Top of page
Global Site Navigation

Centre of Excellence for Alzheimer's Disease Research and Care

Local Section Navigation
You are here: Main Content

Professor Ralph Martins AO

Chair in Aging & Alzheimers Disease

Staff Member Details
Telephone: +61 8 6304 5456
Facsimile: +61 8 6304 5851
Email: r.martins@ecu.edu.au
Campus: Joondalup  
Room: JO17.314  

Ralph is the Foundation Chair in Aging and Alzheimer's Disease within the School of Medical and Health Sciences.

Background

Professor Ralph Martins, Foundation Chair in Aging and Alzheimer’s Disease at Edith Cowan University, was appointed the Director of the Centre.  Ralph Martins graduated from University of Western Australia with a PhD in 1986. In 1987 he won a scholarship to Heidelberg University to work with Konrad Beyreuther. His collaborative seminal research involved isolating and characterising beta-amyloid and its precursor, the amyloid precursor protein (APP), which are now recognized as central to the pathogenesis of Alzheimer's disease.

He was the first to propose and demonstrate that the Alzheimer brain was under oxidative stress, which is now widely recognized by the Alzheimer research community. In 1989 he joined Professor Masters at Melbourne University where he was the first to isolate and characterize the molecular components of the neuropathological hallmarks of Alzheimer’s disease. This led to an international patent and formation of a spin-off company, Alzhyme Pty Ltd. In 2001 he won a Media Fellowship with the ABC and was the first Media Fellow to have his work on the Science Show. In 2002 he won a Biotechnology Innovation Fund grant, which was matched by commercial funding. He established the Sir James McCusker Alzheimer’s Research Unit at Hollywood Hospital, whose research is directed at the cause(s), and development of diagnostics and treatments. He received the UWA "Excellence in Teaching Award - Post Graduate Research" for 2002 and in 2003 was appointed Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease.

Edith Cowan University appointed him to the Inaugural Chair, Ageing and Alzheimer’s Disease in 2004. He has Adjunct Professorial positions and close ties with clinical academics with both the University of Western Australia and Thomas Jefferson University’s Farber Neurosciences Institute. He is instigator and director of the state government funded Centre of Excellence for Alzheimer’s Disease Research and Care composed of researchers from 4 universities, 3 hospitals and 2 healthcare providers.

  • 2004-2006: Professor – Inaugural Chair, Ageing and Alzheimer’s Disease, Edith Cowan University, Western Australia
  • 2004: Adjunct Professor School of Psychiatry & Clinical Neurosciences,University of Western Australia, Adjunct Professor, School of Biomedical Science
    Curtin University of Technology
  • 2001-2002: Associate Professor, Department of Psychiatry and Neurogenetics,University of Western Australia, Hollywood Private Hospital, Western Australia
  • 2001-2004: Professor on Staff, Research Centre and Community Services,Universitas Peila Harapan, Karawaci, Tangerang, Indonesia
  • 1998-2003: Adjunct Associate Professor, School of Biomedical Science,Curtin University
  • 1997-2001: Senior Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1997-1998:Adjunct Teaching Fellow, Curtin University, Western Australia
  • 1990-1997: Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1989: Senior Research Officer, Department of Pathology, University of Melbourne
  • 1984-1988: Research Scientist, Department of Pathology, University of Western Australia
  • 1983-1988: Permanent Part-time Clinical Biochemist, Department of Pathology, King Edward Memorial Hospital for Women
  • 1980-1984: Tutor of 2nd and 3rd year   medical students in Biochemistry at the University of Western Australia
  • 1979-1983: Demonstrator of 2nd year Biochemistry

Professional Memberships

  • 1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
  • 1982-1997: Australian Society for Medical Research
  • 1984-2002: Australian Neuroscience Society
  • 1984-1991: Australian Nutrition Foundation
  • 1991-2002: Surgical Research Society of Australasia
  • 1991-2004: Australian Association of Gerontology (WA)
  • 1992-2004: Alzheimer’s Association (WA)
  • 1996-2004: Society of Neuroscience (USA)
  • 2000-2004: The Australian Menopause Society
  • 2002-2004: Human Genetics Society of Australia
  • 2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)

Research Areas and Interests

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 1987.

Research Outputs

Journal Articles

  • Frost, N., Weinborn, M., Gignac, G., Rainey-Smith, S., Markovic, S., Gordon, N., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., Brown, B. (2021). A Randomized Controlled Trial of High-Intensity Exercise and Executive Functioning in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, 29(2), 129-140. https://doi.org/https://doi.org/10.1016/j.jagp.2020.06.015.
  • Doecke, J., Francois, C., Fowler, C., Stoops, E., Bourgeat, P., Rainey-Smith, S., Li, Q., Masters, C., Martins, R., Villemagne, V., Collins, S., Vanderstichele, H. (2021). Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods. Alzheimer's Research and Therapy, 13(1), Article 79. https://doi.org/10.1186/s13195-021-00812-9.
  • Chatterjee, P., Pedrini, S., Stoops, E., Goozee, K., Villemagne, V., Asih, P., Verberk, I., Dave, P., Taddei, K., Sohrabi, H., Zetterberg, H., Blennow, K., Teunissen, C., Vanderstichele, H., Martins, R. (2021). Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease. Translational Psychiatry, 11(2021), Article 27. https://doi.org/10.1038/s41398-020-01137-1.
  • Tan, S., Porter, T., Bucks, R., Weinborn, M., Milicic, L., Brown, A., Rainey-Smith, S., Taddei, K., Ames, D., Masters, C., Maruff, P., Savage, G., Rowe, C., Villemagne, V., Brown, B., Sohrabi, H., Laws, S., Martins, R. (2021). Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition. Hormones and Behaviour, 131(May), Article 104966. https://doi.org/10.1016/j.yhbeh.2021.104966.
  • Brown, B., Frost, N., Rainey-Smith, S., Doecke, J., Markovic, S., Gordon, N., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Erickson, K., Peiffer, J. (2021). High intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial. Alzheimer's Research and Therapy, 13(Feb), Article number 33. https://doi.org/10.1186/s13195-021-00774-y.
  • Fine, L., Loft, S., Bucks, R., Parker, D., Laws, M., Olaithe, M., Pushpanathan, M., Rainey-Smith, S., Sohrabi, H., Martins, R., Weinborn, M. (2021). Improving prospective memory performance in community-dwelling older adults: Goal management training and implementation intentions. Experimental Aging Research, epub ahead of print(Jan), 1-22. https://doi.org/10.1080/0361073X.2021.1876409.
  • Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D. (2021). Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer's Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment. Journal of the International Neuropsychological Society, 27(2), 146-157. https://doi.org/10.1017/S135561772000079X.
  • Van Der Kall, L., Truong, T., Burnham, S., Dore, V., Mulligan, R., Bozinovski, S., Lamb, F., Bourgeat, P., Fripp, J., Schultz, S., Lim, Y., Laws, S., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Maruff, P., Masters, C., Villemagne, V., Rowe, C. (2021). Association of β-amyloid level, clinical progression and longitudinal cognitive change in normal older individuals. Neurology, 96(5), e662 - e670. https://doi.org/https://doi.org/10.1212/WNL.0000000000011222.

