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State of the Science in Post-Stroke Motor Recovery Symposium 2018

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Speakers

Keynote Speaker

Rajiv Ratan, MD, PhD Rajiv R. Ratan, MD, PhD

Raj Ratan received a B.A. In Neuroscience at Amherst College before joining the National Institute of Health funded Medical Scientist Training Program at NYU School of Medicine where he earned an MD and PhD. He received training in Neurology and Neurorehabilitation at Johns Hopkins. He served as Chief Resident in Neurology and completed a post-doctoral fellowship in the Department of Neuroscience while at Hopkins in the laboratory of Jay Baraban. In 1996 he was recruited to BIDMC/Harvard Institutes of Medicine to set up the Neuroprotection Laboratory and to catalyze seamless clinical efforts in caring for patients with stroke neurological disability between the BIDMC Neurology Unit and a rehabilitation hospital in Cambridge. In 2003, he was recruited to succeed Fletcher McDowell as the Director of Burke Neurological Institute on the Burke Rehabilitation Center campus in White Plains, New York. Burke has been affiliated with Weill Cornell Medicine since 1933. The Institute is focused on protection and repair particularly after stroke, traumatic brain injury and spinal cord injury, but has impairment based programs in vision recovery, motor recovery, cognitive recovery, and pain/sensory recovery that span all neurological conditions. Raj also directs a basic research laboratory which seeks to harness endogenous homeostatic transcriptional mechanisms to protect and repair the brain. He co-edited a text on Cell Death and Diseases of the Nervous System in the late 1990’s, he has published more than 150 primary papers and reviews, and he is an inventor on ten patents.

Opening Speaker

Lyn Beazley, AO FTSELyn Beazley, AO FTSE

After graduating from Oxford and Edinburgh Universities, Professor Lyn Beazley built an internationally renowned research team in Neuroscience that focused on recovery from brain damage, much of her investigations undertaken as Winthrop Professor at The University of Western Australia. Currently Lyn is Adjunct Professor of Science at Murdoch University. As Chief Scientist of Western Australia from 2006 to 2013, Lyn advised the Western Australian Government on science, innovation and technology as well as fulfilling the role of science ambassador locally, nationally and internationally. In 2009, Lyn was awarded Officer of the Order of Australia and was elected a Fellow of the Australian Academy of Technological Sciences and Engineering.  Lyn was honoured in 2013 to be inducted into the Western Australian Science Hall of Fame and to become a Companion of the Institute of Engineers.  Lyn was amazed and delighted to be named the WA Australian of the Year for 2015.

Symposium Chair

Professor Dylan EdwardsDylan Edwards, PhD

Professor Dylan Edwards is a human clinical neuro-rehabilitation scientist who has spent the past decade in New York and Boston at Burke-Cornell and Harvard Medical School respectively, and recently joined School of Medical and Health Sciences, Edith Cowan University. Professor Edwards’ main research interests focus on understanding and promoting neuroplasticity following neurological damage caused by stroke, spinal cord injury, and cerebral palsy. His work incorporates emerging non-invasive technologies of transcranial magnetic stimulation, and rehabilitation robotics for motor recovery. Edwards holds multiple positions in national and international universities. He is the Professor of Neuroscience in the School of Medical and Health Sciences at Edith Cowan University and the Associate Professor of Clinical Neurophysiology at Weill Cornell Medicine, Cornell University, USA. He is also the Director of Moss Rehabilitation Research Institute, as well as the Co-Director of Intensive Course in Transcranial Magnetic Stimulation in Harvard Medical School, USA. Further, he is a scientific consultant for Neuro-rehabilitation in many institutions in Australia, Spain and Brazil. Edwards served as the principal investigator or co-investigator on a number of National and International grants and commissions since 2009 with accumulated earning amount to over $9 million including competitive research grants, commissions and project funds.

