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Professor Ralph Martins AO

Chair in Aging & Alzheimers Disease

Contact Information Telephone: (61 8) 6304 5456, Email: r.martins@ecu.edu.au, Campus: Joondalup, Room: JO17.314
Staff Member Details
Telephone: (61 8)  6304 5456  
Facsimile: (61 8)  6304 5851  
Email: r.martins@ecu.edu.au   
Campus: Joondalup  
Room: JO17.314  

 

Background

Professor Ralph Martins, Foundation Chair Ageing and Alzheimer’s Disease at Edith Cowan University, was appointed the Director of the Centre.  Ralph Martins graduated from University of Western Australia with a PhD in 1986. In 1987 he won a scholarship to Heidelberg University to work with Konrad Beyreuther. His collaborative seminal research involved isolating and characterising beta-amyloid and its precursor, the amyloid precursor protein (APP), which are now recognized as central to the pathogenesis of Alzheimer's disease.

He was the first to propose and demonstrate that the Alzheimer brain was under oxidative stress, which is now widely recognized by the Alzheimer research community. In 1989 he joined Professor Masters at Melbourne University where he was the first to isolate and characterize the molecular components of the neuropathological hallmarks of Alzheimer’s disease. This led to an international patent and formation of a spin-off company, Alzhyme Pty Ltd. In 2001 he won a Media Fellowship with the ABC and was the first Media Fellow to have his work on the Science Show. In 2002 he won a Biotechnology Innovation Fund grant, which was matched by commercial funding. He established the Sir James McCusker Alzheimer’s Research Unit at Hollywood Hospital, whose research is directed at the cause(s), and development of diagnostics and treatments. He received the UWA "Excellence in Teaching Award - Post Graduate Research" for 2002 and in 2003 was appointed Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease.

Edith Cowan University appointed him to the Inaugural Chair, Ageing and Alzheimer’s Disease in 2004. He has Adjunct Professorial positions and close ties with clinical academics with both the University of Western Australia and Thomas Jefferson University’s Farber Neurosciences Institute. He is instigator and director of the state government funded Centre of Excellence for Alzheimer’s Disease Research and Care composed of researchers from 4 universities, 3 hospitals and 2 healthcare providers.

  • 2004-2006: Professor – Inaugural Chair, Ageing and Alzheimer’s Disease, Edith Cowan University, Western Australia
  • 2004: Adjunct Professor School of Psychiatry & Clinical Neurosciences,University of Western Australia, Adjunct Professor, School of Biomedical Science
    Curtin University of Technology
  • 2001-2002: Associate Professor, Department of Psychiatry and Neurogenetics,University of Western Australia, Hollywood Private Hospital, Western Australia
  • 2001-2004: Professor on Staff, Research Centre and Community Services,Universitas Peila Harapan, Karawaci, Tangerang, Indonesia
  • 1998-2003: Adjunct Associate Professor, School of Biomedical Science,Curtin University
  • 1997-2001: Senior Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1997-1998:Adjunct Teaching Fellow, Curtin University, Western Australia
  • 1990-1997: Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1989: Senior Research Officer, Department of Pathology, University of Melbourne
  • 1984-1988: Research Scientist, Department of Pathology, University of Western Australia
  • 1983-1988: Permanent Part-time Clinical Biochemist, Department of Pathology, King Edward Memorial Hospital for Women
  • 1980-1984: Tutor of 2nd and 3rd year   medical students in Biochemistry at the University of Western Australia
  • 1979-1983: Demonstrator of 2nd year Biochemistry

Professional Memberships

  • 1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
  • 1982-1997: Australian Society for Medical Research
  • 1984-2002: Australian Neuroscience Society
  • 1984-1991: Australian Nutrition Foundation
  • 1991-2002: Surgical Research Society of Australasia
  • 1991-2004: Australian Association of Gerontology (WA)
  • 1992-2004: Alzheimer’s Association (WA)
  • 1996-2004: Society of Neuroscience (USA)
  • 2000-2004: The Australian Menopause Society
  • 2002-2004: Human Genetics Society of Australia
  • 2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)

Research Areas and Interests

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Staff Qualifications

  • Doctorate, The University of Western Australia, 1986 .