Journal Articles

  • Tarawneh, H., Mulders, W., Sohrabi, H., Martins, R., Jayakody, D. (2020). Auditory electrophysiological assessments of Alzheimer’s disease and preclinical stages: protocol for a systematic review and meta-analysis. BMJ Open, 10(2020), e033308. https://doi.org/10.1136/bmjopen-2019-033308.
  • Bharadwaj, P., Martins, R. (2020). Autophagy modulates Aβ accumulation and formation of aggregates in yeast. Molecular and Cellular Neuroscience, 104(April 2020), Article 103466. https://doi.org/10.1016/j.mcn.2020.103466.
  • Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R. (2020). Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315. https://doi.org/10.3233/JAD-191304.
  • Barthelemy, N., Li, Y., Joseph-Marthurin, N., Gordon, B., Hassenstab, J., Benzinger, T., Buckles, V., Fagan, A., Perrin, R., Goate, A., Morris, J., Karch, C., Xiong, C., Allegri, R., Mendez, P., Berman, S., Ikeuchi, T., Mori, H., Shimada, H., Shoji, M., Suzuki, K., Noble, J., Farlow, M., Chhatwal, J., Graff-Radford, N., Salloway, S., Schofield, P., Masters, C., Martins, R., O'Connor, A., Fox, N., Levin, J., Jucker, M., Gabelle, A., Lehmann, S., Sato, C., Bateman, R., McDade, E. (2020). A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine, 26(3), 398-407. https://doi.org/10.1038/s41591-020-0781-z.
  • Shen, K., Welton, T., Lyon, M., McCorkindale, A., Sutherland, G., Burnham, S., Fripp, J., Martins, R., Grieve, S. (2020). Structural core of the executive control network: A high angular resolution diffusion MRI study. Human Brain Mapping, 41(5), 1226-1236. https://doi.org/10.1002/hbm.24870.
  • Kivipelto, M., Mangialasche, F., Snyder, H., Allegri, R., Andrieu, S., Arai, H., Baker, L., Belleville, S., Brodaty, H., Brucki, S., Calandri, I., Caramelli, P., Chen, C., Chertkow, H., Chew, E., Choi, S., Chowdhary, N., Crivelli, L., De La Torre, R., Du, Y., Dua, T., Espeland, M., Feldman, H., Hartmanis, M., Hartmann, T., Heffernan, M., Henry, C., Hong, C., Håkansson, K., Iwatsubo, T., Jeong, J., Jimenez-Maggiora, G., Koo, E., Launer, L., Lehtisalo, J., Lopera, F., Martínez-Lage, P., Martins, R., Middleton, L., Molinuevo, J., Montero-Odasso, M., Moon, S., Morales-Pérez, K., Nitrini, R., Nygaard, H., Park, Y., Peltonen, M., Qiu, C., Quiroz, Y., Raman, R., Rao, N., Ravindranath, V., Rosenberg, A., Sakurai, T., Salinas, R., Scheltens, P., Sevlever, G., Soininen, H., Sosa, A., Suemoto, C., Tainta-Cuezva, M., Velilla, L., Wang, Y., Whitmer, R., Xu, X., Bain, L., Solomon, A., Ngandu, T., Carrillo, M. (2020). World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimer's and Dementia, 16(7), 1078-1094. https://doi.org/10.1002/alz.12123.
  • Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
  • Parker, D., Bucks, R., Rainey-Smith, S., Hodgson, E., Fine, L., Sohrabi, H., Martins, R., Weinborn, M. (2020). Sleep Mediates Age-Related Executive Function for Older Adults with Limited Cognitive Reserve. Journal of the International Neuropsychological Society, 2020(Article in press), 11p.. https://doi.org/10.1017/S1355617720001186.
  • Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.
  • Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P., Doecke, J., Ames, D., Laws, S., Fowler, C., Rainey-Smith, S., Martins, R., Maruff, P., Villemagne, V., Masters, C., Rowe, C., Fripp, J., Salvado, O. (2020). Comorbidity of Cerebrovascular and Alzheimer’s Disease in Aging. Journal of Alzheimer's Disease, 78(1), 321-334. https://doi.org/10.3233/JAD-200419.
  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2020). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 2020(Article in press), 14p.. https://doi.org/10.1111/jnc.15128.
  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Martins, R., Peiffer, J. (2020). An intense, but ecologically valid, resistance exercise session does not alter growth factors associated with cognitive health. Journal of Aging and Physical Activity, 28(4), 605-612. https://doi.org/10.1123/japa.2019-0100.
  • Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R. (2020). Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733. https://doi.org/10.3233/JAD-191033.
  • Krishnan, S., Shrestha, Y., Jayatunga, P., Rea, S., Martins, R., Bharadwaj, P. (2020). Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease. International Journal of Molecular Sciences, 21(18), Article number 6739. https://doi.org/10.3390/ijms21186739.
  • Siddiqui, M., Francois, M., Rainey-Smith, S., Martins, R., Masters, C., Ames, D., Rowe, C., Macaulay, L., Fenech, M., Leifert, W. (2020). Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. Life, 10(8), Article number 141. https://doi.org/10.3390/life10080141.
  • Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(1), Article number 5698. https://doi.org/https://doi.org/10.1038/s41467-020-19473-7.
  • Kirby, S., Lyons-Wall, P., Martins, R., Rainey-Smith, S. (2020). Validation and Reliability of the Alzheimer’s Disease-Commonwealth Scientific and Industrial Research Organisation Food Frequency Questionnaire. Nutrients, 12(12), Article number 3605. https://doi.org/10.3390/nu12123605.
  • Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P. (2020). Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356. https://doi.org/10.1038/s41598-020-66602-9.
  • Lim, B., Fowler, C., Li, Q., Rowe, C., Dhiman, K., Gupta, V., Masters, C., Doecke, J., Martins, R., Collins, S., Diamandi, E. (2020). Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer’s disease. Neuroscience Letters, 731(13 July 2020), Article number 135078. https://doi.org/10.1016/j.neulet.2020.135078.
  • Pedrini, S., Chatterjee, P., Hone, E., Martins, R. (2020). High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease. Journal of Neurochemistry, 2020(Article in press), 1-35. https://doi.org/10.1111/jnc.15170.
  • Thota, R., Rosato, J., Burrows, T., Dias, C., Abbott, K., Martins, R., Garg, M. (2020). Docosahexaenoic acid-rich fish oil supplementation reduces kinase associated with insulin resistance in overweight and obese midlife adults. Nutrients, 12(6), Article 1612. https://doi.org/10.3390/nu12061612.
  • Jayakody, D., Tarawneh, H., Menegola, H., Yiannos, J., Friedland, P., Wilson, W., Martins, R., Sohrabi, H. (2020). Systematic review protocol for assessing central auditory functions of Alzheimer's disease and its preclinical stages. BMJ Open, 10(6), Article number e033342. https://doi.org/10.1136/bmjopen-2019-033342.
  • Lai, M., Sharman, M., Ames, D., Ellis, K., Cox, K., Hepworth, G., Desmond, P., Cyarto, E., Martins, R., Masters, C., Lautenschlager, N. (2020). Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration. Journal of Alzheimer's Disease, 74(1), 163-171. https://doi.org/10.3233/JAD-190953.
  • Yassi, N., Hilal, S., Xia, Y., Lim, YY., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P., Masters, C. (2020). Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease. Journal of Alzheimer's Disease, 73(3), 897-907. https://doi.org/10.3233/JAD-191028.
  • Bharadwaj, P., Martins, R. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-B Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease, 74(2), 441-448. https://doi.org/10.3233/JAD-190948.
  • Chatterjee, P., Fernando, M., Fernando, B., Dias, C., Shah, T., Silva, R., Williams, S., Pedrini, S., Hillebrandt, H., Goozee, K., Barin, E., Sohrabi, H., Garg, M., Cunnane, S., Martins, R. (2020). Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development, 186(March 2020), Article number 111209. https://doi.org/10.1016/j.mad.2020.111209.
  • Brini, S., Sohrabi, H., Hebert, J., Forrest, M., Laine, M., Hamalainen, H., Karrasch, M., Peiffer, J., Martins, R., Fairchild, T. (2020). Bilingualism Is Associated with a Delayed Onset of Dementia but Not with a Lower Risk of Developing it: a Systematic Review with Meta-Analyses. Neuropsychology Review, 30(March 2020), 24 p.. https://doi.org/10.1007/s11065-020-09426-8.
  • Lai, M., Ames, D., Cox, K., Ellis, K., Sharman, M., Hepworth, G., Desmond, P., Cyarto, E., Szoeke, C., Martins, R., Masters, C., Lautenschlager, N. (2020). Association between cognitive function and clustered cardiovascular risk of metabolic syndrome in older adults at risk of cognitive decline. Journal of Nutrition, Health and Aging, 24(3), 300-304. https://doi.org/10.1007/s12603-020-1333-4.
  • Aschenbrenner, A., James, B., McDade, E., Wang, G., Lim, YY., Benzinger, T., Cruchaga, C., Goate, A., Xiong, C., Perrin, R., Buckles, V., Allegri, R., Berman, S., Chhatwal, J., Fagan, A., Farlow, M., O'Connor, A., Ghetti, B., Graff-Radford, N., Goldman, J., Gräber, S., Karch, C., Lee, J., Levin, J., Martins, R., Masters, C., Mori, H., Noble, J., Salloway, S., Schofield, P., Morris, J., Bateman, R., Hassenstab, J. (2020). Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's and Dementia, 16(1), 219-228. https://doi.org/10.1002/alz.12010.
  • Dhiman, K., Gupta, V., Villemagne, V., Eratne, D., Graham, P., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Bush, A., Rowe, C., Masters, C., Ames, D., Hone, E., Blennow, K., Zetterberg, H., Martins, R. (2020). Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer’s disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 12(1), Article number e12005. https://doi.org/10.1002/dad2.12005.
  • Bharadwaj, P., Martins, R. (2020). A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast. Neural Regeneration Research, 15(10), 1931-1936. https://doi.org/10.4103/1673-5374.280318.
  • Doecke, J., Ward, L., Burnham, S., Villemagne, V., Li, Q., Collins, S., Fowler, C., Manuilova, E., Widmann, M., Rainey-Smith, S., Martins, R., Masters, C. (2020). Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid- PET imaging. Alzheimer's Research and Therapy, 12(March 2020), Article number 36. https://doi.org/10.1186/s13195-020-00595-5.
  • Thota, R., Rosato, J., Dias, C., Burrows, T., Martins, R., Garg, M. (2020). Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease. Nutrients, 12(4), Article number 1032. https://doi.org/10.3390/nu12041032.
  • Ashraf, A., Ashton, N., Chatterjee, P., Goozee, K., Shen, K., Fripp, J., Ames, D., Rowe, C., Masters, C., Villemagne, V., Hye, A., Martins, R., So, P. (2020). Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology. Alzheimer's Research and Therapy, 12(June 2020), Article number 72. https://doi.org/10.1186/s13195-020-00634-1.
  • Sohrabi, H., Goozee, K., Weinborn, M., Shen, K., Brown, B., Rainey-Smith, S., Salvado, O., Taddei, K., Bucks, R., Maruff, P., Laws, S., Lenzo, N., Laws, M., Deyoung, C., Speelman, C., Laske, C., Ames, D., Savage, G., Martins, R. (2020). Personality factors and cerebral glucose metabolism in community‑dwelling older adults. Brain Structure and Function, 225(5), 1511–1522. https://doi.org/10.1007/s00429-020-02071-0.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.
  • Arnold, M., Nho, K., Kueder-Paisley, A., Massaro, T., Huynh, K., Brauner, B., Mahmoudian Dehkordi, S., Louie, G., Moseley, M., Thompson, JW., St John-Williams, L., Tenenbaum, J., Blach, C., Chang, R., Brinton, R., Baillie, R., Han, X., Trojanowski, J., Shaw, L., Martins, R., Weiner, M., Trushina, E., Toledo, J., Meikle, P., Bennett, D., Krumsiek, J., Murali Doraiswamy, P., Saykin, A., Kaddurah-Daok, R., Kastenmuller, G. (2020). Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome. Nature Communications, 11(1), Article number 1148. https://doi.org/10.1038/s41467-020-14959-w.
  • Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Shen, K., Asih, P., Dave, P., Pedrini, S., Ashton, N., Hye, A., Taddei, K., Lovejoy, D., Zetterberg, H., Blennow, K., Martins, R. (2020). Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(2020), 291-301. https://doi.org/10.3233/JAD-200162.
  • Jayakody, D., Menegola, H., Yiannos, J., Goodman-Simpson, J., Friedland, P., Taddei, K., Laws, S., Weinborn, M., Martins, R., Sohrabi, H. (2020). The peripheral hearing and Central Auditory Processing skills of individuals with subjective memory complaints. Frontiers in Neuroscience, 14(21 August 2020), Article 888. https://doi.org/10.3389/fnins.2020.00888.

