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Dr Nicolas Hart

Senior Research Fellow

Contact Information Telephone: +61 8 6304 3436, Email: n.hart@ecu.edu.au, Campus: Joondalup, Room: JO21.222
Staff Member Details
Telephone: +61 8 6304 3436
Email: n.hart@ecu.edu.au
Campus: Joondalup  
Room: JO21.222  

 

Dr. Nicolas Hart is a Senior Research Fellow at the Exercise Medicine Research Institute (EMRI) situated within the School of Medical and Health Science (SMHS) at Edith Cowan University.

Background

Dr Nicolas Hart, PhD, AES, CSCS, ESSAM is a Senior Research Fellow at the Exercise Medicine Research Institute (an NHMRC Centre of Research Excellence) and an accredited exercise scientist, named 'WA Young Tall Poppy of the Year' (Australian Institute of Policy and Sciences, 2017) and ‘Exercise Scientist of the Year’ (Exercise and Sport Science Australia, 2014).

Dr Hart’s clinical oncology work focuses on the ability of exercise to change tumour biology, and attenuate tumour formation, growth and invasion in primary and secondary carcinomas. He currently leads a series of world-first trials in humans, examining the suppressive and regressive effects of exercise on tumour morphology, tumour vasculature and tumour biomarkers in secondary carcinomas of advanced prostate and breast cancer patients with sclerotic and osteolytic bone metastatic lesions; with studies funded by Cancer Council of Western Australia, National Breast Cancer Foundation and Movember Foundation. Dr Hart is the Global Exercise Coordinator, and Co-Chair of the Protocol Amendment Review Committee for the Movember GAP4 (INTERVAL-MCRPC) trial - (the largest exercise trial in prostate cancer worldwide; investigating exercise and overall survival); and the National Exercise Coordinator for the Movember TrueNTH Australia trial - (the provision of local and remote delivery of exercise as medicine to prostate cancer patients across metropolitan and regional Australia).

Dr Hart is also a founding member of the Western Australian Bone Research Collaboration (WABRC): a cross-institutional and multidisciplinary team of researchers and clinicians investigating bone health and disease. Dr Hart continues to research in high performance sport, and is a consultant sport scientist to the West Coast Eagles (AFL), Fremantle Dockers (AFL), Western Force (Rugby Union) and Perth Glory (Soccer) sporting teams, providing input towards, and assisting in the prevention and management of stress-related bone injuries; stratify musculoskeletal injury risk; and provide a broad range of sport science services on request.

Current Appointments

  • 2017: Senior Research Fellow, Exercise Medicine Research Institute, Edith Cowan University.
  • 2017: Adjunct Research Fellow, Institute of Health Research, University of Notre Dame Australia.
  • 2015: Global Exercise Coordinator, GAP4 – INTERVAL-MCRPC: Movember Foundation
  • 2015: National Exercise Coordinator, TrueNTH Australia: Movember Foundation
  • 2015: DXA and pQCT Trainer, School of Medical and Health Sciences, Edith Cowan University
  • 2015: Consultant Sport Scientist – West Coast Eagles, Fremantle Dockers, Western Force and Perth Glory

Committee Appointments

  • 2017: Pre-Doctoral Research Sub-Committee, Cancer Council of Western Australia
  • 2017: ALLY Network Representative - Equity and Diversity, Edith Cowan University
  • 2016: Co-Chair, Protocol Amendment Review Committee, GAP4 – INTERVAL-MCRPC: Movember Foundation.
  • 2016: Founding Member, Western Australian Bone Research Collaboration (WABRC).
  • 2015: Human Research Ethics Sub-Committee: SMHS and SOS, Edith Cowan University.
  • 2014: Exercise Science Advisory Group (ESAG), Exercise & Sport Science Australia – Australia

Previous Appointments

  • 2015 – 2017: Post-Doctoral Research Fellow, Exercise Medicine Research Institute, Edith Cowan University.
  • 2017 – 2017: NHMRC Grant Review Panel (GRP) Observer, Canberra, Australia.
  • 2015 – 2016: Protocol Development Working Group (PDWG), GAP4 - INTERVAL-MCRPC: Movember Foundation.
  • 2011 – 2014: Sport Scientist, Fremantle Dockers Football Club, Perth, Australia.
  • 2010 – 2014: Sessional Exercise & Sport Science Staff, Edith Cowan University, Perth, Australia.
  • 2008 – 2014: Research Assistant, Centre for Exercise & Sport Science Research, Edith Cowan University, Perth, Australia.