Research

Recent Research Grants

  • 4.6 - Biomarkers for Schizophrenia Sub-Types - Part A Neuroimaging, Part B Biomarker Discovery,  CRC For Mental Illness,  CRC Grant,  2011 - 2018,  $960,146.
  • Biomarkers and Early Intervention for Neurodegeneration,  CRC For Mental Illness,  CRC Grant,  2010,  $299,103.
  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease,  National Health and Medical Research Council,  Project Grants,  2013 - 2015,  $536,949.
  • Evaluation of the Nutritional Extract Bio-curcumax BCM-95 to Preserve Cognitive Functioning in a Cohort of Mild Cognitively Impaired MCI Patients,  McCusker Alzheimer's Research Foundation Inc,  McCusker Alzheimer's Research Foundation - Grant,  2012 - 2016,  $85,625.
  • The influence of exercise intensity on the prevention of cognitive decline in older adults,  Alzheimers Australia Dementia Research Foundation,  Postdoctoral Fellowships,  2014 - 2015,  $238,034.
  • Personality dimensions and increased risk of late onset Alzheimer's disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014 - 2015,  $15,000.
  • Progressing the clinical neuropsychological phenotype of Alzheimer's disease.,  Florey Neuroscience Institutes,  Grant,  2014,  $107,935.
  • Dominantly Inherited Alzheimer Network,  Washington University,  Grant,  2009 - 2014,  $579,710.
  • A study of the kinetics of biomarkers and their presumptive relationship with brain amyloid ,  Commonwealth Scientific and Industrial Research Organisation,  Araclon Biotech,  2014 - 2015,  $148,000.
  • Ocular Imaging Project NeuroVision Imaging,  Commonwealth Scientific and Industrial Research Organisation,  NeuroVision Imaging, LLC Grant,  2013 - 2015,  $152,999.
  • 4.1 Biomarkers for Early Diagnosis of AD and PD,  CRC For Mental Illness,  CRC Grant,  2011 - 2018,  $4,350,034.
  • Dietary short chain fatty acids supplementation as a potential therapy for AD,  Hollywood Private Hospital Research Foundation,  Grant,  2014 - 2015,  $10,000.
  • 4.4B1 Novel Therapeutics for AD Testosterone Trial,  CRC For Mental Illness,  CRC Grant,  2010 - 2016,  $601,938.
  • Head Injury and Testosterone (HIT),  Harry Perkins Institute of Medical Research,  Neurotrauma Research Program,  2013 - 2014,  $148,701.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2013 (Round 17),  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2014 - 2015,  $186,666.
  • CSIRO/Janssen AIBL Data Agreement,  Commonwealth Scientific and Industrial Research Organisation,  Janssen Neuroscience Program,  2014 - 2015,  $130,000.
  • A Pilot Clinical Study to Evaluate the Potential of AMLAMAXa?? (Emblica Officinalis) Extract on Raising HDL-Cholesterol Levels and Decreasing Plasma Amyloid beta (A??) Levels in a Perth Memory,  Hollywood Private Hospital Research Foundation,  Grant,  2010 - 2014,  $14,760.
  • Western Australian Zebrafish Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $687,000.
  • Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias,  Commonwealth Scientific and Industrial Research Organisation,  Merck Sharp and Dohme Corpe Grant,  2011 - 2014,  $265,000.
  • Peripheral Clearance of Amyloid-beta (Aβ) using Novel Binding Peptides,  Alzhyme Pty Ltd,  Grant,  2011 - 2014,  $800,000.
  • An innovative approach to identify specific biomarkers for early diagnosis of Alzheimer's disease,  Australian National University,  ANU - Dementia CRC - Grant,  2013 - 2014,  $115,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease,  National Health and Medical Research Council,  Project Grants,  2011 - 2013,  $494,615.
  • Dementia Collaborative Research Council - Lipid Profiles in Alzheimer's Disease,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2014,  $90,000.
  • AIBL Carer Extension Study (ACES),  Florey Neuroscience Institutes,  Wyeth Caregiver Study,  2013,  $87,840.
  • Protective role of autophagy genes in Alzheimer?s disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014,  $10,000.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2012 Round 16,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2013,  $120,279.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma,  National Health and Medical Research Council,  Project Grants,  2011 - 2013,  $352,524.
  • Discovering Transcriptome and Cytome Biomarkers of Alzheimer's Disease in Isolated Buccal Cells,  Commonwealth Scientific and Industrial Research Organisation,  CSIRO - Scholarship,  2010 - 2012,  $21,000.
  • Proteomics for discovery of novel biomarkers,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2013,  $117,075.
  • Developing a Zebrafish Model for Alzheimer's Disease,  The McCusker Foundation For Alzheimer`s Disease Research,  Scholarship,  2010 - 2012,  $75,000.
  • Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease,  National Health and Medical Research Council,  Grant,  2010 - 2012,  $529,125.
  • Assess suitability of multiplexing,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2013,  $241,785.
  • The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2,  Commonwealth Scientific and Industrial Research Organisation,  Science Industry Endowment Fund Agreement,  2010 - 2013,  $5,008,586.
  • 'Deep Within My Soul': Recovering Memory in Bilingual Early Alzheimer's Patients,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2008 - 2011,  $84,302.
  • Round 15 Medical and Health Research Infrastructure Fund (MHRIF) 2011,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2012,  $41,708.
  • The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro,  National Health and Medical Research Council,  Grant,  2010 - 2012,  $409,650.
  • Initiating an Indo-Australian cooperation for early diagnosis and prediction in the aged population: Partnering the universities for a tactical approach to Alzheimer's disease and other neurodegenerative conditions,  Department of Foreign Affairs and Trade,  Australia-India Council,  2011 - 2012,  $4,000.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2005 - 2009,  $1,568,543.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2012,  $10,927.
  • A high-throughput protein production and structure facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012 - 2013,  $470,000.
  • Evaluation of candidate biomarkers in platelets,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2012,  $89,020.
  • Round 14 - Medical and health research infrastructure fund (MHRIF) 2010,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2011,  $42,757.
  • AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream),  Confidential,  Confidential,  2011 - 2012,  $95,238.
  • Round 13 Medical and Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2010 - 2011,  $36,150.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant,  2011,  $10,881.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization,  Australian Research Council,  Grant - Linkage (Infrastructure),  2011,  $849,590.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease,  National Health and Medical Research Council,  Special Call Complementary & Alternative Medicine,  2008 - 2011,  $484,675.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 3 (ECUPO3) - Plasma IDE Measurement,  Department of Health,  Grant,  2010 - 2011,  $187,075.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 2 (ECUPO2) - Plasma apoE Measurement,  Department of Health,  Grant,  2010 - 2011,  $100,674.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2011,  $22,750.
  • Analysis of Internal Brain Structures using Magnetic Resonance Image - Development of Collaboration with the Perth Neuroscience for Diagnosis of Neurodegenerative Diseases,  Commonwealth Scientific and Industrial Research Organisation,  CSIRO - Fellowship,  2008 - 2011,  $148,500.
  • Diets to Defy Dementia,  Council On The Ageing (WA) Inc,  Grant,  2010 - 2011,  $5,000.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction,  Australian Research Council,  Grant - Centres of Excellence,  2007 - 2010,  $315,000.
  • Round 11 of the Medical & Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2008 - 2010,  $16,645.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $400,278.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund,  2006 - 2011,  $909,328.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Industry and Resources,  Centre of Excellence,  2005 - 2010,  $2,060,186.
  • Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $138,344.
  • Round 12 Medical and Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2008 - 2010,  $24,648.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2000 - 2010,  $322,262.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2010,  $75,000.
  • The role of APOE as a modulator in recovery from traumatic head injury,  Road Safety Council of WA,  Neurotrauma Research Program,  2007 - 2010,  $126,000.
  • CRC for Mental Illness,  The Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education ,  CRC - Grant,  2010,  $4,950.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid,  Centre of Excellence for Alzheimers Disease Research and Care,  Scholarship,  2006 - 2010,  $135,000.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2009,  $446,100.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $193,372.
  • Exercise Physiology,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $252,721.
  • A Multidimensional Approach to Enhanced Diagnostics in Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $367,663.
  • Factors that Modulate Testosterone Action on Cognition,  Well Men Centres Pty Ltd,  Fellowship,  2008 - 2009,  $68,557.
  • Investigating beta amyloid clearance in vivo,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $207,655.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2008,  $25,000.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory,  Edith Cowan University,  Grant,  2007 - 2008,  $12,266.
  • MALDI Imaging and Protein Analysis Facility for WA,  Australian Research Council,  Grant - Linkage (Infrastructure),  2007 - 2008,  $915,000.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health and Medical Research Council,  Grant,  2005 - 2007,  $423,750.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice,  Hollywood Private Hospital,  Grant,  2006 - 2007,  $9,455.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2),  Alzhyme Pty Ltd,  Grant,  2005 - 2007,  $120,384.
  • Novel peptides as inhibitors of human beta amyloid function,  Alzhyme Pty Ltd,  Grant,  2005,  $22,264.
  • Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system,  Ramaciotti Foundations,  Grant,  2004 - 2005,  $49,000.
  • Biophysical tools for molecular interactions (Biacore),  Australian Research Council,  Grant - Linkage (Infrastructure),  2005,  $352,000.

