 129-140. https://doi.org/10.1016/j.jagp.2020.06.015.
Chatterjee, P., Pedrini, S., Stoops, E., Goozee, K., Villemagne, V., Asih, P., Verberk, I., Dave, P., Taddei, K., Sohrabi, H., Zetterberg, H., Blennow, K., Teunissen, C., Vanderstichele, H., Martins, R. (2021). Plasma glial ﬁbrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease. Translational Psychiatry, 11(June 2021), Article number 27. https://doi.org/10.1038/s41398-020-01137-1.
Fine, L., Loft, S., Bucks, R., Parker, D., Laws, M., Olaithe, M., Pushpanathan, M., Rainey-Smith, S., Sohrabi, H., Martins, R., Weinborn, M. (2021). Improving prospective memory performance in community-dwelling older adults: Goal management training and implementation intentions. Experimental Aging Research, 47(5), 414-435. https://doi.org/10.1080/0361073X.2021.1876409.
Fowler, C., Rainey-Smith, S., Bird, S., Bomke, J., Bourgeat, P., Brown, B., Burnham, S., Bush, A., Chadunow, C., Collins, S., Doecke, J., Dore, V., Ellis, K., Evered, L., Fazlollahi, A., Fripp, J., Kirby, S., Gibson, S., Grenfell, R., Harrison, E., Head, R., Jin, L., Kamer, A., Lamb, F., Lautenschlager, N., Laws, S., Li, Q., Lim, L., Lim, Yy., Louey, A., Macaulay, L., Mackintosh, L., Martins, R., Maruff, P., Masters, C., McBride, S., Milicic, L., Peretti, M., Pertile, K., Porter, T., Radler, M., Rembach, A., Robertson, J., Rodriguez, M., Rowe, C., Rumble, R., Salvado, O., Savage, G., Silbert, B., Soh, M., Sohrabi, H., Taddei, K., Taddei, T., Thai, C., Trounson, B., Tyrell, R., Vacher, M., Varghese, S., Villemagne, V., Weinborn, M., Woodward, M., Xia, Y., Ames, D. (2021). Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer's disease. Journal of Alzheimer's Disease Reports, 5(1), 443-468. https://doi.org/10.3233/ADR-210005.
Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D. (2021). Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment. Journal of the International Neuropsychological Society, 27(2), 146-157. https://doi.org/10.1017/S135561772000079X.
Kirby, S., Weinborn, M., Sohrabi, H., Doecke, J., Bourgeat, P., Rainey-Smith, S., Shen, K., Fripp, J., Taddei, K., Maruff, P., Salvado, O., Savage, G., Ames, D., Masters, C., Rowe, C., Martins, R. (2021). Longitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults. Journal of Alzheimer's Disease, 81(3), 1039-1052. https://doi.org/10.3233/JAD-201243.
Brown, B., Frost, N., Rainey-Smith, S., Doecke, J., Markovic, S., Gordon, N., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Erickson, K., Peiffer, J. (2021). High intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial. Alzheimer's Research and Therapy, 13(December 2021), Article number 33. https://doi.org/10.1186/s13195-021-00774-y.
Fernandez, S., Burnham, S., Milicic, L., Savage, G., Maruff, P., Peretti, M., Sohrabi, H., Lam, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Porter, T., Laws, S. (2021). SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults. Journal of Alzheimer's Disease Reports, 5(1), 111-120. https://doi.org/10.3233/ADR-200246.
Moussavi Nik, S., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., Eccles, M., Woodfield, A., Groth, D., Dore, V., Villemagne, V., Masters, C., Martins, R., Laws, S., Lardelli, M., Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 Transcript to Alzheimer's disease and neurodegeneration. Journal of Alzheimer's Disease, 80(4), 1479-1489. https://doi.org/10.3233/jad-201133.
Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2021). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 159(2), 389-402. https://doi.org/10.1111/jnc.15128.
Van Der Kall, L., Truong, T., Burnham, S., Dore, V., Mulligan, R., Bozinovski, S., Lamb, F., Bourgeat, P., Fripp, J., Schultz, S., Lim, Y., Laws, S., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Maruff, P., Masters, C., Villemagne, V., Rowe, C. (2021). Association of β-amyloid level, clinical progression and longitudinal cognitive change in normal older individuals. Neurology, 96(5), e662 - e670. https://doi.org/10.1212/WNL.0000000000011222.
Roe, J., Vidal-Piñeiro, D., Sørensen, ., Brandmaier, A., Düzel, S., Gonzalez, H., Kievit, R., Knights, E., Kühn, S., Lindenberger, U., Mowinckel, A., Nyberg, L., Park, D., Pudas, S., Rundle, M., Walhovd, K., Fjell, A., Westerhausen, R., Masters, C., Bush, A., Fowler, C., Darby, D., Pertile, K., Restrepo, C., Roberts, B., Robertson, J., Rumble, R., Ryan, T., Collins, S., Thai, C., Trounson, B., Lennon, K., Li, Q., Ugarte, F., Volitakis, I., Vovos, M., Williams, R., Baker, J., Russell, A., Peretti, M., Milicic, L., Lim, L., Rodrigues, M., Taddei, K., Taddei, T., Hone, E., Lim, F., Fernandez, S., Rainey-Smith, S., Pedrini, S., Martins, R., Doecke, J., Bourgeat, P., Fripp, J., Gibson, S., Leroux, H., Hanson, D., Dore, V., Zhang, P., Burnham, S., Rowe, C., Villemagne, V., Yates, P., Pejoska, S., Jones, G., Ames, D., Cyarto, E., Lautenschlager, N., Barnham, K., Cheng, L., Hill, A., Killeen, N., Maruff, P., Silbert, B., Brown, B., Sohrabi, H., Savage, G., Vacher, M. (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications, 12(1), Article number 721. https://doi.org/10.1038/s41467-021-21057-y.

2020

Journal Articles

Kivipelto, M., Mangialasche, F., Snyder, H., Allegri, R., Andrieu, S., Arai, H., Baker, L., Belleville, S., Brodaty, H., Brucki, S., Calandri, I., Caramelli, P., Chen, C., Chertkow, H., Chew, E., Choi, S., Chowdhary, N., Crivelli, L., De La Torre, R., Du, Y., Dua, T., Espeland, M., Feldman, H., Hartmanis, M., Hartmann, T., Heffernan, M., Henry, C., Hong, C., Håkansson, K., Iwatsubo, T., Jeong, J., Jimenez-Maggiora, G., Koo, E., Launer, L., Lehtisalo, J., Lopera, F., Martínez-Lage, P., Martins, R., Middleton, L., Molinuevo, J., Montero-Odasso, M., Moon, S., Morales-Pérez, K., Nitrini, R., Nygaard, H., Park, Y., Peltonen, M., Qiu, C., Quiroz, Y., Raman, R., Rao, N., Ravindranath, V., Rosenberg, A., Sakurai, T., Salinas, R., Scheltens, P., Sevlever, G., Soininen, H., Sosa, A., Suemoto, C., Tainta-Cuezva, M., Velilla, L., Wang, Y., Whitmer, R., Xu, X., Bain, L., Solomon, A., Ngandu, T., Carrillo, M. (2020). World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimer's and Dementia, 16(7), 1078-1094. https://doi.org/10.1002/alz.12123.
Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
Shen, K., Welton, T., Lyon, M., McCorkindale, A., Sutherland, G., Burnham, S., Fripp, J., Martins, R., Grieve, S. (2020). Structural core of the executive control network: A high angular resolution diffusion MRI study. Human Brain Mapping, 41(5), 1226-1236. https://doi.org/10.1002/hbm.24870.
Bharadwaj, P., Martins, R. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-B Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease, 74(2), 441-448. https://doi.org/10.3233/JAD-190948.
Sohrabi, H., Goozee, K., Weinborn, M., Shen, K., Brown, B., Rainey-Smith, S., Salvado, O., Taddei, K., Bucks, R., Maruff, P., Laws, S., Lenzo, N., Laws, M., Deyoung, C., Speelman, C., Laske, C., Ames, D., Savage, G., Martins, R. (2020). Personality factors and cerebral glucose metabolism in community‑dwelling older adults. Brain Structure and Function, 225(5), 1511–1522. https://doi.org/10.1007/s00429-020-02071-0.
Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Shen, K., Asih, P., Dave, P., Pedrini, S., Ashton, N., Hye, A., Taddei, K., Lovejoy, D., Zetterberg, H., Blennow, K., Martins, R. (2020). Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(1), 291-301. https://doi.org/10.3233/JAD-200162.
Jayakody, D., Menegola, H., Yiannos, J., Goodman-Simpson, J., Friedland, P., Taddei, K., Laws, S., Weinborn, M., Martins, R., Sohrabi, H. (2020). The peripheral hearing and Central Auditory Processing skills of individuals with subjective memory complaints. Frontiers in Neuroscience, 14(21 August 2020), Article 888. https://doi.org/10.3389/fnins.2020.00888.
Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.
Dhiman, K., Gupta, V., Villemagne, V., Eratne, D., Graham, P., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Bush, A., Rowe, C., Masters, C., Ames, D., Hone, E., Blennow, K., Zetterberg, H., Martins, R. (2020). Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer’s disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 12(1), Article number e12005. https://doi.org/10.1002/dad2.12005.
Arnold, M., Nho, K., Kueder-Paisley, A., Massaro, T., Huynh, K., Brauner, B., Mahmoudian Dehkordi, S., Louie, G., Moseley, M., Thompson, JW., St John-Williams, L., Tenenbaum, J., Blach, C., Chang, R., Brinton, R., Baillie, R., Han, X., Trojanowski, J., Shaw, L., Martins, R., Weiner, M., Trushina, E., Toledo, J., Meikle, P., Bennett, D., Krumsiek, J., Murali Doraiswamy, P., Saykin, A., Kaddurah-Daok, R., Kastenmuller, G. (2020). Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome. Nature Communications, 11(1), Article number 1148. https://doi.org/10.1038/s41467-020-14959-w.
Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P., Doecke, J., Ames, D., Laws, S., Fowler, C., Rainey-Smith, S., Martins, R., Maruff, P., Villemagne, V., Masters, C., Rowe, C., Fripp, J., Salvado, O. (2020). Comorbidity of Cerebrovascular and Alzheimer’s Disease in Aging. Journal of Alzheimer's Disease, 78(1), 321-334. https://doi.org/10.3233/JAD-200419.
Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Martins, R., Peiffer, J. (2020). An intense, but ecologically valid, resistance exercise session does not alter growth factors associated with cognitive health. Journal of Aging and Physical Activity, 28(4), 605-612. https://doi.org/10.1123/japa.2019-0100.
Kirby, S., Lyons-Wall, P., Martins, R., Rainey-Smith, S. (2020). Validation and Reliability of the Alzheimer’s Disease-Commonwealth Scientific and Industrial Research Organisation Food Frequency Questionnaire. Nutrients, 12(12), Article number 3605. https://doi.org/10.3390/nu12123605.
Thota, R., Rosato, J., Burrows, T., Dias, C., Abbott, K., Martins, R., Garg, M. (2020). Docosahexaenoic acid-rich fish oil supplementation reduces kinase associated with insulin resistance in overweight and obese midlife adults. Nutrients, 12(6), Article 1612. https://doi.org/10.3390/nu12061612.
Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R. (2020). Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733. https://doi.org/10.3233/JAD-191033.
Krishnan, S., Shrestha, Y., Jayatunga, P., Rea, S., Martins, R., Bharadwaj, P. (2020). Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease. International Journal of Molecular Sciences, 21(18), Article number 6739. https://doi.org/10.3390/ijms21186739.
Siddiqui, M., Francois, M., Rainey-Smith, S., Martins, R., Masters, C., Ames, D., Rowe, C., Macaulay, L., Fenech, M., Leifert, W. (2020). Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. Life, 10(8), Article number 141. https://doi.org/10.3390/life10080141.
Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P. (2020). Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356. https://doi.org/10.1038/s41598-020-66602-9.
Lim, B., Fowler, C., Li, Q., Rowe, C., Dhiman, K., Gupta, V., Masters, C., Doecke, J., Martins, R., Collins, S., Diamandi, E. (2020). Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer’s disease. Neuroscience Letters, 731(13 July 2020), Article number 135078. https://doi.org/10.1016/j.neulet.2020.135078.
Jayakody, D., Tarawneh, H., Menegola, H., Yiannos, J., Friedland, P., Wilson, W., Martins, R., Sohrabi, H. (2020). Systematic review protocol for assessing central auditory functions of Alzheimer's disease and its preclinical stages. BMJ Open, 10(6), Article number e033342. https://doi.org/10.1136/bmjopen-2019-033342.
Lai, M., Sharman, M., Ames, D., Ellis, K., Cox, K., Hepworth, G., Desmond, P., Cyarto, E., Martins, R., Masters, C., Lautenschlager, N. (2020). Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration. Journal of Alzheimer's Disease, 74(1), 163-171. https://doi.org/10.3233/JAD-190953.
Yassi, N., Hilal, S., Xia, Y., Lim, YY., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P., Masters, C. (2020). Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease. Journal of Alzheimer's Disease, 73(3), 897-907. https://doi.org/10.3233/JAD-191028.
Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.
Ashraf, A., Ashton, N., Chatterjee, P., Goozee, K., Shen, K., Fripp, J., Ames, D., Rowe, C., Masters, C., Villemagne, V., Hye, A., Martins, R., So, P. (2020). Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology. Alzheimer's Research and Therapy, 12(June 2020), Article number 72. https://doi.org/10.1186/s13195-020-00634-1.
Doecke, J., Ward, L., Burnham, S., Villemagne, V., Li, Q., Collins, S., Fowler, C., Manuilova, E., Widmann, M., Rainey-Smith, S., Martins, R., Masters, C. (2020). Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid- PET imaging. Alzheimer's Research and Therapy, 12(March 2020), Article number 36. https://doi.org/10.1186/s13195-020-00595-5.
Bharadwaj, P., Martins, R. (2020). Autophagy modulates Aβ accumulation and formation of aggregates in yeast. Molecular and Cellular Neuroscience, 104(April 2020), Article 103466. https://doi.org/10.1016/j.mcn.2020.103466.
Thota, R., Rosato, J., Dias, C., Burrows, T., Martins, R., Garg, M. (2020). Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease. Nutrients, 12(4), Article number 1032. https://doi.org/10.3390/nu12041032.
Bharadwaj, P., Martins, R. (2020). A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast. Neural Regeneration Research, 15(10), 1931-1936. https://doi.org/10.4103/1673-5374.280318.
Tarawneh, H., Mulders, W., Sohrabi, H., Martins, R., Jayakody, D. (2020). Auditory electrophysiological assessments of Alzheimer’s disease and preclinical stages: protocol for a systematic review and meta-analysis. BMJ Open, 10(7), e033308. https://doi.org/10.1136/bmjopen-2019-033308.
Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R. (2020). Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315. https://doi.org/10.3233/JAD-191304.
Barthelemy, N., Li, Y., Joseph-Marthurin, N., Gordon, B., Hassenstab, J., Benzinger, T., Buckles, V., Fagan, A., Perrin, R., Goate, A., Morris, J., Karch, C., Xiong, C., Allegri, R., Mendez, P., Berman, S., Ikeuchi, T., Mori, H., Shimada, H., Shoji, M., Suzuki, K., Noble, J., Farlow, M., Chhatwal, J., Graff-Radford, N., Salloway, S., Schofield, P., Masters, C., Martins, R., O'Connor, A., Fox, N., Levin, J., Jucker, M., Gabelle, A., Lehmann, S., Sato, C., Bateman, R., McDade, E. (2020). A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine, 26(3), 398-407. https://doi.org/10.1038/s41591-020-0781-z.
Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.
Chatterjee, P., Fernando, M., Fernando, B., Dias, C., Shah, T., Silva, R., Williams, S., Pedrini, S., Hillebrandt, H., Goozee, K., Barin, E., Sohrabi, H., Garg, M., Cunnane, S., Martins, R. (2020). Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development, 186(March 2020), Article number 111209. https://doi.org/10.1016/j.mad.2020.111209.
Brini, S., Sohrabi, H., Hebert, J., Forrest, M., Laine, M., Hamalainen, H., Karrasch, M., Peiffer, J., Martins, R., Fairchild, T. (2020). Bilingualism Is Associated with a Delayed Onset of Dementia but Not with a Lower Risk of Developing it: a Systematic Review with Meta-Analyses. Neuropsychology Review, 30(1), 1-24. https://doi.org/10.1007/s11065-020-09426-8.
Lai, M., Ames, D., Cox, K., Ellis, K., Sharman, M., Hepworth, G., Desmond, P., Cyarto, E., Szoeke, C., Martins, R., Masters, C., Lautenschlager, N. (2020). Association between cognitive function and clustered cardiovascular risk of metabolic syndrome in older adults at risk of cognitive decline. Journal of Nutrition, Health and Aging, 24(3), 300-304. https://doi.org/10.1007/s12603-020-1333-4.
Aschenbrenner, A., James, B., McDade, E., Wang, G., Lim, YY., Benzinger, T., Cruchaga, C., Goate, A., Xiong, C., Perrin, R., Buckles, V., Allegri, R., Berman, S., Chhatwal, J., Fagan, A., Farlow, M., O'Connor, A., Ghetti, B., Graff-Radford, N., Goldman, J., Gräber, S., Karch, C., Lee, J., Levin, J., Martins, R., Masters, C., Mori, H., Noble, J., Salloway, S., Schofield, P., Morris, J., Bateman, R., Hassenstab, J. (2020). Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's and Dementia, 16(1), 219-228. https://doi.org/10.1002/alz.12010.
Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(1), Article number 5698. https://doi.org/10.1038/s41467-020-19473-7.