Professional Associations

  • Exercise and Sport Science Australia – (ESSA)
  • Clinical Oncology Society of Australia – (COSA)
  • Australian Strength and Conditioning Association – (ASCA)
  • National Strength and Conditioning Association – (NSCA)

Awards and Recognition

National and International Awards

  • 2017 – Western Australian, Tall Poppy, Scientist of the Year Award - Australian Institute of Policy and Science.
  • 2016 – NSCA Young Investigator Award (USA), Associate Investigator, 2016, $19,416 AUD.
  • 2015 – Best Paper (Allied Health) – Prostate Cancer World Congress.
  • 2015 – Inaugural Winner, Clinical Exercise Physiology Grant – Exercise and Sport Science Australia.
  • 2014 – Exercise Scientist of the Year – Exercise and Sport Science Australia.
  • 2013 – High Commendation, Sport Science Grant – Exercise and Sport Science Australia.

University Awards

  • 2017 – Visiting Research Fellow Grant, School of Medical and Health Sciences, Edith Cowan University, $3,990 AUD.
  • 2016 – Excellence by Early Career Researcher, Vice-Chancellor's Award, Edith Cowan University, $5,000 AUD.
  • 2016 – eResearch Technology Funding Scheme, Edith Cowan University, 2016, $4,405 AUD.
  • 2011 – Industry PhD Scholarship, Fremantle Dockers Football Club, 2012 – 2014, $78,000 AUD.
  • 2009 – Top 5%, High Achievement Undergraduate Award, Edith Cowan University.

Research Areas and Interests

Exercise Oncology – Research Stream

  • Exercise as Medicine.
  • Modulation of Tumour Biology.
  • Suppression of Bone Metastases.
  • Musculoskeletal Preservation.
  • Muscle-Bone Synergy.

Exercise Science – Research Stream

  • Bone Adaptation to Mechanical Loading.
  • Muscle-Bone Interactions for Musculoskeletal Health.
  • Musculoskeletal Screening, Asymmetry and Injury Prevention.
  • Gait Abnormality, Running Asymmetry and Injury Incidence.
  • Change of Direction and Agility Performance.

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2015.
  • Master of Science Sport Science, Edith Cowan University, 2012.
  • Bachelor of Sport Exercise and Sport Science, Edith Cowan University, 2009.

Research

Recent Research Grants

  • Can Exercise Delay Transition to Active Therapy in Men with Low Grade Prostate Cancer? A Multi-Centre Randomized Controlled Trial.,  National Health and Medical Research Council,  Project Grants,  2018 - 2022,  $596,084.
  • GAP4 Exercise and Metabolic Health Trial - Exercise Central Coordinating Centre ,  The Movember Group,  Movember - GAP4 Prostate Cancer Exercise and Metabolic Health,  2016 - 2021,  $342,985.
  • Mechanical modulation of bone metastases in advanced breast cancer patients: Can targeted exercise suppress osteolytic tumour progression?,  National Breast Cancer Foundation,  Pilot Study Grant,  2016 - 2018,  $184,300.
  • Feasibility and efficacy of dosing exercise medicine immediately before or after chemotherapy infusion,  Edith Cowan University,  ECU Industry Collaboration Grant - 2017 Open Round,  2017 - 2018,  $112,747.
  • Can exercise interfere with sclerotic tumour formation and reduce tumour growth in advanced prostate cancer patients with bone metastasis? ? A phase I, randomised clinical trial examining feasibility, safety and efficacy.,  Cancer Council of WA Inc,  Grant - Early Career Investigator,  2016 - 2018,  $34,742.
  • An exploratory study to determine if exercise can impact the gut microbiota composition of men receiving androgen suppression therapy for prostate cancer,  Prostate Cancer Foundation of Australia,  Grant,  2018,  $98,875.
  • The effect of cognitive and exercise training on Brain Atrophy and Cognitive Decline in Breast Cancer Patients Treated with Adjuvant Chemotherapy Agents,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2018,  $49,966.
  • Characterisation of musculoskeletal health, motor development and exercise capacity of children who have completed therapy for acute lymphoblastic leukaemia (ALL).,  Edith Cowan University,  ECU Early Career Researcher Grant - 2017,  2017 - 2018,  $30,000.
  • New Independent Researcher Infrastructure Support (NIRIS) Awards,  Department of Health WA,  New Independent Researcher Infrastructure Support (NIRIS) Awards,  2017 - 2018,  $10,000.
  • INTense Exercise foR surVivAL among men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL ? MCRPC): A Multicentre, Randomized, Controlled, Phase III Study,  The Movember Group,  Movember - GAP4 Prostate Cancer Exercise and Metabolic Health,  2016 - 2018,  $290,544.
  • TrueNTH solutions: an integrated multi-component intervention to improve the lives of men with prostate cancer in Australia - Demonstration of the Lifestyle and Exercise Program,  The Movember Group,  True NTH,  2016 - 2017,  $122,380.
  • Mechanical modulation of bone metastases in advanced prostate cancer patients: Can targeted exercise suppress sclerotic tumour progression? ? A pilot study.,  Exercise & Sports Science Australia,  Clinical Exercise Physiology Research Grant,  2015 - 2017,  $37,200.
  • Mechanical Specificity of Weightlifting Movements to Athletic Performance,  National Strength and Conditioning Association,  Grant,  2010 - 2013,  $13,591.