Recent Publications (within the last five years)

Book Chapters

  • Maczurek, A., Krautwald, M., Steele, M., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Munch, G., (2010), Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer?s Disease. Micronutrients and Brain Health, 133-148, Boca Raton, FL, USA.
  • Verdile, G., Martins, R., (2009), Molecular Genetics of Alzheimer's Disease. Molecular Biology of Neuropsychiatric Disorders, 23(1), 229-276, Berlin, Germany, DOI: 10.1007/978-3-540-85383-1_8.
  • Verdile, G., Martins, R., (2009), The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies, 259-268, New York, USA.

Journal Articles

  • Lim, F., Martins, I., Martins, R., (2014), The Involvement of Lipids in Alzheimer's Disease. Journal of Geneitics and Genomics, 41(5), 261-274.
  • Carrillo, M., Rowe, C., Szoeke, C., Masters, C., Ames, D., O'Meara, T., Macaulay, SL., Milner, A., Ellis, K., Maruff, P., Rainey-Smith, S., Martins, R., Bain, L., Head, R., (2013), Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia, 9(2), 160-168, United States, DOI: 10.1016/j.jalz.2012.10.006.
  • O' Bryant, S., Xiao, G., Edwards, M., Devous, M., Gupta, V., Martins, R., Zhang, F., Barber, R., (2013), Biomarkers of Alzheimer?s Disease Among Mexican Americans. Journal of Alzheimer's Disease, 34(4), 841-849, Netherlands, DOI: 10.3233/JAD-122074.
  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R., (2013), Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224, United States.
  • Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L., (2013), Modulation of amyloid-? 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103, United Kingdom, DOI: 10.1039/c2fo30111c.
  • Dore, V., Villemagne, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K., Masters, C., Ames, D., Salvado, O., Rowe, C., (2013), Cross-sectional and longitudinal analysis of the relationship between a? deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70(7), 903-911, United States, DOI: 10.1001/jamaneurol.2013.1062.
  • Harrington, K., Lim, YY., Ellis, K., Copolov, C., Darby, D., Weinborn, M., Ames, D., Martins, R., Savage, G., Szoeke, C., Rowe, C., Villemagne, V., Masters, C., Maruff, P., (2013), The association of A? amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10), 1667-1677, United Kingdom, DOI: 10.1017/S1041610213001087.
  • Lim, YY., Ellis, K., Harrington, K., Kamer, A., Pietrzak, R., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Ames, D., Maruff, P., (2013), Cognitive consequences of high a? amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer's disease. Neuropsychology, 27(3), 322-332, United States, DOI: 10.1037/a0032321.
  • Lim, YY., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K., Stoffler, A., Szoeke, C., Lachovitzki, R., Martins, R., Villemagne, V., Bush, A., Masters, C., Rowe, C., Ames, D., Darby, D., Maruff, P., (2013), Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330, United Kingdom.
  • Gardener, S., Rainey-Smith, S., Keogh, J., Mathieson, S., Martins, R., (2013), Dietary Patterns Associated with Alzheimer's Disease and Related Chronic Disease Risk: A Review. Alzheimer's Disease & Parkinsonism, N/A(N/A), 10p, online.
  • Martins, I., Creegan, R., Lim, F., Martins, R., (2013), Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33, United States of America, DOI: 10.4236/ojemd.2013.35A002.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R., (2013), The acceleration of aging and Alzheimer?s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920, United States of America, DOI: 10.4236/health.2013.55121.
  • Gupta, V., Sundaram, R., Martins, R., (2013), Multiplex biomarkers in blood. Alzheimer's Research & Therapy, 5(3), Article 31, United Kingdom, DOI: 10.1186/alzrt185.
  • Lim, YY., Ellis, K., Harrington, K., Pietrzak, R., Gale, J., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2013), Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-?: Prodromal Alzheimer's Disease?. Journal of Alzheimer's Disease, 33(n/a), 1167-1176, Netherlands.
  • Rembach, A., Doecke, JD., Roberts, BR., Watt, AD., Faux, NG., Volitakis, I., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Wilson, W., Ellis, K., Martins, R., Rowe, C., Villemagne, V., Ames, D., Masters, C., Bush, A., (2013), Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease. Journal of Alzheimer's Disease, 34(NA), 171-182, Netherlands.
  • Ellis, K., Lim, YY., Harrington, K., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2013), Decline in Cognitive Function over 18 Months in Healthy Older Adults with High Amyloid-?. Journal of Alzheimer's Disease, 34(n/a), 861-871, Netherlands.
  • Villemagne, V., Burhnham, S., Bourgeat, P., Brown, B., Ellis, KA., Salvado, O., Szoeke, C., Macaulay, L., Martins, R., Maruff, P., Ames, D., Rowe, C., Masters, C., (2013), Amyloid ? deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease : a prospective cohort study. The Lancet Neurology, 12(4), 357-367.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C., Macaulay, L., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R., (2013), Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry, 3(February), 1-8, United Kingdom.
  • Rowe, C., Bourgeat, P., Ellis, K., Brown, B., Yen Ying, L., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., Robins, P., Tochon-Danguy, H., O'Keefe, G., Pike, K., Yates, P., Szoeke, C., Salvado, O., Macaulay, SL., O'Meara, T., Head, R., Cobiac, L., Savage, G., Martins, R., Masters, C., Ames, D., Villemagne, V., (2013), Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6), 905-913, USA, DOI: 10.1002/ana.24040.
  • Benzinger, T., Blazey, T., Jack, C., Koeppe, R., Su, Y., Xiong, C., Raichle, M., Snyder, A., Ances, B., Bateman, R., Cairns, N., Fagan, A., Goate, A., Marcus, D., Aisen, P., Christensen, J., Ercole, L., Hornbeck, R., Farrar, A., Aldea, P., Jasielec, M., Owen, C., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C., Ringman, J., Thompson, P., Ghetti, B., Saykin, A., Sperling, R., Johnson, K., Salloway, S., Correia, S., Schofield, P., Masters, C., Rowe, C., Villemagne, V., Martins, R., Ourselin, S., Rossor, M., Fox, N., Cash, D., Weiner, M., Holtzman, D., Buckles, V., Moulder, K., Morris, J., (2013), Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of USA, 110(47), E4502-E4509, United States, DOI: 10.1073/pnas.1317918110.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Bourgeat, P., Villemagne, V., Rowe, C., Macaulay, SL., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R., (2013), Pupil Response Biomarkers for Early Detection and Monitoring of Alzheimer's Disease. Current Alzheimer Research, 10(9), 931-939.
  • Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M., (2013), Less is more: More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525, United Kingdom.
  • Lim, YY., Pietrzak, RH., Ellis, KA., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R., Bush, AI., Masters, CL., Rowe, CC., Villemagne, VL., Ames, D., Darby, D., Maruff, P., (2013), Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-?. Journal of Alzheimer's Disease, 33(3), 675-679, Netherlands, DOI: 10.3233/JAD-2012-121516.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P., (2013), BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464, United States.
  • Moore, E., Mander, A., Ames, D., Kotowicz, M., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Szoeke, C., Rowe, C., Watters, D., (2013), Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care, 36(10), 2981-2987.
  • Gupta, V., Gupta, V., Martins, R., (2013), Semagacestat for treatment of Alzheimer?s disease. New England Journal of Medicine, 369(17), 1660-1661, DOI: 10.1056/NEJMc1310231.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Taddei, K., Bateman, R., Morris, J., Benzinger, T., Goate, A., Masters, C., Martins, R., (2013), Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers. Current Alzheimer Research, 10(8), 790-796, Netherlands.
  • Foster, J., Albrecht, M., Savage, G., Lautenschlager, N., Ellis, K., Maruff, P., Szoeke, C., Taddei, K., Martins, R., Masters, C., Ames, D., (2013), Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain: a journal of neurology , 136(7), 2201-16.
  • Buckley, R., Saling, M., Ames, D., Rowe, C., Lautenschlager, N., Macaulay, SL., Martins, R., Masters, C., O'Meara, T., Savage, G., Szoeke, C., Villemagne, V., Ellis, K., (2013), Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. International Psychogeriatrics, 25(8), 1307-1315.
  • Drummond, E., Muhling, J., Martins, R., Wijaya, L., Ehlert, E., Harvey, A., (2013), Pathology associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum. PLoS One, 8(3), e59166.
  • Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V., (2013), A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(n/a), 519-526, United Kingdom.
  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G., (2013), The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235.
  • Avdesh, A., Hoe, Y., Martins, R., Martin-Iverson, M., (2013), Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology, 225(2), 483-494, DOI: 10.1007/s00213-012-2834-6.
  • Avdesh, ., Chen, M., Martin-Iverson, MT., Mondal, A., Ong, D., Rainey-Smith, S., Taddei, K., Lardelli, M., Groth, D., Verdile, G., Martins, R., (2012), Regular care and maintenance of a zebrafish (Danio rerio) laboratory: an introduction. Journal of Visualized Experiments: JoVE, 18(69), e4196, DOI: 10.3791/419.
  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid-? plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, n/a(n/a), 1-7, United Kingdom.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325, United States, DOI: 10.1001/archneurol.2012.1282.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S., (2012), Latrepiridine stimulates autophagy and reduces accumulation of alpha-synuclein in cells and in mouse brain. Molecular Psychiatry, n/a(n/a), n/a, United Kingdom, DOI: 10.1038/mp.2012.115.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, n/a(n/a), n/a, United Kingdom, DOI: 10.1038/mp.2012.147.
  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, SL., Szoecke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid-b plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, n/a(n/a), 1-7, United Kingdom, DOI: 10.1038/mp.2012.107.
  • Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R., (2012), Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469, USA, DOI: 10.3233/JAD-2011-110704.
  • Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R., (2012), Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry , 2(n/a), art. no. e118 , DOI: 10.1038/tp.2012.43.
  • Lau, S., Bates, KA., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwa, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2012), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  • Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A., Holtzman, D., Bateman, R., Sohrabi, H., Martins, R., Gandy, S., Urakami, K., Suzuki, T., (2012), Multiple ?-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer?s disease subjects. Molecular Neurodegeneration, 7(1), art. no. 16 , United Kingdom, DOI: 10.1186/1750-1326-7-16.
  • Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, CL., Ames, D., Rowe, C., Martins, R., (2012), Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry, 2(n/a), art. no. e191 , DOI: 10.1038/tp.2012.118.
  • Gardener, S., Gu, Y., Rainey-Smith, S., Keogh, JB., Clifton, PM., Mathieson, SL., Taddei, K., Mondal, A., Ward, V., Scarmeas, N., Barnes, M., Ellis, K., Head, R., Masters, C0., Ames, D., Macaulay, S0., Rowe, C0., Szoeke, C., Martins, R., (2012), Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry, 2(N/A), 7, DOI: 10.1038/tp.2012.91.
  • Drummond, ES., Martins, R., Handelsman, DJ., Harvey, AR., (2012), Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology, 153(6), 2789-2799, DOI: 10.1210/en.2011-2003.
  • Bateman, RJ., Xiong, C., Benzinger, TL., Fagan, AM., Goate, A., Fox, NC., Marcus, DS., Cairns, NJ., Xie, X., Blazey, TM., Holtzman, DM., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, PM., Ghetti, B., Klunk, WM., McDade, E., Martins, R., Masters, CM., Mayeux, R., Ringman, JM., Rossor, MM., Schofield, PM., Sperling, RM., Salloway, S., Morris, JM., (2012), Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine, 367(9), 795-804, DOI: 10.1056/NEJMoa1202753.