2019

Journal Articles

Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.
Chatterjee, P., Elmi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Pedrini, S., Shen, K., Asih, P., Dave, P., Taddei, K., Vanderstichele, H., Zetterberg, H., Blennow, K., Martins, R. (2019). Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 71(3), 775-783. https://doi.org/10.3233/JAD-190533.
Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A. (2019). A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220. https://doi.org/10.1126/sciadv.aau7220.
Moshfegh, A., Javadzadegan, A., Mohammadi, M., Ravipudi, L., Cheng, S., Martins, R. (2019). Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner. Computers in Biology and Medicine, 108(May 2019), 111-121. https://doi.org/10.1016/j.compbiomed.2019.03.008.
Tan, J., Iyer, K., Tang, A., Jamil, A., Martins, R., Sohrabi, H., Nitsche, M., Hinder, M., Fujiyama, H. (2019). Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review. NeuroImage, 185(15 January 2019), 490-512. https://doi.org/10.1016/j.neuroimage.2018.10.044.
Fine, L., Weinborn, M., Ng, A., Loft, S., Li, Y., Hodgson, E., Parker, D., Rainey-Smith, S., Sohrabi, H., Brown, B., Martins, R., Bucks, R. (2019). Sleep disruption explains age-related prospective memory deficits: implications for cognitive aging and intervention. Aging, Neuropsychology and Cognition: A Journal on Normal and Dysfunctional Development, 26(4), 621-636. https://doi.org/10.1080/13825585.2018.1513449.
Preische, O., Schultz, S., Apel, A., Kuhle, J., Kaeser, S., Barro, C., Gräber, S., Kuder-Buletta, E., Lafougere, C., Laske, C., Vöglein, J., Levin, J., Masters, C., Martins, R., Schofield, P., Rossor, M., Graff-Radford, N., Salloway, S., Ghetti, B., Ringman, J., Noble, J., Chhatwal, J., Goate, A., Benzinger, T., Morris, J., Bateman, R., Wang, G., Fagan, A., McDade, E., Gordon, B., Jucker, M. (2019). Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. Nature Medicine, 25(2), 277-283. https://doi.org/10.1038/s41591-018-0304-3.
Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Laws, S., Martins, R., Peiffer, J. (2019). Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized‑controlled trial. European Journal of Applied Physiology, 119(10), 2167-2176. https://doi.org/10.1007/s00421-019-04202-w.
Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T. (2019). Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(1), 740-750. https://doi.org/10.1016/j.trci.2019.09.015.
Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
Nasef, N., Loveday, S., Golding, M., Martins, R., Shah, T., Clarke, M., Coad, J., Moughan, P., Garg, M., Singh, H. (2019). Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans. Food and Function, 10(8), 4584-4592. https://doi.org/10.1039/c9fo01063g.
Marston, K., Peiffer, J., Rainey-Smith, S., Gordon, N., Teo, S., Laws, S., Sohrabi, H., Martins, R., Brown, B. (2019). Resistance training enhances delayed memory in healthy middle-aged and older adults: A randomised controlled trial. Journal of Science and Medicine in Sport, 22(11), 1226-1231. https://doi.org/10.1016/j.jsams.2019.06.013.
Jacobs, K., Lim, C., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R., Brew, B., Guillemin, G., Lovejoy, D. (2019). Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-b and tau. Neurobiology of Aging, 80(August 2019), 11-20. https://doi.org/10.1016/j.neurobiolaging.2019.03.015.
Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., Bharadwaj, P. (2019). Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24(18), Article 3372. https://doi.org/10.3390/molecules24183372.
Dhiman, K., Blennow, K., Zetterberg, H., Martins, R., Gupta, V. (2019). Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis. Cellular and Molecular Life Sciences, 76(10), 1833-1863. https://doi.org/10.1007/s00018-019-03040-5.
Sohrabi, H., Weinborn, M., Laske, C., Bates, K., Christensen, D., Taddei, K., Rainey-Smith, S., Brown, B., Kirby, S., Laws, S., Martins, G., Burnham, S., Bucks, R., Reisberg, B., Lautenschlager, N., Foster, J., Martins, R. (2019). Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, 31(4), 513-525. https://doi.org/10.1017/S1041610218001072.
Brown, B., Castalanelli, N., Rainey-Smith, S., Doecke, J., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Peiffer, J. (2019). Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. Behavioural Brain Research, 362(19 April 2019), 103-108. https://doi.org/10.1016/j.bbr.2019.01.013.
Frost, N., Weinborn, M., Gignac, G., Markovic, S., Rainey-Smith, S., Sohrabi, H., Martins, R., Peiffer, J., Brown, B. (2019). Higher cardiorespiratory fitness is associated with better verbal generativity in community-dwelling older adults. Journal of Aging and Physical Activity, 27(5), 703-710. https://doi.org/10.1123/japa.2018-0382.
Dube, U., Del-Aguila, J., Li, Z., Budde, J., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M., Farias, F., Norton, J., Gentsch, J., Wang, F., Allegri, R., Amtashar, F., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Buck, J., Buckles, V., Chea, S., Chrem, P., Chui, H., Cinco, J., Clifford, J., D’mello, M., Donahue, T., Douglas, J., Edigo, N., Erekin-Taner, N., Fagan, A., Farlow, M., Farrar, A., Feldman, H., Flynn, G., Fox, N., Franklin, E., Fujii, H., Gant, C., Kirby, S., Ghetti, B., Goate, A., Goldman, J., Gordon, B., Gray, J., Gurney, J., Hassenstab, J., Hirohara, M., Holtzman, D., Hornbeck, R., Dibari, S., Ikeuchi, T., Ikonomovic, S., Jerome, G., Jucker, M., Kasuga, K., Kawarabayashi, T., Klunk, W., Koeppe, R., Kuder-Buletta, E., Laske, C., Levin, J., Marcus, D., Martins, R., Mason, N., Maue-Dreyfus, D., McDade, E., Montoya, L., Mori, H., Nagamatsu, A., Neimeyer, K., Noble, J., Perrin, R., Raichle, M., Ringman, J., Roh, J., Schofield, P., Shimada, H., Shiroto, T., Shoji, M., Sigurdson, W., Sohrabi, H., Sparks, P., Suzuki, K., Swisher, L., Taddei, K., Wang, J., Wang, P., Weiner, M., Wolfsberger, M., Xiong, C., Xu, X., Salloway, S., Masters, C., Lee, J., Graff-Radford, N., Chhatwal, J., Bateman, R., Morris, J., Karch, C., Harari, O., Cruchaga, C. (2019). An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nature Neuroscience, 22(11), 1903-1912. https://doi.org/10.1038/s41593-019-0501-5.
Burnham, S., Coloma, P., Li, Q., Collins, S., Savage, G., Laws, S., Doecke, J., Maruff, P., Martins, R., Ames, D., Rowe, C., Masters, C., Villemagne, V. (2019). Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer’s Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study. Journal of Prevention of Alzheimer's Disease, 6(4), 248-255. https://doi.org/10.14283/jpad.2019.25.
Tripathi, T., Kalita, P., Martins, R., Bharadwaj, P. (2019). Autophagy promotes memory function. ACS Chemical Neuroscience, 10(8), 3337-3339. https://doi.org/10.1021/acschemneuro.9b00317.
Tan, S., Sohrabi, H., Weinborn, M., Tegg, M., Bucks, R., Taddei, K., Carruthers, M., Martins, R. (2019). Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials. American Journal of Geriatric Psychiatry, 27(11), 1232-1246. https://doi.org/10.1016/j.jagp.2019.05.008.
Schultz, A., Kloet, R., Sohrabi, H., Van Der Weerd, L., Van Rooden, S., Wermer, M., Moursel, L., Yaqub, M., Van Berckel, B., Chatterjee, P., Kirby, S., Taddei, K., Fagan, A., Benzinger, T., Morris, J., Sperling, R., Johnson, K., Bateman, R., Gurol, ME., Van Buchem, M., Martins, R., Chhatwal, J., Greenberg, S. (2019). Amyloid Imaging of Dutch-Type Hereditary Cerebral Amyloid Angiopathy Carriers. Annals of Neurology, 86(4), 616-625. https://doi.org/10.1002/ana.25560.
Babulal, G., Quiroz, Y., Albensi, B., Arenaza-Urquijo, E., Astell, A., Babiloni, C., Bahar-Fuchs, A., Bell, J., Bowman, G., Brickman, A., Chetelat, G., Ciro, C., Cohen, A., Dilworth-Anderson, P., Dodge, H., Dreux, S., Edland, S., Esbensen, A., Evered, L., Ewers, M., Fargo, K., Fortea, J., Gonzalez, H., Gustafson, D., Head, E., Hendrix, J., Hofer, S., Johnson, L., Jutten, R., Kilborn, K., Lanctot, K., Manly, J., Martins, R., Mielke, M., Morris, M., Murray, M., Oh, E., Parra, M., Rissman, R., Roe, C., Santos, O., Scarmeas, N., Schneider, L., Schupf, N., Sikkes, S., Snyder, H., Sohrabi, H., Stern, Y., Strydom, A., Tang, Y., Terrera, G., Teunissen, C., Van Lent, DM., Weinborn, M., Wesselman, L., Wilcock, D., Zetterberg, H., O’bryant, S. (2019). Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia, 15(2), 292-312. https://doi.org/10.1016/j.jalz.2018.09.009.
Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C., Jacobs, K., Ashton, N., Hye, A., Pedrini, S., Sohrabi, H., Shah, T., Asih, P., Dave, P., Shen, K., Taddei, K., Lovejoy, D., Guillemin, G., Blennow, K., Martins, R. (2019). Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease. Journal of Neuroinflammation, 16(2019), Article number 186. https://doi.org/10.1186/s12974-019-1567-4.
Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.
Sharman, M., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q., Wenk, M., Halliwell, B., Martins, R., Munch, G. (2019). Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?. Neurobiology of Disease, 124(April 2019), 505-519. https://doi.org/10.1016/j.nbd.2018.11.026.

2018

Journal Articles

Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
Jayakody, D., Friedland, PL., Eikelboom, RH., Martins, R., Sohrabi, H. (2018). A novel study on association between untreated hearing loss and cognitive functions of older adults: Baseline non-verbal cognitive assessment results. Clinical Otolaryngology, 43(1), 182-191. https://doi.org/10.1111/coa.12937.
Nakamura, A., Kaneko, N., Villemagne, V., Kato, T., Doecke, J., Dore, V., Fowler, C., Li, Q., Martins, R., Rowe, C., Tomita, T., Matsuzaki, K., Ishii, K., Ishii, K., Arahata, Y., Iwamoto, S., Ito, K., Tanaka, K., Masters, C., Yanagisawa, K. (2018). High performance plasma amyloid-β biomarkers for Alzheimer’s disease. Nature, 554(7691), 249-254. https://doi.org/10.1038/nature25456.
McCabe, K., Woods, S., Weinborn, M., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Taddei, K., Martins, R. (2018). Personality characteristics are independently associated with prospective memory in the laboratory, and in daily Life, among older adults. Journal of Research in Personality, 76(Oct 2018), 32-37. https://doi.org/10.1016/j.jrp.2018.06.006.
Brini, S., Sohrabi, H., Peiffer, J., Karrasch, M., Hamalainen, H., Martins, R., Fairchild, TJ. (2018). Physical activity in preventing Alzheimer's disease and cognitive decline: A narrative review. Sports Medicine, 48(1), 29-44. https://doi.org/10.1007/s40279-017-0787-y.
Holmes, SE., Esterlis, I., Mazure, CM., Lim, YY., Ames, D., Rainey-Smith, S., Fowler, C., Ellis, K., Martins, R., Salvado, O., Doré, V., Villemagne, VL., Rowe, CC., Laws, S., Masters, CL., Pietrzak, RH., Maruff, P. (2018). Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study. International Journal of Geriatric Psychiatry, 33(2), 405-413. https://doi.org/10.1002/gps.4761.
Kinnunen, KM., Cash, DM., Poole, T., Frost, C., Benzinger, TL., Ahsan, RL., Leung, KK., Cardoso, ML., Modat, M., Malone, IB., Morris, JC., Bateman, RJ., Marcus, DS., Goate, A., Salloway, SP., Correia, S., Sperling, RA., Chhatwal, J., Mayeux, R., Brickman, A., Martins, R., Farlow, M., Ghetti, B., Saykin, A., Jack, C., Schofield, P., McDade, E., Weiner, M., Ringman, J., Thompson, P., Masters, C., Rowe, C., Rossor, M., Ourselin, S., Fox, N. (2018). Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimer's and Dementia, 14(1), 43-53. https://doi.org/10.1016/j.jalz.2017.06.2268.
Lan, J., Galindo, A., Doecke, J., Fowler, C., Martins, R., Rainey-Smith, S., Cominetti, O., Dayon, L. (2018). Systematic Evaluation of the Use of Human Plasma and Serum for Mass-Spectrometry-Based Shotgun Proteomics. Journal of Proteome Research, 17(4), 1426-1435. https://doi.org/10.1021/acs.jproteome.7b00788.
Elaskalani, O., Khan, I., Morici, M., Matthysen, C., Sabale, M., Martins, R., Verdile, G., Metharom, P. (2018). Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. Platelets (London), 29(4), 415-420. https://doi.org/10.1080/09537104.2017.1401057.
Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R. (2018). Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651. https://doi.org/10.1016/j.bbamem.2018.03.015.
Jayakody, D., Friedland, P., Martins, R., Sohrabi, H. (2018). Impact of aging on the auditory system and related cognitive functions: A narrative review. Frontiers in Neuroscience, 12(MAR), Article no.125. https://doi.org/10.3389/fnins.2018.00125.
Rainey-Smith, S., Gu, Y., Kirby, S., Doecke, J., Villemagne, V., Brown, B., Taddei, K., Laws, S., Sohrabi, H., Weinborn, M., Ames, D., Fowler, C., Macaulay, SL., Maruff, P., Masters, C., Salvado, O., Rowe, C., Scarmeas, N., Martins, R. (2018). Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(2018), Article Number: 238. https://doi.org/10.1038/s41398-018-0293-5.
Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Manyan, C., Taddei, K., Ayton, S., Garg, M., Kwok, J., Bush, A., Chung, R., Magnussen, J., Martins, R. (2018). Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load. Molecular Psychiatry, 23(8), 1807-1812. https://doi.org/10.1038/mp.2017.146.
Doecke, J., Rembach, A., Villemagne, V., Varghesi, S., Rainey-Smith, S., Sarros, S., Evered, L., Fowler, C., Pertile, K., Rumble, R., Trounson, B., Taddei, K., Laws, S., Macaulay, SL., Bush, A., Ellis, K., Martins, R., Ames, D., Silbert, B., Vanderstichele, H., Masters, C., Darby, D., Li, Q., Collins, S. (2018). Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms. Journal of Alzheimer's Disease, 61(1), 169-183. https://doi.org/10.3233/JAD-170128.
Perin, S., Harrington, K., Lim, YY., Ellis, K., Ames, D., Pietrzak, R., Schembri, A., Rainey-Smith, S., Salvado, O., Laws, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2018). Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. Journal of Affective Disorders, 229(15 March 2018), 269-274. https://doi.org/10.1016/j.jad.2017.12.101.
Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V. (2018). Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's Disease, 63(4), 1299-1305. https://doi.org/10.3233/JAD-170998.
Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.
Lee, S., Zimmerman, M., Narkhede, A., Nasrabady, S., Tosto, G., Meier, I., Benzinger, T., Marcus, D., Fagan, A., Fox, N., Cairns, N., Holtzmann, D., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, A., Masters, C., Ringman, J., Forster, S., Schofield, P., Sperling, R., Johnson, K., Chhatwal, J., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, J., Mayeux, R., Brickman, A. (2018). White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One, 13(5), Article number e0195838. https://doi.org/10.1371/journal.pone.0195838.
Khan, I., Krishnaswamy, S., Sabale, M., Groth, D., Wijaya, L., Morici, M., Berger, I., Schaffitzel, C., Fraser, P., Martins, R., Verdile, G. (2018). Efficient production of a mature and functional gamma secretase protease. Scientific Reports, 8(1), Article no. 12834. https://doi.org/10.1038/s41598-018-30788-w.
Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Gozt, O., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R. (2018). Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study. Psychological Assessment, 30(10), 1308-1316. https://doi.org/10.1037/pas0000565.
Fernando, B., Rainey-Smith, S., Kirby, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R. (2018). Associations of dietary protein and fiber intake with brain and blood amyloid-β. Journal of Alzheimer's Disease, 61(4), 1589-1598. https://doi.org/10.3233/JAD-170742.
Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.
Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
Chhatwal, J., Schultz, A., Johnson, K., Hedden, T., James, S., Benzinger, T., Jack, C., Ances, B., Ringman, J., Marcus, D., Ghetti, B., Farlow, M., Danek, A., Levin, J., Yakushev, I., Laske, C., Koeppe, R., Galasko, D., Xiong, C., Masters, C., Schofield, P., Kinnunen, K., Salloway, S., Martins, R., McDade, E., Cairns, N., Buckles, V., Morris, J., Bateman, R., Sperling, R. (2018). Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain: a journal of neurology, 141(5), 1486-1500. https://doi.org/10.1093/brain/awy053.
Chatterjee, P., Goozee, K., Lim, CK., James, I., Shen, K., Jacobs, K., Sohrabi, H., Shah, T., Asih, P., Dave, P., Manyan, C., Taddei, K., Lovejoy, D., Chung, R., Guillemin, G., Martins, R. (2018). Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-B load: A pilot study. Scientific Reports, 8(2018), Article no. 8008. https://doi.org/10.1038/s41598-018-25968-7.
Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Fox, N., Levin, J., Danek, A., Voglein, J., Salloway, S., Xiong, C., Benzingers, T., Buckless, V., Masters, C., Sperling, R., Bateman, R., Morriss, J., Laske, C. (2018). Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's and Dementia, 14(11), 1427-1437. https://doi.org/10.1016/j.jalz.2018.06.3059.
Chatterjee, P., Goozee, K., Sohrabi, H., Shen, K., Shah, T., Asih, P., Dave, P., Man Yan, C., Taddei, K., Chung, R., Zetterberg, H., Blennow, K., Martins, R. (2018). Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants. Journal of Alzheimer's Disease, 63(2), 479-487. https://doi.org/10.3233/JAD-180025.
Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D. (2018). Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years. Alzheimer Disease and Associated Disorders, 32(3), 190-196. https://doi.org/10.1097/WAD.0000000000000252.
Lim, YY., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., Rowe, C., Masters, C., Maruff, P. (2018). Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA Neurology, 75(4), 488-494. https://doi.org/10.1001/jamaneurol.2017.4325.

