Professor Ralph Martins

Chair in Aging & Alzheimers Disease

Telephone: (61 8)  6304 5456  
Facsimile: (61 8)  6304 5851  
Email: r.martins@ecu.edu.au   
Campus: Joondalup  
Room: JO17.314  

 

Background

Professor Ralph Martins, Foundation Chair Ageing and Alzheimer’s Disease at Edith Cowan University, was appointed the Director of the Centre.  Ralph Martins graduated from University of Western Australia with a PhD in 1986. In 1987 he won a scholarship to Heidelberg University to work with Konrad Beyreuther. His collaborative seminal research involved isolating and characterising beta-amyloid and its precursor, the amyloid precursor protein (APP), which are now recognized as central to the pathogenesis of Alzheimer's disease.

He was the first to propose and demonstrate that the Alzheimer brain was under oxidative stress, which is now widely recognized by the Alzheimer research community. In 1989 he joined Professor Masters at Melbourne University where he was the first to isolate and characterize the molecular components of the neuropathological hallmarks of Alzheimer’s disease. This led to an international patent and formation of a spin-off company, Alzhyme Pty Ltd. In 2001 he won a Media Fellowship with the ABC and was the first Media Fellow to have his work on the Science Show. In 2002 he won a Biotechnology Innovation Fund grant, which was matched by commercial funding. He established the Sir James McCusker Alzheimer’s Research Unit at Hollywood Hospital, whose research is directed at the cause(s), and development of diagnostics and treatments. He received the UWA "Excellence in Teaching Award - Post Graduate Research" for 2002 and in 2003 was appointed Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease.

Edith Cowan University appointed him to the Inaugural Chair, Ageing and Alzheimer’s Disease in 2004. He has Adjunct Professorial positions and close ties with clinical academics with both the University of Western Australia and Thomas Jefferson University’s Farber Neurosciences Institute. He is instigator and director of the state government funded Centre of Excellence for Alzheimer’s Disease Research and Care composed of researchers from 4 universities, 3 hospitals and 2 healthcare providers.

  • 2004-2006: Professor – Inaugural Chair, Ageing and Alzheimer’s Disease, Edith Cowan University, Western Australia
  • 2004: Adjunct Professor School of Psychiatry & Clinical Neurosciences,University of Western Australia, Adjunct Professor, School of Biomedical Science
    Curtin University of Technology
  • 2001-2002: Associate Professor, Department of Psychiatry and Neurogenetics,University of Western Australia, Hollywood Private Hospital, Western Australia
  • 2001-2004: Professor on Staff, Research Centre and Community Services,Universitas Peila Harapan, Karawaci, Tangerang, Indonesia
  • 1998-2003: Adjunct Associate Professor, School of Biomedical Science,Curtin University
  • 1997-2001: Senior Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1997-1998:Adjunct Teaching Fellow, Curtin University, Western Australia
  • 1990-1997: Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1989: Senior Research Officer, Department of Pathology, University of Melbourne
  • 1984-1988: Research Scientist, Department of Pathology, University of Western Australia
  • 1983-1988: Permanent Part-time Clinical Biochemist, Department of Pathology, King Edward Memorial Hospital for Women
  • 1980-1984: Tutor of 2nd and 3rd year   medical students in Biochemistry at the University of Western Australia
  • 1979-1983: Demonstrator of 2nd year Biochemistry

Professional Memberships

  • 1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
  • 1982-1997: Australian Society for Medical Research
  • 1984-2002: Australian Neuroscience Society
  • 1984-1991: Australian Nutrition Foundation
  • 1991-2002: Surgical Research Society of Australasia
  • 1991-2004: Australian Association of Gerontology (WA)
  • 1992-2004: Alzheimer’s Association (WA)
  • 1996-2004: Society of Neuroscience (USA)
  • 2000-2004: The Australian Menopause Society
  • 2002-2004: Human Genetics Society of Australia
  • 2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)

Research Areas and Interests

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Staff Qualifications

  • Doctorate, The University of Western Australia, 1986 .