Journal Articles

  • Frost, N., Weinborn, M., Gignac, G., Markovic, S., Rainey-Smith, S., Sohrabi, H., Martins, R., Peiffer, J., Brown, B. (2019). Higher cardiorespiratory fitness is associated with better verbal generativity in community-dwelling older adults. Journal of Aging and Physical Activity, 27(5), 703-710. https://doi.org/10.1123/japa.2018-0382.
  • Dube, U., Del-Aguila, J., Li, Z., Budde, J., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M., Farias, F., Norton, J., Gentsch, J., Wang, F., Allegri, R., Amtashar, F., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Buck, J., Buckles, V., Chea, S., Chrem, P., Chui, H., Cinco, J., Clifford, J., D’mello, M., Donahue, T., Douglas, J., Edigo, N., Erekin-Taner, N., Fagan, A., Farlow, M., Farrar, A., Feldman, H., Flynn, G., Fox, N., Franklin, E., Fujii, H., Gant, C., Kirby, S., Ghetti, B., Goate, A., Goldman, J., Gordon, B., Gray, J., Gurney, J., Hassenstab, J., Hirohara, M., Holtzman, D., Hornbeck, R., Dibari, S., Ikeuchi, T., Ikonomovic, S., Jerome, G., Jucker, M., Kasuga, K., Kawarabayashi, T., Klunk, W., Koeppe, R., Kuder-Buletta, E., Laske, C., Levin, J., Marcus, D., Martins, R., Mason, N., Maue-Dreyfus, D., McDade, E., Montoya, L., Mori, H., Nagamatsu, A., Neimeyer, K., Noble, J., Perrin, R., Raichle, M., Ringman, J., Roh, J., Schofield, P., Shimada, H., Shiroto, T., Shoji, M., Sigurdson, W., Sohrabi, H., Sparks, P., Suzuki, K., Swisher, L., Taddei, K., Wang, J., Wang, P., Weiner, M., Wolfsberger, M., Xiong, C., Xu, X., Salloway, S., Masters, C., Lee, J., Graff-Radford, N., Chhatwal, J., Bateman, R., Morris, J., Karch, C., Harari, O., Cruchaga, C. (2019). An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nature Neuroscience, 22(11), 1903-1912. https://doi.org/10.1038/s41593-019-0501-5.
  • Sohrabi, H., Weinborn, M., Laske, C., Bates, K., Christensen, D., Taddei, K., Rainey-Smith, S., Brown, B., Kirby, S., Laws, S., Martins, G., Burnham, S., Bucks, R., Reisberg, B., Lautenschlager, N., Foster, J., Martins, R. (2019). Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, 31(4), 513-525. https://doi.org/10.1017/S1041610218001072.
  • Tan, S., Sohrabi, H., Weinborn, M., Tegg, M., Bucks, R., Taddei, K., Carruthers, M., Martins, R. (2019). Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials. American Journal of Geriatric Psychiatry, 27(11), 1232-1246. https://doi.org/10.1016/j.jagp.2019.05.008.
  • Schultz, A., Kloet, R., Sohrabi, H., Van Der Weerd, L., Van Rooden, S., Wermer, M., Moursel, L., Yaqub, M., Van Berckel, B., Chatterjee, P., Kirby, S., Taddei, K., Fagan, A., Benzinger, T., Morris, J., Sperling, R., Johnson, K., Bateman, R., Gurol, ME., Van Buchem, M., Martins, R., Chhatwal, J., Greenberg, S. (2019). Amyloid Imaging of Dutch-Type Hereditary Cerebral Amyloid Angiopathy Carriers. Annals of Neurology, 86(4), 616-625. https://doi.org/10.1002/ana.25560.
  • Babulal, G., Quiroz, Y., Albensi, B., Arenaza-Urquijo, E., Astell, A., Babiloni, C., Bahar-Fuchs, A., Bell, J., Bowman, G., Brickman, A., Chetelat, G., Ciro, C., Cohen, A., Dilworth-Anderson, P., Dodge, H., Dreux, S., Edland, S., Esbensen, A., Evered, L., Ewers, M., Fargo, K., Fortea, J., Gonzalez, H., Gustafson, D., Head, E., Hendrix, J., Hofer, S., Johnson, L., Jutten, R., Kilborn, K., Lanctot, K., Manly, J., Martins, R., Mielke, M., Morris, M., Murray, M., Oh, E., Parra, M., Rissman, R., Roe, C., Santos, O., Scarmeas, N., Schneider, L., Schupf, N., Sikkes, S., Snyder, H., Sohrabi, H., Stern, Y., Strydom, A., Tang, Y., Terrera, G., Teunissen, C., Van Lent, DM., Weinborn, M., Wesselman, L., Wilcock, D., Zetterberg, H., O’bryant, S. (2019). Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia, 15(2), 292-312. https://doi.org/10.1016/j.jalz.2018.09.009.
  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.
  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T. (2019). Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(2019), 740-750. https://doi.org/https://doi.org/10.1016/j.trci.2019.09.015.
  • Chatterjee, P., Elmi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Pedrini, S., Shen, K., Asih, P., Dave, P., Taddei, K., Vanderstichele, H., Zetterberg, H., Blennow, K., Martins, R. (2019). Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 71(3), 775-783. https://doi.org/10.3233/JAD-190533.
  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Laws, S., Martins, R., Peiffer, J. (2019). Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized‑controlled trial. European Journal of Applied Physiology, 119(10), 2167-2176. https://doi.org/10.1007/s00421-019-04202-w.
  • Nasef, N., Loveday, S., Golding, M., Martins, R., Shah, T., Clarke, M., Coad, J., Moughan, P., Garg, M., Singh, H. (2019). Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans. Food and Function, 10(8), 4584-4592. https://doi.org/10.1039/c9fo01063g.
  • Marston, K., Peiffer, J., Rainey-Smith, S., Gordon, N., Teo, S., Laws, S., Sohrabi, H., Martins, R., Brown, B. (2019). Resistance training enhances delayed memory in healthy middle-aged and older adults: A randomised controlled trial. Journal of Science and Medicine in Sport, 22(11), 1226-1231. https://doi.org/10.1016/j.jsams.2019.06.013.
  • Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., Bharadwaj, P. (2019). Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24(18), Article 3372. https://doi.org/10.3390/molecules24183372.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.
  • Sharman, M., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q., Wenk, M., Halliwell, B., Martins, R., Munch, G. (2019). Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?. Neurobiology of Disease, 124(April 2019), 505-519. https://doi.org/10.1016/j.nbd.2018.11.026.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A. (2019). A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220. https://doi.org/10.1126/sciadv.aau7220.
  • Burnham, S., Coloma, P., Li, Q., Collins, S., Savage, G., Laws, S., Doecke, J., Maruff, P., Martins, R., Ames, D., Rowe, C., Masters, C., Villemagne, V. (2019). Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer’s Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study. The Journal of Prevention of Alzheimer's Disease, 6(4), 248-255. https://doi.org/10.14283/jpad.2019.25.
  • Brown, B., Castalanelli, N., Rainey-Smith, S., Doecke, J., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Peiffer, J. (2019). Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. Behavioural Brain Research, 362(19 April 2019), 103-108. https://doi.org/10.1016/j.bbr.2019.01.013.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Moshfegh, A., Javadzadegan, A., Mohammadi, M., Ravipudi, L., Cheng, S., Martins, R. (2019). Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner. Computers in Biology and Medicine, 108(May 2019), 111-121. https://doi.org/10.1016/j.compbiomed.2019.03.008.
  • Tan, J., Iyer, K., Tang, A., Jamil, A., Martins, R., Sohrabi, H., Nitsche, M., Hinder, M., Fujiyama, H. (2019). Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review. NeuroImage, 185(15 January 2019), 490-512. https://doi.org/10.1016/j.neuroimage.2018.10.044.
  • Jacobs, K., Lim, C., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R., Brew, B., Guillemin, G., Lovejoy, D. (2019). Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-b and tau. Neurobiology of Aging, 80(August 2019), 11-20. https://doi.org/10.1016/j.neurobiolaging.2019.03.015.
  • Fine, L., Weinborn, M., Ng, A., Loft, S., Li, Y., Hodgson, E., Parker, D., Rainey-Smith, S., Sohrabi, H., Brown, B., Martins, R., Bucks, R. (2019). Sleep disruption explains age-related prospective memory deficits: implications for cognitive aging and intervention. Aging, Neuropsychology and Cognition: A Journal on Normal and Dysfunctional Development, 26(4), 621-636. https://doi.org/10.1080/13825585.2018.1513449.
  • Dhiman, K., Blennow, K., Zetterberg, H., Martins, R., Gupta, V. (2019). Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis. Cellular and Molecular Life Sciences, 76(10), 1833-1863. https://doi.org/10.1007/s00018-019-03040-5.
  • Tripathi, T., Kalita, P., Martins, R., Bharadwaj, P. (2019). Autophagy promotes memory function. ACS Chemical Neuroscience, 10(8), 3337-3339. https://doi.org/10.1021/acschemneuro.9b00317.
  • Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C., Jacobs, K., Ashton, N., Hye, A., Pedrini, S., Sohrabi, H., Shah, T., Asih, P., Dave, P., Shen, K., Taddei, K., Lovejoy, D., Guillemin, G., Blennow, K., Martins, R. (2019). Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease. Journal of Neuroinflammation, 16(2019), Article number 186. https://doi.org/10.1186/s12974-019-1567-4.