2017

Book Chapters

Shah, T., Martins, R. (2017). Synergistic effects of combined physical activity and brain training on neurological functions. Physical activity and the aging brain: Effects of exercise on neurological function (175-184). Elsevier. https://doi.org/10.1016/B978-0-12-805094-1.00017-4.

Journal Articles

Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., Martins, R. (2017). Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252. https://doi.org/10.1080/00207454.2016.1182527.
Cardoso, B., Hare, D., Bush, A., Li, Q., Fowler, C., Masters, C., Martins, R., Ganio, K., Lothian, A., Mukherjee, S., Kapp, E., Roberts, B. (2017). Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Journal of Alzheimer's Disease, 57(1), 183-193. https://doi.org/10.3233/JAD-160622.
Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.
Mirmosayyeb, O., Tanhaei, A., Sohrabi, H., Martins, R., Tanhaei, M., Najafi, MA., Safaei, A., Meamar, R. (2017). Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease. International Journal of Preventive Medicine, 8(1), article no. 5. https://doi.org/10.4103/2008-7802.199640.
Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Martins, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Dore, V., Villemagne, V., Snyder, P., Masters, C., Maruff, P. (2017). Amyloid β–associated cognitive decline in the absence of clinical disease progression and systemic illness. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(1), 156-164. https://doi.org/10.1016/j.dadm.2017.05.006.
Lim, YY., Williamson, R., Laws, S., Villemagne, V., Bourgeat, P., Fowler, C., Rainey-Smith, S., Salvado, O., Martins, R., Rowe, C., Masters, C., Maruff, P. (2017). Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. Journal of Alzheimer's Disease, 58(4), 1293-1302. https://doi.org/10.3233/JAD-170072.
Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Dietzsch, J., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Graff-Radford, N., Levin, J., Galasko, D., Quaid, K., Salloway, S., Xiong, C., Benzinger, T., Buckles, V., Masters, C., Sperling, R., Bateman, R., Morris, J., Laske, C. (2017). Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease. Scientific Reports, 7(1), Article number 1225. https://doi.org/10.1038/s41598-017-01327-w.
O'Bryan, S., Mielke, M., Rissman, R., Lista, S., Vanderstichele, H., Zetterberg, H., Lewczuk, P., Posner, H., Hall, J., Johnson, L., Fong, Y., Luthman, J., Jeromin, A., Batrla-Utermann, R., Villarreal, A., Britton, G., Snyder, P., Henriksen, K., Grammas, P., Gupta, V., Martins, R., Hampel, H. (2017). Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimer's and Dementia, 13(1), 45-58. https://doi.org/10.1016/j.jalz.2016.09.014.
Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057. https://doi.org/10.1038/s41598-017-14020-9.
Harrington, K., Gould, E., Lim, Y., Ames, D., Pietrzak, R., Rembach, A., Rainey-Smith, S., Martins, R., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2017). Amyloid burden and incident depressive symptoms in cognitively normal older adults. International Journal of Geriatric Psychiatry, 32(4), 455-463. https://doi.org/10.1002/gps.4489.
Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R. (2017). Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80. https://doi.org/10.1007/s11065-016-9338-9.
Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R. (2017). Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72. https://doi.org/10.1016/j.dadm.2017.04.003.
Fernando, B., Somaratne, G., Goozee, K., Williams, S., Singh, H., Martins, R. (2017). Diabetes and Alzheimer's disease: Can tea phytochemicals play a role in prevention?. Journal of Alzheimer's Disease, 59(2), 481-501. https://doi.org/10.3233/JAD-161200.
Cerin, E., Rainey-Smith, S., Ames, D., Lautenschlager, N., Macaulay, S., Fowler, C., Robertson, J., Rowe, C., Maruff, P., Martins, R., Masters, C., Ellis, K. (2017). Associations of neighbourhood environment with brain imaging outcomes in the AIBL cohort. Alzheimer's and Dementia, 13(4), 388-398. https://doi.org/10.1016/j.jalz.2016.06.2364.
Kirby, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R. (2017). Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201. https://doi.org/10.3233/JAD-161158.
Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.
Golzan, SM., Goozee, K., Georgevsky, D., Avolio, A., Chatterjee, P., Shen, K., Gupta, V., Chung, R., Savage, G., Orr, C., Martins, R., Graham, S. (2017). Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease. Alzheimer's Research and Therapy, 9(1), Article number 13. https://doi.org/10.1186/s13195-017-0239-9.
Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Ball, B., Manyan, C., Taddei, K., Chung, R., Garg, M., Martins, R. (2017). Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease. Scientific Reports, 7(1), Article number 676. https://doi.org/10.1038/s41598-017-00751-2.
Shah, T., Gupta, S., Chatterjee, P., Campbell, M., Martins, R. (2017). Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease. Molecular Psychiatry, 22(3), 353-363. https://doi.org/10.1038/mp.2016.251.
Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R. (2017). Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466. https://doi.org/10.3233/JAD-161259.
Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, JJ. (2017). Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 3(4), 562-570. https://doi.org/10.1016/j.trci.2017.09.003.
Brown, B., Sohrabi, H., Taddei, K., Kirby, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickson, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R. (2017). Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimer's and Dementia, 13(11), 1197-1206. https://doi.org/10.1016/j.jalz.2017.03.008.
Huynh, K., Martins, R., Meikle, P. (2017). Lipidomic profiles in Diabetes and Dementia. Journal of Alzheimer's Disease, 59(2), 433-444. https://doi.org/10.3233/JAD-161215.
Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J. (2017). Intense resistance exercise increases peripheral brain-derived neurotrophic factor. Journal of Science and Medicine in Sport, 20(10), 899-903. https://doi.org/10.1016/j.jsams.2017.03.015.
Frost, S., Bhuiyan, A., Offerman, D., Doecke, J., Macaulay, S., Sohrabi, H., Ames, D., Masters, C., Martins, R., Kanagasingam, Y. (2017). Modulation of retinal arteriolar central reflection by APOE genotype. Current Alzheimer Research, 14(9), 916-923. https://doi.org/10.2174/1567205014666170309115016.
Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK. (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685. https://doi.org/10.1038/s41598-017-12858-7.
Frost, S., Robinson, L., Rowe, C., Ames, D., Masters, C., Taddei, K., Rainey-Smith, S., Martins, R., Kanagasingam, Y. (2017). Evaluation of cholinergic deficiency in preclinical Alzheimer's disease using pupillometry. Journal of Ophthalmology, 2017(August 2017), Article no. 7935406. https://doi.org/10.1155/2017/7935406.
Jayakody, D., Friedland, P., Nel, E., Martins, R., Atlas, M., Sohrabi, H. (2017). Impact of cochlear implantation on cognitive function of older adults: Pilot test results. Otology and Neurotology: an international forum, 38(8), e289-e295. https://doi.org/10.1097/MAO.0000000000001502.
Peters, K., Davis, W., Taddei, K., Martins, R., Masters, C., Davis, T., Bruce, D. (2017). Plasma amyloid-β Peptides in Type 2 Diabetes: A matched case-control study. Journal of Alzheimer's Disease, 56(3), 1127-1133. https://doi.org/10.3233/JAD-161050.

2016

Journal Articles

Lee, S., Viqar, F., Zimmerman, ME., Narkhede, A., Tosto, G., Benzinger, T., Marcus, DS., Fagan, A., Goate, A., Fox, N., Cairns, N., Holtzman, DM., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, AJ., Masters, C., Ringman, JM., Ryan, NS., Forster, S., Laske, C., Schofield, PR., Sperling, RA., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, JC., Mayeux, R., Brickman, A. (2016). White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. Annals of Neurology, 79(6), 929-939. https://doi.org/10.1002/ana.24647.
Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P. (2016). Aβ-related memory decline in APOE ε4 non-carriers: Implications for Alzheimer’s disease. Neurology, 86(17), 1635-1642. https://doi.org/10.1212/WNL.0000000000002604.
O'Bryant, S., Lista, S., Rissman, R., Edwards, M., Zhang, F., Hall, J., Zetterberg, H., Lovestone, S., Gupta, V., Graff-Radford, N., Martins, R., Jeromin, A., Waring, S., Oh, E., Kling, M., Baker, L., Hampel, H. (2016). Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 27-34. https://doi.org/10.1016/j.dadm.2015.12.003.
Kirby, S., Rainey-Smith, S., Martins, R. (2016). Diet and Inflammation in Alzheimer's Disease and Related Chronic Diseases: A Review. Journal of Alzheimer's Disease, 50(2), 301-334. https://doi.org/10.3233/JAD-150765.
Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.
Frost, S., Guymer, R., Aung, K., Macaulay, S., Sohrabi, H., Bourgeat, P., Salvado, O., Rowe, C., Ames, D., Masters, C., Martins, R., Kanagasingam, Y. (2016). Alzheimer's disease and the early signs of age-related macular degeneration. Current Alzheimer Research, 13(11), 1259-1266. https://doi.org/10.2174/1567205013666160603003800.
Burnham, S., Rowe, C., Baker, D., Bush, A., Doecke, JD., Faux, N., Laws, S., Martins, R., Maruff, P., Macaulay, S., Rainey-Smith, S., Savage, G., Ames, D., Masters, C., Wilson, W., Villemagne, V. (2016). Predicting Alzheimer disease from a blood-based biomarker profile. Neurology, 87(11), 1093-1101. https://doi.org/10.1212/WNL.0000000000003094.
Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R. (2016). Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559. https://doi.org/10.1074/jbc.M115.679993.
Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V. (2016). Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, 15(10), 1044-1053. https://doi.org/10.1016/S1474-4422(16)30125-9.
Kirby, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R. (2016). Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672. https://doi.org/10.3233/JAD-151084.
Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R. (2016). Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465. https://doi.org/10.1017/S0007114515004687.
Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068. https://doi.org/10.5665/sleep.5756.
Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R. (2016). Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228. https://doi.org/10.1016/j.neubiorev.2016.01.004.
Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R. (2016). Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894. https://doi.org/10.3233/JAD-150948.
Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R. (2016). Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. The British Journal of Nutrition: an international journal of nutritional science, 115(12), 2106-2113. https://doi.org/10.1017/S0007114516001203.
Zwan, MD., Villemagne, VL., Doré, V., Buckley, R., Bourgeat, P., Veljanoski, R., Salvado, O., Williams, R., Margison, L., Rembach, A., Macaulay, SL., Martins, R., Ames, D., Van Der Flier, WM., Ellis, KA., Scheltens, P., Masters, C., Rowe, C. (2016). Subjective memory complaints in APOE e4 carriers are associated with high Amyloid-ß Burden. Journal of Alzheimer's Disease, 49(4), 1115-1122. https://doi.org/10.3233/JAD-150446.
Lim, YY., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., Salvado, O., Rowe, C., Masters, C., Maruff, P. (2016). Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, 60(3), 362-370. https://doi.org/10.1007/s12031-016-0822-8.
Muenchhoff, J., Poljak, A., Thalamuthu, A., Gupta, V., Chatterjee, P., Raffery, M., Masters, C., Morris, J., Bateman, J., Fagan, A., Martins, R., Sachdev, P. (2016). Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease. Scientific Reports, 6(2016), Article no. 29078. https://doi.org/10.1038/srep29078.
Gupta, V., Gupta, V., Chitranshi, N., Gangoda, S., Vander Wall, R., Abbasi, M., Golzan, M., Dheer, Y., Shah, T., Avolio, A., Chung, R., Martins, R., Graham, S. (2016). One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina. Cellular and Molecular Life Sciences, 73(22), 4279-4297. https://doi.org/10.1007/s00018-016-2295-x.
Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.
Holmes, S., Esterlis, I., Mazure, C., Lim, YY., Ames, D., Rainey-Smith, S., Martins, R., Salvado, O., Dore, V., Villemagne, V., Rowe, C., Laws, S., Masters, C., Maruff, P., Pietrzak, R. (2016). β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195. https://doi.org/10.1016/j.jagp.2016.08.007.
Francois, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R., Rainey-Smith, S., Masters, C., Ames, D., Rowe, C., Macaulay, S., Hill, A., Leifert, W. (2016). High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. Current Alzheimer Research, 13(7), 787-799. https://doi.org/10.2174/1567205013666160315112151.
Buckley, R., Maruff, P., Ames, D., Bourgeat, P., Martins, R., Masters, C., Rainey-Smith, S., Lautenschlager, N., Rowe, C., Savage, G., Villemagne, V., Ellis, K. (2016). Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer's and Dementia, 12(7), 796-804. https://doi.org/10.1016/j.jalz.2015.12.013.
Lim, YY., Snyder, PJ., Pietrzak, RH., Ukiqi, A., Villemagne, VL., Ames, D., Salvado, O., Bourgeat, P., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2016). Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2(2016), 19-26. https://doi.org/10.1016/j.dadm.2015.11.003.
Warrier, S., Marimuthu, R., Sekhar, S., Bhuvanalakshmi, G., Arfuso, F., Das, AK., Bhonde, R., Martins, R., Dharmarajan, A. (2016). SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease. International Journal of Biochemistry and Cell Biology, 75(June 2016), 104-111. https://doi.org/10.1016/j.biocel.2016.04.002.
Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R. (2016). The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343. https://doi.org/10.2174/1871527315666151110125704.
Hare, DJ., Faux, NG., Roberts, BR., Volitakis, I., Martins, R., Bush, AI. (2016). Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics, 8(6), 628-632. https://doi.org/10.1039/c6mt00019c.
Tang, M., Ryman, DC., McDade, E., Jasielec, MS., Buckles, VD., Cairns, NJ., Fagan, AM., Goate, A., Marcus, DS., Xiong, C., Allegri, RF., Chhatwal, JP., Danek, A., Farlow, MR., Fox, NC., Ghetti, B., Graff-Radford, NR., Laske, C., Martins, R., Masters, CL., Mayeux, RP., Ringman, JM., Rossor, MN., Salloway, SP., Schofield, PR., Morris, JC., Bateman, RJ. (2016). Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet Neurology, 15(13), 1317-1325. https://doi.org/10.1016/S1474-4422(16)30229-0.

