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Exploring the Impact of Uterine Fibroids on Hypertension through Hypoxia-Inducible Factor-1 alpha-Medicated Regulation of Endothelin-1 and Soluble Fms-like Tyrosine Kinase 1 in Hypoxic Leiomyoma Smooth Muscle Cells

Student name:

Caipan Gong (PhD candidate)

Supervisors:

  1. Professor Wei Wang
  2. Dr Lois Balmer
  3. Dr Xingang Li
  4. Dr Rachel Alexander
  5. Professor Yequn Chen (Shantou University, China)

Summary of thesis:

Hypertension is responsible for more than 20% of female deaths, and uterine fibroids (UFs) may be a risk factor for its development. The mechanism of development of hypertension associated with UFs remains unclear. Therefore, this study aims to investigate the association between UFs and HTN, and the potential mechanism of development of HTN associated with UFs.

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