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Dr Nicolas Hart

Senior Research Fellow

Contact Information Telephone: +61 8 6304 3436, Email: n.hart@ecu.edu.au, Campus: Joondalup, Room: JO21.222
Staff Member Details
Telephone: +61 8 6304 3436
Email: n.hart@ecu.edu.au
Campus: Joondalup  
Room: JO21.222  

 

Dr. Nicolas Hart is a Senior Research Fellow for the Cancer Council of Western Australia (CCWA) at the Exercise Medicine Research Institute (EMRI) situated within the School of Medical and Health Science (SMHS) at Edith Cowan University; and research member of the Australian Centre for Research into Injury in Sport and its Prevention (ACRISP).

Background

Dr Nicolas Hart, PhD, AES, CSCS, ESSAM is a Senior Research Fellow for the Cancer Council of Western Australia at the Exercise Medicine Research Institute (an NHMRC Centre of Research Excellence) and an accredited exercise scientist, named 'WA Young Tall Poppy of the Year' (Australian Institute of Policy and Sciences, 2017) and ‘Exercise Scientist of the Year’ (Exercise and Sport Science Australia, 2014). He is also a research member of ACRISP (an International Olympic Committee (IOC) Centre of Research Excellence).

Dr Hart’s clinical oncology work focuses on the ability of exercise to change tumour biology, and attenuate tumour formation, growth and invasion in primary and secondary carcinomas. He currently leads a series of world-first trials in humans, examining the suppressive and regressive effects of exercise on tumour morphology, tumour vasculature and tumour biomarkers in secondary carcinomas of advanced prostate and breast cancer patients with sclerotic and osteolytic bone metastatic lesions; with studies funded by Cancer Council of Western Australia, National Breast Cancer Foundation and Movember Foundation. Dr Hart is the Global Exercise Coordinator, and Co-Chair of the Protocol Amendment Review Committee for the Movember GAP4 (INTERVAL-MCRPC) trial - (the largest exercise trial in prostate cancer worldwide; investigating exercise and overall survival); and the National Exercise Coordinator for the Movember TrueNTH Australia trial - (the provision of local and remote delivery of exercise as medicine to prostate cancer patients across metropolitan and regional Australia).

Dr Hart is also a founding member of the Western Australian Bone Research Collaboration (WABRC): a cross-institutional and multidisciplinary team of researchers and clinicians investigating bone health and disease. Dr Hart continues to research in high performance sport, and is a consultant sport scientist to the West Coast Eagles (AFL), Fremantle Dockers (AFL), Western Force (Rugby Union) and Perth Glory (Soccer) sporting teams, providing input towards, and assisting in the prevention and management of stress-related bone injuries; stratify musculoskeletal injury risk; and provide a broad range of sport science services on request.

Current Appointments

  • 2018: Senior Research Fellow, Cancer Council of Western Australia
  • 2018: Senior Research Fellow, Australian Centre for Research into Injury in Sport and its Prevention
  • 2017: Senior Research Fellow, Exercise Medicine Research Institute, Edith Cowan University.
  • 2017: Adjunct Research Fellow, Institute of Health Research, University of Notre Dame Australia.
  • 2015: Global Exercise Coordinator, GAP4 – INTERVAL-MCRPC: Movember Foundation
  • 2015: National Exercise Coordinator, TrueNTH Australia: Movember Foundation
  • 2015: DXA and pQCT Trainer, School of Medical and Health Sciences, Edith Cowan University
  • 2015: Consultant Sport Scientist – West Coast Eagles, Fremantle Dockers, Western Force and Perth Glory

