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    Qi Yang

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Urinary and hematic ctDNA profiling for predicting Non-Muscle-Invasive Bladder Cancer (NMIBC) progression and recurrence

Student name: 

Qi Yang (PhD candidate)

Supervisors:

  1. Professor Elin Gray
  2. Dr Aaron Beasley
  3. Professor Wu Song

Summary of thesis:

Firstly, the recurrence rate of NMIBC is high. In previous years, tumor biopsy was broadly applied in tumor progression and recurrence, but there are some limitations of it eg. low sensitivity and specificity. Secondly, the fluid biopsy is a non-invasive, real-time, and molecular landscape of examination methods, some papers have indicated that hotspot mutation and methylation are promising tools in the utility of ctDNA in NMIBC, but there are scarce studies that combine these two tools. Therefore, this study combines these two tools in the fluid biopsy investigation of ctDNA to predict NMIBC progression and recurrence.

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