2015

Journal Articles

Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD. (2015). Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71. https://doi.org/10.1186/s13195-015-0157-7.
Wang, F., Gordon, BA., Ryman, DC., Ma, S., Xiong, C., Hassenstab, J., Goate, A., Fagan, AM., Cairns, NJ., Marcus, DS., McDade, E., Ringman, JM., Graff-Radford, NR., Ghetti, B., Farlow, MR., Sperling, R., Salloway, S., Schofield, PR., Masters, CL., Martins, R., Rossor, MN., Jucker, M., Danek, A., Forster, S., Lane, CA., Morris, JC., Benzinger, TL., Bateman, RJ. (2015). Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology, 85(9), 790-798. https://doi.org/10.1212/WNL.0000000000001903.
Bourgeat, P., Villemagne, V., Dore, V., Brown, B., Macaulay, SL., Martins, R., Masters, C., Ames, D., Ellis, K., Rowe, C., Salvado, O., Fripp, J. (2015). Comparison of MR-less PiB SUVR quantification methods. Neurobiology of Aging, 36(S1), S159-S166. https://doi.org/10.1016/j.neurobiolaging.2014.04.033.
Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.
Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R. (2015). The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14. https://doi.org/10.1017/S0007114515001452.
Lim, YY., Villemagne, VL., Laws, S., Pietrzak, RH., Snyder, PJ., Ames, D., Ellis, KA., Harrington, K., Rembach, A., Martins, R., Rowe, CC., Masters, CL., Maruff, P. (2015). APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Molecular Psychiatry, 20(11), 1322-1328. https://doi.org/10.1038/mp.2014.123.
Cheng, L., Doecke, J., Sharples, RA., Villemagne, VL., Fowler, CJ., Rembach, A., Martins, R., Rowe, CC., Macaulay, SL., Masters, CL., Hill, AF. (2015). Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Molecular Psychiatry, 20(10), 1188-1196. https://doi.org/10.1038/mp.2014.127.
Ying Lim, Y., Pietrzak, RH., Bourgeat, P., Ames, D., Ellis, KA., Rembach, A., Harrington, K., Salvado, O., Martins, R., Snyder, PJ., Masters, C., Rowe, CC., Villemagne, VL., Maruff, P. (2015). Relationships between performance on the cogstate brief battery, neurodegeneration, and aβ accumulation in cognitively normal older adults and adults with MCI. Archives of Clinical Neuropsychology, 30(1), 49-58. https://doi.org/10.1093/arclin/acu068.
Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P. (2015). Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation, 6(2015), Article No. 105828. https://doi.org/10.1155/2015/105828.
Kirby, S., Rainey-Smith, S., Macaulay, SL., Taddei, K., Rembach, A., Maruff, P., Ellis, K., Masters, C., Rowe, C., Ames, D., Keogh, J., Martins, R. (2015). Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ. The British Journal of Nutrition: an international journal of nutritional science, 114(10), 1683-1693. https://doi.org/10.1017/S0007114515003335.
Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA. (2015). Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48. https://doi.org/10.1016/j.nbd.2015.06.016.
Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R. (2015). Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586.
Verdile, G., Fuller, SJ., Martins, R. (2015). The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38. https://doi.org/10.1016/j.nbd.2015.04.008.
Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R. (2015). Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164. https://doi.org/10.2174/1567205012666150204125732.
O'Bryant, SE., Gupta, V., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C., Soares, H., Lovestone, S., Hampel, H., Montine, T., Blennow, K., Foroud, T., Carrillo, M., Graff-Radford, N., Laske, C., Breteler, M., Shaw, L., Trojanowski, J., Schupf, N., Rissman, R., Fagan, A., Oberoi, P., Umek, R., Weiner, M., Grammas, P., Posner, H., Martins, R. (2015). Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's and Dementia, 11(5), 549-560. https://doi.org/10.1016/j.jalz.2014.08.099.
Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R. (2015). The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90. https://doi.org/10.1016/j.yhbeh.2015.05.020.
Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M. (2015). Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678. https://doi.org/10.1093/hmg/ddv110.
Burnham, SC., Raghavan, N., Wilson, W., Baker, D., Ropacki, MT., Novak, G., Ames, D., Ellis, K., Martins, R., Maruff, P., Masters, CL., Romano, G., Rowe, CC., Savage, G., Macaulay, SL., Narayan, V. (2015). Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study. Journal of Alzheimer's Disease, 46(4), 1079-1089. https://doi.org/10.3233/JAD-143015.
Leifert, WR., Nguyen, T., Rembach, A., Martins, R., Rainey-Smith, S., Masters, CL., Ames, D., Rowe, CC., Macaulay, SL., François, M., Fenech, MF. (2015). Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's Disease, 48(2), 443-452. https://doi.org/10.3233/JAD-150330.
Pietrzak, RH., Lim, YY., Ames, D., Harrington, K., Restrepo, C., Martins, R., Rembach, A., Laws, S., Masters, CL., Villemagne, VL., Rowe, CC., Maruff, P. (2015). Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Neurobiology of Aging, 36(3), 1231-1238. https://doi.org/10.1016/j.neurobiolaging.2014.12.015.
Buckley, R., Saling, M., Ellis, K., Rowe, C., Maruff, P., Macaulay, LS., Martins, R., Masters, C., Savage, G., Rainey-Smith, S., Rembach, A., Ames, D. (2015). Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age and Ageing, 44(6), 1012-1019. https://doi.org/10.1093/ageing/afv136.
Narlawar, R., Werry, EL., Scarf, AM., Hanani, R., Chua, SW., King, VA., Barron, ML., Martins, R., Ittner, LM., Rendina, LM., Kassiou, M. (2015). First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO). Journal of Medicinal Chemistry, 58(21), 8743-8749. https://doi.org/10.1021/acs.jmedchem.5b01288.
Albrecht, MA., Szoeke, C., Maruff, P., Savage, G., Lautenschlager, NT., Ellis, KA., Taddei, K., Martins, R., Masters, CL., Ames, D., Foster, JK. (2015). Longitudinal cognitive decline in the AIBL cohort: The role of APOE e4 status. Neuropsychologia, 75(2015), 411-419. https://doi.org/10.1016/j.neuropsychologia.2015.06.008.
Sutton, T., Sohrabi, H., Rainey-Smith, S., Bird, S., Weinborn, M., Martins, R. (2015). The role of APOE-ε4 and beta amyloid in the differential rate of recovery from ECT: a review. Translational Psychiatry, 5(e539), 1-8. https://doi.org/10.1038/tp.2015.39.
Leifert, WR., Tuli, JF., François, M., Nguyen, T., Rembach, A., Rumble, RL., Rainey-Smith, S., Martins, R., Fenech, MF. (2015). Buccal cell cytokeratin 14 identifies mild cognitive impairment and alzheimer’s disease in the AIBL study of aging. Current Alzheimer Research, 12(3), 233-241.
Cysique, LA., Hewitt, T., Croitoru-Lamoury, J., Taddei, K., Martins, R., Chew, CS., Davies, NN., Price, P., Brew, BJ. (2015). APOE e4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - A cross-sectional observational study. BMC Neurology, 15(1), Article no. 51. https://doi.org/10.1186/s12883-015-0298-0.
Lim, YY., Villemagne, VL., Pietrzak, RH., Ames, D., Ellis, KA., Harrington, K., Snyder, PJ., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2015). APOE e4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of Aging, 36(3), 1239-1244. https://doi.org/10.1016/j.neurobiolaging.2014.12.008.
Hollands, S., Lim, Y., Buckley, R., Pietrzak, R., Snyder, P., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2015). Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults. Journal of Alzheimer's Disease, 43(2), 677-686. https://doi.org/10.3233/JAD-140678.
Laske, C., Sohrabi, H., Frost, S., Lopez-De-Ipina, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S., Mueller, S., Linnemann, C., Bridenbaugh, S., Kanagasingam, Y., Martins, R., O’bryant, S. (2015). Innovative diagnostic tools for early detection of Alzheimer’s disease. Alzheimer's and Dementia, 11(5), 561-578. https://doi.org/10.1016/j.jalz.2014.06.004.
Rembach, A., Stingo, FC., Peterson, C., Vannucci, M., Do, K., Wilson, WJ., Macaulay, SL., Ryan, TM., Martins, R., Ames, D., Masters, CL., Doecke, JD. (2015). Bayesian graphical network analyses reveal complex biological interactions specific to Alzheimer's disease. Journal of Alzheimer's Disease, 44(3), 917-925. https://doi.org/10.3233/JAD-141497.
Johnson, L., Sohrabi, H., Hall, J., Taddei, K., Edwards, M., O'Bryant, S., Martins, R. (2015). A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30(8), 881-886. https://doi.org/10.1002/gps.4231.
Buckley, RF., Ellis, KA., Ames, D., Rowe, CC., Lautenschlager, NT., Maruff, P., Villemagne, V., Macaulay, SL., Szoeke, C., Martins, R., Masters, CL., Savage, G., Rainey-Smith, S., Rembach, A., Saling, MM. (2015). Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology, 29(4), 571-581. https://doi.org/10.1037/neu0000156.
Pietrzak, R., Lim, YY., Neumeister, A., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Restrepo, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2015). Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease A Multicenter, Prospective Cohort Study. JAMA Psychiatry, 72(3), 284-291. https://doi.org/10.1001/jamapsychiatry.2014.2476.
Laske, C., Sohrabi, H., Jasielec, MS., Muller, S., Koehler, N., Graber, S., Forster, S., Drzezga, A., Mueller-Sarnowski, F., Danek, A., Jucker, M., Bateman, R., Buckles, V., Saykin, A., Martins, R., Morris, J. (2015). Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International, 2015(2015), Article no. 828120. https://doi.org/10.1155/2015/828120.
Kirby, S., Rainey-Smith, S., Barnes, M., Sohrabi, H., Weinborn, M., Lim, Y., Harrington, K., Taddei, K., Gu, Y., Rembach, A., Szoeke, C., Ellis, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Keogh, J., Scarmeas, N., Martins, R. (2015). Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry, 20(7), 860-866. https://doi.org/10.1038/mp.2014.79.
Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R. (2015). Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16. https://doi.org/10.3389/fnagi.2015.00016.
Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2015). Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease is Dependent on APOE ε4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082. https://doi.org/10.1371/journal.pone.0139082.
Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S. (2015). Alzheimer’s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187. https://doi.org/10.3233/JAD-150247.

2014

Journal Articles

Rembach, A., Watt, A., Wilson, W., Rainey-Smith, S., Ellis, K., Rowe, C., Villemagne, V., Macaulay, S., Bush, A., Martins, R., Ames, D., Masters, C., Doecke, J. (2014). An increased neutrophil-lymphocyte ratio in Alzheimer’s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71. https://doi.org/10.1016/j.jneuroim.2014.05.005.
Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M. (2014). Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617. https://doi.org/10.1093/hmg/ddt448.
Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Lautenschlager, N., Maruff, P., Macaulay, SL., Martins, R., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Szoeke, C., Ellis, K. (2014). Personal memory function in mild cognitive impairment and subjective memory complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study of ageing. Journal of Alzheimer's Disease, 40(3), 551-561. https://doi.org/10.3233/JAD-131820.
Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Bush, A., Martins, R., Masters, C., Rowe, C., Maruff, P. (2014). Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer’s disease: A preliminary study. PLoS One, 9(1), Article no. e86498. https://doi.org/10.1371/journal.pone.0086498.
Francois, M., Leifert, W., Martins, R., Thomas, P., Fenech, M. (2014). Biomarkers of Alzheimer's disease risk in peripheral tissues; focus on buccal cells. Current Alzheimer Research, 11(6), 519-531. https://doi.org/10.2174/1567205011666140618103827.
Francois, M., Leifert, W., Hecker, J., Faunt, G., Martins, R., Thomas, P., Fenech, M. (2014). Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease. Cytometry Part A, 85(8), 698-708. https://doi.org/10.1002/cyto.a.22453.
Ryman, D., Acosta-Baena, N., Aisen, P., Bird, T., Danek, A., Fox, N., Goate, A., Frommelt, P., Ghetti, B., Langbaum, J., Lopera, F., Martins, R., Masters, C., Mayeux, R., McDade, E., Moreno, S., Reiman, E., Ringman, J., Salloway, S., Schofield, P., Sperling, R., Tariot, P., Xiong, C., Morris, J., Bateman, R. (2014). Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology, 83(3), 253-260. https://doi.org/10.1212/WNL.0000000000000596.
Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767. https://doi.org/10.1186/1756-0500-7-767.
Lim, YY., Maruff, P., Pietrzak, R., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C. (2014). Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease. Brain: a journal of neurology, 137(1), 221-231. https://doi.org/10.1093/brain/awt286.
Rembach, A., Watt, A., Wilson, W., Villemagne, V., Burnham, S., Ellis, K., Maruff, P., Ames, D., Rowe, C., Macaulay, S., Bush, A., Martins, R., Masters, C., Doecke, J. (2014). Plasma amyloid-β levels are significantly associated with a transition towards Alzheimer’s disease as measured by cognitive decline and change in neocortical amyloid burden. Journal of Alzheimer's Disease, 40(1), 95-104. https://doi.org/10.3233/JAD-131802.
Fagan, A., Xiong, C., Jasielec, M., Mateusz, R., Goate, A., Benzinger, T., Ghetti, B., Martins, R., Masters, C., Mayeux, R., Ringman, J., Rossor, M., Salloway, S., Schofield, P., Sperling, R., Marcus, D., Cairns, N., Buckles, V., Ladenson, J., Morris, J., Holtzman, D. (2014). Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine, 6(226), Article no. 226ra30. https://doi.org/10.1126/scitranslmed.3007901.
Ellis, K., Szoeke, C., Bush, A., Darby, D., Graham, P., Lautenschlager, N., Macaulay, L., Martins, R., Maruff, P., Masters, C., McBride, S., Pike, K., Rainey-Smith, S., Rembach, A., Robertson, J., Rowe, C., Savage, G., Villemagne, V., Woodward, M., Wilson, W., Zhang, P., Ames, D. (2014). Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26(4), 543-554. https://doi.org/10.1017/S1041610213001956.
Lim, YY., Maruff, P., Pietrzak, R., Ellis, K., Darby, D., Ames, D., Harrington, K., Martins, R., Masters, C., Szoeke, C., Savage, G., Villemagne, V., Rowe, C. (2014). Aβ and cognitive change: Examining the preclinical and prodromal stages of Alzheimer’s disease. Alzheimer's and Dementia, 10(16), 743-751. https://doi.org/10.1016/j.jalz.2013.11.005.
Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V. (2014). A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(2014), 519-526. https://doi.org/10.1038/mp.2013.40.
Moore, E., Ames, D., Mander, A., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Masters, C., Rowe, C., Szoeke, C., Watters, D. (2014). Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from 3 cohorts. Journal of Alzheimer's Disease, 39(2014), 661-668. https://doi.org/10.3233/JAD-131265.
Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R. (2014). Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378. https://doi.org/10.2217/nmt.14.29.
Lim, F., Martins, I., Martins, R. (2014). The Involvement of Lipids in Alzheimer's Disease. Journal of Genetics and Genomics, 41(5), 261-274. https://doi.org/10.1016/j.jgg.2014.04.003.
Yates, P., Desmond, P., Phal, P., Steward, C., Szoeke, C., Salvado, O., Ellis, K., Martins, R., Masters, C., Ames, D., Villemagne, V., Rowe, C. (2014). Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology, 82(14), 1266-1273. https://doi.org/10.1212/WNL.0000000000000285.
Bates, K., Vink, R., Martins, R., Harvey, A. (2014). Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of Aging, 35(6), 1345-1351. https://doi.org/10.1016/j.neurobiolaging.2013.11.020.
Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C. (2014). En Attendant Centiloid. Advances in Research, 2(12), 723-729. https://doi.org/10.9734/AIR/2014/11599.
Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R., Ames, D., Masters, C., Bush, A., Roberts, B. (2014). Decreased serum zinc is an effect of ageing and not Alzheimer’s disease. Metallomics: integrated biometal science, 6(7), 1216-1219. https://doi.org/10.1039/c4mt00060a.
Faux, N., Rembach, A., Wiley, J., Ellis, K., Ames, D., Fowler, C., Martins, R., Pertile, K., Rumble, R., Trounson, B., Masters, C., Bush, A. (2014). An anemia of Alzheimer’s disease. Molecular Psychiatry, 19(11), 1227-1234. https://doi.org/10.1038/mp.2013.178.
Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R. (2014). Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52. https://doi.org/10.1212/WNL.0000000000000867.
Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R. (2014). A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487. https://doi.org/10.1038/tp.2014.122.
Pietrzak, R., Scott, J., Neumeister, A., Lim, YY., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2014). Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry, 204(5), 400-401. https://doi.org/10.1192/bjp.bp.113.134239.
Rembach, A., Faux, N., Watt, A., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Roberts, B., Perez, K., Li, Q., Laws, S., Taddei, K., Rainey-Smith, S., Robertson, J., Vandijck, M., Vanderstichele, H., Barnham, K., Ellis, K., Szoeke, C., Macaulay, L., Rowe, C., Villemagne, V., Ames, D., Martins, R., Bush, A., Masters, C. (2014). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia, 10(1), 53-61. https://doi.org/10.1016/j.jalz.2012.12.006.
Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R. (2014). Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183.
Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Villemagne, V., Lautenschlager, N., Maruff, P., Macaulay, L., Martins, R., Szoeke, C., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Ellis, K. (2014). Autobiographical narratives relate to Alzheimer’s disease biomarkers in older adults. International Psychogeriatrics, 26(10), 1737-1746. https://doi.org/10.1017/S1041610214001136.
Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S. (2014). Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546. https://doi.org/10.3233/JAD-131442.
Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R. (2014). Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75. https://doi.org/10.1038/mp.2012.147.
Thomas, J., Brier, M., Bateman, R., Snyder, A., Benzinger, T., Xiong, C., Raichle, M., Holtzman, D., Sperling, R., Mayeux, R., Ghetti, B., Ringman, J., Salloway, S., McDade, E., Rossor, M., Ourselin, S., Schofield, P., Masters, C., Martins, R., Weiner, M., Thompson, P., Fox, N., Koeppe, R., Jack, C., Mathis, C., Oliver, A., Blazey, T., Moulder, K., Buckles, V., Hornbeck, R., Chhatwal, J., Schultz, A., Goate, A., Fagan, A., Cairns, N., Marcus, D., Morris, C., Ances, B. (2014). Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurology, 71(9), 1111-1122. https://doi.org/10.1001/jamaneurol.2014.1654.