Committee Appointments

  • 2019: ESSA Publications Committee, Exercise and Sport Science Australia
  • 2018: ECU Human Research Ethics Committee – Edith Cowan University
  • 2018: SuRECaP (Survivorship Research in Prostate Cancer) - PCR Working Group
  • 2018: Section Editor (Exercise Oncology) - Journal of Sports Science and Medicine
  • 2018: ASpSc and HPM Professional Standards Review, Exercise & Sport Science Australia – Australia
  • 2018: Professional Development Review Committee, Exercise & Sport Science Australia – Australia
  • 2017: Pre-Doctoral Research Sub-Committee, Cancer Council of Western Australia
  • 2017: ALLY Network Representative - Equity and Diversity, Edith Cowan University
  • 2016: Co-Chair, Protocol Amendment Review Committee, GAP4 – INTERVAL-MCRPC: Movember Foundation.
  • 2016: Founding Member, Western Australian Bone Research Collaboration (WABRC).

Previous Appointments

  • 2018: Guest Lecturer, Harvard Extension School, Harvard University.
  • 2015 – 2018: Human Research Ethics Sub-Committee: SMHS and SOS, Edith Cowan University.
  • 2014 – 2018: Exercise Science Advisory Group (ESAG), Exercise & Sport Science Australia – Australia
  • 2015 – 2017: Post-Doctoral Research Fellow, Exercise Medicine Research Institute, Edith Cowan University.
  • 2017 – 2017: NHMRC Grant Review Panel (GRP) Observer, Canberra, Australia.
  • 2015 – 2016: Protocol Development Working Group (PDWG), GAP4 - INTERVAL-MCRPC: Movember Foundation.
  • 2011 – 2014: Sport Scientist, Fremantle Dockers Football Club, Perth, Australia.
  • 2010 – 2014: Sessional Exercise & Sport Science Staff, Edith Cowan University, Perth, Australia.
  • 2008 – 2014: Research Assistant, Centre for Exercise & Sport Science Research, Edith Cowan University, Perth, Australia.

Professional Associations

  • Exercise and Sport Science Australia – (ESSA)
  • Clinical Oncology Society of Australia – (COSA)
  • American Society of Clinical Oncology – (ASCO)
  • American College of Sports Medicine – (ACSM)
  • Australian Strength and Conditioning Association – (ASCA)
  • National Strength and Conditioning Association – (NSCA)

Awards and Recognition

National and International Awards

  • 2018 – NHMRC CRE-PCS Mentorship Program Award, $4000 AUD.
  • 2016 – NSCA Young Investigator Award (USA), Associate Investigator, 2016, $19,416 AUD.
  • 2015 – Best Paper (Allied Health) – Prostate Cancer World Congress.
  • 2015 – Inaugural Winner, Clinical Exercise Physiology Grant – Exercise and Sport Science Australia.
  • 2014 – Exercise Scientist of the Year – Exercise and Sport Science Australia.
  • 2013 – High Commendation, Sport Science Grant – Exercise and Sport Science Australia.

State Awards

  • 2019 – Finalist, ’40under40 Awards’ [Not for Profit], BusinessNews WA
  • 2018 – Postdoctoral Research Fellowship (2018-2020), Cancer Council Western Australia, $601,459 AUD.
  • 2017 – Western Australian, Tall Poppy, Scientist of the Year Award - Australian Institute of Policy and Science.

University Awards

  • 2018 – Deputy Vice-Chancellor (Research) – EMCRN Research Achievement Award
  • 2017 – Visiting Research Fellow Grant, School of Medical and Health Sciences, Edith Cowan University, $3,990 AUD.
  • 2016 – Excellence by Early Career Researcher, Vice-Chancellor's Award, Edith Cowan University, $5,000 AUD.
  • 2016 – eResearch Technology Funding Scheme, Edith Cowan University, 2016, $4,405 AUD.
  • 2011 – Industry PhD Scholarship, Fremantle Dockers Football Club, 2012 – 2014, $78,000 AUD.
  • 2009 – Top 5%, High Achievement Undergraduate Award, Edith Cowan University.

Research Areas and Interests

Exercise Oncology – Research Stream

  • Exercise as Medicine.
  • Modulation of Tumour Biology.
  • Suppression of Bone Metastases.
  • Musculoskeletal Preservation.
  • Muscle-Bone Synergy.