Session Chairs

Janet Taylor, MD Janet Taylor, MD

Dr Janet Taylor is a Professor of Human Neurophysiology in the School of Medical and Health Sciences at Edith Cowan University. Her research interest is the control of human movement by the nervous system and she has over 170 peer-reviewed publications in the area. Her work focuses on how the motor pathway changes in response to activity such as fatiguing exercise, stimulation of the brain or nerves, and training or practice of motor tasks. Her aim is to better understand how the nervous system contributes to decrements in performance with muscle fatigue, and also to improvements in motor performance with practice in health and disease. Currently, she is a Senior Editor for the Journal of Physiology.

Lay Kun Kho, MD Lay Kun Kho, MD

Dr Kho is a graduate of the University of Sydney, New South Wales and is currently a Consultant Neurologist at Midland St John of God Hospital and Clinical Lead of the Stroke Unit at Royal Perth Hospital. She was previously Head of Neurology at Royal Perth Rehabilitation Hospital Shenton Park and Clinical Lead of the Neuro-rehabilitation Unit at the State Rehabilitation Service at Fiona Stanley Hospital until 2017. Her subspecialty interests are acute stroke management, clinical neuro-rehabilitation and functional neurological disorders.

Taiza Santos, PhD Taiza Santos, PhD

Dr Taiza Santos has built her clinical and research expertise on the post-stroke disorder of postural control, biomechanical investigation, neuroimaging analyses, and non-invasive brain stimulation. She received her PhD in Neuroscience at the University of Sao Paulo, Brazil. Her education and training using non-invasive neuromodulation began with the Intensive Course in Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) at BIDMC/Harvard, in Boston, 2011. Since then, she has developed a new field of research on NIBS at Ribeirao Preto Medical School, University of Sao Paulo, Brazil (FMRP-USP) aiming at providing translational evidence for the neurophysiology investigation and development of new treatments for postural imbalance after stroke. As a Professor of the Post-graduate Program of the Department of Neuroscience – FMRP-USP, Brazil, Dr. Santos has advised a number of undergraduate, masters, and Ph.D. students. Also, she is the local site director of the international training program entitled Principles and Practices of Clinical Research in collaboration with Harvard TH Chan-School of Public Health at the Ribeirão Preto Medical School - University of São Paulo, Brazil.

Tim Bates, MD, FRACP Tim Bates, MD, FRACP

Clinical Associate Professor Tim Bates Graduated from UWA in 1997. Trained in internal medicine and lipid disorders achieving FRACP in 2006, before returning to stroke medicine as the inaugural Head of Comprehensive Stroke Unit at Swan District Hospital in 2008. Currently Head of Service St John of God Midland Hospital Stroke Unit. Clinical Associate Professor Bates has publications in internal medicine, stroke and lipid disorders. Aside from these interests he is active in physician training at a local and national level.

Invited Speakers

Andrew WesseldineAndrew Wesseldine, MD

Dr Wesseldine is a dual trained General Physician, Geriatrician, and Stroke Physician, who commenced work as the inaugural WA State Stroke Director 4 years ago. In this time the WASSP (WA Stroke Services Project) has, in combination with WACHS and under the stewardship of the WA Director General of Health, Dr David Russell-Weisz, seen the development of the metro-rural stroke pathways, the WA tele-stroke project, and the development of a 24/7 ECR service for WA. He also works at Joondalup Health Campus as the Director of Clinical Innovation and Reform, and in a small private practice. Andrew is originally from New Zealand, but moved to Perth in 2002 to complete his dual training in General Medicine and Geriatrics. He worked in the acute stroke unit at Royal Perth Hospital on completion of his fellowship from 2004-2009, and the assumed the Head of Department role at the State Neurorehabilitation Unit (Ward 2) at Shenton Park Hospital until 2014. He is married with 3 wonderful children and remains a loyal All Blacks supporter and lover of Pinot!