Conference Publications

Johnson, P., Vandewater, L., Wilson, W., Maruff, P., Savage, G., Graham, P., Macaulay, LS., Ellis, KA., Szoeke, C., Martins, R., Rowe, C., Masters, CL., Ames, D., Zhang, P. (2014). Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. Proceedings from Asia Pacific Bioinformatics Network Thirteenth International Conference on Bioinformatics (1 - 14). BMC Genomics. https://doi.org/10.1186/1471-2105-15-S16-S11.

2013

Journal Articles

Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S. (2013). Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888. https://doi.org/10.1038/mp.2012.115.
Mills, S., Mallmann, J., Santacruz, A., Fuqua, A., Carril, M., Aisen, P., Althage, M., Belyew, S., Benzinger, T., Brooks, W., Buckles, V., Cairns, N., Clifford, D., Danek, A., Fagan, M., Farlow, N., Fox, N., Ghetti, B., Goate, A., Heinrichs, D., Hornbeck, R., Jack, C., Jucker, M., Klunk, W., Marcus, D., Martins, R., Masters, C., Mayeux, R., McDade, E., Morris, J., Oliver, A., Ringman, J., Rossor, M., Salloway, S., Schofield, P., Snider, J., Snyder, P., Sperling, R., Stewart, C., Thomas, R., Xiong, C., Bateman, R. (2013). Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial. Revue Neurologique, 169(10), 737-743. https://doi.org/10.1016/j.neurol.2013.07.017.
Harrington, K., Lim, YY., Ellis, K., Copolov, C., Darby, D., Weinborn, M., Ames, D., Martins, R., Savage, G., Szoeke, C., Rowe, C., Villemagne, V., Masters, C., Maruff, P. (2013). The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10), 1667-1677. https://doi.org/10.1017/S1041610213001087.
Frost, S., Kanagasingam, Y., Sohrabi, H., Taddei, K., Bateman, R., Morris, J., Benzinger, T., Goate, A., Masters, C., Martins, R. (2013). Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers. Current Alzheimer Research, 10(8), 790-796. https://doi.org/10.2174/15672050113109990154.
Drummond, E., Muhling, J., Martins, R., Wijaya, L., Ehlert, E., Harvey, A. (2013). Pathology associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum. PLoS One, 8(3), e59166. https://doi.org/10.1371/journal.pone.0059166.
Frost, S., Kanagasingam, Y., Sohrabi, H., Bourgeat, P., Villemagne, V., Rowe, C., Macaulay, SL., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R. (2013). Pupil Response Biomarkers for Early Detection and Monitoring of Alzheimer's Disease. Current Alzheimer Research, 10(9), 931-939.
Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P. (2013). BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464. https://doi.org/10.1016/j.neurobiolaging.2013.05.006.
Lim, YY., Ellis, K., Harrington, K., Pietrzak, R., Gale, J., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-β: Prodromal Alzheimer's Disease?. Journal of Alzheimer's Disease, 33(4), 1167-1176. https://doi.org/10.3233/JAD-121771.
Foster, J., Albrecht, M., Savage, G., Lautenschlager, N., Ellis, K., Maruff, P., Szoeke, C., Taddei, K., Martins, R., Masters, C., Ames, D. (2013). Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain: a journal of neurology, 136(7), 2201-16. https://doi.org/10.1093/brain/awt127.
Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L. (2013). Modulation of amyloid-β 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103. https://doi.org/10.1039/c2fo30111c.
Dore, V., Villemagne, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K., Masters, C., Ames, D., Salvado, O., Rowe, C. (2013). Cross-sectional and longitudinal analysis of the relationship between aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70(7), 903-911. https://doi.org/10.1001/jamaneurol.2013.1062.
Kirby, S., Rainey-Smith, S., Keogh, J., Mathieson, S., Martins, R. (2013). Dietary Patterns Associated with Alzheimer's Disease and Related Chronic Disease Risk: A Review. Alzheimer's Disease & Parkinsonism, Special(2013), online.
Avdesh, ., Hoe, Y., Martins, R., Martin-Iverson, M. (2013). Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology, 225(2), 483-494. https://doi.org/10.1007/s00213-012-2834-6.
Lim, YY., Ellis, K., Harrington, K., Kamer, A., Pietrzak, R., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Ames, D., Maruff, P. (2013). Cognitive consequences of high aβ amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer's disease. Neuropsychology, 27(3), 322-332. https://doi.org/10.1037/a0032321.
Lim, YY., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K., Stöffler, A., Szoeke, C., Lachovitzki, R., Martins, R., Villemagne, V., Bush, A., Masters, C., Rowe, C., Ames, D., Darby, D., Maruff, P. (2013). Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330. https://doi.org/10.1093/arclin/act021.
Gupta, V., Sundaram, R., Martins, R. (2013). Multiplex biomarkers in blood. Alzheimer's Research & Therapy, 5(3), Article 31. https://doi.org/10.1186/alzrt185.
Rowe, C., Bourgeat, P., Ellis, K., Brown, B., Yen Ying, L., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., Robins, P., Tochon-Danguy, H., O'Keefe, G., Pike, K., Yates, P., Szoeke, C., Salvado, O., Macaulay, SL., O'Meara, T., Head, R., Cobiac, L., Savage, G., Martins, R., Masters, C., Ames, D., Villemagne, V. (2013). Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6), 905-913. https://doi.org/10.1002/ana.24040.
Rembach, A., Doecke, JD., Roberts, BR., Watt, AD., Faux, NG., Volitakis, I., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Wilson, W., Ellis, K., Martins, R., Rowe, C., Villemagne, V., Ames, D., Masters, C., Bush, A. (2013). Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease. Journal of Alzheimer's Disease, 34(1), 171-182. https://doi.org/10.3233/JAD-121474.
Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G. (2013). The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235. https://doi.org/10.1371/journal.pone.0066235.
Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M. (2013). Less is more: More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525. https://doi.org/10.1038/mp.2013.26.
Lim, YY., Pietrzak, RH., Ellis, KA., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R., Bush, AI., Masters, CL., Rowe, CC., Villemagne, VL., Ames, D., Darby, D., Maruff, P. (2013). Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. https://doi.org/10.3233/JAD-2012-121516.
Ellis, K., Lim, YY., Harrington, K., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Decline in Cognitive Function over 18 Months in Healthy Older Adults with High Amyloid-β. Journal of Alzheimer's Disease, 34(2013), 861-871. https://doi.org/10.3233/JAD-122170.
Villemagne, V., Burhnham, S., Bourgeat, P., Brown, B., Ellis, KA., Salvado, O., Szoeke, C., Macaulay, L., Martins, R., Maruff, P., Ames, D., Rowe, C., Masters, C. (2013). Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease : a prospective cohort study. The Lancet Neurology, 12(4), 357-367. https://doi.org/10.1016/S1474-4422(13)70044-9.
Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C., Macaulay, L., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R. (2013). Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry, 3(February), 1-8. https://doi.org/10.1038/tp.2012.150.
Moore, E., Mander, A., Ames, D., Kotowicz, M., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Szoeke, C., Rowe, C., Watters, D. (2013). Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care, 36(10), 2981-2987. https://doi.org/10.2337/dc13-0229.
Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G. (2013). Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332. https://doi.org/10.1038/tp.2013.97.
Brown, B., Peiffer, JJ., Martins, R. (2013). Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?. Molecular Psychiatry, 18(8), 864-874. https://doi.org/10.1038/mp.2012.162.
Lim, Y., Ellis, K., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Aβ amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia, 9(5), 538-545. https://doi.org/10.1016/j.jalz.2012.07.004.
Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0. (2013). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897. https://doi.org/10.1038/mp.2012.106.
Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R. (2013). Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881. https://doi.org/10.1038/mp.2012.107.
Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R. (2013). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224. https://doi.org/10.1016/j.neurobiolaging.2013.03.012.
O' Bryant, S., Xiao, G., Edwards, M., Devous, M., Gupta, V., Martins, R., Zhang, F., Barber, R. (2013). Biomarkers of Alzheimer’s Disease Among Mexican Americans. Journal of Alzheimer's Disease, 34(4), 841-849. https://doi.org/10.3233/JAD-122074.
Carrillo, M., Rowe, C., Szoeke, C., Masters, C., Ames, D., O'Meara, T., Macaulay, SL., Milner, A., Ellis, K., Maruff, P., Rainey-Smith, S., Martins, R., Bain, L., Head, R. (2013). Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia, 9(2), 160-168. https://doi.org/10.1016/j.jalz.2012.10.006.
Benzinger, T., Blazey, T., Jack, C., Koeppe, R., Su, Y., Xiong, C., Raichle, M., Snyder, A., Ances, B., Bateman, R., Cairns, N., Fagan, A., Goate, A., Marcus, D., Aisen, P., Christensen, J., Ercole, L., Hornbeck, R., Farrar, A., Aldea, P., Jasielec, M., Owen, C., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C., Ringman, J., Thompson, P., Ghetti, B., Saykin, A., Sperling, R., Johnson, K., Salloway, S., Correia, S., Schofield, P., Masters, C., Rowe, C., Villemagne, V., Martins, R., Ourselin, S., Rossor, M., Fox, N., Cash, D., Weiner, M., Holtzman, D., Buckles, V., Moulder, K., Morris, J. (2013). Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of USA, 110(47), E4502-E4509. https://doi.org/10.1073/pnas.1317918110.
Buckley, R., Saling, M., Ames, D., Rowe, C., Lautenschlager, N., Macaulay, SL., Martins, R., Masters, C., O'Meara, T., Savage, G., Szoeke, C., Villemagne, V., Ellis, K. (2013). Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. International Psychogeriatrics, 25(8), 1307-1315. https://doi.org/10.1017/S1041610213000665.

2012

Journal Articles

Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R. (2012). Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325. https://doi.org/10.1001/archneurol.2012.1282.
Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R. (2012). Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056. https://doi.org/10.1016/j.neurobiolaging.2010.09.003.
Kirby, S., Gu, Y., Rainey-Smith, S., Keogh, JB., Clifton, PM., Mathieson, SL., Taddei, K., Mondal, A., Ward, V., Scarmeas, N., Barnes, M., Ellis, K., Head, R., Masters, C0., Ames, D., Macaulay, S0., Rowe, C0., Szoeke, C., Martins, R. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry, 2(2012), e164. https://doi.org/10.1038/tp.2012.91.
Morris, JC., Aisen, PS., Bateman, RJ., Benzinger, TL., Cairns, NJ., Fagan, AM., Ghetti, B., Goate, AM., Holtzman, DM., Klunk, WE., McDade, E., Marcus, DS., Martins, R., Masters, CL., Mayeux, R., Oliver, A., Quaid, K., Ringman, JM., Rossor, MN., Salloway, S., Schofield, PR., Selsor, NJ., Sperling, RA., Weiner, MW., Xiong, C., Moulder, KL., Buckles, VD. (2012). Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network. Clinical Investigation, 2(10), 975-984. https://doi.org/10.4155/cli.12.93.
Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R. (2012). Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469. https://doi.org/10.3233/JAD-2011-110704.
Drummond, ES., Martins, R., Handelsman, DJ., Harvey, AR. (2012). Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology, 153(6), 2789-2799. https://doi.org/10.1210/en.2011-2003.
Newman, M., Nornes, S., Martins, R., Lardelli, MT. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19. https://doi.org/10.1016/j.neulet.2012.04.064.
Villain, N., Chetelat, G., Grassiot, B., Bourqeat, P., Jones, G., Ellis, K., Ames, D., Martins, R., Eustache, F., Salvado, O., Masters, C., Rowe, C., Villemagne, V. (2012). Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: A voxelwise PiB-PET longitudinal study. Brain: a journal of neurology, 135(7), 2126-2139. https://doi.org/10.1093/brain/aws125.
Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R. (2012). Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967. https://doi.org/10.3233/JAD-2012-120178.
Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R. (2012). Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry, 2(2012), art. no. e118. https://doi.org/10.1038/tp.2012.43.
Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A., Holtzman, D., Bateman, R., Sohrabi, H., Martins, R., Gandy, S., Urakami, K., Suzuki, T. (2012). Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects. Molecular Neurodegeneration, 7(1), art. no. 16. https://doi.org/10.1186/1750-1326-7-16.
Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, CL., Ames, D., Rowe, C., Martins, R. (2012). Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry, 2(2012), art. no. e191. https://doi.org/10.1038/tp.2012.118.
Lim, YY., Ellis, KA., Pietrzak, RH., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Villemagne, V0., Maruff, P. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645-1652. https://doi.org/10.1212/WNL.0b013e31826e9ae6.
Barber, B., Ames, D., Ellis, K., Martins, R., Masters, C., Szoeke, C. (2012). Lifestyle and late life cognitive health: Sufficient evidence to act now?. International Psychogeriatrics, 24(5), 683-688. https://doi.org/10.1017/S1041610211002912.
Chetelat, G., Villemagne, V., Villain, N., Jones, G., Ellis, K., Ames, D., Martins, R., Masters, C., Rowe, C. (2012). Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition. Neurology, 78(7), 477-484. https://doi.org/10.1212/WNL.0b013e318246d67a.
Acosta, O., Fripp, J., Dore, V., Bourgeat, P., Favreau, JM., Chetelat, G., Rueda, A., Villemagne, VL., Szoeke, C., Ames, D., Ellis, K., Martins, R., Masters, CA., Rowe, CA., Bonner, E., Gris, F., Xiao, D., Raniga, P., Barra, V., Salvado, O. (2012). Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods, 205(1), 96-109. https://doi.org/10.1016/j.jneumeth.2011.12.011.
Cyarto, EV., Lautenschlager, NT., Desmond, PM., Ames, D., Szoeke, C., Salvado, O., Sharman, M., Ellis, KA., Phal, PM., Masters, CL., Rowe, CC., Martins, R., Cox, KL. (2012). Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry, 12(11 October 2012), Article 167. https://doi.org/10.1186/1471-244X-12-167.
Lim, YY., Ellis, KA., Harrington, K., Ames, D., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Darby, D., Maruff, P. (2012). Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345-358. https://doi.org/10.1080/13803395.2011.643227.
Bateman, RJ., Xiong, C., Benzinger, TL., Fagan, AM., Goate, A., Fox, NC., Marcus, DS., Cairns, NJ., Xie, X., Blazey, TM., Holtzman, DM., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, PM., Ghetti, B., Klunk, WM., McDade, E., Martins, R., Masters, CM., Mayeux, R., Ringman, JM., Rossor, MM., Schofield, PM., Sperling, RM., Salloway, S., Morris, JM. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine, 367(9), 795-804. https://doi.org/10.1056/NEJMoa1202753.
Sona, A., Zhang, P., Ames, D., Bush, AI., Lautenschlager, NT., Martins, R., Masters, CL., Rowe, CC., Szoeke, C., Taddei, K., Ellis, KA. (2012). Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics, 24(2), 197-204. https://doi.org/10.1017/S1041610211001335.