Exercise Science – Research Stream

  • Bone Adaptation to Mechanical Loading.
  • Muscle-Bone Interactions for Musculoskeletal Health.
  • Musculoskeletal Screening, Asymmetry and Injury Prevention.
  • Gait Abnormality, Running Asymmetry and Injury Incidence.
  • Change of Direction and Agility Performance.

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2015.
  • Master of Science Sport Science, Edith Cowan University, 2012.
  • Bachelor of Sport Exercise and Sport Science, Edith Cowan University, 2009.

Research

Recent Research Grants

  • Can Exercise Delay Transition to Active Therapy in Men with Low Grade Prostate Cancer? A Multi-Centre Randomized Controlled Trial.,  National Health and Medical Research Council,  Project Grants,  2018 - 2023,  $596,084.
  • Australian Centre for Research into Injury in Sport and its Prevention (ACRISP),  International Olympic Committee,  Research Centres for Prevention of Injury and Protection of Athlete Health,  2019 - 2022,  $568,107.
  • GAP4 Exercise and Metabolic Health Trial - Exercise Central Coordinating Centre ,  The Movember Group,  Movember - GAP4 Prostate Cancer Exercise and Metabolic Health,  2016 - 2021,  $342,985.
  • INTense Exercise foR surVivAL among men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL – MCRPC): A Multicentre, Randomized, Controlled, Phase III Study,  The Movember Group,  Movember - GAP4 Prostate Cancer Exercise and Metabolic Health,  2016 - 2021,  $439,524.
  • Feasibility and efficacy of dosing exercise medicine immediately before or after chemotherapy infusion,  Edith Cowan University,  ECU Industry Collaboration Grant - 2017 Open Round,  2018 - 2020,  $135,247.
  • Examining the effect of creatine supplementation in augmenting adaptations to resistance training in prostate cancer patients undergoing androgen deprivation therapy: a randomised, double-blind, placebo controlled trial. ,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2019 - 2020,  $64,560.
  • Exercise medicine for advanced cancer patients: a synergistic and targeted approach to delay disease progression and extend survival.,  Cancer Council of WA Inc,  Fellowship,  2018 - 2020,  $601,458.
  • From Research to Practice: the development, implementation and evaluation of an intervention to integrate exercise into standard of care for people with cancer,  Genesis Cancer Care Pty Ltd,  Genesis Cancer Care - Grant,  2018 - 2020,  $10,000.
  • Mechanical modulation of bone metastases in advanced breast cancer patients: Can targeted exercise suppress osteolytic tumour progression?,  National Breast Cancer Foundation,  Pilot Study Grant,  2016 - 2019,  $184,300.
  • An exploratory study to determine if exercise can impact the gut microbiota composition of men receiving androgen suppression therapy for prostate cancer,  Prostate Cancer Foundation of Australia,  Grant,  2018 - 2019,  $98,875.
  • TrueNTH solutions: an integrated multi-component intervention to improve the lives of men with prostate cancer in Australia - Demonstration of the Lifestyle and Exercise Program,  The Movember Group,  True NTH,  2016 - 2019,  $262,420.
  • The effect of cognitive and exercise training on Brain Atrophy and Cognitive Decline in Breast Cancer Patients Treated with Adjuvant Chemotherapy Agents,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2018 - 2019,  $49,966.
  • Characterisation of musculoskeletal health, motor development and exercise capacity of children who have completed therapy for acute lymphoblastic leukaemia (ALL).,  Edith Cowan University,  ECU Early Career Researcher Grant - 2017,  2017 - 2019,  $30,000.
  • Can exercise interfere with sclerotic tumour formation and reduce tumour growth in advanced prostate cancer patients with bone metastasis? – A phase I, randomised clinical trial examining feasibility, safety and efficacy.,  Cancer Council of WA Inc,  Grant - Early Career Investigator,  2016 - 2018,  $34,742.
  • New Independent Researcher Infrastructure Support (NIRIS) Awards,  Department of Health WA,  New Independent Researcher Infrastructure Support (NIRIS) Awards,  2017 - 2018,  $10,000.
  • Mechanical modulation of bone metastases in advanced prostate cancer patients: Can targeted exercise suppress sclerotic tumour progression? – A pilot study.,  Exercise & Sports Science Australia,  Clinical Exercise Physiology Research Grant,  2015 - 2017,  $37,200.
  • Mechanical Specificity of Weightlifting Movements to Athletic Performance,  National Strength and Conditioning Association,  Grant,  2010 - 2013,  $13,591.