Associate Professor Bruno MeloniBruno Meloni, PhD

Associate Professor Bruno Meloni is currently Head of Laboratory Research of the Experimental Stroke Research Group at the Perron Institute, Perth, Western Australia. He has been working in the experimental stroke field for over 20 years. His research focuses on molecular mechanisms of neurodegeneration and neuroprotection with the aim of developing treatments to minimise brain damage following stroke and other acute brain injuries (e.g. neonatal hypoxia-ischaemia, cardiac arrest and traumatic brain injury). To this end, Associate Professor Meloni and his team have made the exciting discovery that cationic arginine-rich peptides (CARPs) possess potent neuroprotective properties, and have the potential to be developed into a therapeutic treatment to reduce brain injury after stroke and other neurodegenerative disorders.

Cathy Stinear, PhDCathy Stinear, PhD

Dr Cathy Stinear is an Associate Professor in the Department of Medicine, at the University of Auckland, New Zealand. Her research group is based in Auckland City Hospital, where they develop ways to predict and promote motor recovery after stroke. Her work on biomarkers of motor recovery after stroke has been published in leading journals, such as Stroke, Brain, and Lancet Neurology.

David BlackerDavid Blacker, MBBS, FRACP

David Blacker is a neurologist and stroke physician at Sir Charles Gairdner Hospital, Clinical Professor of Neurology at UWA and Medical Director of the Perron Institute for neurological and translational science. He is the neurology subspecialty editor of the Internal Medicine Journal, and an editor of the journal Future Neurology. He has a wide range clinical and research interests in stroke from basic science and animal research at the Perron Institute, acute clinical treatment trials and neurorehabilitation utilizing pharmacological agents and technological devices. He was one of the first clinicians in WA to use thrombolysis for ischemic stroke, and established the acute stroke service at SCGH in 2003, which has expanded to become one of the busiest acute services in Australia and one of the leading thrombectomy centres. He was on the Medical Board of St John’s ambulance service and helped to shape the ambulance pathways for the Perth metropolitan area during the mid 2000s. He continues as an advisor to the WA Health Department on the broader application of interventional stroke services to regional and rural WA.

Erin GodeckeErin Godecke, PhD

Associate Professor Erin Godecke is a Senior Research Fellow at Edith Cowan University and completed her PhD in 2009. She has been a practising speech pathologist for over 20 years, working in acute stroke care and rehabilitation. Her research primarily focuses on therapy intensity and therapy type in very early aphasia recovery and measuring stroke outcomes in healthcare services. She is the Clinical Director of the largest trial in early aphasia recovery; VERSE, which is investigating the clinical and health-economic effects of very early aphasia rehabilitation. She is passionate about improving and promoting community participation for people with aphasia and their families; and about working with allied health professionals to develop their research.

Hermano Igo Krebs Hermano Igo Krebs, PhD

Dr Hermano Igo Krebs has been a Principal Research Scientist and Lecturer at MIT’s Mechanical Engineering Department since 1997. He also holds an affiliate position as an Adjunct Professor at University of Maryland School of Medicine, Department of Neurology, and as a Visiting Professor at Fujita Health University, Department of Physical Medicine and Rehabilitation (Japan), at University of Newcastle, Institute of Neuroscience (UK), at Osaka University, Mechanical Science and Bioengineering Department (Japan), and at Loughborough University, Rehabilitation Robotics of The Wolfson School of Mechanical, Electrical, and Manufacturing Engineering (UK). He is a member of the Collegio dei Docenti of the PhD programme in Biomedical Engineering of the University Campus Bio-Medico of Rome, Italy (“Dottorato di Ricerca in Ingegneria Biomedica”). He is a Fellow of the IEEE. Dr. Krebs was nominated by two of IEEE societies: IEEE-EMBS (Engineering in Medicine & Biology Society) and IEEE-RAS (Robotics and Automation Society) to this distinguished engineering status “for contributions to rehabilitation robotics and the understanding of neuro-rehabilitation.” His work goes beyond Stroke and has been extended to Cerebral Palsy for which he received “The 2009 Isabelle and Leonard H. Goldenson Technology and Rehabilitation Award,” from the Cerebral Palsy International Research Foundation (CPIRF). In 2015, he received the IEEE-INABA Technical Award for Innovation leading to Production “for contributions to medical technology innovation and translation into commercial applications for Rehabilitation Robotics.” His goal is to revolutionize the way rehabilitation medicine is practiced today by applying robotics and information technology to assist, enhance, and quantify rehabilitation. He was one of the founders, member of the Board of Directors, and the Chairman of the Board of Directors of Interactive Motion Technologies from 1998 to 2016. He successfully sold it to Bionik Laboratories, a publicly traded company, where he served as its Chief Science Officer and as a member of the Board of Directors until July 2017. He founded 4Motion Robotics in August 2017.

