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Genomic Leader/Deputy CSO (CRC-MH)

Staff Qualifications

• Doctor of Philosophy, The University of Western Australia, 2003 .
• Bachelor of Science, Curtin University of Technology, 1999 .

Research

Recent Research Grants

• Discovery and Validation of Alzheimers Biomarkers in Human Plasma,  National Health and Medical Research Council,  Project Grants,  2011,  $119,623.
• Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011,  $10,928.
• NEW INDEPENDENT RESEARCHER INFRASTRUCTURE SUPPORT (NIRIS) AWARDS 2011,  Medical and Health Research Infrastructure Council WA,  New Independent Researcher Infrastructure Support (NIRIS),  2011,  $10,000.
• AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream),  Confidential,  Confidential,  2011,  $76,190.

Recent Publications (within the last five years)

Journal Articles

• Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R., (2012), Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. J Transl. Psychiatry, 2(e118), 7, DOI: 10.1038/tp.2012.43.
• Lau, S., Bates, KA., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwa, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2012), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-6, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
• Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Association of plasma A? peptides with blood pressure in the elderly. PLoS One, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
• Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC., (2011), Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390, DOI: 10.1016/j.neuropsychologia.2011.04.012.
• Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A., (2011), Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. Journal of Alzheimer's Disease, 27(4), 909-922 , Netherlands, DOI: 10.3233/JAD-2011-I10752.
• Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R., (2011), Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098, DOI: 10.1212/WNL.0b013e318211c352.
• Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R., (2010), Plasma amyloid-? as a biomarker in Alzheimer?s disease: the AIBL study of aging. Journal of Alzheimer's Disease, 20(4), 1233-1242, Netherlands, DOI: 10.3233/JAD-2010-090249.
• Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, TU., Forstl, H., Reimenschneider, M., (2010), No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, 31(12), 2192-2193 , United States, DOI: 10.1016/j.neurobiolaging.2008.12.004.
• Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Riehle, C., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Forstl, H., Kurz, A., Reimenschneider, M., (2010), Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, 15(7), 756?766, United Kingdom, DOI: 10.1038/mp.2008.141.
• Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2010), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
• Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-? Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318, The Netherlands, DOI: 10.3233/JAD-2009-1050.
• Diehl-Schmid, J., Neumann, M., Laws, S., Perneczky, R., Grimmer, T., Danek, A., Kurz, A., Riemenschneider, M., Forstl, H., (2009), Frontotemporale Lobardegenerationen. Fortschritte der Neurologie, Psychiatrie, 77(5), 295-304, Germany, DOI: 10.1055/s-0028-1109107.
• Friedrich, P., Feulner, T., Laws, S., Eckart, K., Perneczky, R., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States.
• Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States.
• Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Forstl, H., Riemenschneider, M., (2009), Lack of evidence to support the association of polymorphisms within the ? and ? secretase genes (ADAM10/BACE1) with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2009.02.023.
• Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Schoepfer-Wendels, A., Mueller, J., Konta, L., Laws, S., Kurz, A., Forstl, H., Riemenschneider, M., (2009), No Association of Common VCP Variants With Sporadic Frontotemporal Dementia. Neurobiology of Aging, 30(2), 333-335, United States, DOI: 10.1016/j.neurobiolaging.2007.05.023.
• Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R., (2009), Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142, The Netherlands, DOI: 10.3233/JAD-2009-1020.
• Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R., (2009), The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein e?4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79, The Netherlands, DOI: 10.3233/JAD-2009-1018.
• Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers. Journal of Alzheimer's disease, 17(2), 305-18, Amsterdam.
• Danek, A., Diehl-Schmid, J., Grimmer, T., Laws, S., Neumann, M., Perneczky, R., Riemenschneider, M., Kurz, A., Forstl, H., (2009), Frontotemporale Lobardegenerationen, Teil 1: Diagnose und Therapie. Fortschritte der Neurologie-Psychiatrie, 77(3), 169-176, Germany, DOI: 10.1055/s-0028-1109070.
• Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Forstl, H., Kurz, A., Riemenschneider, M., (2009), Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, n/a(n/a), n/a, United Kingdom.
• Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R., (2008), Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages, United States.
• Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R., (2008), Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274, Amsterdam.
• Laws, S., Friedrich, P., Diehl-Schmid, J., Muller, J., Ibach, B., Bauml, J., Eisele, T., Forstl, H., Kurz, A., Riemenschneider, M., (2008), Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. Neurobiology of Aging, 29(8), 1276-1278, United States.