Research

Recent Research Grants

  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund(**),  2010,  $376,167.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant(**),  2010,  $5,250.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease,  National Health and Medical Research Council,  Special Call Complementary & Alternative Medicine(**),  2010,  $149,341.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 2 (ECUPO2) - Plasma apoE Measurement,  Dept of Health and Ageing,  Grant(**),  2010,  $32,733.
  • Discovering Transcriptome and Cytome Biomarkers of Alzheimer's Disease in Isolated Buccal Cells,  Commonwealth Scientific and Industrial Research Organisation,  Scholarship(**),  2010,  $7,000.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 3 (ECUPO3) - Plasma IDE Measurement,  Dept of Health and Ageing,  Grant(**),  2010,  $59,267.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry and Resources,  Centre of Excellence(**),  2010,  $50,000.
  • Round 13 Medical and Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant(**),  2010,  $36,150.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant(**),  2010,  $25,000.
  • Developing a Zebrafish Model for Alzheimer's Disease,  The McCusker Foundation For Alzheimer`s Disease Research,  Scholarship(**),  2010,  $25,000.
  • Diets to Defy Dementia,  Council On The Ageing (WA) Inc,  Grant(**),  2010,  $5,000.
  • Dominantly Inherited Alzheimer Network,  Washington University,  Grant(**),  2010,  $41,618.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health and Medical Research Council,  Grant - Projects(**),  2010,  $-497.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health & Medical Research Council,  Grant - Projects,  2009,  $115,429.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2009,  $25,000.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2009,  $365,750.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund,  2009,  $441,265.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease,  National Health & Medical Research Council,  Special Call Complementary & Alternative Medicine,  2009,  $207,869.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction,  Australian National University,  Centre of Execellence,  2009,  $52,000.
  • Factors that Modulate Testosterone Action on Cognition,  Well Men Centres Pty Ltd,  Fellowship,  2009,  $68,557.
  • The role of APOE as a modulator in recovery from traumatic head injury,  Road Safety Council of WA,  Neurotrauma Research Program,  2009,  $44,000.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2009,  $10,500.
  • Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin,  University of Adelaide,  NHMRC - Grant,  2009,  $68,792.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry & Resources,  Centre of Execellence,  2009,  $90,000.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008,  $25,000.
  • Round 12 Medical and Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  Grant,  2008,  $24,648.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise,  J.O. & J.R. Wicking Trust,  Grant,  2008,  $123,000.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction,  Australian National University,  Centre of Execellence,  2008,  $102,000.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund,  2008,  $342,181.
  • The role of APOE as a modulator in recovery from traumatic head injury,  Road Safety Council of WA,  Neurotrauma Research Program,  2008,  $42,000.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease,  National Health & Medical Research Council,  Special Call Complementary & Alternative Medicine,  2008,  $127,465.
  • Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin,  University of Adelaide,  NHMRC - Grant,  2008,  $69,552.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2008,  $157,000.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry & Resources,  Centre of Execellence,  2008,  $345,000.
  • Round 11 of the Medical & Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  Grant,  2008,  $16,645.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health & Medical Research Council,  Grant - Projects,  2008,  $284,849.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health & Medical Research Council,  Grant,  2007,  $120,750.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry & Resources,  Centre of Execellence,  2007,  $501,747.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2007,  $390,144.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund,  2007,  $125,882.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2),  Alzhyme Pty Ltd,  Grant,  2007,  $13,794.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise,  J.O. & J.R. Wicking Trust,  Grant,  2007,  $167,500.
  • The role of APOE as a modulator in recovery from traumatic head injury,  Road Safety Council of WA,  Neurotrauma Research Program,  2007,  $40,000.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction,  Australian National University,  Centre of Execellence,  2007,  $161,000.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2),  Alzhyme Pty Ltd,  Grant,  2006,  $21,813.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health & Medical Research Council,  Grant,  2006,  $126,500.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2006,  $242,417.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice,  Hollywood Private Hospital,  Grant,  2006,  $9,455.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2006,  $105,019.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry & Resources,  Centre of Execellence,  2006,  $443,439.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2005,  $79,845.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2),  Alzhyme Pty Ltd,  Grant,  2005,  $77,600.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model,  J.O. & J.R. Wicking Trust,  Grant,  2005,  $25,000.
  • Biophysical tools for molecular interactions (Biacore),  University of Western Australia,  Grant - Linkage (Infrastructure),  2005,  $352,000.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise,  J.O. & J.R. Wicking Trust,  Grant,  2005,  $155,600.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health & Medical Research Council,  Grant,  2005,  $176,500.
  • Novel peptides as inhibitors of human beta amyloid function,  Alzhyme Pty Ltd,  Grant,  2005,  $22,264.
  • Exercise, prevention and the pathogenesis of AD,  American Health Assistance Foundation,  Grant,  2005,  .
  • Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system,  Ramaciotti Foundations,  Grant,  2005,  $30,000.

