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Centre for Precision Health Seminar Series - From Cell State to Clinical Risk: The daHep Story

Tuesday, 09 June 2026

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The Centre for Precision Health welcomes Dr Rodrigo Carlessi to the CPH Seminar Series. Dr Carlessi leads the Genomics Group in the Liver Disease and Regeneration Laboratory at the Curtin Medical Research Institute.

His research integrates genomics, transcriptomics, and DNA methylation profiling to investigate mechanisms, biomarkers and therapeutic targets in liver disease and cancer. His work led to the discovery of disease-associated hepatocytes (daHeps), a pre-malignant hepatocyte population that precedes liver cancer, first characterised in Cell Genomics (2023) and subsequently validated through mechanistic studies in Science Advances (2023), Nature (2025) and human outcome prediction in Gut (2026). This body of work established that daHeps predict survival and hepatic decompensation independently of fibrosis staging, representing a paradigm shift in liver cancer risk prediction. His work aims to transform liver cancer surveillance by developing non-invasive methods to estimate risk and track disease progression through circulating cell-free DNA profiling.

Date: Wednesday 24 June 2026

Time: 11.00am - 12.00pm (WST)

Venue: ECU Joondalup, Building 19, Level 1 (Room 19.143)

If not on campus, you may join online via Teams:

https://teams.microsoft.com/meet/47985564924144?p=SrwrjlR8kdg6Mer9L9

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