The Edith Cowan University Centre for Integrative Metabolomics & Computational Biology (CIMCB) is a newly established multi-million dollar facility founded on an innovative collaboration between ECU and the multinational biotechnology company Thermo Fischer Scientific, who are world leaders in the provision of mass-spectrometry based analytical instrumentation and integrated informatics solutions.
As a sponsored “proof of concept” facility, CIMCB has preferential access to Thermo equipment, training and expertise, whilst also partnering in the development of new innovations to the benefit of the scientific community.
CIMCB is based at the School of Science, Joondalup Campus. It aims to revolutionise phenomic research by providing a unique data-centric collaborative research facility. The centre will provide state-of-the-art mass spectrometry analytical facilities supported by a comprehensive computational biology capability for the provision of reproducible data, mathematical modelling, and biological interpretation. It will pool university expertise in small molecule analytical chemistry, experimental design, biostatistics, and machine learning.
The core of the facility is a trio of high-resolution mass spectrometers: (1) Thermo Q Exactive™ LC-MS/MS, (2) Thermo Q Exactive™ GC-MS/MS, (3) Thermo Quantiva™ QQQ LC-MS, which will enable the centre to provide comprehensive coverage of the metabolome at a resolution only available through the Thermo Orbitrap™ technology.
The centre’s vision is to provide a centralised incubator for rigorous world-class systems-biology research, linking scientists and students from a broad range of scientific disciplines within ECU and across WA, combined with establishing long-term collaboration with centres of excellence across the globe. Our focus on robust workflows, quality control, and intuitive data integration, will allow vibrant and innovative research to flourish, encouraging stimulating interactions between biological, medical, and computational scientists.
Professor David Broadhurst (www.davidbroadhurst.net) is the director of the centre. David is an internationally recognised metabolomics researcher. He has been working in metabolomics, and systems biology, since its inception just over 20 years ago. He is currently the only Professor of Biostatistics & Machine Learning specialising in Metabolomics based in Australia. The deputy director of the centre is Associate Professor Mary Boyce, an analytical chemist with 20 years experience in electrophoretic and chromatographic separations, and expertise in mass-spectrometry based analytical chemistry.
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