Associate Professor Mel Ziman
Current Teaching
- Developmental Biology
- Pharmacology
- Fundamental Biomedical Techniques
- Postgraduate Supervision
Background
- 2011-present: Associate Professor, School of Medical Sciences, ECU
- 2005-2010: Associate Professor, School of Exercise, Biomedical and Health Science, ECU
- 2003-2005: Senior Lecturer, School of Exercise, Biomedical and Health Science, ECU
- 2001-2003: Lecturer, School of Exercise, Biomedical and Health Science, ECU
- 1996-2001: Senior Research Fellowship, School of Pathology and Laboratory Medicine, UWA
Professional Memberships
- International Society of Differentiation (ISD)
- Australian Neuroscience Society
- Human Genetics Society of Australia
- Australian Society for Medical Research
- HERDSA
- Australian and New Zealand Society of Development and Cell Biology
Awards and Recognition
University and National Teaching Awards
- 2008: VC Citation for excellence in development of a Teaching and Research Nexus
- 2008: Citation for Outstanding Contribution to Student Learning – Australian Learning and Teaching Council (Carrick)
- 2008: ECU Certificate of excellence in Learning and Teaching – UTEI over 85
Other
- 2010, 2011: NHMRC grant review panel member
- 2009, 2010: National ALTC citation review panel member
- 2008: ECU Certificate of excellence in Research – Research Activity index in top 10 at ECU
- 2005: ECU award for Excellence in Postgraduate Supervision
Research Areas and Interests
- The role of developmental genes in the proliferation, differentiation and migration of cells in the embryo and in disease processes such as cancer including Cutaneous Malignant Melanoma and neurodegenerative diseases including Huntington’s disease.
- Characterisation of circulating cells in Melanoma Environmental enrichment and neurogenesis in Huntington’s disease.
Staff Qualifications
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Bachelor of Science Honours, South Africa .
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Doctor of Philosophy, South Africa, 1983 .
Research
Recent Research Grants
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Nature's Wonder,
Cocky Smart,
Grant,
2011,
$125,016.
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CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,
National Health and Medical Research Council,
Equipment Grant,
2011,
$10,811.
-
The association between environmental stresses (UV, heat and chemicals) and melanoma incidence amongst staff at Telfer gold mine.,
Edith Cowan University,
ECU Industry Collaboration - Grant,
2011,
$10,000.
-
Detection and Characterisation of Circulating Cutaneous Malignant Melanoma Cells,
Edith Cowan University,
ECU Industry Collaboration - Grant(**),
2011,
$5,000.
-
The Effects of Environmental Enrichment on Clinical Measures of Disease Progression and Quality of Life for Patients with Huntington's Disease,
Australian Huntington Disease Association (Inc) WA,
Grant,
2011,
$134,234.
-
Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,
National Health and Medical Research Council,
Equipment Grant 2011,
2011,
$10,928.
-
Characterisation and Quantification of Circulating Melanoma Cells,
Cancer Council of WA Inc,
Cancer Council, Scholarship(**),
2010,
$3,000.
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The Effects of Environmental Enrichment on Clinical Measures of Disease Progression and Quality of Life for Patients with Huntington's Disease,
Australian Huntington Disease Association (Inc) WA,
Grant(**),
2010,
$191,510.
-
Evaluation of Paramedic Treatment Techniques to Assess Contributing Factors to Mortality in the Pre Hospital Management of Traumatic Brain Injury,
Edith Cowan University,
Grant - Industry Collaboration,
2009,
$5,000.
-
Quantification and Characterisation of Circulating Cutaneous Malignant Melanoma Cells,
Cancer Council of WA Inc,
Grant,
2009,
$70,000.
-
Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. ,
Australian Research Council,
Grant - Discovery,
2009,
$14,938.
-
Patient outcome affected by paramedic pre hospital treatment of patients with severe brain injuries,
Edith Cowan University,
Grant - Industry Collaboration,
2008,
$28,162.