Journal Articles

  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.
  • Jayakody, D., Friedland, PL., Eikelboom, RH., Martins, R., Sohrabi, H. (2018). A novel study on association between untreated hearing loss and cognitive functions of older adults: Baseline non-verbal cognitive assessment results. Clinical Otolaryngology, 43(1), 182-191. https://doi.org/10.1111/coa.12937.
  • Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Fox, N., Levin, J., Danek, A., Voglein, J., Salloway, S., Xiong, C., Benzingers, T., Buckless, V., Masters, C., Sperling, R., Bateman, R., Morriss, J., Laske, C. (2018). Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's and Dementia, 14(11), 1427-1437. https://doi.org/10.1016/j.jalz.2018.06.3059.
  • Lan, J., Galindo, A., Doecke, J., Fowler, C., Martins, R., Rainey-Smith, S., Cominetti, O., Dayon, L. (2018). Systematic Evaluation of the Use of Human Plasma and Serum for Mass-Spectrometry-Based Shotgun Proteomics. Journal of Proteome Research, 17(4), 1426-1435. https://doi.org/10.1021/acs.jproteome.7b00788.
  • Khan, I., Krishnaswamy, S., Sabale, M., Groth, D., Wijaya, L., Morici, M., Berger, I., Schaffitzel, C., Fraser, P., Martins, R., Verdile, G. (2018). Efficient production of a mature and functional gamma secretase protease. Scientific Reports, 8(1), Article no. 12834. https://doi.org/10.1038/s41598-018-30788-w.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
  • Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R. (2018). Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651. https://doi.org/10.1016/j.bbamem.2018.03.015.
  • Jayakody, D., Friedland, P., Martins, R., Sohrabi, H. (2018). Impact of aging on the auditory system and related cognitive functions: A narrative review. Frontiers in Neuroscience, 12(MAR), Article no.125. https://doi.org/10.3389/fnins.2018.00125.
  • Chhatwal, J., Schultz, A., Johnson, K., Hedden, T., James, S., Benzinger, T., Jack, C., Ances, B., Ringman, J., Marcus, D., Ghetti, B., Farlow, M., Danek, A., Levin, J., Yakushev, I., Laske, C., Koeppe, R., Galasko, D., Xiong, C., Masters, C., Schofield, P., Kinnunen, K., Salloway, S., Martins, R., McDade, E., Cairns, N., Buckles, V., Morris, J., Bateman, R., Sperling, R. (2018). Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain: a journal of neurology, 141(5), 1486-1500. https://doi.org/10.1093/brain/awy053.
  • Lim, YY., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., Rowe, C., Masters, C., Maruff, P. (2018). Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA Neurology, 75(4), 488-494. https://doi.org/10.1001/jamaneurol.2017.4325.
  • Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Gozt, O., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R. (2018). Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study. Psychological Assessment, 30(10), 1308-1316. https://doi.org/10.1037/pas0000565.
  • Fernando, B., Rainey-Smith, S., Kirby, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R. (2018). Associations of dietary protein and fiber intake with brain and blood amyloid-β. Journal of Alzheimer's Disease, 61(4), 1589-1598. https://doi.org/10.3233/JAD-170742.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.
  • Chatterjee, P., Goozee, K., Lim, CK., James, I., Shen, K., Jacobs, K., Sohrabi, H., Shah, T., Asih, P., Dave, P., Manyan, C., Taddei, K., Lovejoy, D., Chung, R., Guillemin, G., Martins, R. (2018). Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-B load: A pilot study. Scientific Reports, 8(2018), Article no. 8008. https://doi.org/10.1038/s41598-018-25968-7.
  • Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V. (2018). Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's Disease, 63(4), 1299-1305. https://doi.org/10.3233/JAD-170998.
  • Nakamura, A., Kaneko, N., Villemagne, V., Kato, T., Doecke, J., Dore, V., Fowler, C., Li, Q., Martins, R., Rowe, C., Tomita, T., Matsuzaki, K., Ishii, K., Ishii, K., Arahata, Y., Iwamoto, S., Ito, K., Tanaka, K., Masters, C., Yanagisawa, K. (2018). High performance plasma amyloid-β biomarkers for Alzheimer’s disease. Nature, 554(7691), 249-254. https://doi.org/10.1038/nature25456.
  • McCabe, K., Woods, S., Weinborn, M., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Taddei, K., Martins, R. (2018). Personality characteristics are independently associated with prospective memory in the laboratory, and in daily Life, among older adults. Journal of Research in Personality, 76(Oct 2018), 32-37. https://doi.org/10.1016/j.jrp.2018.06.006.
  • Rainey-Smith, S., Gu, Y., Kirby, S., Doecke, J., Villemagne, V., Brown, B., Taddei, K., Laws, S., Sohrabi, H., Weinborn, M., Ames, D., Fowler, C., Macaulay, SL., Maruff, P., Masters, C., Salvado, O., Rowe, C., Scarmeas, N., Martins, R. (2018). Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(1), 238-244. https://doi.org/10.1038/s41398-018-0293-5.
  • Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Manyan, C., Taddei, K., Ayton, S., Garg, M., Kwok, J., Bush, A., Chung, R., Magnussen, J., Martins, R. (2018). Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load. Molecular Psychiatry, 23(8), 1807-1812. https://doi.org/10.1038/mp.2017.146.
  • Chatterjee, P., Goozee, K., Sohrabi, H., Shen, K., Shah, T., Asih, P., Dave, P., Man Yan, C., Taddei, K., Chung, R., Zetterberg, H., Blennow, K., Martins, R. (2018). Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants. Journal of Alzheimer's Disease, 63(2), 479-487. https://doi.org/10.3233/JAD-180025.
  • Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D. (2018). Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years. Alzheimer Disease and Associated Disorders, 32(3), 190-196. https://doi.org/10.1097/WAD.0000000000000252.
  • Doecke, J., Rembach, A., Villemagne, V., Varghesi, S., Rainey-Smith, S., Sarros, S., Evered, L., Fowler, C., Pertile, K., Rumble, R., Trounson, B., Taddei, K., Laws, S., Macaulay, SL., Bush, A., Ellis, K., Martins, R., Ames, D., Silbert, B., Vanderstichele, H., Masters, C., Darby, D., Li, Q., Collins, S. (2018). Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms. Journal of Alzheimer's Disease, 61(1), 169-183. https://doi.org/10.3233/JAD-170128.
  • Perin, S., Harrington, K., Lim, YY., Ellis, K., Ames, D., Pietrzak, R., Schembri, A., Rainey-Smith, S., Salvado, O., Laws, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2018). Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. Journal of Affective Disorders, 229(15 March 2018), 269-274. https://doi.org/10.1016/j.jad.2017.12.101.
  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Lee, S., Zimmerman, M., Narkhede, A., Nasrabady, S., Tosto, G., Meier, I., Benzinger, T., Marcus, D., Fagan, A., Fox, N., Cairns, N., Holtzmann, D., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, A., Masters, C., Ringman, J., Forster, S., Schofield, P., Sperling, R., Johnson, K., Chhatwal, J., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, J., Mayeux, R., Brickman, A. (2018). White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One, 13(5), Article number e0195838. https://doi.org/10.1371/journal.pone.0195838.
  • Brini, S., Sohrabi, H., Peiffer, J., Karrasch, M., Hamalainen, H., Martins, R., Fairchild, TJ. (2018). Physical activity in preventing Alzheimer's disease and cognitive decline: A narrative review. Sports Medicine, 48(1), 29-44. https://doi.org/10.1007/s40279-017-0787-y.
  • Kinnunen, KM., Cash, DM., Poole, T., Frost, C., Benzinger, TL., Ahsan, RL., Leung, KK., Cardoso, ML., Modat, M., Malone, IB., Morris, JC., Bateman, RJ., Marcus, DS., Goate, A., Salloway, SP., Correia, S., Sperling, RA., Chhatwal, J., Mayeux, R., Brickman, A., Martins, R., Farlow, M., Ghetti, B., Saykin, A., Jack, C., Schofield, P., McDade, E., Weiner, M., Ringman, J., Thompson, P., Masters, C., Rowe, C., Rossor, M., Ourselin, S., Fox, N. (2018). Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimer's and Dementia, 14(1), 43-53. https://doi.org/10.1016/j.jalz.2017.06.2268.
  • Holmes, SE., Esterlis, I., Mazure, CM., Lim, YY., Ames, D., Rainey-Smith, S., Fowler, C., Ellis, K., Martins, R., Salvado, O., Doré, V., Villemagne, VL., Rowe, CC., Laws, S., Masters, CL., Pietrzak, RH., Maruff, P. (2018). Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study. International Journal of Geriatric Psychiatry, 33(2), 405-413. https://doi.org/10.1002/gps.4761.
  • Elaskalani, O., Khan, I., Morici, M., Matthysen, C., Sabale, M., Martins, R., Verdile, G., Metharom, P. (2018). Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. Platelets (London), 29(4), 415-420. https://doi.org/10.1080/09537104.2017.1401057.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.

Book Chapters

  • Shah, T., Martins, R. (2017). Synergistic effects of combined physical activity and brain training on neurological functions. Physical activity and the aging brain: Effects of exercise on neurological function (175-184). Elsevier. https://doi.org/10.1016/B978-0-12-805094-1.00017-4.

Journal Articles

  • Frost, S., Bhuiyan, A., Offerman, D., Doecke, J., Macaulay, S., Sohrabi, H., Ames, D., Masters, C., Martins, R., Kanagasingam, Y. (2017). Modulation of retinal arteriolar central reflection by APOE genotype. Current Alzheimer Research, 14(9), 916-923. https://doi.org/10.2174/1567205014666170309115016.
  • Cerin, E., Rainey-Smith, S., Ames, D., Lautenschlager, N., Macaulay, S., Fowler, C., Robertson, J., Rowe, C., Maruff, P., Martins, R., Masters, C., Ellis, K. (2017). Associations of neighbourhood environment with brain imaging outcomes in the AIBL cohort. Alzheimer's and Dementia, 13(4), 388-398. https://doi.org/10.1016/j.jalz.2016.06.2364.
  • Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, JJ. (2017). Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia, 3(4), 562-570. https://doi.org/10.1016/j.trci.2017.09.003.
  • Brown, B., Sohrabi, H., Taddei, K., Kirby, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickson, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R. (2017). Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimer's and Dementia, 13(11), 1197-1206. https://doi.org/10.1016/j.jalz.2017.03.008.
  • Huynh, K., Martins, R., Meikle, P. (2017). Lipidomic profiles in Diabetes and Dementia. Journal of Alzheimer's Disease, 59(2), 433-444. https://doi.org/10.3233/JAD-161215.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057. https://doi.org/10.1038/s41598-017-14020-9.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R. (2017). Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72. https://doi.org/10.1016/j.dadm.2017.04.003.
  • Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK. (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685. https://doi.org/10.1038/s41598-017-12858-7.
  • Fernando, B., Somaratne, G., Goozee, K., Williams, S., Singh, H., Martins, R. (2017). Diabetes and Alzheimer's disease: Can tea phytochemicals play a role in prevention?. Journal of Alzheimer's Disease, 59(2), 481-501. https://doi.org/10.3233/JAD-161200.
  • Kirby, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R. (2017). Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201. https://doi.org/10.3233/JAD-161158.
  • Shah, T., Gupta, S., Chatterjee, P., Campbell, M., Martins, R. (2017). Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease. Molecular Psychiatry, 22(3), 353-363. https://doi.org/10.1038/mp.2016.251.
  • Jayakody, D., Friedland, P., Nel, E., Martins, R., Atlas, M., Sohrabi, H. (2017). Impact of cochlear implantation on cognitive function of older adults: Pilot test results. Otology and Neurotology: an international forum, 38(8), e289-e295. https://doi.org/10.1097/MAO.0000000000001502.
  • Mirmosayyeb, O., Tanhaei, A., Sohrabi, H., Martins, R., Tanhaei, M., Najafi, MA., Safaei, A., Meamar, R. (2017). Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease. International Journal of Preventive Medicine, 8(1), article no. 5. https://doi.org/10.4103/2008-7802.199640.
  • Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J. (2017). Intense resistance exercise increases peripheral brain-derived neurotrophic factor. Journal of Science and Medicine in Sport, 20(10), 899-903. https://doi.org/10.1016/j.jsams.2017.03.015.
  • Frost, S., Robinson, L., Rowe, C., Ames, D., Masters, C., Taddei, K., Rainey-Smith, S., Martins, R., Kanagasingam, Y. (2017). Evaluation of cholinergic deficiency in preclinical Alzheimer's disease using pupillometry. Journal of Ophthalmology, 2017(August 2017), Article no. 7935406. https://doi.org/10.1155/2017/7935406.
  • Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Martins, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Dore, V., Villemagne, V., Snyder, P., Masters, C., Maruff, P. (2017). Amyloid β–associated cognitive decline in the absence of clinical disease progression and systemic illness. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(1), 156-164. https://doi.org/10.1016/j.dadm.2017.05.006.
  • Lim, YY., Williamson, R., Laws, S., Villemagne, V., Bourgeat, P., Fowler, C., Rainey-Smith, S., Salvado, O., Martins, R., Rowe, C., Masters, C., Maruff, P. (2017). Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. Journal of Alzheimer's Disease, 58(4), 1293-1302. https://doi.org/10.3233/JAD-170072.
  • Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R. (2017). Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466. https://doi.org/10.3233/JAD-161259.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Dietzsch, J., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Graff-Radford, N., Levin, J., Galasko, D., Quaid, K., Salloway, S., Xiong, C., Benzinger, T., Buckles, V., Masters, C., Sperling, R., Bateman, R., Morris, J., Laske, C. (2017). Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease. Scientific Reports, 7(1), Article number 1225. https://doi.org/10.1038/s41598-017-01327-w.
  • Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., Martins, R. (2017). Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252. https://doi.org/10.1080/00207454.2016.1182527.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.
  • Golzan, SM., Goozee, K., Georgevsky, D., Avolio, A., Chatterjee, P., Shen, K., Gupta, V., Chung, R., Savage, G., Orr, C., Martins, R., Graham, S. (2017). Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease. Alzheimer's Research and Therapy, 9(1), Article number 13. https://doi.org/10.1186/s13195-017-0239-9.
  • Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Ball, B., Manyan, C., Taddei, K., Chung, R., Garg, M., Martins, R. (2017). Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease. Scientific Reports, 7(1), Article number 676. https://doi.org/10.1038/s41598-017-00751-2.
  • Peters, K., Davis, W., Taddei, K., Martins, R., Masters, C., Davis, T., Bruce, D. (2017). Plasma amyloid-β Peptides in Type 2 Diabetes: A matched case-control study. Journal of Alzheimer's Disease, 56(3), 1127-1133. https://doi.org/10.3233/JAD-161050.
  • O'Bryan, S., Mielke, M., Rissman, R., Lista, S., Vanderstichele, H., Zetterberg, H., Lewczuk, P., Posner, H., Hall, J., Johnson, L., Fong, Y., Luthman, J., Jeromin, A., Batrla-Utermann, R., Villarreal, A., Britton, G., Snyder, P., Henriksen, K., Grammas, P., Gupta, V., Martins, R., Hampel, H. (2017). Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimer's and Dementia, 13(1), 45-58. https://doi.org/10.1016/j.jalz.2016.09.014.
  • Harrington, K., Gould, E., Lim, Y., Ames, D., Pietrzak, R., Rembach, A., Rainey-Smith, S., Martins, R., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2017). Amyloid burden and incident depressive symptoms in cognitively normal older adults. International Journal of Geriatric Psychiatry, 32(4), 455-463. https://doi.org/10.1002/gps.4489.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.
  • Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R. (2017). Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80. https://doi.org/10.1007/s11065-016-9338-9.
  • Cardoso, B., Hare, D., Bush, A., Li, Q., Fowler, C., Masters, C., Martins, R., Ganio, K., Lothian, A., Mukherjee, S., Kapp, E., Roberts, B. (2017). Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Journal of Alzheimer's Disease, 57(1), 183-193. https://doi.org/10.3233/JAD-160622.

