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Dr Stephanie Rainey-Smith

Senior Research Fellow

Contact Information Telephone: +61 8 6304 2649, Email: s.rainey-smith@ecu.edu.au, Campus: Joondalup, Room: JO17.310
Staff Member Details
Telephone: +61 8 6304 2649
Email: s.rainey-smith@ecu.edu.au
Campus: Joondalup  
Room: JO17.310  

 

Stephanie is a Clinical Trials Coordinator within the School of Medical and Health Sciences.

Qualifications

  • Doctor of Philosophy in Neuroscience, United Kingdom, 2010.
  • Bachelor of Science, United Kingdom, 2001.

Research

Recent Research Grants

  • AIBL: Agreement with Biogen for provision of AIBL Data and samples,  Florey Institute of Neuroscience and Mental Health,  Grant,  2016 - 2022,  $2,161,504.
  • Improving sleep to promote healthy brain aging: an intervention study ,  Alzheimer's Association USA,  Alzheimer's Association Research Grant,  2019 - 2021,  $205,386.
  • Genetic and lifestyle susceptibility and resilience factors affecting rates of change in preclinical Alzheimer's Disease,  National Health and Medical Research Council,  Project Grants,  2019 - 2021,  $940,788.
  • Improving sleep to prevent Alzheimer's disease,  BrightFocus Foundation,  Alzheimer's Disease Research - Postdoctoral Fellowship Awards,  2018 - 2020,  $319,150.
  • The contribution of sleep factors to healthy cognitive ageing: longitudinal and intervention studies of cognition and neuroimaging,  Department of Health WA,  Near Miss Merit Awards,  2017 - 2018,  $75,000.
  • The contribution of sleep factors to healthy cognitive ageing: A pilot sleep-specific cognitive behavioural intervention study,  Equity Trustees Limited,  Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation),  2017 - 2018,  $60,000.
  • Validation of a modified dietary questionnaire for use in Alzheimer’s disease research,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2017,  2017 - 2018,  $9,997.
  • Impact of genetics on the effect that modifiable lifestyle factors have on rates of change in Alzheimers Disease,  Equity Trustees Limited,  Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation),  2016 - 2017,  $55,370.
  • The effect of high-intensity exercise on Alzheimer’s disease-related gene expression,  Brain Foundation,  Research Gifts Program,  2017,  $39,875.
  • Development and refinement of methods for early and specific diagnosis of Alzheimer's disease, quantification of rates of change in the pathological processes and determination of the resultant effects on cognition.,  Fil Foundation,  Grant,  2015 - 2017,  $417,506.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. ,  Hollywood Private Hospital Research Foundation,  Grant,  2013 - 2016,  $20,000.
  • Progressing the clinical neuropsychological phenotype of Alzheimer's disease.,  Florey Institute of Neuroscience and Mental Health,  Grant,  2014 - 2015,  $107,935.
  • CSIRO/Janssen AIBL Neuroscience Program,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Janssen Neuroscience Program,  2014 - 2015,  $231,018.
  • A study of the kinetics of biomarkers and their presumptive relationship with brain amyloid ,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Araclon Biotech ,  2014 - 2015,  $132,200.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease,  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2014 - 2015,  $12,555.
  • AIBL Carer Extension Study (ACES),  Florey Institute of Neuroscience and Mental Health,  Wyeth Caregiver Study,  2013 - 2014,  $87,840.
  • A Pilot Clinical Study to Evaluate the Potential of AMLAMAX™ (Emblica Officinalis) Extract on Raising HDL-Cholesterol Levels and Decreasing Plasma Amyloid beta (Aβ) Levels in a Perth Memory,  Hollywood Private Hospital Research Foundation,  Grant,  2010 - 2014,  $14,760.
  • Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Merck Sharp and Dohme Corpe Grant,  2011 - 2014,  $265,000.
  • The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Science Industry Endowment Fund Agreement,  2010 - 2013,  $5,341,586.
  • Evaluation of the protective benefit of leisure-time physical activity for the prevention of Alzheimer's disease in older adults,  Edith Cowan University,  ECU Early Career Researcher - Grant,  2010 - 2012,  $24,750.

