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Dr Elin Gray

Senior Research Fellow

Contact Information Telephone: +61 8 6304 2756, Mobile: 0406840197, Email:, Campus: Joondalup, Room: JO17.309
Staff Member Details
Telephone: +61 8 6304 2756
Mobile: 0406840197
Campus: Joondalup  
Room: JO17.309  


Elin is a Postdoctoral Research Fellow in Melanoma within the School of Medical and Health Sciences.


Dr Elin Gray is a Cancer Research Trust Postdoctoral Fellow and Senior Researcher at the Melanoma Research Group, within the School of Medical and Health Sciences at ECU. Prior to appointment at ECU, Elin worked at the National Institute for Communicable Diseases in South Africa; the Vaccine Research Center at the NIH, USA and the Duke Human Vaccine Institute, Duke University, USA. Elin’s previous research focused in immunology and virology before relocating to Edith Cowan University in 2011. Dr Gray current research aims to  identify blood biomarkers for diagnosis of melanoma and to guide treatment decisions. Her team utilises and develops novel genetic analysis methodologies to interrogate biomarkers such as circulating tumour cells, circulating tumour DNA and exosomes, to provide information on the tumour evolution and cancer development. In addition, Elin is interested in identifying mechanisms of drug resistance and developing better treatment strategies. Dr Gray works in close collaboration with leading oncologists and pathologists to translate these results into clinical application.


  • Doctor of Philosophy, South Africa, 2008.
  • Master in Biochemistry, Cuba, 2001.
  • Bachelor of Biochemistry, Cuba, 1997.