Journal Articles

  • Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P. (2016). Aβ-related memory decline in APOE ε4 non-carriers: Implications for Alzheimer’s disease. Neurology, 86(17), 1635-1642. https://doi.org/10.1212/WNL.0000000000002604.
  • Gupta, V., Gupta, V., Chitranshi, N., Gangoda, S., Vander Wall, R., Abbasi, M., Golzan, M., Dheer, Y., Shah, T., Avolio, A., Chung, R., Martins, R., Graham, S. (2016). One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina. Cellular and Molecular Life Sciences, 73(22), 4279-4297. https://doi.org/10.1007/s00018-016-2295-x.
  • Tang, M., Ryman, DC., McDade, E., Jasielec, MS., Buckles, VD., Cairns, NJ., Fagan, AM., Goate, A., Marcus, DS., Xiong, C., Allegri, RF., Chhatwal, JP., Danek, A., Farlow, MR., Fox, NC., Ghetti, B., Graff-Radford, NR., Laske, C., Martins, R., Masters, CL., Mayeux, RP., Ringman, JM., Rossor, MN., Salloway, SP., Schofield, PR., Morris, JC., Bateman, RJ. (2016). Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet Neurology, 15(13), 1317-1325. https://doi.org/10.1016/S1474-4422(16)30229-0.
  • Lim, YY., Snyder, PJ., Pietrzak, RH., Ukiqi, A., Villemagne, VL., Ames, D., Salvado, O., Bourgeat, P., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2016). Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2(2016), 19-26. https://doi.org/10.1016/j.dadm.2015.11.003.
  • Warrier, S., Marimuthu, R., Sekhar, S., Bhuvanalakshmi, G., Arfuso, F., Das, AK., Bhonde, R., Martins, R., Dharmarajan, A. (2016). SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease. International Journal of Biochemistry and Cell Biology, 75(June 2016), 104-111. https://doi.org/10.1016/j.biocel.2016.04.002.
  • Lee, S., Viqar, F., Zimmerman, ME., Narkhede, A., Tosto, G., Benzinger, T., Marcus, DS., Fagan, A., Goate, A., Fox, N., Cairns, N., Holtzman, DM., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, AJ., Masters, C., Ringman, JM., Ryan, NS., Forster, S., Laske, C., Schofield, PR., Sperling, RA., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, JC., Mayeux, R., Brickman, A. (2016). White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. Annals of Neurology, 79(6), 929-939. https://doi.org/10.1002/ana.24647.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.
  • Kirby, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R. (2016). Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672. https://doi.org/10.3233/JAD-151084.
  • O'Bryant, S., Lista, S., Rissman, R., Edwards, M., Zhang, F., Hall, J., Zetterberg, H., Lovestone, S., Gupta, V., Graff-Radford, N., Martins, R., Jeromin, A., Waring, S., Oh, E., Kling, M., Baker, L., Hampel, H. (2016). Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 27-34. https://doi.org/10.1016/j.dadm.2015.12.003.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.
  • Frost, S., Guymer, R., Aung, K., Macaulay, S., Sohrabi, H., Bourgeat, P., Salvado, O., Rowe, C., Ames, D., Masters, C., Martins, R., Kanagasingam, Y. (2016). Alzheimer's disease and the early signs of age-related macular degeneration. Current Alzheimer Research, 13(11), 1259-1266. https://doi.org/10.2174/1567205013666160603003800.
  • Burnham, S., Rowe, C., Baker, D., Bush, A., Doecke, JD., Faux, N., Laws, S., Martins, R., Maruff, P., Macaulay, S., Rainey-Smith, S., Savage, G., Ames, D., Masters, C., Wilson, W., Villemagne, V. (2016). Predicting Alzheimer disease from a blood-based biomarker profile. Neurology, 87(11), 1093-1101. https://doi.org/10.1212/WNL.0000000000003094.
  • Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V. (2016). Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, 15(10), 1044-1053. https://doi.org/10.1016/S1474-4422(16)30125-9.
  • Holmes, S., Esterlis, I., Mazure, C., Lim, YY., Ames, D., Rainey-Smith, S., Martins, R., Salvado, O., Dore, V., Villemagne, V., Rowe, C., Laws, S., Masters, C., Maruff, P., Pietrzak, R. (2016). β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195. https://doi.org/10.1016/j.jagp.2016.08.007.
  • Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R. (2016). The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343. https://doi.org/10.2174/1871527315666151110125704.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R. (2016). Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228. https://doi.org/10.1016/j.neubiorev.2016.01.004.
  • Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R. (2016). Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894. https://doi.org/10.3233/JAD-150948.
  • Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R. (2016). Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. The British Journal of Nutrition: an international journal of nutritional science, 115(12), 2106-2113. https://doi.org/10.1017/S0007114516001203.
  • Kirby, S., Rainey-Smith, S., Martins, R. (2016). Diet and Inflammation in Alzheimer's Disease and Related Chronic Diseases: A Review. Journal of Alzheimer's Disease, 50(2), 301-334. https://doi.org/10.3233/JAD-150765.
  • Francois, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R., Rainey-Smith, S., Masters, C., Ames, D., Rowe, C., Macaulay, S., Hill, A., Leifert, W. (2016). High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. Current Alzheimer Research, 13(7), 787-799. https://doi.org/10.2174/1567205013666160315112151.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R. (2016). Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559. https://doi.org/10.1074/jbc.M115.679993.
  • Buckley, R., Maruff, P., Ames, D., Bourgeat, P., Martins, R., Masters, C., Rainey-Smith, S., Lautenschlager, N., Rowe, C., Savage, G., Villemagne, V., Ellis, K. (2016). Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer's and Dementia, 12(7), 796-804. https://doi.org/10.1016/j.jalz.2015.12.013.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R. (2016). Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465. https://doi.org/10.1017/S0007114515004687.
  • Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068. https://doi.org/10.5665/sleep.5756.
  • Zwan, MD., Villemagne, VL., Doré, V., Buckley, R., Bourgeat, P., Veljanoski, R., Salvado, O., Williams, R., Margison, L., Rembach, A., Macaulay, SL., Martins, R., Ames, D., Van Der Flier, WM., Ellis, KA., Scheltens, P., Masters, C., Rowe, C. (2016). Subjective memory complaints in APOE e4 carriers are associated with high Amyloid-ß Burden. Journal of Alzheimer's Disease, 49(4), 1115-1122. https://doi.org/10.3233/JAD-150446.
  • Lim, YY., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., Salvado, O., Rowe, C., Masters, C., Maruff, P. (2016). Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, 60(3), 362-370. https://doi.org/10.1007/s12031-016-0822-8.
  • Muenchhoff, J., Poljak, A., Thalamuthu, A., Gupta, V., Chatterjee, P., Raffery, M., Masters, C., Morris, J., Bateman, J., Fagan, A., Martins, R., Sachdev, P. (2016). Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease. Scientific Reports, 6(2016), Article no. 29078. https://doi.org/10.1038/srep29078.
  • Hare, DJ., Faux, NG., Roberts, BR., Volitakis, I., Martins, R., Bush, AI. (2016). Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics, 8(6), 628-632. https://doi.org/10.1039/c6mt00019c.