  • Villain, N., Chetelat, G., Grassiot, B., Bourqeat, P., Jones, G., Ellis, K., Ames, D., Martins, R., Eustache, F., Salvado, O., Masters, C., Rowe, C., Villemagne, V., (2012), Regional dynamics of amyloid-? deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: A voxelwise PiB-PET longitudinal study. Brain: a journal of neurology , 135(7), 2126-2139.
  • Lim, Y., Ellis, K., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P., (2012), A? amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia, n/a(n/a), 8, United States, DOI: 10.1016/j.jalz.2012.07.004.
  • Chetelat, G., Villemagne, V., Villain, N., Jones, G., Ellis, K., Ames, D., Martins, R., Masters, C., Rowe, C., (2012), Accelerated cortical atrophy in cognitively normal elderly with high ?-amyloid deposition. Neurology, 78(7), 477-484, United States, DOI: 10.1212/WNL.0b013e318246d67a.
  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R., (2012), Latrepirdine (Dimebon?) enhances autophagy and reduces intracellular GFP-A?42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967, Netherlands, DOI: 10.3233/JAD-2012-120178.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoecke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer?s disease. Molecular Psychiatry, 7, United Kingdom, DOI: 10.1038/mp.2012.147.
  • Steele, J., Su, J., Lachenmayer, L., Liken, J., Stock, A., Kim, S., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S., (2012), Latrepirdine stimulates autophagy and reduces accumulation of a-synuclein in cells and in mouse brain. Molecular Psychiatry, n/a(n/a), 1-7, United Kingdom, DOI: 10.1038/mp.2012.115.
  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R., (2012), Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer?s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456, DOI: 10.4236/health.2012.412A209.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0., (2012), Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 1-9, United Kingdom, DOI: 10.1038/mp.2012.106.
  • Acosta, O., Fripp, J., Dore, V., Bourgeat, P., Favreau, JM., Chetelat, G., Rueda, A., Villemagne, VL., Szoeke, C., Ames, D., Ellis, K., Martins, R., Masters, CA., Rowe, CA., Bonner, E., Gris, F., Xiao, D., Raniga, P., Barra, V., Salvado, O., (2012), Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods, 205(1), 96-109, DOI: 10.1016/j.jneumeth.2011.12.011.
  • Sona, A., Zhang, P., Ames, D., Bush, AI., Lautenschlager, NT., Martins, R., Masters, CL., Rowe, CC., Szoeke, C., Taddei, K., Ellis, KA., (2012), Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics, 24(2), 197-204, DOI: 10.1017/S1041610211001335.
  • Cyarto, EV., Lautenschlager, NT., Desmond, PM., Ames, D., Szoeke, C., Salvado, O., Sharman, M., Ellis, KA., Phal, PM., Masters, CL., Rowe, CC., Martins, R., Cox, KL., (2012), Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry, 12, , n/a, DOI: 10.1186/1471-244X-12-167.
  • Newman, M., Nornes, S., Martins, R., Lardelli, MT., (2012), Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19, DOI: 10.1016/j.neulet.2012.04.064.
  • Lim, YY., Ellis, KA., Harrington, K., Ames, D., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Darby, D., Maruff, P., (2012), Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345-358, DOI: 10.1080/13803395.2011.643227.
  • Lim, YY., Ellis, KA., Pietrzak, RH., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Villemagne, V0., Maruff, P., (2012), Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645-1652, DOI: 10.1212/WNL.0b013e31826e9ae6.
  • Barber, B., Ames, D., Ellis, K., Martins, R., Masters, C., Szoeke, C., (2012), Lifestyle and late life cognitive health: Sufficient evidence to act now?. International Psychogeriatrics, 24(5), 683-688, DOI: 10.1017/S1041610211002912.
  • Brown, B., Peiffer, JJ., Martins, R., (2012), Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?. Molecular Psychiatry, N/A(N/A), 1-11, United Kingdom, DOI: 10.1038/mp.2012.162.
  • Sohrabi, H., Bates, K., Weinborn, M., Johnston, AN., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R., (2012), Olfactory discrimination predicts cognitive decline among community-dwelling older adults. Translational Psychiatry, 2, , 1-7, DOI: 10.1038/tp.2012.43.
  • Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R., (2011), The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605, Netherlands, DOI: 10.3233/JAD-2011-110584.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC., (2011), Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390, DOI: 10.1016/j.neuropsychologia.2011.04.012.
  • Sohrabi, H., Weinborn, M., Badcock, J., Bates, K., Clarnette, R., Trivedi, D., Verdile, G., Sutton, T., Lenzo, N., Gandy, S., Martins, R., (2011), New lexicon and criteria for the diagnosis of Alzheimer's disease. Lancet Neurology, 10(4), 299-300, DOI: 10.1016/S1474-4422(11)70056-4.
  • Chetelat, G., Villemagne, VL., Pike, KE., Ellis, KA., Bourgeat, P., Jones, G., O'Keefe, GJ., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, CC., (2011), Independent contribution of temporal ?-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain, 134(3), 798-807, United Kingdom, DOI: 10.1093/brain/awq383.
  • Ellis, KA., Rowe, CC., Szoeke, CE., Villemagne, VL., Ames, D., Chetelat, G., Martins, R., Masters, CL., Fripp, J., Acosta, O., Raniga, P., Bourgeat, PT., Salvado, O., (2011), Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 194(4), S20-S23, Australia.
  • Avdesh, ., Wong, P., Martins, R., Martin-Iverson, MT., (2011), Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 433-444, Netherlands, DOI: 10.3233/JAD-2011-101944.
  • McBride, SJ., Szoeke, CE., Good, NM., Ames, D., Martins, R., Masters, CL., Maruff, PT., Rowe, CC., Savage, G., Ellis, KA., (2011), A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia, 194(4), S12-S14, Australia.
  • Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P., (2011), Association of plasma A? peptides with blood pressure in the elderly. PLoS One, 6(4), e18536, DOI: 10.1371/journal.pone.0018536.