Recent Research Grants

  • Enabling Advanced Single Cell Cancer Genomics in Western Australia,  Cancer Research Trust,  The Grant,  2017 - 2022,  $305,925.
  • Liquid biopsy for personalised monitoring of melanoma patients ,  National Health and Medical Research Council,  Development Grants,  2017 - 2020,  $950,389.
  • Characterisation of Melanoma Circulating Tumour Cells for Personalised Treatment,  Cancer Research Trust,  Postdoctoral Fellowship,  2014 - 2019,  $830,000.
  • Predictive significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA) and serum vascular endothelial growth factor (VEGF) in advanced melanoma patients treated with pembrolizumab,  Merck Sharp and Dohme (Australia) Pty Ltd,  Grant,  2016 - 2018,  $73,300.
  • Understanding the Role of Melanoma Exosomes in Intercellular Communication,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2017 - 2018,  $43,230.
  • Circulating Tumour DNA to Predict and Monitor Treatment Response and Detect Acquired Resistance in Patients with Metastatic Melanoma,  Ramaciotti Foundation,  Grant,  2015 - 2018,  $99,911.
  • Genetic Analysis of Blood Markers for Prognosis in Patients with Uveal Melanoma,  University of Western Australia,  Raine Foundation Grant,  2016 - 2018,  $100,000.
  • Medical and Health Infrastructure Fund award 2016 Round 20,  Department of Health WA,  Medical and Health Research Infrastructure,  2017 - 2018,  $19,463.
  • Blood based biomarkers predictive of treatment efficacy in metastatic melanoma,  Spinnaker Health Research Foundation,  Collaborative Research Partnership Grants,  2017 - 2018,  $107,448.
  • Blood Based Biomarkers Predictive of Treatment Response in Melanoma,  Cancer Council of WA Inc,  Grant,  2016 - 2018,  $246,822.
  • A Blood Based `Liquid Biopsy? to Improve Healthcare for Metastatic Melanoma Patients,  Department of Health WA,  SHRAC Research Translation Projects,  2016 - 2018,  $4,075,030.
  • New Independent Research Infrastructure Support Award 2016,  Department of Health WA,  New Independent Researcher Infrastructure Support (NIRIS) Awards,  2016 - 2017,  $10,000.
  • Using a Functional Protein Array to Identify Autoantibody Biomarkers with Diagnostic Potential for Melanoma,  National Health and Medical Research Council,  Development Grants,  2014 - 2017,  $778,368.
  • Western Australia Single-Cell Isolation and Genomics Preparation Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2017,  $430,000.
  • Circulating Melanoma Cells as Predictive Biomarkers of Treatment Response and Disease Status,  Cancer Council of WA Inc,  Grant,  2015 - 2017,  $111,519.
  • Gene expression profiling of circulating tumour cells (CTCs) isolated from metastatic melanoma patients using a microfluidic chip,  Cancer Council of WA Inc,  Grant - Early Career Investigator,  2016 - 2017,  $35,000.
  • NHMRC Fellowship 'near-miss' funding,  Department of Health WA,  Near Miss Merit Awards,  2016 - 2017,  $50,000.
  • Transcriptomic profiling of Circulating Tumour Cells (CTCs) isolated from metastatic melanoma patients,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $10,000.
  • A Single-Molecule Super-Resolution Microscopy Facility in Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2016,  $2,094,000.
  • Mass Cytometry: A breakthrough in multidimensional systems biology,  Australian Research Council,  Grant - Linkage (Infrastructure),  2015 - 2016,  $1,081,489.
  • Circulating Tumour Cells (CTCs) as a diagnostic tool to monitor disease progression in melanoma patients,  Edith Cowan University,  ECU Industry Collaboration Grant - 2015 (Round 1),  2015 - 2016,  $137,227.
  • Melanoma Mutation Profiling For Personalised Treatment,  National Health and Medical Research Council,  Project Grants,  2013 - 2016,  $765,359.
  • Detection of Vemurafenib Resistance in Circulating Tumour Cells for Personalised Treatment of Melanoma,  Harry Perkins Institute of Medical Research,  Scott Kirkbride Melanoma Research Centre - Discovery Research Priming Grant,  2013 - 2014,  $68,182.
  • Genetic Analysis of Melanoma Cells in Blood For Personalised Treatment Management,  Edith Cowan University,  ECU Early Career Researcher Grant - 2013,  2013 - 2014,  $24,083.
  • Expanding Capacity and Capability in Western Australian Flow Cytometry for Earth, Oceans, Environmental and Biomedical Science: State-of-the-Art Four Laser and 12 Colour Analysis,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012 - 2013,  $598,000.
  • Detection of stem cell markers expression in circulating melanoma cells using multiparameter flow cytometry as a prognosis tool,  Edith Cowan University,  ECU Early Career Researcher Grant - 2012 (Round 1),  2012 - 2013,  $19,480.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.

Recent Publications (within the last five years)

Book Chapters

  • Freeman, J., Gray, E., Ziman, M., (2015), Circulating Tumor Cells as Biomarkers in Cancer. Biomarkers in Cancer, 31-51, London, UK, Springer, DOI: 10.1007/978-94-007-7681-4_21.

