Top of page

Student/Staff Portal
Global Site Navigation

Centre for Precision Health - ECU Strategic Research Centre

Local Section Navigation
You are here: Main Content
  • Photo of a PhD student

    Jiangyue Yao

Related Contents

Developing humanized bi-specific antibodies through BCR mapping for Sarcoma immunotherapy

Student name:

Jiangyue Yao (PhD candidate)

Supervisors:

  1. Professor Wei Wang
  2. Dr Lois Balmer
  3. Dr Ivan Li
  4. Dr Manshu Song
  5. Dr Rachel Alexander

Summary of thesis:

lmmunotherapy has shown potential, but monoclonal antibodies against a single target are often insufficient. Developing bispecific antibodies targeting two different epitopes of cancer/immune cells has demonstrated promise. This study aims to develop high-specific parental antibodies targeting B7-H3 and PD-1  by LIBRA-seq technology, and to develop bi-specific lgG antibody by genetic engineering. The eventually developed bispecific antibody will specifically recognize sarcoma cells (through B7-H3) and exert ADCC- mediated killing to B7-H3 positive sarcoma, and block both PD-1  and B7-H3 pathways to activate T cell-mediated cancer immunotherapy.

Skip to top of page