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Construction of causal regulatory network of Type 2 Diabetes Mellitus based on multi-omics integration

Student name:

Huiying Pan (PhD candidate)

Supervisors:

  1. Professor Wei Wang
  2. Dr Manshu Song
  3. Dr Eben Afrifa-Yamoah
  4. Professor Xiuhua Guo

Summary of thesis:

Type 2 diabetes mellitus (T2DM) is a prevalent chronic noncommunicable disease influenced by both genetic and environmental factors; yet its specific pathogenesis remains unclear. The multifactorial and progressive nature of T2DM suggests that a single omics approach may not adequately elucidate its development. Therefore, this current research aims to integrate genomics, glycomics and metabolomic data, along with physical examination and questionnaire information, to construct a comprehensive multi-omics integrated regulatory network. The resulting network is expected to provide a basis for early prevention and effective management of T2DM.

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