Recent Publications (within the last five years)

Journal Articles

  • Hart, N., Galvao, D., Newton, R., (2017), Exercise Medicine for Advanced Prostate Cancer. Current Opinion in Supportive and Palliative Care, 11(3), 247-257, London, United Kingdom, Lippincott Williams & Wilkins, DOI: 10.1097/SPC.0000000000000276.
  • Rantalainen, T., Chivers, P., Beck, B., Robertson, S., Hart, N., Nimphius, S., Weeks, B., McIntyre, F., Hands, B., Siafarikas, A., (2017), Please don?t move - evaluating motion artifact from peripheral Quantitative Computed Tomography scans using textural features. Journal of Clinical Densitometry, 000-000, DOI: http://dx.doi.org/10.1016/j.jocd.2017.07.002.
  • Galvao, D., Taaffe, D., Spry, N., Cormie, P., Joseph, D., Chambers, S., Chee, R., McIntyre, C., Hart, N., Baumann, FT., Denham, J., Baker, M., Newton, R., (2017), Exercise preserves physical function in prostate cancer patients with bone metastases. Medicine and Science in Sports and Exercise, 000-000, DOI: 10.1249/MSS.0000000000001454.
  • Hart, N., Newton, R., Spry, N., Taaffe, D., Chambers, S., Feeney, K., Joseph, D., Redfern, A., Ferguson, T., Galvao, D., (2017), Can exercise suppress tumour growth in advanced prostate cancer patients with sclerotic bone metastases? A randomised, controlled study protocol examining feasibility, safety and efficacy. BMJ Open, 7(5), article no.e014458, DOI: 10.1136/bmjopen-2016-014458.
  • Hart, N., Nimphius, S., Rantalainen, T., Ireland, A., Siafarikas, A., Newton, R., (2017), Mechanical basis of bone strength: influence of bone material, bone structure and muscle action. The Journal of Musculoskeletal and Neuronal Interactions, 17(3), 114-139, Nafplion, Greece, The International Society of Musculoskeletal and Neuronal Interactions.
  • Hart, N., Cochrane Wilkie, J., Spiteri, T., Nimphius, S., Newton, R., (2016), Relationship between leg mass, leg composition and foot velocity on kicking accuracy in Australian Football. Journal of Sport Science and Medicine, 15(2), 344-351, Turkey, Journal of Sports Science and Medicine.
  • Hart, N., Nimphius, S., Weber, J., Spiteri, T., Rantalainen, T., Dobbin, M., Newton, R., (2016), Musculoskeletal asymmetry in football athletes: A product of limb function over time. Medicine and Science in Sports and Exercise, 48(7), 1379-1387, Lippincott Williams and Wilkins, DOI: 10.1249/MSS.0000000000000897.
  • Rantalainen, T., Hart, N., Nimphius, S., Wundersitz, D., (2016), Associations between step duration variability and inertial measurement unit derived gait characteristics. Journal of Applied Biomechanics, 32(4), 401-406, USA, Human Kinetics Inc, DOI: 10.1123/jab.2015-0266.
  • Hart, N., Nimphius, S., Spiteri, T., Cochrane Wilkie, J., Newton, R., (2015), Segmental musculoskeletal examinations using dual-energy X-ray absorptiometry (DXA): Positioning and analysis considerations. Journal of Sport Science and Medicine, 14(3), 620-626, Turkey, Journal of Sports Science and Medicine.
  • Spiteri, T., Newton, R., Binetti, M., Hart, N., Sheppard, J., Nimphius, S., (2015), Mechanical determinants of faster change of direction and agility performance in female basketball athletes. Journal of Strength and Conditioning Research, 29(8), 2205-2214, United States, National Strength and Conditioning Association, DOI: 10.1519/JSC.0000000000000876.
  • Hart, N., Spiteri, T., Lockie, RG., Nimphius, S., Newton, R., (2014), Detecting deficits in change of direction performance using the preplanned multidirectional Australian Football League Agility Test. Journal of Strength and Conditioning Research, 28(12), 3552-3556, United States, Lippincott Williams & Wilkins.
  • Spiteri, T., Nimphius, S., Hart, N., Specos, C., Sheppard, J., Newton, R., (2014), Contribution of strength characteristics to change of direction and agility performance in female basketball athletes. Journal of Strength and Conditioning Research, 28(9), 2415-2423, United States, Lippincott Williams & Wilkins.
  • Hart, N., Nimphius, S., Spiteri, T., Newton, R., (2014), Leg strength and lean mass symmetry influences kicking performance in Australian Football. Journal of Sports Science and Medicine, 13(1), 157-165, Turkey, Journal of Sports Science and Medicine.
  • Spiteri, T., Hart, N., Nimphius, S., (2014), Offensive and defensive agility: a sex comparison of lower body kinematics and ground reaction forces. Journal of Applied Biomechanics, 30(4), 514-520, USA, Human Kinetics Inc, DOI: 10.1123/jab.2013-0259.
  • Spiteri, T., Cochrane Wilkie, J., Hart, N., Haff, G., Nimphius, S., (2013), Effect of strength on plant foot kinetics and kinematics during a change of direction task. European Journal of Sport Science, 13(6), 646-652, Routledge, DOI: 10.1080/17461391.2013.774053.
  • Hart, N., Nimphius, S., Cochrane Wilkie, J., Newton, R., (2013), Leg mass characteristics of accurate and inaccurate kickers - an Australian football perspective. Journal of Sports Sciences, 31(15), 1647-1655, United Kingdom, Routledge, DOI: 10.1080/02640414.2013.793377.