  • Villemagne, VL., Pike, KE., Chetelat, G., Ellis, KA., Mulligan, RS., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, CC., (2011), Longitudinal assessment of A? and cognition in aging and Alzheimer disease. Annals of Neurology, 69(1), 181-192, DOI: 10.1002/ana.22248.
  • Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A., (2011), Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study. Journal of Alzheimer's Disease, 27(4), 909-922 , Netherlands, DOI: 10.3233/JAD-2011-I10752.
  • Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, SD., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, MA., Carrillo, MC., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, AM., Forlenza, O., Frisone , GB., Galasko, D., Galimberti, D., Hampel, H., Handberg, A., Heneka, MT., Herskovits, AZ., Herukka , S., Holtzmann, DM., Humpel, C., Hyman, B., Iqbal, K., Jucker, M., Kaeser , S., Kaiser, E., Kapaki, E., Kidd, D., Kilvenyi, P., Knudsen, CS., Kummer, M., Lui, J., Llado, A., Lewczuk, P., Li, Q., Martins, R., Masters, C., McAuliffe, J., Mercken, M., Moghekar, A., Molinuevo, JL., Montine, TJ., Nowatzke, W., O'Brien, R., Otto, M., Paraskevas, GP., Parnetti, L., Petersen, RC., Prvulovic, D., De Reus, HP., Rissman, RA., Scarpini, E., Stefani, A., Soininen, H., Schroeder , J., Shaw, LM., Skinningsrud, A., Skrogstad, B., Spreer, A., Talib, L., Teunissen, C., Trojanowski, JQ., Tunami, H., Umek, RM., Van Broeck, B., Vanderstichele, H., Vecsei, L., Verbeek, M., Windisch, M., Zhang, J., Zetterberg, H., Blennow, K., (2011), The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers and Dementia, 7(4), 386-395, United States, DOI: 10.1016/j.jalz.2011.05.2243.
  • Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R., (2011), Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098, DOI: 10.1212/WNL.0b013e318211c352.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R., (2011), Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322, DOI: 10.1159/000330812.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., Martins, R., Rowe, C., Szoeke, C., Ellis, K., (2011), Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178, DOI: 10.1159/000325171.
  • Newman, M., Verdile, G., Martins, R., Lardelli, M., (2011), Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352, DOI: 10.1016/j.bbadis.2010.09.012.
  • Sharman, M., Shui, G., Fernandis, A., Lim, WL., Berger, T., Hone, E., Taddei, K., Martins, I., Ghiso, J., Buxbaum, JD., Gandy, S., Wenk, M., Martins, R., (2010), Profiling brain and plasma lipids in human APOE ?2, ?3 and ?4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's Disease, 20(1), 105-111, Netherlands, DOI: 10.3233/JAD-2010-1348.
  • Ellis, K., Rowe, C., Villemagne, V., Martins, R., Masters, C., Salvado, O., Szoeke, C., Ames, D., (2010), Addressing population aging and Alzheimer's disease through the Australian Imaging Biomarkers and Lifestyle study: Collaboration with the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's and Dementia, 6(3), 291-296, United States, DOI: 10.1016/j.jalz.2010.03.009.
  • Rowe, C., Ellis, K., Rimajova, M., Bourgeat, P., Pike, KE., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., Price, R., Raniga, P., Robins, P., Acosta, O., Lenzo, N., Szoeke, C., Salvado, O., Head, R., Martins, R., Masters, C., Ames, D., Villemagne, VL., (2010), Amyloid imaging results, from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31(8), 1275-1283, United States, DOI: 10.1016/j.neurobiolaging.2010.04.007.
  • Rodrigues, M., Foster, J., Verdile, G., Joesbury, K., Prince, R., Devine, A., Mehta, P., Beilby, J., Martins, R., (2010), Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: Quod erat demonstrandum?. International Psychogeriatrics, 22(2), 332-335, United Kingdom, DOI: 10.1017/S1041610209991190.
  • Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., Haroutunian, V., Fried, U., Ehrlich, M., Martins, R., Gandy, S., (2010), Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration, 5(1), Article No.1, United Kingdom, DOI: 10.1186/1750-1326-5-1.
  • Chetelat, G., Villemagne, VL., Pike, KE., Baron, J., Bourgeat, P., Jones, G., Faux, NG., Ellis, K., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, C., Rowe, C., (2010), Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain, 133(11), 3349-3358, United Kingdom, DOI: 10.1093/brain/awq187.
  • Barron, A., Verdile, G., Taddei, K., Bates, K., Martins, R., (2010), Effect of Chronic hCG Administration on Alzheimer's-Related Cognition and A? accumulation in PS1KI mice. Endocrinology, 151(11), 5380?5388, United States, DOI: 10.1210/en.2009-1168.
  • Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., Lardelli, M., (2010), A Zebrafish melanophore model of Amyloid ? toxicity. Zebrafish, 7(2), 155-159, DOI: 10.1089/zeb.2009.0628.
  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R., (2010), Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, 31(2), 203-214, United States, DOI: 10.1016/j.neurobiolaging.2008.03.023.
  • Bourgeat, P., Chetelat, G., Villemagne, V., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C., Ourselin, S., Ames, D., Ellis, KA., Martins, R., Masters, C., Rowe, C., Salvado, O., (2010), ?-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 74(2), 121-127, United States, DOI: 10.1212/WNL.0b013e3181c918b5.
  • Bharadwaj, P., Martins, R., Macreadie, I., (2010), Yeast as a model for studying Alzheimer's disease. F E M S Yeast Research, 10(8), 961?969, United Kingdom, DOI: 10.1111/j.1567-1364.2010.00658.x.
  • Peiffer, J., Galvao, D., Gibbs, Z., Smith, K., Turner, D., Foster, J., Martins, R., Newton, R., (2010), Strength and Functional Characteristics of Men and women 65 Years and Older. Rejuvenation Research, 13(1), 75-82, United States, DOI: 10.1089/rej.2009.0916.
  • Chetelat, G., Villemagne, V., Bourgeat, P., Pike, K., Jones, G., Ames, D., Ellis, K., Szoeke, C., Martins, R., O'Keefe, G., Salvado, O., Masters, C., Rowe, C., (2010), Relationship between Atrophy and B-Amyloid Deposition in Alzheimer Disease. Annals of Neurology, 67(3), 317-324, United States, DOI: 10.1002/ana.21955.