Recent Publications (within the last five years)

Journal Articles

  • Fine, L., Weinborn, M., Ng, A., Loft, S., Li, Y., Hodgson, E., Parker, D., Rainey-Smith, S., Sohrabi, H., Brown, B., Martins, R., Bucks, R., (2019), Sleep disruption explains age-related prospective memory deficits: implications for cognitive aging and intervention. Aging, Neuropsychology and Cognition: A Journal on Normal and Dysfunctional Development, epub ahead of print(Aug 2018), 17p., United Kingdom, Routledge, DOI: 10.1080/13825585.2018.1513449.
  • Dang, C., Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., Rowe, C., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Masters, C., Maruff, P., (2019), Superior Memory Reduces 8-year Risk of Mild Cognitive Impairment and Dementia But Not Amyloid β-Associated Cognitive Decline in Older Adults. Archives of Clinical Neuropsychology, In Press(2018), 14p., United Kingdom, Oxford University Press, DOI: 10.1093/arclin/acy078.
  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Laws, S., Martins, R., Peiffer, J., (2019), Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized‑controlled trial. European Journal of Applied Physiology, epub ahead of Print(August 2019), 10p., Germany, Springer, DOI: 10.1007/s00421-019-04202-w.
  • Sohrabi, H., Weinborn, M., Laske, C., Bates, K., Christensen, D., Taddei, K., Rainey-Smith, S., Brown, B., Gardener, S., Laws, S., Martins, G., Burnham, S., Bucks, R., Reisberg, B., Lautenschlager, N., Foster, J., Martins, R., (2019), Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, In Press(2018), 13p., United Kingdom, Cambridge University Press, DOI: 10.1017/S1041610218001072.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2019), Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2018.12.014.
  • Brown, B., Castalanelli, N., Rainey-Smith, S., Doecke, J., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., (2019), Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. Behavioural Brain Research, 362(19 April 2019), 103-108, DOI: 10.1016/j.bbr.2019.01.013.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2019), COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152, DOI: 10.1016/j.ibror.2019.05.001.
  • Harrington, K., Dang, C., Lim, YY., Ames, D., Laws, S., Pietrzak, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Villemagne, V., Masters, C., Maruff, P., (2018), The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults. Intelligence, 70(Sept-Oct 2018), 22-29, United Kingdom, Elsevier, DOI: 10.1016/j.intell.2018.07.004.
  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2018.00423.
  • Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V., (2018), Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's Disease, 63(4), 1299-1305, Netherlands, IOS Press, DOI: 10.3233/JAD-170998.
  • Lan, J., Galindo, A., Doecke, J., Fowler, C., Martins, R., Rainey-Smith, S., Cominetti, O., Dayon, L., (2018), Systematic Evaluation of the Use of Human Plasma and Serum for Mass-Spectrometry-Based Shotgun Proteomics. Journal of Proteome Research, 17(4), 1426-1435, United States, American Chemical Society, DOI: 10.1021/acs.jproteome.7b00788.
  • Perin, S., Harrington, K., Lim, YY., Ellis, K., Ames, D., Pietrzak, R., Schembri, A., Rainey-Smith, S., Salvado, O., Laws, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Maruff, P., (2018), Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. Journal of Affective Disorders, 229(15 March 2018), 269-274, Netherlands, Elsevier, DOI: 10.1016/j.jad.2017.12.101.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-20513-y.
  • Lim, YY., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., Rowe, C., Masters, C., Maruff, P., (2018), Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA Neurology, 75(4), 488-494, United States, American Medical Association, DOI: 10.1001/jamaneurol.2017.4325.
  • Fernando, B., Rainey-Smith, S., Gardener, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R., (2018), Associations of dietary protein and fiber intake with brain and blood amyloid-B. Journal of Alzheimer's Disease, 61(2018), 1589-1598, Netherlands, IOS Press, DOI: 10.3233/JAD-170742.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • McCabe, K., Woods, S., Weinborn, M., Sohrabi, H., Rainey-Smith, S., Brown, B., Gardener, S., Taddei, K., Martins, R., (2018), Personality characteristics are independently associated with prospective memory in the laboratory, and in daily Life, among older adults. Journal of Research in Personality, 76(Oct 2018), 32-37, United States, Academic Press, DOI: 10.1016/j.jrp.2018.06.006.