Recent Publications (within the last five years)

Journal Articles

  • Meghji, M., Balloch, A., Habibi, D., Ahmad, I., Hart, N., Newton, R., Weber, J., Waqar, A., (2019), An Algorithm for the Automatic Detection and Quantification of Athletes’ Change of Direction Incidents Using IMU Sensor Data. IEEE Sensors Journal, X(X), xxx-xxx, IEEE Sensors Council.
  • Fairman, C., Kendall, K., Hart, N., Taaffe, D., Galvao, D., Newton, R., (2019), The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer. Critical Reviews in Oncology Hematology, 00(00), 1-16, DOI: 10.1016/j.critrevonc.2018.11.003.
  • Chivers, P., Rantalainen, T., McIntyre, F., Hands, B., Weeks, B., Beck, B., Hart, N., Siafarikas, A., (2019), Suboptimal bone status for adolescents with Low Motor Competence and Developmental Coordination Disorder - it's sex specific. Research in Developmental Disabilities, 84(January 2019), 57-65.
  • Newton, R., Christophersen, C., Fairman, C., Hart, N., Taaffe, D., Broadhurst, D., Devine, A., Chee, R., Tang, C., Spry, N., Galvao, D., (2019), Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial. BMJ Open, 9(4), e024872, DOI: http://dx.doi.org/10.1136/bmjopen-2018-024872.
  • Balloch, A., Meghji, M., Newton, R., Hart, N., Weber, J., Ahmad, I., Habibi, D., (2019), Assessment of a Novel Algorithm to Determine Change of Direction Angles Whilst Running Using Inertial Sensors. Journal of Strength and Conditioning Research, X(X), 1-15, United States, Lippincott Williams & Wilkins, DOI: 10.1519/JSC.0000000000003064.
  • Jenkins, M., Hart, N., Rantalainen, T., Chivers, P., Newton, R., Nimphius, S., (2018), Reliability of upper-limb diaphyseal mineral and soft-tissue measurements using peripheral Quantitative Computed Tomography (pQCT). The Journal of Musculoskeletal and Neuronal Interactions, 18(4), 438-445.
  • Galvao, D., Taaffe, D., Spry, N., Cormie, P., Joseph, D., Chambers, S., Chee, R., McIntyre, C., Hart, N., Baumann, FT., Denham, J., Baker, M., Newton, R., (2018), Exercise preserves physical function in prostate cancer patients with bone metastases. Medicine and Science in Sports and Exercise, 50(3), 393-399, Philadelphia, USA, Lippincott Williams & Wilkins, DOI: 10.1249/MSS.0000000000001454.
  • Rantalainen, T., Chivers, P., Beck, B., Robertson, S., Hart, N., Nimphius, S., Weeks, B., McIntyre, F., Hands, B., Siafarikas, A., (2018), Please don’t move - evaluating motion artifact from peripheral Quantitative Computed Tomography scans using textural features. Journal of Clinical Densitometry, 21(2), 260-268, DOI: 10.1016/j.jocd.2017.07.002.
  • Newton, R., Kenfield, S., Hart, N., Chan, J., Courneya, K., Catto, J., Finn, S., Greenwood, R., Hughes, D., Mucci, L., Plymate, S., Praet, S., Guinan, E., Van Blarigan, E., Casey, O., Buzza, M., Gledhill, S., Zhang, L., Galvao, D., Ryan, C., Saad, F., (2018), Intense exercise for survival among men with metastatic castrate-resistant prostate cancer (INTERVAL-GAP4): A multicentre, randomised, controlled phase III study protocol. BMJ Open, 8(5), article no.e022899, DOI: 10.1136/bmjopen-2018-022899.
  • Galvao, D., Hayne, D., Frydenburg, M., Chambers, S., Taaffe, D., Spry, N., Scuffham, P., Ware, R., Hart, N., Newton, R., (2018), Can exercise delay transition to active therapy in men with low-grade prostate cancer? A multi-centre randomised controlled trial. BMJ Open, 8(4), e022331, DOI: 10.1136/bmjopen-2018-022331.