  • Miklossy, J., Qing, H., Radenovic, A., Kis, A., Vileno, B., Laszlo, F., Miller, L., Martins, R., Waeber, G., Mooser, V., Bosman, F., Khalili, K., Darbinian, N., McGeer, P., (2010), Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging, 31(9), 1503-1515, United States, DOI: 10.1016/j.neurobiolaging.2008.08.019.
  • Jenner, A., Lim, FW., Ng, M., Wenk, MR., Shui, G., Sharman, M., Gandy, S., Martins, R., (2010), The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ?2,?3 and ?4 knock-in mice. Neuroscience, 169(1), 109-115, United Kingdom, DOI: 10.1016/j.neuroscience.2010.04.026.
  • Frost, S., Martins, R., Kanagasingam, Y., (2010), Ocular biomarkers for early detection of Alzheimer's Disease. Journal of Alzheimer's Disease, 22(1), 1-16, Netherlands, DOI: 10.3233/JAD-2020-100819.
  • Ford, A., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O., (2010), Vitamins B??, B?, and folic acid for cognition in older men. Neurology, 75(17), 1540-1547, United States, DOI: 10.1212/WNL.0b013e3181f962c4.
  • Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R., (2010), Plasma amyloid-? as a biomarker in Alzheimer?s disease: the AIBL study of aging. Journal of Alzheimer's Disease, 20(4), 1233-1242, Netherlands, DOI: 10.3233/JAD-2010-090249.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2010), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, n/a(n/a), n/a, United States, DOI: 10.1016/j.neurobiolaging.2010.09.003.
  • Jenner, A., Lim, F., Ng, M., Wenk, M., Shui, G., Sharman, M., Gandy, S., Martins, R., (2010), The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ?2,?3 and ?4 knock-in mice. Neuroscience, 169(1), 109-115, United Kingdom, DOI: 10.1016/j.neuroscience.2010.04.026.
  • Sharman, M., Morici, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R., (2010), APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-?42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409, Netherlands, DOI: 10.3233/JAD2010100141.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers. Journal of Alzheimer's disease, 17(2), 305-18, Amsterdam.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R., (2009), The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein e?4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79, The Netherlands, DOI: 10.3233/JAD-2009-1018.
  • Drummond, E., Harvey, AR., Martins, R., (2009), Androgens and Alzheimer's Disease. Current Opinion in Endocrinology, Diabetes and Obesity, 16(3), 254-259, United Kingdom, DOI: 10.1097/MED.0b013e32832b101f.
  • Pedrini, S., Thomas, C., Brautigam, H., Schmeidler, J., Ho, L., Fraser, P., Westaway, D., St George Hyslop, P., Martins, R., Buxbaum, D., Pasinetti, GM., Dickstein, DL., Hof, PR., Ehrlich, M., Gandy, S., (2009), Dietary composition modulates brain mass and solubilizable A levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration, 4(1), Article No. 40, United Kingdom, DOI: 10.1186/1750-1326-4-40.
  • Bharadwaj, P., Dubey, AK., Masters, CL., Martins, R., Macreadie, I., (2009), A ? aggregation and possible implications in Alzheimer's disease pathogenesis. Journal of Cell and Molecular Medicine, 13(3), 412-421, United Kingdom, DOI: 10.1111/j.1582-4934.2008.00609.x.
  • Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R., (2009), Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308, United Kingdom, DOI: 10.1111/j.1471-4159.2009.06408.x.
  • Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., Martins, R., (2009), Clearance mechanisms of Alzheimer?s amyloid-? peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry, 14(5), 469-486 , United Kingdom, DOI: 10.1038/mp.2008.96.
  • Chen, M., Martins, R., Lardelli, M., (2009), Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317, Netherlands, DOI: 10.3233/JAD-2009-1145.
  • Krishnaswamy, S., Verdile, G., Groth, D., Kanyenda, L., Martins, R., (2009), The structure and function of Alzheimer's gamma secretase enzyme complex. Critical Reviews in Clinical Laboratory Science, 46(5-6), 282-301, United Kingdom, DOI: 10.3109/10408360903335821.
  • Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., Lardelli, M., (2009), Independent an cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 315(16), 2791-2801, DOI: 10.1016/j.yexcr.2009.06.023.
  • Barron, A., Cake, M., Verdile, G., Martins, R., (2009), Ovariectomy and 17?-Estradiol Replacement Do Not Alter beta-Amyloid Levels in Sheep Brain. Endocrinology, 150(7), 3228-3236, United States, DOI: 10.1210/en.2008-1252.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R., (2009), Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-? Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318, The Netherlands, DOI: 10.3233/JAD-2009-1050.
  • Ellis, K., Bush, A., Darby, D., De Fazio, D., Foster, J., Hudson, P., Lautenschlager, N., Lenzo, N., Martins, R., Maruff, P., Masters, C., Milner, A., Pike, K., Rowe, C., Savage, G., Szoeke, C., Taddei, K., Villemagne, V., Woodward, M., Ames, D., Aibl Research Group, T., (2009), The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21(4), 672-687, United Kingdom, DOI: 10.1017/S1041610209009405.
  • Foster, J., Verdile, G., Bates, K., Martins, R., (2009), Immunization in Alzheimer's disease: naive hope or realistic clinical potential. Molecular Psychiatry, 14(3), 239-251, United Kingdom, DOI: 10.1038/mp.2008.115.
  • De Silva, R., Disanayaka, S., De Zoysa, N., Sanjeewanie, N., Somaratne, S., Foster, J., Srikanth, S., Kathriarachchi, S., Martins, R., (2009), Norms for the mini-mental state examination from a sample of Sri Lankan older people. International Journal of Geriatric Psychiatry, 24(7), 666-670, DOI: 10.1002/gps.2168.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R., (2009), Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142, The Netherlands, DOI: 10.3233/JAD-2009-1020.
  • Hata, S., Fujishige, S., Araki, Y., Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S., Suzuki, T., (2009), Alcadein Cleavages by Amyloid ? -Precursor Protein (APP) ? -and ? -Secretases Generate Small Peptides, p3-Alcs, Indicating Alzhiemer Disease-related ? -Secretase Dysfunction. The Journal of Biological Chemistry, 284(52), 36024-36033, United States, DOI: 10.1074/jbc.M109.057497.