  • Dang, C., Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Rowe, C., Masters, C., Maruff, P., (2018), Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 65(4), 1313-1325, Netherlands, IOS Press, DOI: 10.3233/JAD-180507.
  • Doecke, J., Rembach, A., Villemagne, V., Varghesi, S., Rainey-Smith, S., Sarros, S., Evered, L., Fowler, C., Pertile, K., Rumble, R., Trounson, B., Taddei, K., Laws, S., Macaulay, SL., Bush, A., Ellis, K., Martins, R., Ames, D., Silbert, B., Vanderstichele, H., Masters, C., Darby, D., Li, Q., Collins, S., (2018), Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms. Journal of Alzheimer's Disease, 61(1), 169-183, Netherlands, IOS Press, DOI: 10.3233/JAD-170128.
  • Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Gardener, S., Gozt, O., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R., (2018), Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study. Psychological Assessment, 30(10), 1308-1316, United States, American Psychological Association, DOI: 10.1037/pas0000565.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S., (2018), Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41398-018-0094-x.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S., (2018), Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20, United States, Elsevier, DOI: 10.1016/j.pmip.2018.03.001.
  • Holmes, SE., Esterlis, I., Mazure, CM., Lim, YY., Ames, D., Rainey-Smith, S., Fowler, C., Ellis, K., Martins, R., Salvado, O., Doré, V., Villemagne, VL., Rowe, CC., Laws, S., Masters, CL., Pietrzak, RH., Maruff, P., (2018), Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study. International Journal of Geriatric Psychiatry, 33(2), 405-413, DOI: 10.1002/gps.4761.
  • Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D., (2018), Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years. Alzheimer Disease and Associated Disorders, 32(3), 190-196, United States, Lippincott Williams & Wilkins, DOI: 10.1097/WAD.0000000000000252.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211, Netherlands, IOS Press, DOI: 10.3233/JAD-180713.
  • Gardener, S., Rainey-Smith, S., (2018), The Role of Nutrition in Cognitive Function and Brain Ageing in the Elderly. Current Nutrition Reports, 7(3), 139-149, Current Science Inc., DOI: 10.1007/s13668-018-0229-y.
  • Rainey-Smith, S., Gu, Y., Gardener, S., Doecke, J., Villemagne, V., Brown, B., Taddei, K., Laws, S., Sohrabi, H., Weinborn, M., Ames, D., Fowler, C., Macaulay, SL., Maruff, P., Masters, C., Salvado, O., Rowe, C., Scarmeas, N., Martins, R., (2018), Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(1), 238-244, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41398-018-0293-5.
  • Harrington, K., Schembri, A., Lim, YY., Dang, C., Ames, D., Hassenstab, J., Laws, S., Rainey-Smith, S., Robertson, J., Rowe, C., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Masters, C., Maruff, P., (2018), Estimates of age-related memory decline are inflated by unrecognized Alzheimer’s disease. Neurobiology of Aging, 70(Oct 2018), 170-179, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2018.06.005.
  • Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, JJ., (2017), Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia, 3(4), 562-570, United States, Elsevier Science Inc., DOI: 10.1016/j.trci.2017.09.003.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P., (2017), BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S1041610217001284.
  • Gardener, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R., (2017), Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161158.
  • Brown, B., Sohrabi, H., Taddei, K., Gardener, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickson, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R., (2017), Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimer's and Dementia, 13(11), 1197-1206, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2017.03.008.
  • Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Martins, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Dore, V., Villemagne, V., Snyder, P., Masters, C., Maruff, P., (2017), Amyloid b–associated cognitive decline in the absence of clinical disease progression and systemic illness. Alzheimer's and Dementia, 8(2017), 156-164, Philadelphia, USA, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.05.006.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G., (2017), Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-09577-4.
  • Lim, YY., Williamson, R., Laws, S., Villemagne, V., Bourgeat, P., Fowler, C., Rainey-Smith, S., Salvado, O., Martins, R., Rowe, C., Masters, C., Maruff, P., (2017), Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. Journal of Alzheimer's Disease, 58(4), 1293-1302, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-170072.
  • Frost, S., Robinson, L., Rowe, C., Ames, D., Masters, C., Taddei, K., Rainey-Smith, S., Martins, R., Kanagasingam, Y., (2017), Evaluation of cholinergic deficiency in preclinical Alzheimer's disease using pupillometry. Journal of Ophthalmology, 2017(August 2017), Article no. 7935406, New York, USA, Hindawi Ltd., DOI: 10.1155/2017/7935406.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P., (2017), Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52, DOI: 10.1016/j.bpsc.2016.08.006.
  • Harrington, K., Gould, E., Lim, Y., Ames, D., Pietrzak, R., Rembach, A., Rainey-Smith, S., Martins, R., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Maruff, P., (2017), Amyloid burden and incident depressive symptoms in cognitively normal older adults. International Journal of Geriatric Psychiatry, 32(4), 455-463, John Wiley & Sons, DOI: 10.1002/gps.4489.
  • Cerin, E., Rainey-Smith, S., Ames, D., Lautenschlager, N., Macaulay, S., Fowler, C., Robertson, J., Rowe, C., Maruff, P., Martins, R., Masters, C., Ellis, K., (2017), Associations of neighbourhood environment with brain imaging outcomes in the AIBL cohort. Alzheimer's and Dementia, 13(4), 388-398, United States, Elsevier, DOI: 10.1016/j.jalz.2016.06.2364.
  • Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J., (2017), Intense resistance exercise increases peripheral brain-derived neurotrophic factor. Journal of Science and Medicine in Sport, 20(10), 899-903, Chatswood, NSW, Elsevier Australia, DOI: 10.1016/j.jsams.2017.03.015.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P., (2017), APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422, Netherlands, IOS Press, DOI: 10.3233/JAD-161019.
  • Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., Martins, R., (2017), Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252, Taylor and Francis Ltd, DOI: 10.1080/00207454.2016.1182527.
  • Harrington, K., Lim, Y., Ames, D., Hassenstab, J., Rainey-Smith, S., Robertson, J., Salvado, O., Masters, CL., Maruff, P., (2017), Using robust normative data to investigate the neuropsychology of cognitive aging. Archives of Clinical Neuropsychology, 32(2), 142-154, Oxford University Press, DOI: 10.1093/arclin/acw106.
  • Mo, Y., Stromswold, J., Wilson, K., Holder, D., Sur, C., Laterza, O., Savage, MJ., Struyk, A., Scheltens, P., Teunissen, C., Burke, J., Macaulay, SL., Bråthen, G., Sando, S., White, L., Weiss, C., Cowes, A., Bush, M., Desilva, G., Darby, D., Rainey-Smith, S., Surls, J., Sagini, E., Tanen, M., Altman, A., Luthman, J., Egan, M., (2017), A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 6(March), 201-209, Elsevier, DOI: 10.1016/j.dadm.2017.02.004.
  • Burnham, S., Rowe, C., Baker, D., Bush, A., Doecke, JD., Faux, N., Laws, S., Martins, R., Maruff, P., Macaulay, S., Rainey-Smith, S., Savage, G., Ames, D., Masters, C., Wilson, W., Villemagne, V., (2016), Predicting Alzheimer disease from a blood-based biomarker profile. Neurology, 87(11), 1093-1101, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000003094.
  • Francois, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R., Rainey-Smith, S., Masters, C., Ames, D., Rowe, C., Macaulay, S., Hill, A., Leifert, W., (2016), High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. Current Alzheimer Research, 13(7), 787-799, DOI: 10.2174/1567205013666160315112151.