Journal Articles

  • Hollands, S., Lim, Y., Buckley, R., Pietrzak, R., Snyder, P., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2015). Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults. Journal of Alzheimer's Disease, 43(2), 677-686. https://doi.org/10.3233/JAD-140678.
  • O'Bryant, SE., Gupta, V., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C., Soares, H., Lovestone, S., Hampel, H., Montine, T., Blennow, K., Foroud, T., Carrillo, M., Graff-Radford, N., Laske, C., Breteler, M., Shaw, L., Trojanowski, J., Schupf, N., Rissman, R., Fagan, A., Oberoi, P., Umek, R., Weiner, M., Grammas, P., Posner, H., Martins, R. (2015). Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's and Dementia, 11(5), 549-560. https://doi.org/10.1016/j.jalz.2014.08.099.
  • Bourgeat, P., Villemagne, V., Dore, V., Brown, B., Macaulay, SL., Martins, R., Masters, C., Ames, D., Ellis, K., Rowe, C., Salvado, O., Fripp, J. (2015). Comparison of MR-less PiB SUVR quantification methods. Neurobiology of Aging, 36(S1), S159-S166. https://doi.org/10.1016/j.neurobiolaging.2014.04.033.
  • Rembach, A., Stingo, FC., Peterson, C., Vannucci, M., Do, K., Wilson, WJ., Macaulay, SL., Ryan, TM., Martins, R., Ames, D., Masters, CL., Doecke, JD. (2015). Bayesian graphical network analyses reveal complex biological interactions specific to Alzheimer's disease. Journal of Alzheimer's Disease, 44(3), 917-925. https://doi.org/10.3233/JAD-141497.
  • Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R. (2015). The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14. https://doi.org/10.1017/S0007114515001452.
  • Lim, YY., Villemagne, VL., Laws, S., Pietrzak, RH., Snyder, PJ., Ames, D., Ellis, KA., Harrington, K., Rembach, A., Martins, R., Rowe, CC., Masters, CL., Maruff, P. (2015). APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Molecular Psychiatry, 20(11), 1322-1328. https://doi.org/10.1038/mp.2014.123.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R. (2015). Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16. https://doi.org/10.3389/fnagi.2015.00016.
  • Wang, F., Gordon, BA., Ryman, DC., Ma, S., Xiong, C., Hassenstab, J., Goate, A., Fagan, AM., Cairns, NJ., Marcus, DS., McDade, E., Ringman, JM., Graff-Radford, NR., Ghetti, B., Farlow, MR., Sperling, R., Salloway, S., Schofield, PR., Masters, CL., Martins, R., Rossor, MN., Jucker, M., Danek, A., Forster, S., Lane, CA., Morris, JC., Benzinger, TL., Bateman, RJ. (2015). Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology, 85(9), 790-798. https://doi.org/10.1212/WNL.0000000000001903.
  • Laske, C., Sohrabi, H., Jasielec, MS., Muller, S., Koehler, N., Graber, S., Forster, S., Drzezga, A., Mueller-Sarnowski, F., Danek, A., Jucker, M., Bateman, R., Buckles, V., Saykin, A., Martins, R., Morris, J. (2015). Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International, 2015(2015), Article no. 828120. https://doi.org/10.1155/2015/828120.
  • Kirby, S., Rainey-Smith, S., Barnes, M., Sohrabi, H., Weinborn, M., Lim, Y., Harrington, K., Taddei, K., Gu, Y., Rembach, A., Szoeke, C., Ellis, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Keogh, J., Scarmeas, N., Martins, R. (2015). Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry, 20(7), 860-866. https://doi.org/10.1038/mp.2014.79.
  • Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA. (2015). Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48. https://doi.org/10.1016/j.nbd.2015.06.016.
  • Verdile, G., Fuller, SJ., Martins, R. (2015). The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38. https://doi.org/10.1016/j.nbd.2015.04.008.
  • Laske, C., Sohrabi, H., Frost, S., Lopez-De-Ipina, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S., Mueller, S., Linnemann, C., Bridenbaugh, S., Kanagasingam, Y., Martins, R., O’bryant, S. (2015). Innovative diagnostic tools for early detection of Alzheimer’s disease. Alzheimer's and Dementia, 11(5), 561-578. https://doi.org/10.1016/j.jalz.2014.06.004.
  • Lim, YY., Villemagne, VL., Pietrzak, RH., Ames, D., Ellis, KA., Harrington, K., Snyder, PJ., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2015). APOE e4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of Aging, 36(3), 1239-1244. https://doi.org/10.1016/j.neurobiolaging.2014.12.008.
  • Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2015). Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease is Dependent on APOE ε4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082. https://doi.org/10.1371/journal.pone.0139082.
  • Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD. (2015). Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71. https://doi.org/10.1186/s13195-015-0157-7.
  • Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S. (2015). Alzheimer’s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187. https://doi.org/10.3233/JAD-150247.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.
  • Pietrzak, R., Lim, YY., Neumeister, A., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Restrepo, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2015). Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease A Multicenter, Prospective Cohort Study. JAMA Psychiatry, 72(3), 284-291. https://doi.org/10.1001/jamapsychiatry.2014.2476.
  • Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P. (2015). Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation, 6(2015), Article No. 105828. https://doi.org/10.1155/2015/105828.
  • Kirby, S., Rainey-Smith, S., Macaulay, SL., Taddei, K., Rembach, A., Maruff, P., Ellis, K., Masters, C., Rowe, C., Ames, D., Keogh, J., Martins, R. (2015). Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ. The British Journal of Nutrition: an international journal of nutritional science, 114(10), 1683-1693. https://doi.org/10.1017/S0007114515003335.
  • Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R. (2015). Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586.
  • Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R. (2015). Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164. https://doi.org/10.2174/1567205012666150204125732.
  • Cheng, L., Doecke, J., Sharples, RA., Villemagne, VL., Fowler, CJ., Rembach, A., Martins, R., Rowe, CC., Macaulay, SL., Masters, CL., Hill, AF. (2015). Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Molecular Psychiatry, 20(10), 1188-1196. https://doi.org/10.1038/mp.2014.127.
  • Burnham, SC., Raghavan, N., Wilson, W., Baker, D., Ropacki, MT., Novak, G., Ames, D., Ellis, K., Martins, R., Maruff, P., Masters, CL., Romano, G., Rowe, CC., Savage, G., Macaulay, SL., Narayan, V. (2015). Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study. Journal of Alzheimer's Disease, 46(4), 1079-1089. https://doi.org/10.3233/JAD-143015.
  • Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R. (2015). The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90. https://doi.org/10.1016/j.yhbeh.2015.05.020.
  • Ying Lim, Y., Pietrzak, RH., Bourgeat, P., Ames, D., Ellis, KA., Rembach, A., Harrington, K., Salvado, O., Martins, R., Snyder, PJ., Masters, C., Rowe, CC., Villemagne, VL., Maruff, P. (2015). Relationships between performance on the cogstate brief battery, neurodegeneration, and aβ accumulation in cognitively normal older adults and adults with MCI. Archives of Clinical Neuropsychology, 30(1), 49-58. https://doi.org/10.1093/arclin/acu068.
  • Leifert, WR., Nguyen, T., Rembach, A., Martins, R., Rainey-Smith, S., Masters, CL., Ames, D., Rowe, CC., Macaulay, SL., François, M., Fenech, MF. (2015). Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's Disease, 48(2), 443-452. https://doi.org/10.3233/JAD-150330.
  • Pietrzak, RH., Lim, YY., Ames, D., Harrington, K., Restrepo, C., Martins, R., Rembach, A., Laws, S., Masters, CL., Villemagne, VL., Rowe, CC., Maruff, P. (2015). Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Neurobiology of Aging, 36(3), 1231-1238. https://doi.org/10.1016/j.neurobiolaging.2014.12.015.
  • Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M. (2015). Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678. https://doi.org/10.1093/hmg/ddv110.
  • Sutton, T., Sohrabi, H., Rainey-Smith, S., Bird, S., Weinborn, M., Martins, R. (2015). The role of APOE-ε4 and beta amyloid in the differential rate of recovery from ECT: a review. Translational Psychiatry, 5(e539), 1-8. https://doi.org/10.1038/tp.2015.39.
  • Buckley, R., Saling, M., Ellis, K., Rowe, C., Maruff, P., Macaulay, LS., Martins, R., Masters, C., Savage, G., Rainey-Smith, S., Rembach, A., Ames, D. (2015). Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age and Ageing, 44(6), 1012-1019. https://doi.org/10.1093/ageing/afv136.
  • Narlawar, R., Werry, EL., Scarf, AM., Hanani, R., Chua, SW., King, VA., Barron, ML., Martins, R., Ittner, LM., Rendina, LM., Kassiou, M. (2015). First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO). Journal of Medicinal Chemistry, 58(21), 8743-8749. https://doi.org/10.1021/acs.jmedchem.5b01288.
  • Albrecht, MA., Szoeke, C., Maruff, P., Savage, G., Lautenschlager, NT., Ellis, KA., Taddei, K., Martins, R., Masters, CL., Ames, D., Foster, JK. (2015). Longitudinal cognitive decline in the AIBL cohort: The role of APOE e4 status. Neuropsychologia, 75(2015), 411-419. https://doi.org/10.1016/j.neuropsychologia.2015.06.008.
  • Leifert, WR., Tuli, JF., François, M., Nguyen, T., Rembach, A., Rumble, RL., Rainey-Smith, S., Martins, R., Fenech, MF. (2015). Buccal cell cytokeratin 14 identifies mild cognitive impairment and alzheimer’s disease in the AIBL study of aging. Current Alzheimer Research, 12(3), 233-241.
  • Buckley, RF., Ellis, KA., Ames, D., Rowe, CC., Lautenschlager, NT., Maruff, P., Villemagne, V., Macaulay, SL., Szoeke, C., Martins, R., Masters, CL., Savage, G., Rainey-Smith, S., Rembach, A., Saling, MM. (2015). Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology, 29(4), 571-581. https://doi.org/10.1037/neu0000156.
  • Cysique, LA., Hewitt, T., Croitoru-Lamoury, J., Taddei, K., Martins, R., Chew, CS., Davies, NN., Price, P., Brew, BJ. (2015). APOE e4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - A cross-sectional observational study. BMC Neurology, 15(1), Article no. 51. https://doi.org/10.1186/s12883-015-0298-0.
  • Johnson, L., Sohrabi, H., Hall, J., Taddei, K., Edwards, M., O'Bryant, S., Martins, R. (2015). A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30(8), 881-886. https://doi.org/10.1002/gps.4231.

