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Profiling of Oxidative Stress, Angiogenic Growth Mediators, and Metabolic Measures for Early Risk Stratification of Preeclampsia: A Longitudinal Nested-Case Control Study

Student name:

Dong Lin (PhD candidate)

Supervisors:

  1. Professor Wei Wang
  2. Dr Lois Balmer
  3. Dr Enoch Anto (Kwame Nkurmah University of Science and Technology,  Ghana)

Summary of thesis:

Preeclampsia (PE), a severe hypertensive disorder of pregnancy, is associated with the impairment of endothelial function. However, the development of effective therapies and appropriate diagnosis has been impeded by the unclear pathogenesis of PE. Adropin is a novel endothelial protective cytokine and may contribute to preventing PE by protecting endothelial function. The present project will investigate the longitudinal changes in serum adropin levels and its associations with the development of PE in a prospective cohort study.

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