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Associate Professor Simon Laws

Genomic Leader/Deputy CSO (CRC-MH)

Contact Information Telephone: (61 8) 6304 5128, Mobile: 0408 789 680, Email: s.laws@ecu.edu.au, Campus: Joondalup, Room: JO17.310
Staff Member Details
Telephone: (61 8)  6304 5128  
Mobile: 0408 789 680  
Email: s.laws@ecu.edu.au   
Campus: Joondalup  
Room: JO17.310  

 

Staff Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2003 .
  • Bachelor of Science, Curtin University of Technology, 1999 .

Research

Recent Research Grants

  • 4.1 Biomarkers for Early Diagnosis of AD and PD,  CRC For Mental Health,  CRC Grant,  2011 - 2018,  $4,350,034.
  • Biomarkers and Early Intervention for Neurodegeneration,  CRC For Mental Health,  CRC Grant,  2010,  $299,103.
  • Validation of genetic variants and their functional implications in Alzheimers Disease,  ANZ Executors and Trustee Company Limited,  Judith Jane Mason and Harold Stannett Williams Memorial Foundation - National Medical & Scientific Grants,  2014,  $40,000.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma,  National Health and Medical Research Council,  Project Grants,  2011 - 2013,  $352,524.
  • Western Australian Zebrafish Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $687,000.
  • NEW INDEPENDENT RESEARCHER INFRASTRUCTURE SUPPORT (NIRIS) AWARDS 2011,  Medical and Health Research Infrastructure Council WA,  New Independent Researcher Infrastructure Support (NIRIS),  2011,  $10,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2012,  $10,927.
  • AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream),  Confidential,  Confidential,  2011 - 2012,  $95,238.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health and Medical Research Council,  Grant,  2005 - 2007,  $423,750.

Recent Publications (within the last five years)

Journal Articles

  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G., (2013), The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235.
  • Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V., (2013), A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(2014), 519-526, United Kingdom.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P., (2013), BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464, United States.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R., (2013), The acceleration of aging and Alzheimer?s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920, United States of America, DOI: 10.4236/health.2013.55121.
  • Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R., (2012), Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry , 2(2012), art. no. e118 , DOI: 10.1038/tp.2012.43.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75, United Kingdom, DOI: 10.1038/mp.2012.147.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325, United States, DOI: 10.1001/archneurol.2012.1282.
  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid-? plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881, United Kingdom.
  • Guo, LH., Westerteicher, C., Wang, X., Kratzer, M., Tsolakidou, A., Jiang, M., Grimmer, T., Laws, S., Alexopoulos, P., Bujo, H., Kurz, A., Perneczky, R., (2012), SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience, 262(6), 529-534, DOI: 10.1007/s00406-012-0295-x.
  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R., (2012), Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer?s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456, United States, DOI: 10.4236/health.2012.412A209.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoecke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer?s disease. Molecular Psychiatry, 7, United Kingdom, DOI: 10.1038/mp.2012.147.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Foster, J., Phillips, J., Martins, R., (2012), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC., (2011), Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390, DOI: 10.1016/j.neuropsychologia.2011.04.012.
  • Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R., (2011), Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098, DOI: 10.1212/WNL.0b013e318211c352.
  • Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A., (2011), Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. Journal of Alzheimer's Disease, 27(4), 909-922 , Netherlands, DOI: 10.3233/JAD-2011-I10752.
  • Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Association of plasma A? peptides with blood pressure in the elderly. PLoS One, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
  • Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Riehle, C., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Forstl, H., Kurz, A., Reimenschneider, M., (2010), Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, 15(7), 756?766, United Kingdom, DOI: 10.1038/mp.2008.141.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2010), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, TU., Forstl, H., Reimenschneider, M., (2010), No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, 31(12), 2192-2193 , United States, DOI: 10.1016/j.neurobiolaging.2008.12.004.
  • Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R., (2010), Plasma amyloid-? as a biomarker in Alzheimer?s disease: the AIBL study of aging. Journal of Alzheimer's Disease, 20(4), 1233-1242, Netherlands, DOI: 10.3233/JAD-2010-090249.
  • Danek, A., Diehl-Schmid, J., Grimmer, T., Laws, S., Neumann, M., Perneczky, R., Riemenschneider, M., Kurz, A., Forstl, H., (2009), Frontotemporale Lobardegenerationen, Teil 1: Diagnose und Therapie. Fortschritte der Neurologie-Psychiatrie, 77(3), 169-176, Germany, DOI: 10.1055/s-0028-1109070.
  • Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Schoepfer-Wendels, A., Mueller, J., Konta, L., Laws, S., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No Association of Common VCP Variants With Sporadic Frontotemporal Dementia. Neurobiology of Aging, 30(2), 333-335, United States, DOI: 10.1016/j.neurobiolaging.2007.05.023.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers. Journal of Alzheimer's disease, 17(2), 305-18, Amsterdam.
  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Forstl, H., Riemenschneider, M., (2009), Lack of evidence to support the association of polymorphisms within the ? and ? secretase genes (ADAM10/BACE1) with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2009.02.023.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-? Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318, The Netherlands, DOI: 10.3233/JAD-2009-1050.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R., (2009), The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein e?4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79, The Netherlands, DOI: 10.3233/JAD-2009-1018.
  • Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Forstl, H., Kurz, A., Riemenschneider, M., (2009), Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, n/a(n/a), n/a, United Kingdom.
  • Friedrich, P., Feulner, T., Laws, S., Eckart, K., Perneczky, R., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States.
  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R., (2009), Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142, The Netherlands, DOI: 10.3233/JAD-2009-1020.
  • Diehl-Schmid, J., Neumann, M., Laws, S., Perneczky, R., Grimmer, T., Danek, A., Kurz, A., Riemenschneider, M., Forstl, H., (2009), Frontotemporale Lobardegenerationen. Fortschritte der Neurologie, Psychiatrie, 77(5), 295-304, Germany, DOI: 10.1055/s-0028-1109107.
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