Journal Articles

  • Lim, YY., Maruff, P., Pietrzak, R., Ellis, K., Darby, D., Ames, D., Harrington, K., Martins, R., Masters, C., Szoeke, C., Savage, G., Villemagne, V., Rowe, C. (2014). Aβ and cognitive change: Examining the preclinical and prodromal stages of Alzheimer’s disease. Alzheimer's and Dementia, 10(16), 743-751. https://doi.org/10.1016/j.jalz.2013.11.005.
  • Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R. (2014). A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487. https://doi.org/10.1038/tp.2014.122.
  • Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C. (2014). En Attendant Centiloid. Advances in Research, 2(12), 723-729. https://doi.org/10.9734/AIR/2014/11599.
  • Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R. (2014). Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378. https://doi.org/10.2217/nmt.14.29.
  • Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Lautenschlager, N., Maruff, P., Macaulay, SL., Martins, R., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Szoeke, C., Ellis, K. (2014). Personal memory function in mild cognitive impairment and subjective memory complaints: Results from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study of ageing. Journal of Alzheimer's Disease, 40(3), 551-561. https://doi.org/10.3233/JAD-131820.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Bush, A., Martins, R., Masters, C., Rowe, C., Maruff, P. (2014). Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer’s disease: A preliminary study. PLoS One, 9(1), Article no. e86498. https://doi.org/10.1371/journal.pone.0086498.
  • Francois, M., Leifert, W., Martins, R., Thomas, P., Fenech, M. (2014). Biomarkers of Alzheimer's disease risk in peripheral tissues; focus on buccal cells. Current Alzheimer Research, 11(6), 519-531. https://doi.org/10.2174/1567205011666140618103827.
  • Pietrzak, R., Scott, J., Neumeister, A., Lim, YY., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P. (2014). Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry, 204(5), 400-401. https://doi.org/10.1192/bjp.bp.113.134239.
  • Rembach, A., Faux, N., Watt, A., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Roberts, B., Perez, K., Li, Q., Laws, S., Taddei, K., Rainey-Smith, S., Robertson, J., Vandijck, M., Vanderstichele, H., Barnham, K., Ellis, K., Szoeke, C., Macaulay, L., Rowe, C., Villemagne, V., Ames, D., Martins, R., Bush, A., Masters, C. (2014). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia, 10(1), 53-61. https://doi.org/10.1016/j.jalz.2012.12.006.
  • Rembach, A., Watt, A., Wilson, W., Rainey-Smith, S., Ellis, K., Rowe, C., Villemagne, V., Macaulay, S., Bush, A., Martins, R., Ames, D., Masters, C., Doecke, J. (2014). An increased neutrophil-lymphocyte ratio in Alzheimer’s disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71. https://doi.org/10.1016/j.jneuroim.2014.05.005.
  • Buckley, R., Saling, M., Irish, M., Ames, D., Rowe, C., Villemagne, V., Lautenschlager, N., Maruff, P., Macaulay, L., Martins, R., Szoeke, C., Masters, C., Rainey-Smith, S., Rembach, A., Savage, G., Ellis, K. (2014). Autobiographical narratives relate to Alzheimer’s disease biomarkers in older adults. International Psychogeriatrics, 26(10), 1737-1746. https://doi.org/10.1017/S1041610214001136.
  • Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S. (2014). Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546. https://doi.org/10.3233/JAD-131442.
  • Thomas, J., Brier, M., Bateman, R., Snyder, A., Benzinger, T., Xiong, C., Raichle, M., Holtzman, D., Sperling, R., Mayeux, R., Ghetti, B., Ringman, J., Salloway, S., McDade, E., Rossor, M., Ourselin, S., Schofield, P., Masters, C., Martins, R., Weiner, M., Thompson, P., Fox, N., Koeppe, R., Jack, C., Mathis, C., Oliver, A., Blazey, T., Moulder, K., Buckles, V., Hornbeck, R., Chhatwal, J., Schultz, A., Goate, A., Fagan, A., Cairns, N., Marcus, D., Morris, C., Ances, B. (2014). Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurology, 71(9), 1111-1122. https://doi.org/10.1001/jamaneurol.2014.1654.
  • Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R. (2014). Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183.
  • Francois, M., Leifert, W., Hecker, J., Faunt, G., Martins, R., Thomas, P., Fenech, M. (2014). Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease. Cytometry Part A, 85(8), 698-708. https://doi.org/10.1002/cyto.a.22453.
  • Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V. (2014). A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(2014), 519-526. https://doi.org/10.1038/mp.2013.40.
  • Moore, E., Ames, D., Mander, A., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Masters, C., Rowe, C., Szoeke, C., Watters, D. (2014). Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from 3 cohorts. Journal of Alzheimer's Disease, 39(2014), 661-668. https://doi.org/10.3233/JAD-131265.
  • Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M. (2014). Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617. https://doi.org/10.1093/hmg/ddt448.
  • Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767. https://doi.org/10.1186/1756-0500-7-767.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R. (2014). Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75. https://doi.org/10.1038/mp.2012.147.
  • Ryman, D., Acosta-Baena, N., Aisen, P., Bird, T., Danek, A., Fox, N., Goate, A., Frommelt, P., Ghetti, B., Langbaum, J., Lopera, F., Martins, R., Masters, C., Mayeux, R., McDade, E., Moreno, S., Reiman, E., Ringman, J., Salloway, S., Schofield, P., Sperling, R., Tariot, P., Xiong, C., Morris, J., Bateman, R. (2014). Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology, 83(3), 253-260. https://doi.org/10.1212/WNL.0000000000000596.
  • Lim, YY., Maruff, P., Pietrzak, R., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Szoeke, C., Martins, R., Masters, C., Villemagne, V., Rowe, C. (2014). Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease. Brain: a journal of neurology, 137(1), 221-231. https://doi.org/10.1093/brain/awt286.
  • Rembach, A., Watt, A., Wilson, W., Villemagne, V., Burnham, S., Ellis, K., Maruff, P., Ames, D., Rowe, C., Macaulay, S., Bush, A., Martins, R., Masters, C., Doecke, J. (2014). Plasma amyloid-β levels are significantly associated with a transition towards Alzheimer’s disease as measured by cognitive decline and change in neocortical amyloid burden. Journal of Alzheimer's Disease, 40(1), 95-104. https://doi.org/10.3233/JAD-131802.
  • Fagan, A., Xiong, C., Jasielec, M., Mateusz, R., Goate, A., Benzinger, T., Ghetti, B., Martins, R., Masters, C., Mayeux, R., Ringman, J., Rossor, M., Salloway, S., Schofield, P., Sperling, R., Marcus, D., Cairns, N., Buckles, V., Ladenson, J., Morris, J., Holtzman, D. (2014). Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine, 6(226), Article no. 226ra30. https://doi.org/10.1126/scitranslmed.3007901.
  • Ellis, K., Szoeke, C., Bush, A., Darby, D., Graham, P., Lautenschlager, N., Macaulay, L., Martins, R., Maruff, P., Masters, C., McBride, S., Pike, K., Rainey-Smith, S., Rembach, A., Robertson, J., Rowe, C., Savage, G., Villemagne, V., Woodward, M., Wilson, W., Zhang, P., Ames, D. (2014). Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics, 26(4), 543-554. https://doi.org/10.1017/S1041610213001956.
  • Yates, P., Desmond, P., Phal, P., Steward, C., Szoeke, C., Salvado, O., Ellis, K., Martins, R., Masters, C., Ames, D., Villemagne, V., Rowe, C. (2014). Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology, 82(14), 1266-1273. https://doi.org/10.1212/WNL.0000000000000285.
  • Bates, K., Vink, R., Martins, R., Harvey, A. (2014). Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of Aging, 35(6), 1345-1351. https://doi.org/10.1016/j.neurobiolaging.2013.11.020.
  • Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R. (2014). Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52. https://doi.org/10.1212/WNL.0000000000000867.
  • Rembach, A., Hare, D., Doecke, J., Burnham, S., Volitakis, I., Fowler, C., Cherny, R., McLean, C., Grimm, R., Martins, R., Ames, D., Masters, C., Bush, A., Roberts, B. (2014). Decreased serum zinc is an effect of ageing and not Alzheimer’s disease. Metallomics: integrated biometal science, 6(7), 1216-1219. https://doi.org/10.1039/c4mt00060a.
  • Faux, N., Rembach, A., Wiley, J., Ellis, K., Ames, D., Fowler, C., Martins, R., Pertile, K., Rumble, R., Trounson, B., Masters, C., Bush, A. (2014). An anemia of Alzheimer’s disease. Molecular Psychiatry, 19(11), 1227-1234. https://doi.org/10.1038/mp.2013.178.
  • Lim, F., Martins, I., Martins, R. (2014). The Involvement of Lipids in Alzheimer's Disease. Journal of Genetics and Genomics, 41(5), 261-274. https://doi.org/10.1016/j.jgg.2014.04.003.

Conference Publications

  • Johnson, P., Vandewater, L., Wilson, W., Maruff, P., Savage, G., Graham, P., Macaulay, LS., Ellis, KA., Szoeke, C., Martins, R., Rowe, C., Masters, CL., Ames, D., Zhang, P. (2014). Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. Proceedings from Asia Pacific Bioinformatics Network Thirteenth International Conference on Bioinformatics (1 - 14). BMC Genomics. https://doi.org/10.1186/1471-2105-15-S16-S11.