Journal Articles

  • Aya-Bonilla, C., Marsavela, G., Freeman, J., Lomma, C., Frank, M., Khattak, M., Tarek, M., Millward, M., Warkiani, M., Gray, E., Ziman, M., (2017), Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device. Oncotarget, 8(40), 67355-67368, New York, USA, Impact Journals LLC.
  • Calapre, L., Warburton, L., Millward, M., Ziman, M., Gray, E., (2017), Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma. Cancer Letters, 404(28 Sept, 2017), 62-69, Ireland, Elsevier, DOI: 10.1016/j.canlet.2017.06.030.
  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Descargues, P., Ziman, M., (2017), SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes. BMC Dermatology, 17(June 2017), Article No. 8, London, United Kingdom, BioMed Central, DOI: 10.1186/s12895-017-0060-y.
  • McEvoy, A., Calapre, L., Pereira, M., Giardina, T., Robinson, C., Khattak, M., Meniawy, T., Pritchard, A., Hayward, N., Amanuel, B., Millward, M., Ziman, M., Gray, E., (2017), Sensitive droplet digital PCR method for detection of TERT promoter mutations in cell free DNA from patients with metastatic melanoma. Oncotarget, In Press(In Press), 11p., United States, Impact Journals LLC.
  • Mufhandu, HT., Alexandre, KB., Gray, E., Morris, L., Khati, M., (2016), UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance. Biochemistry and Biophysics Reports, 7(1), 408-414, Amsterdam, Netherlands, Elsevier B.V., DOI: 10.1016/j.bbrep.2016.07.005.
  • Bradley, T., Trama, A., Tumba, N., Gray, E., Lu, X., Madani, N., Jahanbakhsh, F., Eaton, A., Xia, S., Parks, R., Lloyd, KE., Sutherland, LL., Scearce, RM., Bowman, CM., Barnett, SW., Abdool-Karim, SS., Boyd, SD., Melillo, BN., Smith III, AB., Sodroski, JG., Kepler, TB., Alam, SM., Gao, F., Bonsignori, M., Liao, H., Moody, MA., Montefiori, DC., Santra, S., Morris, L., Haynes, BF., (2016), Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. EBioMedicine, 12(October), 196-207, Elsevier B.V., DOI: 10.1016/j.ebiom.2016.08.045.
  • Zaenker, P., Gray, E., Ziman, M., (2016), Autoantibody Production in Cancer?The Humoral Immune Response toward Autologous Antigens in Cancer Patients. Autoimmunity Reviews, 15(5), 477-483, Elsevier, DOI: 10.1016/j.autrev.2016.01.017.
  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Hart, P., Descargues, P., Ziman, M., (2016), Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo. BMC Dermatology, 16(1), Article no. 6, London, UK, BioMed Central Ltd., DOI: 10.1186/s12895-016-0043-4.
  • Bandawe, G., Moore, P., Werner, L., Gray, E., Sheward, D., Madiga, M., Nofemela, A., Thebus, R., Marais, J., Maboko, L., Karim, S., Hoelscher, M., Morris, L., Williamson, C., (2015), Differences in HIV type 1 neutralization breadth in 2 geographically distinct cohorts in Africa. Journal of Infectious Diseases, 211(9), 1461-1466, Oxford University Press, DOI: 10.1093/infdis/jiu633.
  • Reid, A., Freeman, J., Millward, M., Ziman, M., Gray, E., (2015), Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR. Clinical Biochemistry, 48(15), 999-1002, Philadelphia, USA, Elsevier, DOI: 10.1016/j.clinbiochem.2014.12.007.
  • Gray, E., Reid, A., Bowyer, S., Calapre, L., Siew, K., Pearce, R., Cowell, L., Frank, M., Millward, M., Ziman, M., (2015), Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment. Journal of Investigative Dermatology, 135(8), 2040-2048, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/jid.2015.127.
  • Moody, A., Gao, F., Gurley, T., Amos, J., Kumar, A., Hora, B., Marshall, D., Whitesides, J., Xia, S., Parks, R., Lloyd, K., Hwang, K., Lu, X., Bonsignori, M., Finzi, A., Vandergrift, N., Alam, M., Ferrari, G., Shen, X., Tomaras, G., Kamanga, G., Cohen, M., Sam, N., Kapiga, S., Gray, E., Tumba, N., Morris, L., Zolla-Pazner, S., Gorny, M., Mascola, J., Hahn, B., Shaw, G., Sodroski, J., Liao, H., Montefiori, D., Hraber, P., Korber, B., Haynes, B., (2015), Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host and Microbe, 18(3), 354-362, Cell Press, DOI: 10.1016/j.chom.2015.08.006.