Julie BernhardtJulie Bernhardt, PhD

Professor Julie Bernhardt has worked for over 30 years in the field of stroke, first as a physiotherapist, then later as a clinician researcher.  Julie is a Senior Principal Research Fellow, Co-head of the Stroke Division, and Deputy Director of The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. She also directs the National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) Stroke Rehabilitation & Brain Recovery, a collaborative research program of eminent stroke researchers from The Florey, Hunter Medical Research Institute (Newcastle, Australia) and other leading institutes. Julie’s research is focused on development and testing of new interventions that aim to improve outcomes for people with stroke. She has been awarded 28 prizes and distinctions, including being named the 2016 winner of the Global category in the Top 100 Women of Influence Awards in Australia. Known best for being Principal Investigator for the international AVERT early rehabilitation trial that ran in 5 countries (Australia, New Zealand, Malaysia, Singapore and the UK) and included over 2000 patients, Julie loves large, complex trials. She has received >60 grants (28 as primary) totalling over $36 million. She was recently awarded a prestigious NHMRC project grant. The results of this trial will provide the first level one evidence for the specific dose of mobilisation to improve outcome for people with stroke.

Lauren Buxbaum, PsyDLaurel Buxbaum, PsyD

Laurel J. Buxbaum, Psy.D., is Associate Director of the Moss Rehabilitation Research Institute (MRRI) in Elkins Park, PA, USA, Director of MRRI’s Cognition and Action Laboratory, and Professor of Rehabilitation Medicine at Thomas Jefferson University in Philadelphia. She has authored more than 90 articles and chapters and has served as Associate Editor of the journals Cognition,Cortex, and Journal of Neuropsychology. Her laboratory has received grant funding from the National Institute of Health, National Institute of Disability and Rehabiltiation Research, and the James S. McDonnell Foundation. Dr. Buxbaum is the recipient of the International Neuropsychological Society’s Arthur Benton Mid-Career Award, the Widener University Graduate Award for Excellence in Professional Psychology, and the American Society of Neurorehabilitation’s Viste Award. Her work spans a translational “pipeline” from basic cognitive neuroscience to neurorehabilitation.

Nick Ward, MD Nick Ward, MD

Nick Ward is a Professor of Clinical Neurology & Neurorehabilitation at UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square. He is lead of the first dedicated upper limb neurorehabilitation programme in the UK. He also runs a research programme using structural and functional brain imaging to understand the mechanisms of recovery of movement after stroke so that we might predict both optimal treatments of upper limb impairment and long term outcomes after stroke. He is Co-editor of the Oxford Textbook of Neurorehabilitation and is Associate Editor of both the Journal for Neurology, Neurosurgery and Psychiatry and Neurorehabilitation and Neural Repair.