Conference Publications

Dore, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Szoeke, C., Ellis, K., Martins, R., Villemagne, V., Masters, CL., Ames, D., Rowe, C0., Salvado, O. (2012). A surface based approach for cortical thickness comparison between PiB+ and PiB-healthy control subjects. Proceedings of SPIE: Medical Imaging 2012: Image Processing, 831413 (February 23, 2012) (831413-1to 831413-6). SPIE. https://doi.org/10.1117/12.911752.

2011

Journal Articles

Villemagne, VL., Pike, KE., Chetelat, G., Ellis, KA., Mulligan, RS., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, CC. (2011). Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Annals of Neurology, 69(1), 181-192. https://doi.org/10.1002/ana.22248.
Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390. https://doi.org/10.1016/j.neuropsychologia.2011.04.012.
Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., Martins, R., Rowe, C., Szoeke, C., Ellis, K. (2011). Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. https://doi.org/10.1159/000325171.
Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R. (2011). Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098. https://doi.org/10.1212/WNL.0b013e318211c352.
Avdesh, ., Wong, P., Martins, R., Martin-Iverson, MT. (2011). Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 433-444. https://doi.org/10.3233/JAD-2011-101944.
Newman, M., Verdile, G., Martins, R., Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352. https://doi.org/10.1016/j.bbadis.2010.09.012.
Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, SD., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, MA., Carrillo, MC., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, AM., Forlenza, O., Frisone , GB., Galasko, D., Galimberti, D., Hampel, H., Handberg, A., Heneka, MT., Herskovits, AZ., Herukka , S., Holtzmann, DM., Humpel, C., Hyman, B., Iqbal, K., Jucker, M., Kaeser , S., Kaiser, E., Kapaki, E., Kidd, D., Kilvenyi, P., Knudsen, CS., Kummer, M., Lui, J., Llado, A., Lewczuk, P., Li, Q., Martins, R., Masters, C., McAuliffe, J., Mercken, M., Moghekar, A., Molinuevo, JL., Montine, TJ., Nowatzke, W., O'Brien, R., Otto, M., Paraskevas, GP., Parnetti, L., Petersen, RC., Prvulovic, D., De Reus, HP., Rissman, RA., Scarpini, E., Stefani, A., Soininen, H., Schroeder , J., Shaw, LM., Skinningsrud, A., Skrogstad, B., Spreer, A., Talib, L., Teunissen, C., Trojanowski, JQ., Tunami, H., Umek, RM., Van Broeck, B., Vanderstichele, H., Vecsei, L., Verbeek, M., Windisch, M., Zhang, J., Zetterberg, H., Blennow, K. (2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers and Dementia, 7(4), 386-395. https://doi.org/10.1016/j.jalz.2011.05.2243.
McBride, SJ., Szoeke, CE., Good, NM., Ames, D., Martins, R., Masters, CL., Maruff, PT., Rowe, CC., Savage, G., Ellis, KA. (2011). A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia, 194(4), S12-S14.
Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A. (2011). Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study.. Journal of Alzheimer's Disease, 27(4), 909-922. https://doi.org/10.3233/JAD-2011-110752.
Chetelat, G., Villemagne, VL., Pike, KE., Ellis, KA., Bourgeat, P., Jones, G., O'Keefe, GJ., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, CC. (2011). Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain, 134(3), 798-807. https://doi.org/10.1093/brain/awq383.
Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R. (2011). The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605. https://doi.org/10.3233/JAD-2011-110584.
Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P. (2011). Association of plasma Aβ peptides with blood pressure in the elderly. PLoS One, 6(4), e18536. https://doi.org/10.1371/journal.pone.0018536.
Ellis, KA., Rowe, CC., Szoeke, CE., Villemagne, VL., Ames, D., Chetelat, G., Martins, R., Masters, CL., Fripp, J., Acosta, O., Raniga, P., Bourgeat, PT., Salvado, O. (2011). Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 194(4), S20-S23.
Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R. (2011). Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels.. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322. https://doi.org/10.1159/000330812.

2010

Book Chapters

Maczurek, A., Krautwald, M., Steele, M., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Munch, G. (2010). Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease. Micronutrients and Brain Health (133-148). Routledge.

Journal Articles

Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., Haroutunian, V., Fried, U., Ehrlich, M., Martins, R., Gandy, S. (2010). Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration, 5(1), Article No.1.
Bourgeat, P., Chetelat, G., Villemagne, V., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C., Ourselin, S., Ames, D., Ellis, KA., Martins, R., Masters, C., Rowe, C., Salvado, O. (2010). β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 74(2), 121-127.
Sharman, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R. (2010). APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-ß42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409. https://doi.org/10.3233/JAD-2010-100141.
Rodrigues, M., Foster, J., Verdile, G., Joesbury, K., Prince, R., Devine, A., Mehta, P., Beilby, J., Martins, R. (2010). Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: Quod erat demonstrandum?. International Psychogeriatrics, 22(2), 332-335. https://doi.org/10.1017/S1041610209991190.
Sharman, M., Shui, G., Fernandis, A., Lim, WL., Berger, T., Hone, E., Taddei, K., Martins, I., Ghiso, J., Buxbaum, JD., Gandy, S., Wenk, M., Martins, R. (2010). Profiling brain and plasma lipids in human APOE ε2, ε3 and ε4 knock-in mice using electrospray ionization mass spectrometry.. Journal of Alzheimer's Disease, 20(1), 105-111.
Jenner, A., Lim, F., Ng, M., Wenk, MR., Shui, G., Sharman, M., Gandy, S., Martins, R. (2010). The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2,ε3 and ε4 knock-in mice. Neuroscience, 169(1), 109-115. https://doi.org/10.1016/j.neuroscience.2010.04.026.
Barron, A., Verdile, G., Taddei, K., Bates, K., Martins, R. (2010). Effect of Chronic hCG Administration on Alzheimer's-Related Cognition and Aβ accumulation in PS1KI mice. Endocrinology, 151(11), 5380–5388.
Bharadwaj, P., Martins, R., Macreadie, I. (2010). Yeast as a model for studying Alzheimer's disease. F E M S Yeast Research, 10(8), 961–969.
Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R. (2010). Plasma amyloid-β as a biomarker in Alzheimer’s disease: the AIBL study of aging.. Journal of Alzheimer's Disease, 20(4), 1233-1242.
Rowe, C., Ellis, K., Rimajova, M., Bourgeat, P., Pike, KE., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., Price, R., Raniga, P., Robins, P., Acosta, O., Lenzo, N., Szoeke, C., Salvado, O., Head, R., Martins, R., Masters, C., Ames, D., Villemagne, VL. (2010). Amyloid imaging results, from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31(8), 1275-1283.
Chetelat, G., Villemagne, V., Bourgeat, P., Pike, K., Jones, G., Ames, D., Ellis, K., Szoeke, C., Martins, R., O'Keefe, G., Salvado, O., Masters, C., Rowe, C. (2010). Relationship between Atrophy and B-Amyloid Deposition in Alzheimer Disease. Annals of Neurology, 67(3), 317-324.
Miklossy, J., Qing, H., Radenovic, A., Kis, A., Vileno, B., Laszlo, F., Miller, L., Martins, R., Waeber, G., Mooser, V., Bosman, F., Khalili, K., Darbinian, N., McGeer, P. (2010). Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging, 31(9), 1503-1515.
Frost, S., Martins, R., Kanagasingam, Y. (2010). Ocular biomarkers for early detection of Alzheimer's Disease. Journal of Alzheimer's Disease, 22(1), 1-16.
Ellis, K., Rowe, C., Villemagne, V., Martins, R., Masters, C., Salvado, O., Szoeke, C., Ames, D. (2010). Addressing population aging and Alzheimer's disease through the Australian Imaging Biomarkers and Lifestyle study: Collaboration with the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's and Dementia, 6(3), 291-296.
Peiffer, J., Galvao, D., Gibbs, Z., Smith, K., Turner, D., Foster, J., Martins, R., Newton, R. (2010). Strength and Functional Characteristics of Men and women 65 Years and Older. Rejuvenation Research, 13(1), 75-82.
Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., Lardelli, M. (2010). A Zebrafish melanophore model of Amyloid β toxicity. Zebrafish, 7(2), 155-159.
Ford, A., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. (2010). Vitamins B12, B6, and folic acid for cognition in older men. Neurology, 75(17), 1540-1547. https://doi.org/10.1212/WNL.0b013e3181f962c4.
Chetelat, G., Villemagne, VL., Pike, KE., Baron, J., Bourgeat, P., Jones, G., Faux, NG., Ellis, K., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, C., Rowe, C. (2010). Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain, 133(11), 3349-3358.

2009

Book Chapters

Verdile, G., Martins, R. (2009). The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism.. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies (259-268). Cambridge University Press.
Verdile, G., Martins, R. (2009). Molecular Genetics of Alzheimer's Disease. Molecular Biology of Neuropsychiatric Disorders (229-276). Springer Verlag. https://doi.org/10.1007/978-3-540-85383-1_8.

Journal Articles

Pedrini, S., Thomas, C., Brautigam, H., Schmeidler, J., Ho, L., Fraser, P., Westaway, D., St George Hyslop, P., Martins, R., Buxbaum, D., Pasinetti, GM., Dickstein, DL., Hof, PR., Ehrlich, M., Gandy, S. (2009). Dietary composition modulates brain mass and solubilizable A levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration, 4(1), Article No. 40.
Krishnaswamy, S., Verdile, G., Groth, D., Kanyenda, L., Martins, R. (2009). The structure and function of Alzheimer's gamma secretase enzyme complex. Critical Reviews in Clinical Laboratory Science, 46(5-6), 282-301.
Foster, J., Verdile, G., Bates, K., Martins, R. (2009). Immunization in Alzheimer's disease: naive hope or realistic clinical potential. Molecular Psychiatry, 14(3), 239-251.
Ellis, K., Bush, A., Darby, D., De Fazio, D., Foster, J., Hudson, P., Lautenschlager, N., Lenzo, N., Martins, R., Maruff, P., Masters, C., Milner, A., Pike, K., Rowe, C., Savage, G., Szoeke, C., Taddei, K., Villemagne, V., Woodward, M., Ames, D., Aibl Research Group, T. (2009). The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21(4), 672-687.
Hata, S., Fujishige, S., Araki, Y., Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S., Suzuki, T. (2009). Alcadein Cleavages by Amyloid β -Precursor Protein (APP) α -and γ -Secretases Generate Small Peptides, p3-Alcs, Indicating Alzhiemer Disease-related γ -Secretase Dysfunction. The Journal of Biological Chemistry, 284(52), 36024-36033.
Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., Martins, R. (2009). Clearance mechanisms of Alzheimer’s amyloid-β peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry, 14(5), 469-486.
Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R. (2009). Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142.
Barron, A., Cake, M., Verdile, G., Martins, R. (2009). Ovariectomy and 17β-Estradiol Replacement Do Not Alter beta-Amyloid Levels in Sheep Brain. Endocrinology, 150(7), 3228-3236.
De Silva, R., Disanayaka, S., De Zoysa, N., Sanjeewanie, N., Somaratne, S., Foster, J., Srikanth, S., Kathriarachchi, S., Martins, R. (2009). Norms for the mini-mental state examination from a sample of Sri Lankan older people. International Journal of Geriatric Psychiatry, 24(7), 666-670.
Chen, M., Martins, R., Lardelli, M. (2009). Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317.
Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R. (2009). Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308.
Bharadwaj, P., Dubey, AK., Masters, CL., Martins, R., Macreadie, I. (2009). A β aggregation and possible implications in Alzheimer's disease pathogenesis. Journal of Cell and Molecular Medicine, 13(3), 412-421.
Drummond, E., Harvey, AR., Martins, R. (2009). Androgens and Alzheimer's Disease. Current Opinion in Endocrinology, Diabetes and Obesity, 16(3), 254-259.
Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R. (2009). Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-β Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318.
Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., Lardelli, M. (2009). Independent an cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 315(16), 2791-2801.
Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein eε4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79.

2008

Journal Articles

Urosevic, N., Martins, R. (2008). Infection and Alzheimer's Disease: The APOE epsilon 4 Connection and Lipid Metabolism. Journal of Alzheimer's Disease, 13(4), 421-435.
Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R. (2008). Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274.
Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Muench, G. (2008). Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Advanced Drug Delivery Reviews, 60(13-14), 1463-1470. https://doi.org/10.1016/j.addr.2008.04.015.
Foster, J., Sohrabi, H., Verdile, G., Martins, R. (2008). Research Criteria for the Diagnosis of Alzheimer'S Disease: Genetic Risk Factors, Blood Biomarkers and Olfactory Dysfunction. International Psychogeriatrics, 20(4), 853-855.
Wahjoepramono, EJ., Wijaya, L., Taddei, K., Martins, G., Howard, M., De Ruyck, K., Bates, K., Dhaliwal, S., Verdile, G., Carruthers, M., Martins, R. (2008). Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137.
Verdile, G., Yeap, B., Clarnette, R., Dhaliwal, S., Burkhart, M., Chubb, SA., De Ruyck, K., Rodrigues, M., Mehta, PD., Foster, J., Bruce, D., Martins, R. (2008). Luteinizing Hormone Levels are Positively Correlated with Plasma Amyloid-beta Protein Levels in Elderly Men. Journal of Alzheimer's Disease, 14(2), 201-208.
Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Sleptsova - Fredrich, I., Martins, R., Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412. https://doi.org/10.1093/hmg/ddm317.
Rimajova, M., Lenzo, N., Wu, J., Bates, K., Campbell, A., Dhaliwald, SS., McCarthy, M., Rodrigues, M., Paton, A., Rowe, C., Foster, J., Martins, R. (2008). Fluoro-2-deoxy-D-glucose (FDG)-PET in APOE epsilon 4 carriers in the Australian population. Journal of Alzheimer's disease, 13(2), 137-146.
Gnjec, A., D'costa, K., Laws, S., Hedley, R., Balakrishnan, K., Taddei, K., Martins, G., Paton, A., Verdile, G., Gandy, S., Broe, A., Brooks, W., Bennett, H., Piguet, O., Price, P., Miklossy, J., Hallmayer, J., McGeer, P., Martins, R. (2008). Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation, 5(36), 1-10. https://doi.org/10.1186/1742-2094-5-36.
Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R. (2008). Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages.
Flicker, L., Martins, R., Thomas, J., Acres, J., Taddei, K., Vasikaran, S., Norman, P., Jamrozik, K., Almeida, O. (2008). B-Vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29(2), 303-305. https://doi.org/10.1016/j.neurobiolaging.2006.10.007.

2007

Journal Articles

Bates, K., Martins, R., Harvey, A. (2007). Oxidative Stress in a Rat Model of Chronic Gliosis. Neurobiology of Aging, 28(7), 995-1008.
McRae, A., Martins, R., Fonte, J., Kraftsik, R., Hirt, L., Miklossy, J. (2007). Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: A putative marker of an ongoing inflammatory process. Experimental Gerontology, 42(4), 355-363.
Verdile, G., Gandy, S., Martins, R. (2007). The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer's Beta Amyloid. Neurochemical Research, 32(4-5), 609-623.
Fuller, S., Tan, R., Martins, R. (2007). Androgens in the Etiology of Alzheimer's Disease in Aging Men and Possible Therapeutic Interventions. Journal of Alzheimer's disease, 12(2), 129-142.