  • Lim, YY., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., Salvado, O., Rowe, C., Masters, C., Maruff, P., (2016), Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, 60(3), 362-370, Springer New York LLC, DOI: 10.1007/s12031-016-0822-8.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2016), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515004687.
  • Gardener, S., Rainey-Smith, S., Martins, R., (2016), Diet and Inflammation in Alzheimer's Disease and Related Chronic Diseases: A Review. Journal of Alzheimer's disease, 50(2016), 301-334, Netherlands, IOS Press, DOI: 10.3233/JAD-150765.
  • Buckley, R., Maruff, P., Ames, D., Bourgeat, P., Martins, R., Masters, C., Rainey-Smith, S., Lautenschlager, N., Rowe, C., Savage, G., Villemagne, V., Ellis, K., (2016), Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer's and Dementia, 12(7), 796-804, United States, Elsevier, DOI: 10.1016/j.jalz.2015.12.013.
  • Holmes, S., Esterlis, I., Mazure, C., Lim, YY., Ames, D., Rainey-Smith, S., Martins, R., Salvado, O., Dore, V., Villemagne, V., Rowe, C., Laws, S., Masters, C., Maruff, P., Pietrzak, R., (2016), β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195, Elsevier B.V., DOI: 10.1016/j.jagp.2016.08.007.
  • Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R., (2016), Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 115(2), 2106-2113, Cambridge University Press, DOI: 10.1017/S0007114516001203.
  • Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R., (2016), The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068, Westchester, USA, Associated Professional Sleep Societies,LLC, DOI: 10.5665/sleep.5756.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P., (2016), Aβ-related memory decline in APOE ε4 non-carriers: Implications for Alzheimer’s disease. Neurology, 86(17), 1635-1642, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000002604.
  • Gardener, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R., (2016), Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672, Netherlands, IOS Press, DOI: 10.3233/JAD-151084.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.12.001.
  • Creegan, R., Hunt, W., McManus, A., Rainey-Smith, S., (2015), Diet, nutrients and metabolism: cogs in the wheel driving Alzheimer’s disease pathology?. British Journal of Nutrition, 113(10), 1499-1517, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515000926.
  • Buckley, RF., Ellis, KA., Ames, D., Rowe, CC., Lautenschlager, NT., Maruff, P., Villemagne, V., Macaulay, SL., Szoeke, C., Martins, R., Masters, CL., Savage, G., Rainey-Smith, S., Rembach, A., Saling, MM., (2015), Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology, 29(4), 571-581, Washington DC, United States, American Psychological Association, DOI: 10.1037/neu0000156.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16, Lausanne, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2015.00016.
  • Leifert, WR., Nguyen, T., Rembach, A., Martins, R., Rainey-Smith, S., Masters, CL., Ames, D., Rowe, CC., Macaulay, SL., François, M., Fenech, MF., (2015), Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's Disease, 48(2), 443-452, Netherlands, IOS Press, DOI: 10.3233/JAD-150330.
  • Leifert, WR., Tuli, JF., François, M., Nguyen, T., Rembach, A., Rumble, RL., Rainey-Smith, S., Martins, R., Fenech, MF., (2015), Buccal cell cytokeratin 14 identifies mild cognitive impairment and alzheimer’s disease in the AIBL study of aging. Current Alzheimer Research, 12(3), 233-241, Bentham Science Publishers.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0105-6.
  • Sutton, T., Sohrabi, H., Rainey-Smith, S., Bird, S., Weinborn, M., Martins, R., (2015), The role of APOE-ε4 and beta amyloid in the differential rate of recovery from ECT: a review. Translational Psychiatry, 5(e539), 1-8, London, UK, Nature Publishing Group, DOI: 10.1038/tp.2015.39.
  • Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD., (2015), Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71, London, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0157-7.
  • Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S., (2015), Alzheimer’s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-150247.