Conference Publications

  • Dore, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Szoeke, C., Ellis, K., Martins, R., Villemagne, V., Masters, CL., Ames, D., Rowe, C0., Salvado, O., (2012), A surface based approach for cortical thickness comparison between PiB+ and PiB-healthy control subjects. Proceedings of SPIE: Medical Imaging 2012: Image Processing, 831413 (February 23, 2012), 8314(6 February 2012), 831413-1to 831413-6, DOI: 10.1117/12.911752.

Research Student Supervision

Principal Supervisor

  • Doctor of Philosophy,  Role Of Testosterone In Prevention Of Alzheimer's Disease..
  • Doctor of Philosophy,  Pharmacological Modulation Of Learning And Memory In Mice And Zebrafish: Implications For Alzheimers Disease Animal Models..
  • Doctor of Philosophy,  Discovery Of New Biomarkers Of Mild Cognitive Impairment And Alzheimer's Disease Risk In Buccal Cells Using Laser Scanning Cytometry..
  • Doctor of Philosophy,  Identifying Gamma Secretase Enzyme Domains Responsible For The Generation Of Alzheimer's Beta Amyloid Protein..
  • Doctor of Philosophy,  Yeast As A Model For Studying Ab Aggregation, Toxicity And Clearance.
  • Master of Science (Human Biology),  Plasma Insulin-degrading Enzyme: Characterisation And Evaluation As A Potential Biomarker For Alzheimer's Disease..
  • Master of Science (Human Biology),  The Role Of Luteninizing Hormone (lh) And Human Chorionic Gonadotropin (hcg) In The Aetiology Of Alzheimer's Disease..
  • Doctor of Philosophy,  Investigating The Impact Of Cd147 And Its Expression On Neuordegeneration And Alzheimer's Disease Ad.

Co-principal Supervisor

Associate Supervisor

  • Doctor of Philosophy,  Evolutionary Approaches For Feature Selection In Biological Data.
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