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Dr Belinda Brown

Belinda is a Research Fellow in Neuroscience based at the McCusker Foundation.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2014.
  • Bachelor of Science (Molecular Biotechnology), Curtin University of Technology, 2007.

Research

Recent Research Grants

  • The role of intense physical activity in protecting the ageing brain,  National Health and Medical Research Council,  Dementia Research Development Fellowship,  2016 - 2020,  $778,579.
  • The effect of high-intensity exercise on Alzheimer?s disease-related gene expression,  Brain Foundation,  Research Gifts Program,  2017,  $39,875.
  • The influence of exercise intensity on the prevention of cognitive decline in older adults,  Alzheimers Australia Dementia Research Foundation,  AADRF - Postdoctoral Fellowships,  2014 - 2016,  $238,034.
  • Exercise intensity and prevention of cognitive decline in older adults,  Edith Cowan University,  ECU Early Career Researcher Grant - 2015,  2015 - 2016,  $24,066.
  • Application for travel to the Brain Aging and Cognitive Health Laboratory at the University of Pittsburgh,  Alzheimers Australia Dementia Research Foundation,  AADRF - Rosemary Foundation Travel Fellowship,  2015 - 2016,  $15,000.

Recent Publications (within the last five years)

Journal Articles

  • Brown, B., Sohrabi, H., Taddei, K., Gardener, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickson, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R., (2017), Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer?s disease. Alzheimer's and Dementia, In Press(In Press), 10p., United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2017.03.008.
  • Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J., (2017), Intense resistance exercise increases peripheral brain-derived neurotrophic factor. Journal of Science and Medicine in Sport, 20(10), 899-903, Elsevier, DOI: 10.1016/j.jsams.2017.03.015.
  • Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V., (2016), Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, 15(10), 1044-1053, London, UK, Lancet Publishing Group, DOI: 10.1016/S1474-4422(16)30125-9.
  • Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R., (2016), Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 115(2), 2106-2113, Cambridge University Press, DOI: 10.1017/S0007114516001203.
  • Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R., (2016), The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068, Westchester, USA, Associated Professional Sleep Societies,LLC, DOI: 10.5665/sleep.5756.
  • Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894, Netherlands, IOS Press, DOI: 10.3233/JAD-150948.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-? accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16, Lausanne, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2015.00016.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2015), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515004687.
  • Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R., (2015), Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164, Bussum, Netherlands, Bentham Science Publishers.
  • Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C., (2014), En Attendant Centiloid. Advances in Research, 2(12), 723-729, Online, Science Domain International, DOI: 10.9734/AIR/2014/11599.
  • Bourgeat, P., Villemagne, V., Dore, V., Brown, B., Macaulay, SL., Martins, R., Masters, C., Ames, D., Ellis, K., Rowe, C., Salvado, O., Fripp, J., (2014), Comparison of MR-less PiB SUVR quantification methods. Neurobiology of Aging, 36(S1), S159-S166, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2014.04.033.
  • Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R., (2014), Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000000867.
  • Villemagne, V., Burhnham, S., Bourgeat, P., Brown, B., Ellis, KA., Salvado, O., Szoeke, C., Macaulay, L., Martins, R., Maruff, P., Ames, D., Rowe, C., Masters, C., (2013), Amyloid ? deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease : a prospective cohort study. The Lancet Neurology, 12(4), 357-367, The Lancet Publishing Group.
  • Rowe, C., Bourgeat, P., Ellis, K., Brown, B., Yen Ying, L., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., Robins, P., Tochon-Danguy, H., O'Keefe, G., Pike, K., Yates, P., Szoeke, C., Salvado, O., Macaulay, SL., O'Meara, T., Head, R., Cobiac, L., Savage, G., Martins, R., Masters, C., Ames, D., Villemagne, V., (2013), Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6), 905-913, USA, Jossey Bass, Ed. & Pub., DOI: 10.1002/ana.24040.
  • Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, CL., Ames, D., Rowe, C., Martins, R., (2012), Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry, 2(2012), art. no. e191 , DOI: 10.1038/tp.2012.118.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R., (2012), Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325, United States, American Medical Association, DOI: 10.1001/archneurol.2012.1282.
  • Brown, B., Peiffer, JJ., Martins, R., (2012), Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?. Molecular Psychiatry, 18(8), 864-874, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.162.
  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R., (2012), Physical activity and amyloid-? plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881, United Kingdom, Nature Publishing Group.
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