2006

Journal Articles

Pickering-Brown, S., Baker, M., Gass, J., Boeve, B., Loy, C., Brooks, W., Mackenzie, I., Martins, R., Kwok, J., Halliday, G., Kril, J., Schofield, P., Mann, D., Hutton, M. (2006). Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain: a Journal of Neurology, 129(11), 3124-3126.
Barron, A., Fuller, S., Verdile, G., Martins, R. (2006). Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling, 8(11), 2047-2059.
Burkhardt, M., Foster, J., Clarnette, R., Chubb, P., Bruce, D., Drummond, P., Martins, R., Yeap, B. (2006). Interaction between Testosterone and Apolipoprotein E4 Status on Cognition in Healthy Older Men. Journal of Clinical Endocrinology and Metabolism, 9(13), 116-1172.
Barron, A., Verdile, G., Martins, R. (2006). Gonadotropins: potential targets for preventative and therapeutic interventions in Alzheimer's Disease. Future Neurology, 1(2), 189-202.
House, M., St Pierre, T., Foster, J., Martins, R., Clarnette, RM. (2006). Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss. American Journal of Neuroradiology, 27(2), 430-439.
Butterfield, A., Gnjec, A., Poon, H., Castegna, A., Pierce, W., Klein, JB., Martins, R. (2006). Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment. Journal of Alzheimer's disease, 10(4), 391-397.
Riemenschneider, M., Konta, L., Friedrich, P., Schwarz, S., Taddei, K., Neff, F., Padovani, A., Kolsch, H., Laws, S., Klopp, N., Bickeboller, H., Wagenpfeil, S., Mueller, J., Rosenberger, A., Diehl-Schmid, J., Archetti, S., Lautenschlager, N., Borroni, B., Muller, U., Illig, T., Heun, R., Egensperger, R., Schlegel, J., Forstl, H., Martins, R., Kurz, A. (2006). A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. Human Molecular Genetics, 15(16), 2446-2456.
Burkhardt, M., Foster, J., Clarnette, RM., Chubb, P., Bruce, D., Drummond, P., Martins, R., Yeap, B. (2006). Interaction between Testosterone and Apolipoprotein E epsilon4 Status on Cognition in Healthy Older Men. Journal of Clinical Endocrinology & Metabolism, 91(3), 1168-1172.
Barron, A., Verdile, G., Martins, R. (2006). The Role of Gonadotropins in Alzheimer's Disease. Endocrine, 9(2), 257-269.
Martins, I., Hone, E., Foster, J., Sunram-Lea, S., Gnjec, A., Fuller, S., Nolan, DA., Gandy, S., Martins, R. (2006). Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry, 11(8), 721-736.
Miklossy, J., Kis, A., Radenovic, A., Miller, L., Forro, L., Martins, R., Reiss, K., Darbinian, N., Darekar, P., Mihaly, L., Khalili, K. (2006). Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiology of Aging, 27(2), 228-236.

2005

Journal Articles

Laws, S., Perneczky, R., Wagenpfeil, S., Muller, U., Forstl, H., Martins, R., Kurz, A., Riemenschneider, M. (2005). TNF Polymorphisms in Alzheimer Disease and Functional Implications on CSF Beta-Amyloid Levels. Human Mutation, 26(1), 29-35.
Lautenschlager, N., Wu, J., Laws, S., Almeida, O., Clarnette, R., Joesbury, K., Wagenpfeil, S., Martins, G., Paton, A., Gandy, S., Forstl, H., Martins, R. (2005). Neurological soft signs are associated with APOE genotype, age and cognitive performance. Journal of Alzheimer's disease, 7(1), 325-330.
Lautenschlager, N., Martins, R. (2005). Common versus uncommon causes of dementia. International Psychogeriatics, 17(1), S27-S34.
Balakrishnan, K., Verdile, G., Mehta, P., Beilby, J., Nolan, DA., Galvao, D., Newton, R., Gandy, S., Martins, R. (2005). Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's disease, 8(3), 269-282.
Hone, E., Martins, I., Jeoung, M., Ji, T., Gandy, S., Martins, R. (2005). Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. Journal of Alzheimer's disease, 7(4), 303-314.
Bates, K., Harvey, AR., Carruthers, M., Martins, R. (2005). Androgens, andropause and neurodegeneration: Exploring the link between steroidogenesis, androgens and Alzheimer's disease. CMLS Cellular and Molecular Life Sciences, 62(3), 281-292.
James, V., Richardson, J., Robertson, T., Papadimitriou, J., Dutton, N., Maley, M., Berstein, L., Lantseva, O., Martins, R. (2005). Fibre diffraction of hair can provide a screening test for Alzheimer's Disease: a human and animal model study. Medical Science Monitor, 11(2), 53-57.

2004

Journal Articles

Stanford, P., Brooks, W., Teber, E., Hallupp, M., McLean, C., Halliday, G., Martins, R. (2004). Frequency of Tau Mutations in Familial and Sporadic Frontotemporal Dementia and other Tauopathies. Journal of Neurology, 251(9), 1098-1104.
Sweeney, D., Martins, R., Levine III, H., Smith, J., Gandy, S. (2004). Similar promotion of Abeta 1-42 fibrillogenesis by native apolipoprotein E epsilon3 and epsilon4 isoforms. Journal of Neuroinflammation, 1(15), 1-4. https://doi.org/10.1186/1742-2094-1-15.
Burkhardt, M., Foster, J., Martins, R. (2004). The significance of age-related androgen depletion in cognitive impairment: A review. Brain impairment, 5(2), 166-176.
Carter, T., Verdile, G., Groth, D., Bogush, A., Thomas, S., Shen, P., Fraser, P., Matthews, P., Nixon, R., Ehrlich, M., Kwok, J., St-George Hyslop, P., Schofeild, P., Li, Y., Yang, A., Martins, R., Gandy, S. (2004). Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer disease and associated disorders, 18(4), 261-263.
Flicker, L., Martins, R., Thomas, J., Acres, J., Taddei, K., Norman, P., Jamrozik, K., Almeida, O. (2004). Homocysteine, Alzheimer genes and proteins, and measures of cognition and depression in older men. Journal of Alzheimer's disease, 6(3), 329-336.
Pocernich, C., Sultana, R., Hone, E., Turchan, J., Martins, R., Calabrese, V., Nath, A., Butterfield, D. (2004). Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes. Neuroscience Research, 77(4), 532-539.
Martins, R., Hallmayer, J. (2004). Age at onset: Important marker of genetic heterogeneity in alzheimer's disease. The pharmacogenomics journal, 4(n/a), 138-140.
Almeida, O., Waterreus, A., Spry, N., Flicker, L., Martins, R. (2004). One Year Follow-up Study of the Association between Chemical Castration, Sex Hormones, Beta-Amyloid, Memory and Depression in Men. Psychoneuroendocrinology, 29(8), 1071-1081.
Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: Still a cause of everything or the only one who got caught?. Pharmacological research, 50(4), 397-409.
Burkhardt, M., Foster, J., Martins, R. (2004). The significance of age-related androgen depletion in cognitive impairment: A review. Brain impairment, 5(2), 166-176.
Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K., Kakulas, B., Mehta, P., Milward, E., Tan, N., Lareu, R., Lim, D., Dharmarajan, A., Martins, R. (2004). Protein markers for alzheimer disease in the frontal cortex and cerebellum. Neurology, 63(8), 1385-1392.
Burkhardt, M., Foster, J., Laws, S., Baker, L., Craft, S., Gandy, S., Stuckey, B., Clarnette, R., Nolan, D., Hewson-Bower, B., Martins, R. (2004). Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. Journal of Alzheimer's Disease, 6(3), 221-228.
Verdile, G., Groth, D., Matthews, P., St Geroge Hyslop, P., Fraser, P., Ramabhadran, T., Kwok, J., Schofeild, P., Carter, T., Gandy, S., Martins, R. (2004). Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular psychiatry, 9(6), 594-602.
Liu, T., Perry, G., Chan, H., Verdile, G., Martins, R., Smith, M., Atwood, C. (2004). Amyloid-b-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Journal of Neurochemistry, 88(3), 554-563.
Bowen, R., Verdile, G., Liu, T., Parlow, A., Perry, G., Smith, M., Martins, R., Atwood, C. (2004). Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-Beta precursor protein and amyloid-Beta deposition. The journal of biological chemistry, 279(19), 20539-20545.
Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?. Pharmacological Research, 50(4), 397-409.
Yao, J., Petanceska, S., Montine, T., Holtzman, D., Schmidt, S., Parker, C., Callahan, M., Lipinski, W., Bisgaier, C., Turner, B., Nixon, R., Martins, R., Ouimet, C., Smith, J., Davies, P., Laska, E., Ehrlich, M., Walker, L., Mathews, P., Gandy, S. (2004). Aging, gender and APOE isotype modulate metabolism of Alzheimer's ABeta peptides and F2-isoprostanes in the absence of detectable amyloid deposits. The journal of neurochemistry, 90(4), 1011-1018. https://doi.org/10.1111/j.1471-4159.2004.02532.x.

2003

Book Chapters

Verdile, G., Gandy, S., Fraser, P., Atwood, C., Martins, R. (2003). The Presenilins and their Role in Amyloid-β Generation Production. Focus on Alzheimer’s Disease Research (167-210). Nova Science Publishers.

Journal Articles

Dean, B., Laws, S., Hone, E., Taddei, K., Scarr, E., Thomas, E., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry, 54(6), 616-622.
Gandy, S., Martins, R., Buxbaum, JD. (2003). Molecular and Cellular Basis for Anti-Amyloid Therapy in Alzheimer Disease. Alzheimer Disease and Associated Disorders, 17(4), 259-266.
Christen-Zaech, S., Kraftsik, R., Pillevuit, O., Kiraly, M., Martins, R., Miklossy, J. (2003). Early olfactory involvement in Alzheimer's disease. Canadian Journal of Neurological Sciences, 30(1), 20-25.
Veurink, G., Liu, D., Taddei, K., Perry, G., Smith, MA., Robertson, T., Hone, E., Groth, D., Atwood, CS., Martins, R. (2003). Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radical Biology and Medicine, 34(8), 1070-1077.
Lim, D., Flicker, L., Dharmarajan, A., Martins, R. (2003). Can Testosterone Replacement Decrease the Memory Problem of Old Age?. Medical Hypotheses, 60(6), 893-896.
Laws, S., Hone, E., Gandy, S., Martins, R. (2003). Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of Neurochemistry, 84(6), 1215-1236.
Gillet, M., Martins, R., Clarnette, R., Chubb, P., Bruce, D., Yeap, B. (2003). Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia.. Journal of Alzheimer's Disease, 5(4), 267-269.
Veurink, G., Fuller, S., Atwood, C., Martins, R. (2003). Genetics, Lifestyle and the Roles of Amyloid beta and Oxidative Stress in Alzheimer's Disease. Annals of Human Biology, 30(6), 639-667.
Thomas, E., Laws, S., Sutcliffe, J., Harper, C., Dean, B., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological Psychiatry, 54(2), 136-141.
Hone, E., Martins, I., Fonte, J., Martins, R. (2003). Apolipoprotein E influences amyloid-beta clearance from the murine periphery. Journal of Alzheimer's Disease, 5(1), 1-8.
Atwood, C., Obrenovich, M., Liu, T., Chan, H., Perry, G., Smith, M., Martins, R. (2003). Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Research Reviews, 43(1), 1-16.
Stanford, P., Shepherd, C., Halliday, G., Brooks, W., Schofield, PW., Brodaty, H., Martins, R., Kwok, J., Schofield, PR. (2003). Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain, 126(4), 814-826.
Sumioka, A., Imoto, S., Martins, R., Kirino, Y., Suzuki, T. (2003). XB51 isopforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Biochemical Journal, 374(n/a), 261-268.
Miklossy, J., Taddei, K., Suva, D., Verdile, G., Fonte, J., Fisher, C., Gnjec, A., Ghika, J., Suard, F., Mehta, P., McLean, C., Masters, C., Brooks, W., Martins, R. (2003). Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging, 24(5), 655-662.