Recent Publications (within the last five years)

Book Chapters

  • Maczurek, A., Krautwald, M., Steele, M., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Munch, G., (2010), Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer?s Disease. Micronutrients and Brain Health, 133-148, Boca Raton, FL, USA.
  • Verdile, G., Martins, R., (2009), Molecular Genetics of Alzheimer's Disease. Molecular Biology of Neuropsychiatric Disorders, 23(1), 229-276, Berlin, Germany, DOI: 10.1007/978-3-540-85383-1_8.
  • Verdile, G., Martins, R., (2009), The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies, 259-268, New York, USA.

Journal Articles

  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., Martins, R., Rowe, C., Szoeke, C., Ellis, K., (2011), Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178, DOI: 10.1159/000325171.
  • Newman, M., Verdile, G., Martins, R., Lardelli, M., (2011), Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352, DOI: 10.1016/j.bbadis.2010.09.012.
  • Avdesh, A., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Ladelli, M., Groth, DM., Verdile, G., Martins, R., (2011), Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469, USA, DOI: 10.3233/JAD-2011-110704.
  • Chetelat, G., Villemagne, V., Pike, K., Ellis, K., Bourgeat, P., Jones, G., O'Keefe, G., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, C., (2011), Independent contribution of temporal ?-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain: a journal of neurology , 134(3), 798-807, United States, DOI: doi:10.1093/brain/awq383.
  • Lambert, J., Dallongeville, J., Ellis, K., Schraen-Maschke , S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, C., Rowe, C., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Associatioin of Plasma A? Peptides with Blood Pressure in the Elderly. PLoS One, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
  • Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R., (2011), Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098, DOI: 10.1212/WNL.0b013e318211c352.
  • Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R., (2011), The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605, Netherlands, DOI: 10.3233/JAD-2011-110584.
  • Villemagne, VL., Pike, KE., Chetelat, G., Ellis, KA., Mulligan, RS., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, CC., (2011), Longitudinal assessment of A? and cognition in aging and Alzheimer disease. Annals of Neurology, 69(1), 181-192, DOI: 10.1002/ana.22248.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, PM., Verdile, G., Martins, R., (2011), Direct exposure of guinea pig CNS to human luteinizing hormone increases cerebrospinal fluid and cerebral beta amyloid levels. Neuroendocrinology, 94(4), 313-322, DOI: 10.1159/000330812.
  • Avdesh, A., Wong, P., Martins, R., Martin-Iverson, MT., (2011), Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 433-444, Netherlands, DOI: 10.3233/JAD-2011-101944.
  • Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Association of plasma A? peptides with blood pressure in the elderly. PLoS ONE, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
  • McBride, SJ., Szoeke, CE., Good, NM., Ames, D., Martins, R., Masters, CL., Maruff, PT., Rowe, CC., Savage, G., Ellis, KA., (2011), A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia, 194(4), S12-S14, Australia.
  • Ellis, KA., Rowe, CC., Szoeke, CE., Villemagne, VL., Ames, D., Chetelat, G., Martins, R., Masters, CL., Fripp, J., Acosta, O., Raniga, P., Bourgeat, PT., Salvado, O., (2011), Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 194(4), S20-S23, Australia.
  • Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A., (2011), Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. Journal of Alzheimer's Disease, 27(4), 909-922 , Netherlands, DOI: 10.3233/JAD-2011-I10752.
  • Villemagne, V., Pike, K., Chetelat, G., Ellis, K., Mulligan, R., Bourgeat, P., Ackermann , U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, C., (2011), Longitudinal Assessment of A? and Cognition in Aging and Alzheimer Disease. Annals of Neurology, 69(1), 181-192, United States, DOI: 10.1002/ana.22248.
  • Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, SD., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, MA., Carrillo, MC., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, AM., Forlenza, O., Frisone , GB., Galasko, D., Galimberti, D., Hampel, H., Handberg, A., Heneka, MT., Herskovits, AZ., Herukka , S., Holtzmann, DM., Humpel, C., Hyman, B., Iqbal, K., Jucker, M., Kaeser , S., Kaiser, E., Kapaki, E., Kidd, D., Kilvenyi, P., Knudsen, CS., Kummer, M., Lui, J., Llado, A., Lewczuk, P., Li, Q., Martins, R., Masters, C., McAuliffe, J., Mercken, M., Moghekar, A., Molinuevo, JL., Montine, TJ., Nowatzke, W., O'Brien, R., Otto, M., Paraskevas, GP., Parnetti, L., Petersen, RC., Prvulovic, D., De Reus, HP., Rissman, RA., Scarpini, E., Stefani, A., Soininen, H., Schroeder , J., Shaw, LM., Skinningsrud, A., Skrogstad, B., Spreer, A., Talib, L., Teunissen, C., Trojanowski, JQ., Tunami, H., Umek, RM., Van Broeck, B., Vanderstichele, H., Vecsei, L., Verbeek, M., Windisch, M., Zhang, J., Zetterberg, H., Blennow, K., (2011), The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers and Dementia, 7(4), 386-395, United States, DOI: 10.1016/j.jalz.2011.05.2243.
  • Sohrabi, H., Weinborn, M., Badcock, J., Bates, K., Clarnette, R., Trivedi, D., Verdile, G., Sutton, T., Lenzo, N., Gandy, S., Martins, R., (2011), New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet Neurology, 10(4), 299-300, DOI: 10.1016/S1474-4422(11)70056-4.
  • Chetelat, G., Villemagne, VL., Pike, KE., Ellis, KA., Bourgeat, P., Jones, G., O'Keefe, GJ., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, CC., (2011), Independent contribution of temporal ?-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain, 134(3), 798-807, United Kingdom, DOI: 10.1093/brain/awq383.
  • Avdesh, A., Wong, P., Martins, R., Martin-Iverson, M., (2011), Memory Function in a Mouse Genetic Model of Alzheimer's disease Memory function in a Mouse Genetic Model of Alzheimer's Disease. Journal of Alzheimer's Disease, 25(NA), 433-444, Netherlands.
  • Ellis, K., Rowe, C., Szoeke, C., Villemagne, V., Ames, D., Chetelat, G., Martins, R., Masters, C., Fripp, J., Acosta, O., Raniga, P., Bourgeat, P., Salvado, O., (2011), Advances in strucutural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 94(194), S20-S23, Australia.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R., (2011), Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322, DOI: 10.1159/000330812.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC., (2011), Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390, DOI: 10.1016/j.neuropsychologia.2011.04.012.
  • Rowe, C., Ellis, K., Rimajova, M., Bourgeat, P., Pike, KE., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., Price, R., Raniga, P., Robins, P., Acosta, O., Lenzo, N., Szoeke, C., Salvado, O., Head, R., Martins, R., Masters, C., Ames, D., Villemagne, VL., (2010), Amyloid imaging results, from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31(8), 1275-1283, United States, DOI: 10.1016/j.neurobiolaging.2010.04.007.
  • Rodrigues, M., Foster, J., Verdile, G., Joesbury, K., Prince, R., Devine, A., Mehta, P., Beilby, J., Martins, R., (2010), Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: Quod erat demonstrandum?. International Psychogeriatrics, 22(2), 332-335, United Kingdom, DOI: 10.1017/S1041610209991190.
  • Ellis, K., Rowe, C., Villemagne, V., Martins, R., Masters, C., Salvado, O., Szoeke, C., Ames, D., (2010), Addressing population aging and Alzheimer's disease through the Australian Imaging Biomarkers and Lifestyle study: Collaboration with the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's and Dementia, 6(3), 291-296, United States, DOI: 10.1016/j.jalz.2010.03.009.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2010), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  • Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R., (2010), Plasma amyloid-? as a biomarker in Alzheimer?s disease: the AIBL study of aging. Journal of Alzheimer's Disease, 20(4), 1233-1242, Netherlands, DOI: 10.3233/JAD-2010-090249.
  • Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., Lardelli, M., (2010), A Zebrafish melanophore model of Amyloid ? toxicity. Zebrafish, 7(2), 155-159, DOI: 10.1089/zeb.2009.0628.
  • Ford, A., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O., (2010), Vitamins B??, B?, and folic acid for cognition in older men. Neurology, 75(17), 1540-1547, United States, DOI: 10.1212/WNL.0b013e3181f962c4.
  • Chetelat, G., Villemagne, V., Bourgeat, P., Pike, K., Jones, G., Ames, D., Ellis, K., Szoeke, C., Martins, R., O'Keefe, G., Salvado, O., Masters, C., Rowe, C., (2010), Relationship between Atrophy and B-Amyloid Deposition in Alzheimer Disease. Annals of Neurology, 67(3), 317-324, United States, DOI: 10.1002/ana.21955.
  • Miklossy, J., Qing, H., Radenovic, A., Kis, A., Vileno, B., Laszlo, F., Miller, L., Martins, R., Waeber, G., Mooser, V., Bosman, F., Khalili, K., Darbinian, N., McGeer, P., (2010), Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging, 31(9), 1503-1515, United States, DOI: 10.1016/j.neurobiolaging.2008.08.019.
  • Bourgeat, P., Chetelat, G., Villemagne, V., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C., Ourselin, S., Ames, D., Ellis, KA., Martins, R., Masters, C., Rowe, C., Salvado, O., (2010), ?-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 74(2), 121-127, United States, DOI: 10.1212/WNL.0b013e3181c918b5.
  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R., (2010), Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, 31(2), 203-214, United States, DOI: 10.1016/j.neurobiolaging.2008.03.023.
  • Frost, S., Martins, R., Kanagasingam, Y., (2010), Ocular biomarkers for early detection of Alzheimer's Disease. Journal of Alzheimer's Disease, 22(1), 1-16, Netherlands, DOI: 10.3233/JAD-2020-100819.
  • Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., Haroutunian, V., Fried, U., Ehrlich, M., Martins, R., Gandy, S., (2010), Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration, 5(1), Article No.1, United Kingdom, DOI: 10.1186/1750-1326-5-1.
  • Chetelat, G., Villemagne, VL., Pike, KE., Baron, J., Bourgeat, P., Jones, G., Faux, NG., Ellis, K., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, C., Rowe, C., (2010), Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain, 133(11), 3349-3358, United Kingdom, DOI: 10.1093/brain/awq187.
  • Barron, A., Verdile, G., Taddei, K., Bates, K., Martins, R., (2010), Effect of Chronic hCG Administration on Alzheimer's-Related Cognition and A? accumulation in PS1KI mice. Endocrinology, 151(11), 5380?5388, United States, DOI: 10.1210/en.2009-1168.
  • Bharadwaj, P., Martins, R., Macreadie, I., (2010), Yeast as a model for studying Alzheimer's disease. F E M S Yeast Research, 10(8), 961?969, United Kingdom, DOI: 10.1111/j.1567-1364.2010.00658.x.
  • Peiffer, J., Galvao, D., Gibbs, Z., Smith, K., Turner, D., Foster, J., Martins, R., Newton, R., (2010), Strength and Functional Characteristics of Men and women 65 Years and Older. Rejuvenation Research, 13(1), 75-82, United States, DOI: 10.1089/rej.2009.0916.
  • Sharman, M., Shui, G., Fernandis, A., Lim, WL., Berger, T., Hone, E., Taddei, K., Martins, I., Ghiso, J., Buxbaum, JD., Gandy, S., Wenk, M., Martins, R., (2010), Profiling brain and plasma lipids in human APOE ?2, ?3 and ?4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's Disease, 20(1), 105-111, Netherlands, DOI: 10.3233/JAD-2010-1348.
  • Sharman, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R., (2010), APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-?42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409, Netherlands, DOI: 10.3233/JAD2010100141.
  • Jenner, A., Lim, FW., Ng, M., Wenk, MR., Shui, G., Sharman, M., Gandy, S., Martins, R., (2010), The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ?2,?3 and ?4 knock-in mice. Neuroscience, 169(1), 109-115, United Kingdom, DOI: 10.1016/j.neuroscience.2010.04.026.
  • Krishnaswamy, S., Verdile, G., Groth, D., Kanyenda, L., Martins, R., (2009), The structure and function of Alzheimer's gamma secretase enzyme complex. Critical Reviews in Clinical Laboratory Science, 46(5-6), 282-301, United Kingdom, DOI: 10.3109/10408360903335821.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-? Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318, The Netherlands, DOI: 10.3233/JAD-2009-1050.
  • Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., Martins, R., (2009), Clearance mechanisms of Alzheimer?s amyloid-? peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry, 14(5), 469-486 , United Kingdom, DOI: 10.1038/mp.2008.96.
  • Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R., (2009), Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308, United Kingdom, DOI: 10.1111/j.1471-4159.2009.06408.x.
  • Chen, M., Martins, R., Lardelli, M., (2009), Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317, Netherlands, DOI: 10.3233/JAD-2009-1145.
  • De Silva, R., Disanayaka, S., De Zoysa, N., Sanjeewanie, N., Somaratne, S., Foster, J., Srikanth, S., Kathriarachchi, S., Martins, R., (2009), Norms for the mini-mental state examination from a sample of Sri Lankan older people. International Journal of Geriatric Psychiatry, 24(7), 666-670, DOI: 10.1002/gps.2168.
  • Barron, A., Cake, M., Verdile, G., Martins, R., (2009), Ovariectomy and 17?-Estradiol Replacement Do Not Alter beta-Amyloid Levels in Sheep Brain. Endocrinology, 150(7), 3228-3236, United States, DOI: 10.1210/en.2008-1252.
  • Foster, J., Verdile, G., Bates, K., Martins, R., (2009), Immunization in Alzheimer's disease: naive hope or realistic clinical potential. Molecular Psychiatry, 14(3), 239-251, United Kingdom, DOI: 10.1038/mp.2008.115.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R., (2009), Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142, The Netherlands, DOI: 10.3233/JAD-2009-1020.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R., (2009), The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein e?4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79, The Netherlands, DOI: 10.3233/JAD-2009-1018.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers. Journal of Alzheimer's disease, 17(2), 305-18, Amsterdam.
  • Ellis, K., Bush, A., Darby, D., De Fazio, D., Foster, J., Hudson, P., Lautenschlager, N., Lenzo, N., Martins, R., Maruff, P., Masters, C., Milner, A., Pike, K., Rowe, C., Savage, G., Szoeke, C., Taddei, K., Villemagne, V., Woodward, M., Ames, D., Aibl Research Group, T., (2009), The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21(4), 672-687, United Kingdom, DOI: 10.1017/S1041610209009405.
  • Bharadwaj, P., Dubey, AK., Masters, CL., Martins, R., Macreadie, I., (2009), A ? aggregation and possible implications in Alzheimer's disease pathogenesis. Journal of Cell and Molecular Medicine, 13(3), 412-421, United Kingdom, DOI: 10.1111/j.1582-4934.2008.00609.x.
  • Drummond, E., Harvey, AR., Martins, R., (2009), Androgens and Alzheimer's Disease. Current Opinion in Endocrinology, Diabetes and Obesity, 16(3), 254-259, United Kingdom, DOI: 10.1097/MED.0b013e32832b101f.
  • Pedrini, S., Thomas, C., Brautigam, H., Schmeidler, J., Ho, L., Fraser, P., Westaway, D., St George Hyslop, P., Martins, R., Buxbaum, D., Pasinetti, GM., Dickstein, DL., Hof, PR., Ehrlich, M., Gandy, S., (2009), Dietary composition modulates brain mass and solubilizable A levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration, 4(1), Article No. 40, United Kingdom, DOI: 10.1186/1750-1326-4-40.
  • Hata, S., Fujishige, S., Araki, Y., Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S., Suzuki, T., (2009), Alcadein Cleavages by Amyloid ? -Precursor Protein (APP) ? -and ? -Secretases Generate Small Peptides, p3-Alcs, Indicating Alzhiemer Disease-related ? -Secretase Dysfunction. The Journal of Biological Chemistry, 284(52), 36024-36033, United States, DOI: 10.1074/jbc.M109.057497.
  • Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., Lardelli, M., (2009), Independent an cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 315(16), 2791-2801, DOI: 10.1016/j.yexcr.2009.06.023.
  • Urosevic, N., Martins, R., (2008), Infection and Alzheimer's Disease: The APOE epsilon 4 Connection and Lipid Metabolism. Journal of Alzheimer's Disease, 13(4), 421-435, Netherlands.
  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R., (2008), Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages, United States.