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Detection of Migrating Melanoma Cells in Peripheral Blood of Patients with Metastatic Melanoma,
Cancer Council of WA Inc,
Grant,
2008,
$2,000.
-
Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. ,
Australian Research Council,
Grant - Discovery,
2008,
$13,456.
-
Patient outcome affected by paramedic pre hospital treatment of patients with severe brain injuries,
Edith Cowan University,
Grant - Industry Collaboration,
2007,
$5,000.
-
Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. ,
Australian Research Council,
Grant - Discovery,
2007,
$89,782.
-
Development of a blood test for Cutaneous Malignant Melanoma,
Edith Cowan University,
Grant - Industry Collaboration,
2007,
$6,000.
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Development of a Blood Test for Cutaneous Malignant Melanoma,
Edith Cowan University Foundation,
Donation,
2007,
$34,485.
-
Developmental genes and Melanoma detection,
Edith Cowan University,
Grant - Industry Collaboration,
2005,
$8,000.
-
Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system,
Ramaciotti Foundations,
Grant,
2005,
$30,000.
-
Matching the developmental transcription factor profiles of transplanted cells and host injured brain regions is crucial for successful cell transplant therapies,
Western Australian Institute for Medical Research Inc,
Grant,
2005,
$60,000.
-
A role for PAX3 in the metastasis of Cutaneous Malignant Melanoma (CMM),
Cancer Council of WA Inc,
Grant,
2004,
$2,000.
Recent Publications (within the last five years)
Book Chapters
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Ziman, M., Millward, M., Pearce, R., Lee, M., (2011), Serological Biomarkers in Melanoma. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma, 195-208, USA, DOI: 10.1007/978-1-60761-433-3_15.
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Ziman, M., (2011), Circulating melanoma cells. Breakthroughs in Melanoma Research, 43-56, Croatia.
Journal Articles
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Charytonowicz, E., Matushansky, I., Castillo-Martin, M., Hricik, T., Cordon-Cardo, C., Ziman, M., (2011), Alternate PAX3 and PAX7 C-terminal isoforms in myogenic differentiation and sarcomagenesis. Clinical and Translational Oncology, 13(3), 194-203, DOI: 10.1007/s12094-011-0640-y.
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Ireland, A., Millward, M., Pearce, R., Lee, M., Ziman, M., (2011), Genetic factors in metastatic progression of cutaneous melanoma: The future role of circulating melanoma cells in prognosis and management. Clinical and Experimental Metastasis, 28(4), 327-336, DOI: 10.1007/s10585-010-9368-2.
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Thompson, J., Ziman, M., (2011), Pax genes during neural development and their potential role in neuroregeneration. Progress in Neurobiology, 95(3), 334-351, DOI: 10.1016/j.pneurobio.2011.08.012.
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Thomas, M., Stone, L., Evill, L., Ong, S., Ziman, M., Hool, L., (2011), Bone marrow stromal cells as replacement cells for Parkinson's disease: generation of an anatomical but not functional neuronal phenotype. Translational Research: the journal of laboratory and clinical medicine, 157(2), 56-63, DOI: 10.1016/j.trsl.2010.11.001.
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Charytonowicz, E., Matushansky, I., Castillo-Martin, M., Ladanyi, M., Cordon-Cardo, C., Domingo-Domenech, J., Ziman, M., (2011), PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation. Clinical and Translational Oncology, 14(3), 197-206, DOI: 10.1007/s12094-012-0784-4.
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Medic, S., Rizos, H., Ziman, M., (2011), Differential PAX3 functions in normal skin melanocytes and melanoma cells. Biochemical and Biophysical Research Communications, 411(4), 832-837, DOI: 10.1016/j.bbrc.2011.07.053.
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Johnston, S., Wilkes, G., Thompson, J., Ziman, M., Brightwell, R., (2010), Inhaled methoxyflurane and intranasal fentanyl for prehospital management of visceral pain in an Australian ambulance service. Emergency Medicine Journal, 28(1), 57-63, DOI: 10.1136/emj.2009.078717.
