Top of page

Student/Staff Portal
Global Site Navigation

Centre for Precision Health - ECU Strategic Research Centre

Local Section Navigation
You are here: Main Content

Related Contents

    • Sanjeev Kumar Adhikari
      https://www.ecu.edu.au/__data/assets/image/0008/938321/Sanjeev_Picture4web.jpg
    • Photo of Sanjeev Kumar Adhikari

      Sanjeev Kumar Adhikari

Investigating the mechanism of release of circulating tumour DNA by melanoma cells

Student name:

Sanjeev Kumar Adhikari (PhD candidate)

Supervisors:

1. Professor Elin Gray
2. Dr Aaron Beasley
3. Professor Fiona PIxley (UWA)

Summary of thesis:

Circulating tumour DNA (ctDNA) are shed from a tumour into the bloodstream. CtDNA as a potential biomarker has enhanced treatment response and monitoring of melanomas. However, there are instances when ctDNA levels are not concordant with tumour burden and fail to provide prognostic information. So, this project aims to assess cell intrinsic and extrinsic factors that may affect ctDNA release utilising BRAF inhibitor-resistant and matched drug-naïve cell lines, in in-vitro and in-vivo experiments. We will evaluate the difference in ctDNA to get insights into the mechanisms of ctDNA release from melanomas.

Skip to top of page