  • Gray, E., Rizos, H., Reid, A., Boyd, S., Pereira, M., Lo, J., Tembe, V., Freeman, J., Lee, J., Scolyer, R., Siew, K., Lomma, C., Cooper, A., Khattak, M., Meniawy, T., Long, G., Carlino, M., Millward, M., Ziman, M., (2015), Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget, 6(39), 42008-42018, New York, USA, Impact Journals LLC, DOI: 10.18632/oncotarget.5788.
  • Richardson, S., Gray, E., Mkhize, N., Sheward, D., Lambson, B., Wibmer, CK., Masson, L., Werner, L., Garrett, N., Passmore, J., Abdool Karim, Q., Abdool Karim, S., Williamson, C., Moore, P., Morris, L., (2015), South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on a?4?7 for replication. Retrovirology , 12(54), Article Number 54, DOI: 10.1186/s12977-015-0183-3.
  • Klinac, D., Gray, E., Freeman, J., Reid, A., Bowyer, S., Millward, M., Ziman, M., (2014), Monitoring changes in circulating tumour cells as a prognostic indicator of overall survival and treatment response in patients with metastatic melanoma. BMC Cancer, 14(1), Article number 423, United Kingdom, BioMed Central Ltd, DOI: 10.1186/1471-2407-14-423.
  • Alexandre, K., Moore, P., Nonyane, M., Gray, E., Ranchobe, N., Chakauya, E., McMahon, J., O'Keefe, B., Chikwamba, R., Morris, L., (2013), Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN. Virology, 446(1-2), 66-76, Elsevier, DOI: 10.1016/j.virol.2013.07.019.
  • Moore, PL., Sheward, D., Nonyane, M., Ranchobe, N., Hermanus, T., Gray, E., Karim, SS., Williamson, C., Morris, L., (2013), Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies. Journal of Virology, 87(9), 4882-4894, United States, American Society for Microbiology, DOI: 10.1128/JVI.03424-12.
  • Lacerda, M., Moore, P., Ngandu, N., Seaman, M., Gray, E., Murrell, B., Krishnamoorthy, M., Nonyane, M., Madiga, M., Wibmer, C., Sheward, D., Bailer, R., Gao, H., Greene, K., Karim, S., Mascola, J., Korber, B., Montefiori, D., Morris, L., Williamson, C., Seoighe, C., (2013), Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models. Virology Journal, 10(Article no. 347), 18 p., London, United Kingdom, BioMed Central, DOI: 10.1186/1743-422X-10-347.
  • Wibmer, C., Bhiman, J., Gray, E., Tumba, N., Abdool Karim, SS., Williamson, C., Morris, L., Moore, P., (2013), Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes. PLoS Pathogens, 9(10), 16p., United States, Public Library of Science, DOI: 10.1371/journal.ppat.1003738.
  • Calapre, L., Gray, E., Ziman, M., (2013), Heat stress: a risk factor for skin carcinogenesis. Cancer Letters, 337(1), 35-40, Ireland, Elsevier Ireland Ltd.
  • Klinac, D., Gray, E., Milward, M., Ziman, M., (2013), Advances in personalized targeted treatment of metastatic melanoma and non-invasive tumor monitoring. Frontiers in Oncology, 3(March 2013), Article 00054, DOI: 10.3389/fonc.2013.00054.

Conference Publications

  • Maurya, D., Fooladvand, M., Gray, E., Ziman, M., Alameh, K., (2015), Lab-on-chip platform for circulating tumor cells isolation. Micro+Nano Materials, Devices, and Systems, 9668(6-9 Dec, 2015), 9668-34, Sydney, Australia, SPIE.

Research Student Supervision

Principal Supervisor

  • Master of Science (Human Biology),  Genetic Markers In Circulating Tumour Cells As A Measure Of The Metastatic Propensity Of Uveal Melanoma

Associate Supervisor

  • Doctor of Philosophy,  Heat Stress: A Risk Factor For Skin Carcinogenesis
  • Master of Science (Human Biology),  Optimisation Of The Isolation And Identification Of Circulating Melanoma Cells
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