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Dr Florence Lim

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Staff Member Details
Email: f.lim@ecu.edu.au

Florence is a Postdoctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.

Research Areas and Interests

Understanding the role of lipids in Alzheimer’s disease and other neurodegenerative diseases.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2012.
  • Bachelor of Science Molecular Genetics First Class Honours, Curtin University of Technology, 2004.

Research Outputs

Journal Articles

  • Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R. (2020). Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315. https://doi.org/10.3233/JAD-191304.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2020). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 2020(Article in press), 14p.. https://doi.org/10.1111/jnc.15128.
  • Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.
  • Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(1), Article number 5698. https://doi.org/https://doi.org/10.1038/s41467-020-19473-7.

Book Chapters

  • Hone, E., Lim, F., Martins, I. (2019). Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease. Neurodegeneration and Alzheimer's Disease The role of diabetes, Genetics, Hormones and Lifestyle (189-230). John Wiley & Sons. https://doi.org/10.1002/9781119356752.ch7.

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

Journal Articles

  • Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R. (2016). Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894. https://doi.org/10.3233/JAD-150948.

Journal Articles

  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.

Journal Articles

Journal Articles

  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R. (2013). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224. https://doi.org/10.1016/j.neurobiolaging.2013.03.012.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R. (2013). The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920. https://doi.org/10.4236/health.2013.55121.
  • Martins, I., Creegan, R., Lim, F., Martins, R. (2013). Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33. https://doi.org/10.4236/ojemd.2013.35A002.

Journal Articles

  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R. (2012). Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456. https://doi.org/10.4236/health.2012.412A209.

Journal Articles

  • Jenner, A., Lim, F., Ng, M., Wenk, MR., Shui, G., Sharman, M., Gandy, S., Martins, R. (2010). The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2,ε3 and ε4 knock-in mice. Neuroscience, 169(1), 109-115. https://doi.org/10.1016/j.neuroscience.2010.04.026.

Research Projects

  • Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort, National Health and Medical Research Council, Project Grants, 2017 ‑ 2022, $1,125,804.
  • Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer's disease pathology, National Health and Medical Research Council, Project Grants, 2016 ‑ 2019, $100,000.
  • 4.6 - Biomarkers for Schizophrenia Sub-Types - Part A Neuroimaging, Part B Biomarker Discovery, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $1,202,364.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $352,524.
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