  • Gardener, S., Rainey-Smith, S., Macaulay, SL., Taddei, K., Rembach, A., Maruff, P., Ellis, K., Masters, C., Rowe, C., Ames, D., Keogh, J., Martins, R., (2015), Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ. The British Journal of Nutrition: an international journal of nutritional science, 114(10), 1683-1693, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515003335.
  • Buckley, R., Saling, M., Ellis, K., Rowe, C., Maruff, P., Macaulay, LS., Martins, R., Masters, C., Savage, G., Rainey-Smith, S., Rembach, A., Ames, D., (2015), Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age and Ageing, 44(6), 1012-1019, Oxford University Press, DOI: 10.1093/ageing/afv136.
  • Gardener, S., Rainey-Smith, S., Barnes, M., Sohrabi, H., Weinborn, M., Lim, Y., Harrington, K., Taddei, K., Gu, Y., Rembach, A., Szoeke, C., Ellis, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Keogh, J., Scarmeas, N., Martins, R., (2015), Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry, 20(7), 860-866, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2014.79.
  • Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P., (2015), Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease is Dependent on APOE ε4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082, San Francisco, California, United States, Public Library of Science, DOI: 10.1371/journal.pone.0139082.
  • Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C., (2014), En Attendant Centiloid. Advances in Research, 2(12), 723-729, Online, Science Domain International, DOI: 10.9734/AIR/2014/11599.
  • Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R., (2014), Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000000867.
  • Ellis, K., Szoeke, C., Bush, A., Darby, D., Graham, P., Lautenschlager, N., Macaulay, L., Martins, R., Maruff, P., Masters, C., McBride, S., Pike, K., Rainey-Smith, S., Rembach, A., Robertson, J., Rowe, C., Savage, G., Villemagne, V., Woodward, M., Wilson, W., Zhang, P., Ames, D., (2014), Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26(4), 543-554, Cambridge University Press, DOI: 10.1017/S1041610213001956.
  • Rembach, A., Faux, N., Watt, A., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Roberts, B., Perez, K., Li, Q., Laws, S., Taddei, K., Rainey-Smith, S., Robertson, J., Vandijck, M., Vanderstichele, H., Barnham, K., Ellis, K., Szoeke, C., Macaulay, L., Rowe, C., Villemagne, V., Ames, D., Martins, R., Bush, A., Masters, C., (2014), Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia, 10(1), 53-61, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2012.12.006.
  • Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Lautenschlager, N., Maruff, P., Macaulay, SL., Martins, R., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Szoeke, C., Ellis, K., (2014), Personal memory function in mild cognitive impairment and subjective memory complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study of ageing. Journal of Alzheimer's Disease, 40(3), 551-561 , Netherlands, IOS Press, DOI: 10.3233/JAD-131820.
  • Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Villemagne, V., Lautenschlager, N., Maruff, P., Macaulay, L., Martins, R., Szoeke, C., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Ellis, K., (2014), Autobiographical narratives relate to Alzheimer’s disease biomarkers in older adults. International Psychogeriatrics, 26(10), 1737-1746, International Psychogeriatric Association, DOI: 10.1017/S1041610214001136.
  • Rembach, A., Watt, A., Wilson, W., Rainey-Smith, S., Ellis, K., Rowe, C., Villemagne, V., Macaulay, S., Bush, A., Martins, R., Ames, D., Masters, C., Doecke, J., (2014), An increased neutrophil-lymphocyte ratio in Alzheimer’s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71, Elsevier, DOI: 10.1016/j.jneuroim.2014.05.005.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy,  IMPACT OF NUTRITION ON COGNITION AND ITS ASSOCIATION WITH BLOOD AND BRAIN ALZHEIMER DISEASE RELATED BIOMARKERS
  • Doctor of Philosophy,  INVESTIGATION OF THE ROLE OF AMLA IN MODULATING CHOLESTEROL METABOLISM, AND UNDERSTANDING ITS MECHANISM OF ACTION IN REDUCING ALZHEIMER'S RISK
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