  • Schofield, C., Newton, R., Cohen, P., Galvao, D., McVeigh, J., Hart, N., Mohan, G., Tan, J., Salfinger, S., Straker, L., McIntyre, C., (2018), Activity behaviours and physiological characteristics of women with advanced-stage Ovarian Cancer: a preliminary cross-sectional investigation. International Journal of Gynecological Cancer, 28(3), 604-613, DOI: 10.1097/IGC.0000000000001197.
  • Jenkins, M., Nimphius, S., Hart, N., Chivers, P., Rantalainen, T., Rueter, K., Borland, M., McIntyre, F., Stannage, K., Siafarikas, A., (2018), Appendicular fracture epidemiology of children and adolescents: A 10-year case review in Western Australia (2005 to 2015). Archives of Osteoporosis, 13(1), article no.63, DOI: 10.1007/s11657-018-0478-9.
  • Jacob, Y., Spiteri, T., Hart, N., Anderton, R., (2018), The potential role of genetic markers in talent identification and athlete assessment in elite sport. Sports, 6(3), article no.88, DOI: 10.3390/sports6030088.
  • Dolci, F., Hart, N., Kilding, A., Chivers, P., Piggott, B., Spiteri, T., (2018), Movement economy in soccer: current data and limitations. Sports, 6(4), article no.124, DOI: 10.3390/sports6040124.
  • Hart, N., Newton, R., Weber, J., Spiteri, T., Rantalainen, T., Dobbin, M., Chivers, P., Nimphius, S., (2018), Functional basis of asymmetrical lower-body skeletal morphology in professional Australian Rules Footballers. Journal of Strength and Conditioning Research, 00(00), 1-10, United States, Lippincott Williams & Wilkins.
  • Hart, N., Galvao, D., Saunders, C., Taaffe, D., Feeney, K., Spry, N., Tsoi, D., Martin, H., Chee, R., Clay, T., Redfern, A., Newton, R., (2018), Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: a randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine. Trials, 19(1), Article no.695, DOI: 10.1186/s13063-018-3091-8.
  • Hart, N., Nimphius, S., Rantalainen, T., Ireland, A., Siafarikas, A., Newton, R., (2017), Mechanical basis of bone strength: influence of bone material, bone structure and muscle action. The Journal of Musculoskeletal and Neuronal Interactions, 17(3), 114-139, Nafplion, Greece, The International Society of Musculoskeletal and Neuronal Interactions.
  • Hart, N., Galvao, D., Newton, R., (2017), Exercise Medicine for Advanced Prostate Cancer. Current Opinion in Supportive and Palliative Care, 11(3), 247-257, London, United Kingdom, Lippincott Williams & Wilkins, DOI: 10.1097/SPC.0000000000000276.
  • Hart, N., Newton, R., Spry, N., Taaffe, D., Chambers, S., Feeney, K., Joseph, D., Redfern, A., Ferguson, T., Galvao, D., (2017), Can exercise suppress tumour growth in advanced prostate cancer patients with sclerotic bone metastases? A randomised, controlled study protocol examining feasibility, safety and efficacy. BMJ Open, 7(5), article no.e014458, DOI: 10.1136/bmjopen-2016-014458.
  • Rantalainen, T., Hart, N., Nimphius, S., Wundersitz, D., (2016), Associations between step duration variability and inertial measurement unit derived gait characteristics. Journal of Applied Biomechanics, 32(4), 401-406, USA, Human Kinetics Inc, DOI: 10.1123/jab.2015-0266.