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Medic, S., Ziman, M., (2010), PAX3 expression in normal skin melanocytes and melanocytic lesions (naevi and melanomas). PLoS One, 5(4), e9977, United States, DOI: 10.1371/journal.pone.0009977.
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Thomas, M., Tyers, P., Lazic, S., Barker, R., Beazley, L., Ziman, M., (2009), Graft outcomes influenced by co-expression of Pax7 in graft and host tissue. Journal of Anatomy, 214(3), 396-405, United Kingdom, DOI: 10.1111/j.1469-7580.2009.01049.x.
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Medic, S., Ziman, M., (2009), PAX3 across the spectrum: from melanoblast to melanoma. Critical Reviews in Biochemistry and Molecular Biology, 44(2-3), 85-97, United Kingdom, DOI: 10.1080/10409230902755056.
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Charytonowicz, E., Cordon-Cardo, C., Matushansky, I., Ziman, M., (2009), Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell?. Cancer Letters, 279(2), 126?136, Ireland, DOI: 10.1016/j.canlet.2008.09.039.
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Thompson, J., Zembrzycki, A., Mansouri, A., Ziman, M., (2008), Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superioir collicular development. BMC Developmental Biology, 8(30 May 2008), 62-72, Middlesex House, 34-42 Cleveland Street, London W1T 4LB, UK.
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Blake, J., Thomas, M., Thompson, J., White, R., Ziman, M., (2008), Perplexing Pax: From Puzzle to Paradigm. Developmental Dynamics, 237(10), 2791-2803, USA.
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White, R., Ziman, M., (2008), Genome-wide discovery of Pax7 target genes during development. Physiological Genomics, 33(1), 41-49, Stanford University, USA, DOI: 10.1152/physiolgenomics.00256.2007.
Research Student Supervision
Principal Supervisor
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Doctor of Philosophy, New Perspectives On Melanoma: The Role Of Pax3.
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Master of Science (Human Biology), Pax3 And Cutaneous Malignant Melanoma.
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Doctor of Philosophy, An Investigation Of The Mechanism Of Pax7 Mediated Oncogenesis Via In Silico Biology..
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Doctor of Philosophy, The Role Of Pax3/pax7-fkhr In Mesenchymal Stem Cell Myogenic Differentiation And Rhabdomyosarcomagenesis..
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Doctor of Philosophy, New Perspectives On Melanoma: The Role Of Pax3.
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Master of Science (Human Biology), Pax3 And Cutaneous Malignant Melanoma.
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A Possible Role For Pax7 In Initiating Differentiation Of Neuronal Cells In The Optic Tectum During Normal Development And After Injury.
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Master of Science (Human Biology), Molecular Genetic Investigation Of Autosomal Dominant Hemifacial Microsomia..
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Doctor of Philosophy, The Developmental Function Of Pax 7: Chromatin-immunoprecipitation Discovery Of Pax7 Target Genes.
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Master of Science (Human Biology), The Efficacy Of Inhaled Methoxyflurance And Intranasal Fentanyl For The Pre Hospital Management Of Cardiac Or Visceral Pain..
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The Role Of Pax3 And Pax7 In Alveolar Rhabdomyosarcoma Focusing On Dna Binding Domains, Alternative Splicing And Target Gene Analysis By Microarray.
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Master of Science (Human Biology), The Role Of Pax3 In The Metastasis Of Cutaneous Malignant Melanoma..
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Doctor of Philosophy, The Characterisation Of Pax3 Expressant Cells In Adult Peripheral Nerve.
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Doctor of Philosophy, The Role Of Pax7 In The Formation Of The Superior Colliculus And The Vertebrate Visual System..
Co-principal Supervisor
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Master of Science (Human Biology), The Evaluation Of Midazolam On Head Injured Patients In The Prehospital Setting.