Dr Stephen Scott, PhD Stephen Scott, PhD

Dr. Stephen Scott is the inaugural holder of the GSK Chair in Neuroscience and Professor in the Department of Biomedical and Molecular Sciences at Queen’s University. He received a B.A.Sc. and a M.A.Sc. in Systems Design Engineering from the University of Waterloo, and a Ph.D. in physiology from Queen’s University. His basic research program explores the neural, behavioural and mechanical basis voluntary motor control including studies on human and non-human primates. His clinical research program explores the potential of robotic technologies as a next generation technology for neurological assessment related to stroke and other neurological disorders/injuries. He has published over 130 journal articles and given 180 invited talks. He is the inventor of the KINARM robot and is actively involved in the development of advanced technologies for use in basic and clinical research.  He is Co-Founder and Chief Scientific Officer of BKIN Technologies that commercialises the KINARM robotic platform.

Steven C CramerSteven C. Cramer, MD

Dr Steven C. Cramer is a Professor of Neurology, Anatomy & Neurobiology, and Physical Medicine & Rehabilitation at the University of California, Irvine.  He is also the Associate Director of the Institute for Clinical & Translational Science at UC Irvine, and co-PI of the NIH StrokeNet clinical trials network. Dr. Cramer graduated with Highest Honors from University of California, Berkeley; received his medical degree from University of Southern California; did a residency in internal medicine at UCLA; and did a residency in neurology plus and a fellowship in cerebrovascular disease at Massachusetts General Hospital.  He also earned a Masters Degree in Clinical Investigation from Harvard Medical School. His research focuses on neural repair after central nervous system injury in humans, with an emphasis on stroke and recovery of movement. Treatments examined include robotic, stem cell, monoclonal antibody, brain stimulation, drug, and telehealth methods.  A major emphasis is on translating new drugs and devices to reduce disability after stroke, and on individualizing therapy for each person’s needs.  Dr. Cramer co-edited the book “Brain Repair after Stroke” and is the author of over 250 manuscripts.

Sunghee Cho, PhD Sunghee Cho, PhD

Sunghee Cho received her B.S. in Chemistry from Yonsei University, M.S. in Nutrition from Cornell University and Ph.D. from the Department of Neurology/Neuroscience at Weill Cornell Medical College. She is currently a professor in the Brain Mind Research Institute at Weill Cornell Medicine. She is an editorial board member of Stroke, the Journal of Cerebral Blood Flow & Metabolism, and Translational Stroke Research. She is a Fellow of the American Heart/Stroke Association (FAHA) and a Council Member on Stroke. She is a chartered NIH neural oxidative metabolism and death (NOMD) study section member and participates as a US representative of the National Institute of Neurological Disorders and Stroke (NINDS) in the European Multi-Preclinical Animal Research Team Network Consortium. She served as a panelist for the NIH translational stroke research workshop and currently serves on the steering committee for the upcoming NIH Stroke Recovery workshop. The Cho laboratory focuses on neuro-immune interactions in stroke-induced brain injury and stroke repair mechanisms. These studies are funded by the NIH (NINDS, NHLBI, NCRR), American Heart Association, Sanofi, and the Burke Foundation.

Tim MurphyTim Murphy, PhD

Dr Murphy obtained his Ph.D. from Johns Hopkins in 1989 and is currently a Professor in the Department of Psychiatry at the University of British Columbia. He is a basic scientist who applies high-resolution imaging and optogenetic techniques to questions involving stroke in live mice. Dr. Murphy’s lab has evaluated relationships between synaptic structure and brain circuit function during and after ischemia.  He is actively constructing and optimizing instrumentation for in vivo structural and functional brain imaging to investigate mouse models of human disease. The lab employs optogenetic tools to provide local light-activated loss or gain of circuit function to test circuit-based hypotheses about stroke recovery. The lab uses these approaches to take a connections-based approach to stroke, as well as other disorders such as autism and depression. Currently, the lab is optimizing optical methods in mice that have parallels to clinical interventional (TMS) and assessment tools (fMRI), with the hope that translational treatments which correct aberrant functional connectivity in human can be piloted in mice.

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