  • Hart, N., Nimphius, S., Weber, J., Spiteri, T., Rantalainen, T., Dobbin, M., Newton, R., (2016), Musculoskeletal asymmetry in football athletes: A product of limb function over time. Medicine and Science in Sports and Exercise, 48(7), 1379-1387, Lippincott Williams and Wilkins, DOI: 10.1249/MSS.0000000000000897.
  • Hart, N., Cochrane Wilkie, J., Spiteri, T., Nimphius, S., Newton, R., (2016), Relationship between leg mass, leg composition and foot velocity on kicking accuracy in Australian Football. Journal of Sport Science and Medicine, 15(2), 344-351, Turkey, Journal of Sports Science and Medicine.
  • Spiteri, T., Newton, R., Binetti, M., Hart, N., Sheppard, J., Nimphius, S., (2015), Mechanical determinants of faster change of direction and agility performance in female basketball athletes. Journal of Strength and Conditioning Research, 29(8), 2205-2214, United States, National Strength and Conditioning Association, DOI: 10.1519/JSC.0000000000000876.
  • Hart, N., Nimphius, S., Spiteri, T., Cochrane Wilkie, J., Newton, R., (2015), Segmental musculoskeletal examinations using dual-energy X-ray absorptiometry (DXA): Positioning and analysis considerations. Journal of Sport Science and Medicine, 14(3), 620-626, Turkey, Journal of Sports Science and Medicine.
  • Spiteri, T., Nimphius, S., Hart, N., Specos, C., Sheppard, J., Newton, R., (2014), Contribution of strength characteristics to change of direction and agility performance in female basketball athletes. Journal of Strength and Conditioning Research, 28(9), 2415-2423, United States, Lippincott Williams & Wilkins.
  • Spiteri, T., Hart, N., Nimphius, S., (2014), Offensive and defensive agility: a sex comparison of lower body kinematics and ground reaction forces. Journal of Applied Biomechanics, 30(4), 514-520, USA, Human Kinetics Inc, DOI: 10.1123/jab.2013-0259.
  • Hart, N., Nimphius, S., Spiteri, T., Newton, R., (2014), Leg strength and lean mass symmetry influences kicking performance in Australian Football. Journal of Sports Science and Medicine, 13(1), 157-165, Turkey, Journal of Sports Science and Medicine.
  • Hart, N., Spiteri, T., Lockie, RG., Nimphius, S., Newton, R., (2014), Detecting deficits in change of direction performance using the preplanned multidirectional Australian Football League Agility Test. Journal of Strength and Conditioning Research, 28(12), 3552-3556, United States, Lippincott Williams & Wilkins.

Conference Publications

  • Hart, N., Nimphius, S., Weber, J., Dobbin, M., Joyce, D., Higgins, C., Haff, G., Newton, R., (2014), Muscle-bone differences between elite Australian football and rugby union players. Journal of Australian Strength and Conditioning, 99-101, Australian Strength and Conditioning Association.
  • Blanco Ochoa, P., Haff, G., Hart, N., Seitz, L., Spiteri, T., Tufano, J., Nimphius, S., (2014), Bone; Body composition and isometric rate of force development are associated in female ballet students and university ballet students. Journal of Australian Strength and Conditioning, 106-110, Australian Strength and Conditioning Association.

Research Student Supervision

Co-principal Supervisor

  • Doctor of Philosophy,  BONE FRACTURE INCIDENCE, MEASUREMENT AND ADAPTATION: AN EXPLORATION THROUGH THE CONTINUUM FROM INCIDENCE TO MEASUREMENT AND ADAPTATION
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