  • Gnjec, A., D'costa, K., Laws, S., Hedley, R., Balakrishnan, K., Taddei, K., Martins, G., Paton, A., Verdile, G., Gandy, S., Broe, A., Brooks, W., Bennett, H., Piguet, O., Price, P., Miklossy, J., Hallmayer, J., McGeer, P., Martins, R., (2008), Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation, 5(36), 1-10.
  • Rimajova, M., Lenzo, N., Wu, J., Bates, K., Campbell, A., Dhaliwald, SS., McCarthy, M., Rodrigues, M., Paton, A., Rowe, C., Foster, J., Martins, R., (2008), Fluoro-2-deoxy-D-glucose (FDG)-PET in APOE epsilon 4 carriers in the Australian population. Journal of Alzheimer's disease, 13(2), 137-146, Amsterdam.
  • Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Sleptsova - Fredrich, I., Martins, R., Lardelli, M., (2008), Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412.
  • Flicker, L., Martins, R., Thomas, J., Acres, J., Taddei, K., Vasikaran, S., Norman, P., Jamrozik, K., Almeida, O., (2008), B-Vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29(2), 303-305, United States.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Martins, G., Howard, M., De Ruyck, K., Bates, K., Dhaliwal, S., Verdile, G., Carruthers, M., Martins, R., (2008), Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137, Netherlands.
  • Chan, H., Liu, T., Verdile, G., Glenda, B., Haasl, R., Smith, M., Perry, G., Martins, R., Atwood, C., (2008), Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the txJ Mouse is a Better Model of Hepatic than Brain Cu Toxicity. International Journal of Clinical and Experimental Medicine, 1(1), 76-88.
  • Miklossy, J., Martins, R., (2008), Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease: The Emerging role of Infection. Journal of Alzheimer's Disease, 13(4), 357, Netherlands.
  • Foster, J., Sohrabi, H., Verdile, G., Martins, R., (2008), Research criteria for the diagnosis of Alzheimer's disease: genetic risk factors, blood biomarkers and olfactory dysfunction. International Psychogeriatics, 20(4), 853-857, Cambride UK.
  • Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R., (2008), Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274, Amsterdam.
  • Foster, J., Sohrabi, H., Verdile, G., Martins, R., (2008), Research Criteria for the Diagnosis of Alzheimer'S Disease: Genetic Risk Factors, Blood Biomarkers and Olfactory Dysfunction. International Psychogeriatrics, 20(4), 853-855, 32 Avenue of the Americas, New York, NY 10013-2473.
  • Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Munch, G., (2008), Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Advanced Drug Delivery Reviews, 60(13-14), 1463-1470.
  • Verdile, G., Yeap, B., Clarnette, R., Dhaliwal, S., Burkhart, M., Chubb, SA., De Ruyck, K., Rodrigues, M., Mehta, PD., Foster, J., Bruce, D., Martins, R., (2008), Luteinizing Hormone Levels are Positively Correlated with Plasma Amyloid-beta Protein Levels in Elderly Men. Journal of Alzheimer's Disease, 14(2), 201-208, Netherlands.
  • McRae, A., Martins, R., Fonte, J., Kraftsik, R., Hirt, L., Miklossy, J., (2007), Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: A putative marker of an ongoing inflammatory process. Experimental Gerontology, 42(4), 355-363, USA.
  • Fuller, S., Tan, R., Martins, R., (2007), Androgens in the Etiology of Alzheimer's Disease in Aging Men and Possible Therapeutic Interventions. Journal of Alzheimer's disease, 12(2), 129-142, Amsterdam.
  • Verdile, G., Gandy, S., Martins, R., (2007), The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer's Beta Amyloid. Neurochemical Research, 32(4-5), 609-623.
  • Bates, K., Martins, R., Harvey, A., (2007), Oxidative Stress in a Rat Model of Chronic Gliosis. Neurobiology of Aging, 28(7), 995-1008, United States.

Research Student Supervision

Principal Supervisor

  • Doctor of Philosophy,  Identifying Gamma Secretase Enzyme Domains Responsible For The Generation Of Alzheimer's Beta Amyloid Protein..
  • Doctor of Philosophy,  Yeast As A Model For Studying Ab Aggregation, Toxicity And Clearance.
  • Master of Science (Human Biology),  The Role Of Luteninizing Hormone (lh) And Human Chorionic Gonadotropin (hcg) In The Aetiology Of Alzheimer's Disease..

Co-principal Supervisor