Conference Publications

  • Hart, N., Nimphius, S., Weber, J., Dobbin, M., Joyce, D., Higgins, C., Haff, G., Newton, R., (2014), Muscle-bone differences between elite Australian football and rugby union players. Journal of Australian Strength and Conditioning, 99-101, Australian Strength and Conditioning Association.
  • Blanco Ochoa, P., Haff, G., Hart, N., Seitz, L., Spiteri, T., Tufano, J., Nimphius, S., (2014), Bone; Body composition and isometric rate of force development are associated in female ballet students and university ballet students. Journal of Australian Strength and Conditioning , 106-110, Australian Strength and Conditioning Association.
  • Spiteri, T., Hart, N., (2013), Ball inclusion into the AFL agility test can improve change of direction performance. Journal of Australian Strength and Conditioning, 75-77, Melbourne, Vic, Australian Strength and Conditioning Association.
  • Hart, N., Spiteri, T., (2013), Quantifying performance deficits between limbs using a modified version of the AFL agility test. Journal of Australian Strength and Conditioning, 21(8-10 November 2013), 105-107, Australian Strength and Conditioning Association.
  • Hart, N., Dobbin, M., Weber, J., Nimphius, S., Newton, R., (2013), Physical load tolerance differs between kicking and support limbs in Australian Footballers. Journal of Australian Strength and Conditioning, 102-104, Melbourne, Australian Strength and Conditioning Association.
  • Hart, N., Nimphius, S., Weber, J., Dobbin, M., Newton, R., (2013), Lower body bone mass characteristics of elite, sub-elite and amateur Australian footballers. Journal of Australian Strength and Conditioning, 21(8 - 10 November), 50-53, Beenleigh, Queensland, Australian Strength and Conditioning Association.
  • Hart, N., Nimphius, S., Dorman, C., Newton, R., (2013), Influence of leg strength and lean mass on kicking accuracy in Australian Football. Journal of Australian Strength and Conditioning, 21(8-10 November), 99-101, Australian Strength and Conditioning Association.
  • Hart, N., Nimphius, S., Cochrane Wilkie, J., Newton, R., (2012), Reliability And Validity Of Unilateral And Bilateral Isometric Strength Measures Using A Customised, Portable Apparatus. Journal of Australian Strength and Conditioning, 20(11-13 November 2011), 61-67, Helensvale, QLD, Australian Strength and Conditioning Association.
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