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Roles of monocytes and macrophages in the development of Type 2 diabetes and cardiovascular diseases

Student Name

Dan Wu

Supervisors

Professor Wei Wang and Dr Lois Balmer

Summary of thesis

Monocytes and their differentiated macrophages have been proposed to be engaged greatly in the pathogenesis of Type2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR), has been suggested to be a novel chronic inflammatory marker and potentially a predictor for incident T2DM or CVDs. The alterations in the inflammatory pattern within macrophages and serum beta-hydroxybutyrate (BHB) level were notable after SGLT2i treatment. My research will offer opportunities for discovering new markers for early prediction of developing T2DM and CVDs and provide insights for further exploring the molecular pathways of lipid-metabolism and inflammation regulation involving monocytes and macrophages.

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