Research Projects

Determination of the link between anti inflammatory properties, biomarkers, cognitive decline and life style factors (Diet) of older adults who are at a risk of getting Alzheimer’s, Sarathchandra Group of Companies, Industry Engagement PhD Scholarship Scheme, 2022 ‑ 2027, $176,000.
Assessing the anti-inflammatory properties of short chain fatty acids in Alzheimer's disease (AD) , Premium International (Pvt) Ltd, Scholarships to support Industry Engagement PhD Projects, 2021 ‑ 2026, $80,500.
Investigating the anti-inflammatory properties of gut microorganisms in Alzheimer’s Disease (AD) , Delite Agro Polymers (pvt) Ltd, Scholarships to support Industry Engagement PhD Projects, 2021 ‑ 2026, $140,000.
Analysis of neurofilament biomarkers for Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and childhood dementia, National Foundation for Medical Research and Innovation, Alzheimer's Disease, 2023 ‑ 2025, $250,000.
Generation and Validation of 3 antibodies for the detection of GFAP isoforms for the diagnosis of preclinical Alzheimer’s Disease, Perron Institute for Neurological and Translational Science, Bryant Stokes Neurological Research Fund - Early Career Researcher, 2024, $100,000.
AIBL: Agreement with Biogen for provision of AIBL Data and samples, Florey Institute of Neuroscience and Mental Health, Grant, 2016 ‑ 2024, $3,278,875.
TRACK D-CAA: Tracking the Natural History of Dutch-type Hereditary Cerebral Amyloid Angiopathy, Leiden University Medical Centre, Grant, 2021 ‑ 2024, $765,000.
AIBL: Agreement with Biogen for provision of AIBL Data and samples, Florey Institute of Neuroscience and Mental Health, Grant, 2022 ‑ 2024, $3,305,552.
Exploring genetic biomarkers associated with neurodegeneration in childhood dementia, Department of Health WA, FHRIF Research Excellence Awards 2022, 2022 ‑ 2024, $160,000.
Early Detection of Neurodegenerative Diseases (EDoN) - Integration of multiple digital technologies for the early detection of neurodegenerative diseases - Western Australia Memory Study (WAMS), Alzheimer's Research UK, Alzheimer's Drug Discovery Foundation Grant, 2021 ‑ 2024, $1,236,139.
Developing retinal biomarkers in Autosomal Dominant Alzheimer’s disease: A pilot study, National Institutes of Health, Grant, 2021 ‑ 2024, $34,241.
Prognostic biomarkers for childhood dementia, Department of Health WA, WA Child Research Fund, 2021 ‑ 2024, $249,967.
Dominantly Inherited Alzheimer Network, Washington University, Grant, 2019 ‑ 2024, $474,340.
In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease, National Foundation for Medical Research and Innovation, NFMRI - Grant, 2020 ‑ 2024, $170,000.
The Australian Dementia Network (ADNeT): Bringing together Australia’s dementia stakeholders, National Health and Medical Research Council, Boosting Dementia Research Grants Scheme, 2019 ‑ 2024, $1,263,998.
The AUstralian-multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention (AU-ARROW) Study, National Health and Medical Research Council, MRFF International Clinical Trial Collaborations grant program, 2020 ‑ 2024, $1,411,151.
Sponsorship Agreement for Research Associate (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2022 ‑ 2023, $327,000.
In vitro assessment to evaluate the potential effect of Gallic acid on Alzheimer’s disease, Al Faris Food Industries Pvt. Ltd., Scholarships to Support Industry Engagement MBR Projects, 2018 ‑ 2023, $39,000.
Sponsorship of Research Fellows (multiple roles), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2022 ‑ 2023, $815,000.
Sponsorship of Research Fellow (multiple roles), Lions Alzheimer's Foundation, Sponsorship, 2022 ‑ 2023, $753,000.
In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease (AD), CWEK Pty Ltd, Scholarships to Support Industry Engagement PhD Projects, 2018 ‑ 2023, $32,500.
WA Memory Study (WAMS), Australian Alzheimer's Research Foundation, McCusker Alzheimer's Research Foundation - Grant, 2019 ‑ 2022, $357,468.
Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort, National Health and Medical Research Council, Project Grants, 2017 ‑ 2022, $1,125,804.
Improving sleep to promote healthy brain aging: an intervention study , Alzheimer's Association USA, Alzheimer's Association Research Grant, 2019 ‑ 2022, $220,992.
A systems epidemiology approach to define metabolic and genomic determinants of Alzheimer's disease , National Health and Medical Research Council, Project Grants, 2019 ‑ 2022, $305,290.
Medical and Health Research Infrastructure Fund (MHRIF) 2021, Department of Health WA, Medical and Health Research Infrastructure, 2021 ‑ 2022, $81,114.
Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2021, $190,000.
Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
Medical and Health Research Infrastructure Fund 2019 (Round 23), Department of Health WA, Medical and Health Research Infrastructure, 2020 ‑ 2021, $122,964.
Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2020, $210,393.
Medical and Health Research Infrastructure Fund 2018 (Round 22), Department of Health WA, Medical and Health Research Infrastructure, 2019 ‑ 2020, $150,771.
Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer's disease pathology, National Health and Medical Research Council, Project Grants, 2016 ‑ 2019, $100,000.
Genetic Linkages to mTOR pathway dysregulation and development of Alzheimers Disease, CRC For Mental Health, WES Study, 2015 ‑ 2019, $524,000.
High-frequency ultrasound and photoacoustic imaging for Western Australia, Australian Research Council, Grant - Linkage (Infrastructure), 2018 ‑ 2019, $621,198.
Dominantly Inherited Alzheimer Network, Washington University, Grant, 2009 ‑ 2019, $1,398,587.
Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2019, $90,198.
Sponsorship of Research Fellow (Hamid Soharbi), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2019, $47,130.
Sponsorship Agreement Post-Doctoral Research Fellow, Australian Alzheimer's Research Foundation, Neuroscience Research Institute - Sponsorship, 2018 ‑ 2019, $94,922.
4.1 Biomarkers for Early Diagnosis of AD and PD, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $7,524,765.
4.6 - Biomarkers for Schizophrenia Sub-Types - Part A Neuroimaging, Part B Biomarker Discovery, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $1,202,364.
4.4B1 Novel Therapeutics for AD Testosterone Trial, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $1,068,045.
Biomarkers and Early Intervention for Neurodegeneration, CRC For Mental Health, CRC Grant, 2012 ‑ 2018, $674,185.
Medical and Health Research Infrastructure Fund 2016 (Round 20), Department of Health WA, Medical and Health Research Infrastructure, 2017 ‑ 2018, $158,564.
The contribution of sleep factors to healthy cognitive ageing: A pilot sleep-specific cognitive behavioural intervention study, Equity Trustees Limited, Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation), 2017 ‑ 2018, $60,000.
Developing a blood-based biomarker panel for Alzheimer's disease, BrightFocus Foundation, Alzheimer's Disease Research - Postdoctoral Fellowship Awards, 2015 ‑ 2018, $126,876.
The effect of high-intensity exercise on Alzheimer’s disease-related gene expression, Brain Foundation, Research Gifts Program, 2017, $39,875.
Development and refinement of methods for early and specific diagnosis of Alzheimer's disease, quantification of rates of change in the pathological processes and determination of the resultant effects on cognition., Fil Foundation, Grant, 2015 ‑ 2017, $417,506.
Head Injury and Testosterone (HIT), Harry Perkins Institute of Medical Research, Neurotrauma Research Program, 2013 ‑ 2017, $148,701.
Medical and Health Research Infrastructure Fund (MHRIF) 2015 (Round 19), Department of Health WA, Medical and Health Research Infrastructure, 2016 ‑ 2017, $193,336.
Use of coconut oil as a novel neuro protective agent for Alzheimer’s disease, Edith Cowan University, School of Medical and Health Sciences Research Grant Scheme 2016, 2016, $9,203.
Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. , Hollywood Private Hospital Research Foundation, Grant, 2013 ‑ 2016, $20,000.
Medical and Health Research Infrastructure Fund (MHRIF) 2014 Round 18, Department of Health WA, Medical and Health Research Infrastructure, 2015 ‑ 2016, $230,341.
Exercise intensity and prevention of cognitive decline in older adults, Edith Cowan University, ECU Early Career Researcher Grant - 2015, 2015 ‑ 2016, $24,066.
The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease, National Health and Medical Research Council, Project Grants, 2013 ‑ 2016, $536,949.
High resolution mass spectrometry for metabolomics and proteomics research, Australian Research Council, Grant - Linkage (Infrastructure), 2015 ‑ 2016, $1,140,000.
Mass Cytometry: A breakthrough in multidimensional systems biology, Australian Research Council, Grant - Linkage (Infrastructure), 2015 ‑ 2016, $1,081,489.
The influence of exercise intensity on the prevention of cognitive decline in older adults, Dementia Australia Research Foundation, AADRF - Postdoctoral Fellowships, 2014 ‑ 2016, $214,900.
Progressing the clinical neuropsychological phenotype of Alzheimer's disease., Florey Institute of Neuroscience and Mental Health, Grant, 2014 ‑ 2015, $85,000.
CSIRO/Janssen AIBL Neuroscience Program, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Janssen Neuroscience Program, 2014 ‑ 2015, $200,000.
Continuation of the 15M S.A work & In vitro testing of the Phylomers, Alzhyme Pty Ltd, Grant, 2015, $103,875.
Personality dimensions and increased risk of late onset Alzheimer's disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014 ‑ 2015, $15,000.
Medical and Health Research Infrastructure Fund (MHRIF) 2013 (Round 17), Department of Health WA, Medical and Health Research Infrastructure, 2014 ‑ 2015, $186,666.
Establishing a combined ocular and blood biomarker panel for Alzheimer’s disease., Australian National University, ANU - Dementia CRC - Grant, 2014 ‑ 2015, $517,977.
Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2014 ‑ 2015, $12,555.
Ocular Imaging Project NeuroVision Imaging, Commonwealth Scientific and Industrial Research Organisation (CSIRO), NeuroVision Imaging, LLC Grant, 2013 ‑ 2015, $152,999.
Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease., Hollywood Private Hospital Research Foundation, Grant, 2015, $15,000.
A study of the kinetics of biomarkers and their presumptive relationship with brain amyloid , Commonwealth Scientific and Industrial Research Organisation (CSIRO), Araclon Biotech , 2014 ‑ 2015, $132,200.
Discovery and Validation of Alzheimer's disease biomarkers in human plasma, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $352,524.
Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $494,615.
A Pilot Clinical Study to Evaluate the Potential of AMLAMAX™ (Emblica Officinalis) Extract on Raising HDL-Cholesterol Levels and Decreasing Plasma Amyloid beta (Aβ) Levels in a Perth Memory, Hollywood Private Hospital Research Foundation, Grant, 2010 ‑ 2014, $14,760.
Dementia Collaborative Research Council - Lipid Profiles in Alzheimer's Disease, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2014, $90,000.
Peripheral Clearance of Amyloid-beta (Aβ) using Novel Binding Peptides, Alzhyme Pty Ltd, Grant, 2011 ‑ 2014, $600,000.
Medical and Health Research Infrastructure Fund (MHRIF) 2012 Round 16, Department of Health WA, Medical and Health Research Infrastructure, 2013 ‑ 2014, $120,279.
AIBL Carer Extension Study (ACES), Florey Institute of Neuroscience and Mental Health, Wyeth Caregiver Study, 2013 ‑ 2014, $78,396.
Protective role of autophagy genes in Alzheimer’s disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014, $10,000.
An innovative approach to identify specific biomarkers for early diagnosis of Alzheimer's disease, Australian National University, ANU - Dementia CRC - Grant, 2013 ‑ 2014, $115,000.
Western Australian Zebrafish Facility, Australian Research Council, Grant - Linkage (Infrastructure), 2014, $620,000.
Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Merck Sharp and Dohme Corpe Grant, 2011 ‑ 2014, $265,000.
Proteomics for discovery of novel biomarkers, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2013, $74,045.
The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $409,650.
Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $529,125.
Alzheimers Disease Research - McCusker Foundation, The McCusker Foundation For Alzheimer`s Disease Research, Grant, 2004 ‑ 2013, $1,568,543.
Round 15 Medical and Health Research Infrastructure Fund (MHRIF) 2011, Department of Health WA, Medical and Health Research Infrastructure, 2012 ‑ 2013, $41,708.
Evaluation of the Nutritional Extract Bio-Curcumax BCM-95 to Preserve Cognitive Functioning, Arjuna Natural Extracts, Grant, 2011 ‑ 2013, $90,641.
The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Science Industry Endowment Fund Agreement, 2010 ‑ 2013, $2,013,000.
'Deep Within My Soul': Recovering Memory in Bilingual Early Alzheimer's Patients, Edith Cowan University, ECU Industry Collaboration - Grant, 2008 ‑ 2013, $25,282.
Assess suitability of multiplexing, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2013, $198,755.
Discovering Transcriptome and Cytome Biomarkers of Alzheimer's Disease in Isolated Buccal Cells, Commonwealth Scientific and Industrial Research Organisation (CSIRO), CSIRO - Scholarship, 2010 ‑ 2013, $21,000.
Developing a Zebrafish Model for Alzheimer's Disease, The McCusker Foundation For Alzheimer`s Disease Research, Scholarship, 2009 ‑ 2013, $75,000.
Initiating an Indo-Australian cooperation for early diagnosis and prediction in the aged population: Partnering the universities for a tactical approach to Alzheimer's disease and other neurodegenerative conditions, Department of Foreign Affairs and Trade, Australia-India Council, 2011 ‑ 2013, $4,000.
A high-throughput protein production and structure facility, Australian Research Council, Grant - Linkage (Infrastructure), 2012, $470,000.
AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream), Confidential, Confidential, 2011 ‑ 2012, $95,238.
Round 14 - Medical and health research infrastructure fund (MHRIF) 2010, Department of Health WA, Medical and Health Research Infrastructure, 2011 ‑ 2012, $42,757.
Evaluation of candidate biomarkers in platelets, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2012, $67,990.
Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research, National Health and Medical Research Council, Equipment Grant 2011, 2011 ‑ 2012, $10,927.
Analysis of Internal Brain Structures using Magnetic Resonance Image - Development of Collaboration with the Perth Neuroscience for Diagnosis of Neurodegenerative Diseases, Commonwealth Scientific and Industrial Research Organisation (CSIRO), CSIRO - Fellowship, 2008 ‑ 2011, $148,500.
CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research, National Health and Medical Research Council, Equipment Grant, 2010 ‑ 2011, $10,881.
Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization, Australian Research Council, Grant - Linkage (Infrastructure), 2011, $849,590.
Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 2 (ECUPO2) - Plasma apoE Measurement, Department of Health and Aged Care, Grant, 2010 ‑ 2011, $100,674.
Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 3 (ECUPO3) - Plasma IDE Measurement, Department of Health and Aged Care, Grant, 2010 ‑ 2011, $187,075.
Diets to Defy Dementia, Council On The Ageing (WA) Inc, Grant, 2010 ‑ 2011, $5,000.
Round 13 Medical and Health Research Infrastructure Fund, Medical and Health Research Infrastructure Fund, MHRIF - Grant, 2010 ‑ 2011, $36,150.
Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro, Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2011, $22,750.
Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease, National Health and Medical Research Council, Special Call Complementary & Alternative Medicine, 2008 ‑ 2011, $484,675.
Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin, National Health and Medical Research Council, Project Grants, 2007 ‑ 2010, $138,344.
Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid, Centre of Excellence for Alzheimers Disease Research and Care, Scholarship, 2006 ‑ 2010, $135,000.
The role of APOE as a modulator in recovery from traumatic head injury, Road Safety Council of WA, Neurotrauma Research Program, 2007 ‑ 2010, $126,000.
CRC for Mental Illness, The Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education , CRC - Grant, 2010, $4,950.
Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction, Australian Research Council, Grant - Centres of Excellence, 2007 ‑ 2010, $315,000.
The role of gonadotropins in regulating the production of Alzheimer's beta amyloid, National Health and Medical Research Council, Project Grants, 2007 ‑ 2010, $400,278.
Round 11 of the Medical & Health Research Infrastructure Fund, Department of Health WA, Medical and Health Research Infrastructure, 2008 ‑ 2010, $16,645.
The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB), Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2010, $75,000.
Round 12 Medical and Health Research Infrastructure Fund, Department of Health WA, Medical and Health Research Infrastructure, 2008 ‑ 2010, $24,648.
Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions, Neurosciences Australia Ltd, Flagship Collaboration Research Fund, 2007 ‑ 2010, $909,328.
McCusker Therapeutic Research - Clinical trial, The McCusker Foundation For Alzheimer`s Disease Research, Grant, 2000 ‑ 2010, $322,262.
Centre of Excellence for Alzheimer's Disease Research and Care, Department of Mines and Petroleum, Centre of Excellence, 2005 ‑ 2010, $2,060,186.
Developing and validating a transgenic zebrafish model for Alzheimer's Disease, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $193,372.
Factors that Modulate Testosterone Action on Cognition, Well Men Centres Pty Ltd, Fellowship, 2008 ‑ 2009, $68,557.
Keeping the aged healthy, happy and independent through physical and cognitive exercise, J.O. and J.R. Wicking Trust, Grant, 2005 ‑ 2009, $446,100.
Exercise Physiology, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $252,721.
Investigating beta amyloid clearance in vivo, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $207,655.
A Multidimensional Approach to Enhanced Diagnostics in Alzheimer's Disease, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $367,663.
Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model, J.O. and J.R. Wicking Trust, Grant, 2005 ‑ 2008, $25,000.
MALDI Imaging and Protein Analysis Facility for WA, Australian Research Council, Grant - Linkage (Infrastructure), 2007 ‑ 2008, $915,000.
-30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory, Edith Cowan University, Grant, 2007 ‑ 2008, $12,266.
Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice, Hollywood Private Hospital, Grant, 2006 ‑ 2007, $9,455.
Molecular & neuropsychological predictive markers of cognitive decline, National Health and Medical Research Council, Grant, 2005 ‑ 2007, $423,750.
Novel peptides as inhibitors of human beta amyloid function (Stage 2), Alzhyme Pty Ltd, Grant, 2005 ‑ 2007, $120,384.
Novel peptides as inhibitors of human beta amyloid function, Alzhyme Pty Ltd, Grant, 2005, $22,264.
Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system, Ramaciotti Foundation, Grant, 2004 ‑ 2005, $49,000.
Biophysical tools for molecular interactions (Biacore), Australian Research Council, Grant - Linkage (Infrastructure), 2005, $352,000.

Research Student Supervision

Current Supervisions

Co-principal Supervisor

Doctor of Philosophy, Small molecule proteostasis enhancers for Alzheimer's Disease (AD)
Doctor of Philosophy, Role of Microbial Dysbiosis in Alzheimer's Disease
Doctor of Philosophy, Assessing neuroprotective effects of short chain fatty acids and medium chain fatty acids in Alzheimer's disease
Doctor of Philosophy, Crosstalk between Microbiota Gut-Brain Axis and Alzheimer's Disease; Role of gut dysbiosis in cognitive impairment

Associate Supervisor

Doctor of Philosophy, Hyperspectral retinal imaging method for early non-invasive detection of Alzheimer's disease
Doctor of Philosophy, In vivo Analysis of Sorghum Polyphenols in Alzheimer's Disease Worm Models
Doctor of Philosophy, Development and Validation of an Ultrasensitive Single Molecule Array Digital Assay for Human Glial Fibrillary Acidic Protein (GFAP)
Doctor of Philosophy, The Contribution of Diet to the Relationship Between Depression and Alzheimer's Phenotypes

Completed Supervisions

Principal Supervisor

Doctor of Philosophy, Investigating the impact of cd147 and its expression on neuordegeneration and alzheimer's disease ad
Master of Science (Human Biology), Plasma insulin-degrading enzyme: Characterisation and evaluation as a potential biomarker for alzheimer's disease.
Doctor of Philosophy, Identifying gamma secretase enzyme domains responsible for the generation of alzheimer's beta amyloid protein.
Doctor of Philosophy, Yeast as a model for studying ab aggregation, toxicity and clearance
Doctor of Philosophy, Role of testosterone in prevention of alzheimer's disease.
Doctor of Philosophy, Impact of nutrition on cognition and its association with blood and brain alzheimer disease related biomarkers
Master of Science (Human Biology), The role of luteninizing hormone (lh) and human chorionic gonadotropin (hcg) in the aetiology of alzheimer's disease.
Master of Medical and Health Science by Research, Developing and optimizing methods for grape seed polyphenol extraction
Doctor of Philosophy, Discovery of new biomarkers of mild cognitive impairment and alzheimer's disease risk in buccal cells using laser scanning cytometry.
Doctor of Philosophy, Identification of plasma lipid biomarkers in alzheimer's disease.
Doctor of Philosophy, An Overview of Blood-Based Biomarkers in AD
Doctor of Philosophy, Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing alzheimer's risk
Doctor of Philosophy, Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer's disease
Doctor of Philosophy, In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease
Doctor of Philosophy, Pharmacological modulation of learning and memory in mice and zebrafish: Implications for alzheimers disease animal models.

Associate Supervisor

Doctor of Philosophy, Evolutionary approaches for feature selection in biological data
Master of Science (Sports Science), Effects of long-term participation in tennis on cognitive function in elderly individuals
Doctor of Philosophy, Utility of CSF Biomarkers for the Diagnosis, Prognosis and Assessment of Cognitive Decline in Alzheimer’s disease
Doctor of Philosophy, Comparing live to recorded music and stories using multiple psychoneuroendocrine and psychological measures

School of Medical and Health Sciences

Related Contents

Professor Ralph Martins AO

Chair in Aging & Alzheimers Disease

Background

Professional Memberships

Research Areas and Interests

Qualifications

Research Outputs

2024

Journal Articles

2023

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2022

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2021

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2020

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2019

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2018

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2017

Book Chapters

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2016

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2015

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2014

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Conference Publications

2013

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2012

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Conference Publications

2011

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2010

Book Chapters

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2009

Book Chapters

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2008

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2007

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2006

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2005

Journal Articles

2004

Journal Articles

2003

Book Chapters

Journal Articles

Research Projects

Research Student Supervision

Current Supervisions

Co-principal Supervisor

Associate Supervisor

Completed Supervisions

Principal Supervisor

Associate Supervisor

Contacting ECU

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Contacting ECU

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