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    Désirée Sexauer

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A Multiomic Approach for the Diagnosis of Melanoma Brain Metastases

Student name:

Désirée Sexauer (PhD candidate)

Supervisors:

  1. Dr Pauline Zaenker
  2. Dr Aaron Beasley
  3. Professor Elin Gray

Summary of thesis:

Brain metastases develop in ~70% of advanced stage melanoma patients and are associated with a dismal prognosis. As brain scans are not conducted routinely and expose the patient to radiation, most asymptomatic patients are identified at later stages and present with numerous or enlarged metastases that may already be accompanied by debilitating neurological symptoms and neurocognitive impairment. This leads to a decrease in quality of life and survival, highlighting the need for the identification of diagnostic biomarkers. This project aims to identify an accurate diagnostic liquid biopsy signature for melanoma brain metastases by implementing a novel multiomic approach.

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