Journal Articles

  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R. (2013). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224. https://doi.org/10.1016/j.neurobiolaging.2013.03.012.
  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R. (2013). Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881. https://doi.org/10.1038/mp.2012.107.
  • Brown, B., Peiffer, JJ., Martins, R. (2013). Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease?. Molecular Psychiatry, 18(8), 864-874. https://doi.org/10.1038/mp.2012.162.
  • Lim, Y., Ellis, K., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Aβ amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia, 9(5), 538-545. https://doi.org/10.1016/j.jalz.2012.07.004.
  • O' Bryant, S., Xiao, G., Edwards, M., Devous, M., Gupta, V., Martins, R., Zhang, F., Barber, R. (2013). Biomarkers of Alzheimer’s Disease Among Mexican Americans. Journal of Alzheimer's Disease, 34(4), 841-849. https://doi.org/10.3233/JAD-122074.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0. (2013). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897. https://doi.org/10.1038/mp.2012.106.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S. (2013). Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888. https://doi.org/10.1038/mp.2012.115.
  • Carrillo, M., Rowe, C., Szoeke, C., Masters, C., Ames, D., O'Meara, T., Macaulay, SL., Milner, A., Ellis, K., Maruff, P., Rainey-Smith, S., Martins, R., Bain, L., Head, R. (2013). Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia, 9(2), 160-168. https://doi.org/10.1016/j.jalz.2012.10.006.
  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G. (2013). The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235. https://doi.org/10.1371/journal.pone.0066235.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Vignarajan, J., Bourgeat, P., Salvado, O., Villemagne, V., Rowe, C., Macaulay, L., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R. (2013). Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry, 3(February), 1-8. https://doi.org/10.1038/tp.2012.150.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R. (2013). The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920. https://doi.org/10.4236/health.2013.55121.
  • Drummond, E., Muhling, J., Martins, R., Wijaya, L., Ehlert, E., Harvey, A. (2013). Pathology associated with AAV Mediated Expression of Beta Amyloid or C100 in Adult Mouse Hippocampus and Cerebellum. PLoS One, 8(3), e59166. https://doi.org/10.1371/journal.pone.0059166.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Bourgeat, P., Villemagne, V., Rowe, C., Macaulay, SL., Szoeke, C., Ellis, K., Ames, D., Masters, C., Rainey-Smith, S., Martins, R. (2013). Pupil Response Biomarkers for Early Detection and Monitoring of Alzheimer's Disease. Current Alzheimer Research, 10(9), 931-939.
  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G. (2013). Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332. https://doi.org/10.1038/tp.2013.97.
  • Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L. (2013). Modulation of amyloid-β 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103. https://doi.org/10.1039/c2fo30111c.
  • Gupta, V., Sundaram, R., Martins, R. (2013). Multiplex biomarkers in blood. Alzheimer's Research & Therapy, 5(3), Article 31. https://doi.org/10.1186/alzrt185.
  • Benzinger, T., Blazey, T., Jack, C., Koeppe, R., Su, Y., Xiong, C., Raichle, M., Snyder, A., Ances, B., Bateman, R., Cairns, N., Fagan, A., Goate, A., Marcus, D., Aisen, P., Christensen, J., Ercole, L., Hornbeck, R., Farrar, A., Aldea, P., Jasielec, M., Owen, C., Xie, X., Mayeux, R., Brickman, A., McDade, E., Klunk, W., Mathis, C., Ringman, J., Thompson, P., Ghetti, B., Saykin, A., Sperling, R., Johnson, K., Salloway, S., Correia, S., Schofield, P., Masters, C., Rowe, C., Villemagne, V., Martins, R., Ourselin, S., Rossor, M., Fox, N., Cash, D., Weiner, M., Holtzman, D., Buckles, V., Moulder, K., Morris, J. (2013). Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of USA, 110(47), E4502-E4509. https://doi.org/10.1073/pnas.1317918110.
  • Mills, S., Mallmann, J., Santacruz, A., Fuqua, A., Carril, M., Aisen, P., Althage, M., Belyew, S., Benzinger, T., Brooks, W., Buckles, V., Cairns, N., Clifford, D., Danek, A., Fagan, M., Farlow, N., Fox, N., Ghetti, B., Goate, A., Heinrichs, D., Hornbeck, R., Jack, C., Jucker, M., Klunk, W., Marcus, D., Martins, R., Masters, C., Mayeux, R., McDade, E., Morris, J., Oliver, A., Ringman, J., Rossor, M., Salloway, S., Schofield, P., Snider, J., Snyder, P., Sperling, R., Stewart, C., Thomas, R., Xiong, C., Bateman, R. (2013). Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial. Revue Neurologique, 169(10), 737-743. https://doi.org/10.1016/j.neurol.2013.07.017.
  • Valenzuela, M., Bartres-Faz, D., Bullmore, E., Fjell, A., Maletic-Savetic, M., Martins, R., Solowij, N., Yucel, M. (2013). Less is more: More thinking about less data: a perspective from the 2nd Provence Summer Workshop. Molecular Psychiatry, 18(5), 524-525. https://doi.org/10.1038/mp.2013.26.
  • Lim, YY., Pietrzak, RH., Ellis, KA., Jaeger, J., Harrington, K., Ashwood , T., Szoeke, C., Martins, R., Bush, AI., Masters, CL., Rowe, CC., Villemagne, VL., Ames, D., Darby, D., Maruff, P. (2013). Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. https://doi.org/10.3233/JAD-2012-121516.
  • Ellis, K., Lim, YY., Harrington, K., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Decline in Cognitive Function over 18 Months in Healthy Older Adults with High Amyloid-β. Journal of Alzheimer's Disease, 34(2013), 861-871. https://doi.org/10.3233/JAD-122170.
  • Villemagne, V., Burhnham, S., Bourgeat, P., Brown, B., Ellis, KA., Salvado, O., Szoeke, C., Macaulay, L., Martins, R., Maruff, P., Ames, D., Rowe, C., Masters, C. (2013). Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease : a prospective cohort study. The Lancet Neurology, 12(4), 357-367. https://doi.org/10.1016/S1474-4422(13)70044-9.
  • Moore, E., Mander, A., Ames, D., Kotowicz, M., Carne, R., Brodaty, H., Woodward, M., Boundy, K., Ellis, K., Bush, A., Faux, N., Martins, R., Szoeke, C., Rowe, C., Watters, D. (2013). Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care, 36(10), 2981-2987. https://doi.org/10.2337/dc13-0229.
  • Harrington, K., Lim, YY., Ellis, K., Copolov, C., Darby, D., Weinborn, M., Ames, D., Martins, R., Savage, G., Szoeke, C., Rowe, C., Villemagne, V., Masters, C., Maruff, P. (2013). The association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics, 25(10), 1667-1677. https://doi.org/10.1017/S1041610213001087.
  • Buckley, R., Saling, M., Ames, D., Rowe, C., Lautenschlager, N., Macaulay, SL., Martins, R., Masters, C., O'Meara, T., Savage, G., Szoeke, C., Villemagne, V., Ellis, K. (2013). Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age. International Psychogeriatrics, 25(8), 1307-1315. https://doi.org/10.1017/S1041610213000665.
  • Frost, S., Kanagasingam, Y., Sohrabi, H., Taddei, K., Bateman, R., Morris, J., Benzinger, T., Goate, A., Masters, C., Martins, R. (2013). Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers. Current Alzheimer Research, 10(8), 790-796. https://doi.org/10.2174/15672050113109990154.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P. (2013). BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464. https://doi.org/10.1016/j.neurobiolaging.2013.05.006.
  • Lim, YY., Ellis, K., Harrington, K., Pietrzak, R., Gale, J., Ames, D., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Maruff, P. (2013). Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-β: Prodromal Alzheimer's Disease?. Journal of Alzheimer's Disease, 33(4), 1167-1176. https://doi.org/10.3233/JAD-121771.
  • Foster, J., Albrecht, M., Savage, G., Lautenschlager, N., Ellis, K., Maruff, P., Szoeke, C., Taddei, K., Martins, R., Masters, C., Ames, D. (2013). Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain: a journal of neurology, 136(7), 2201-16. https://doi.org/10.1093/brain/awt127.
  • Dore, V., Villemagne, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Zhou, L., Martins, R., Ellis, K., Masters, C., Ames, D., Salvado, O., Rowe, C. (2013). Cross-sectional and longitudinal analysis of the relationship between aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease. JAMA Neurology, 70(7), 903-911. https://doi.org/10.1001/jamaneurol.2013.1062.
  • Kirby, S., Rainey-Smith, S., Keogh, J., Mathieson, S., Martins, R. (2013). Dietary Patterns Associated with Alzheimer's Disease and Related Chronic Disease Risk: A Review. Alzheimer's Disease & Parkinsonism, Special(2013), online.
  • Martins, I., Creegan, R., Lim, F., Martins, R. (2013). Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33. https://doi.org/10.4236/ojemd.2013.35A002.
  • Avdesh, ., Hoe, Y., Martins, R., Martin-Iverson, M. (2013). Pharmacological effects of cannabinoids on the reference and working memory functions in mice. Psychopharmacology, 225(2), 483-494. https://doi.org/10.1007/s00213-012-2834-6.
  • Lim, YY., Ellis, K., Harrington, K., Kamer, A., Pietrzak, R., Bush, A., Darby, D., Martins, R., Masters, C., Rowe, C., Savage, G., Szoeke, C., Villemagne, V., Ames, D., Maruff, P. (2013). Cognitive consequences of high aβ amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of Alzheimer's disease. Neuropsychology, 27(3), 322-332. https://doi.org/10.1037/a0032321.
  • Lim, YY., Jaeger, J., Harrington, K., Ashwood, T., Ellis, K., Stöffler, A., Szoeke, C., Lachovitzki, R., Martins, R., Villemagne, V., Bush, A., Masters, C., Rowe, C., Ames, D., Darby, D., Maruff, P. (2013). Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology, 28(4), 320-330. https://doi.org/10.1093/arclin/act021.
  • Rowe, C., Bourgeat, P., Ellis, K., Brown, B., Yen Ying, L., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., Robins, P., Tochon-Danguy, H., O'Keefe, G., Pike, K., Yates, P., Szoeke, C., Salvado, O., Macaulay, SL., O'Meara, T., Head, R., Cobiac, L., Savage, G., Martins, R., Masters, C., Ames, D., Villemagne, V. (2013). Predicting Alzheimer disease with beta-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology, 74(6), 905-913. https://doi.org/10.1002/ana.24040.
  • Rembach, A., Doecke, JD., Roberts, BR., Watt, AD., Faux, NG., Volitakis, I., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Wilson, W., Ellis, K., Martins, R., Rowe, C., Villemagne, V., Ames, D., Masters, C., Bush, A. (2013). Longitudinal Analysis of Serum Copper and Ceruloplasmin in Alzheimer's Disease. Journal of Alzheimer's Disease, 34(1), 171-182. https://doi.org/10.3233/JAD-121474.

Journal Articles

  • Sona, A., Zhang, P., Ames, D., Bush, AI., Lautenschlager, NT., Martins, R., Masters, CL., Rowe, CC., Szoeke, C., Taddei, K., Ellis, KA. (2012). Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics, 24(2), 197-204. https://doi.org/10.1017/S1041610211001335.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R. (2012). Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056. https://doi.org/10.1016/j.neurobiolaging.2010.09.003.
  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R. (2012). Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967. https://doi.org/10.3233/JAD-2012-120178.
  • Villain, N., Chetelat, G., Grassiot, B., Bourqeat, P., Jones, G., Ellis, K., Ames, D., Martins, R., Eustache, F., Salvado, O., Masters, C., Rowe, C., Villemagne, V. (2012). Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: A voxelwise PiB-PET longitudinal study. Brain: a journal of neurology, 135(7), 2126-2139. https://doi.org/10.1093/brain/aws125.
  • Brown, B., Peiffer, J., Sohrabi, H., Mondal, A., Gupta, V., Rainey-Smith, S., Taddei, K., Burnham, S., Ellis, K., Szoeke, C., Masters, CL., Ames, D., Rowe, C., Martins, R. (2012). Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry, 2(2012), art. no. e191. https://doi.org/10.1038/tp.2012.118.
  • Lim, YY., Ellis, KA., Pietrzak, RH., Ames, D., Darby, D., Harrington, K., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Villemagne, V0., Maruff, P. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology, 79(16), 1645-1652. https://doi.org/10.1212/WNL.0b013e31826e9ae6.
  • Barber, B., Ames, D., Ellis, K., Martins, R., Masters, C., Szoeke, C. (2012). Lifestyle and late life cognitive health: Sufficient evidence to act now?. International Psychogeriatrics, 24(5), 683-688. https://doi.org/10.1017/S1041610211002912.
  • Drummond, ES., Martins, R., Handelsman, DJ., Harvey, AR. (2012). Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice. Endocrinology, 153(6), 2789-2799. https://doi.org/10.1210/en.2011-2003.
  • Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R. (2012). Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry, 2(2012), art. no. e118. https://doi.org/10.1038/tp.2012.43.
  • Newman, M., Nornes, S., Martins, R., Lardelli, MT. (2012). Robust homeostasis of Presenilin1 protein levels by transcript regulation. Neuroscience Letters, 519(1), 14-19. https://doi.org/10.1016/j.neulet.2012.04.064.
  • Cyarto, EV., Lautenschlager, NT., Desmond, PM., Ames, D., Szoeke, C., Salvado, O., Sharman, M., Ellis, KA., Phal, PM., Masters, CL., Rowe, CC., Martins, R., Cox, KL. (2012). Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial. BMC Psychiatry, 12(11 October 2012), Article 167. https://doi.org/10.1186/1471-244X-12-167.
  • Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A., Holtzman, D., Bateman, R., Sohrabi, H., Martins, R., Gandy, S., Urakami, K., Suzuki, T. (2012). Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects. Molecular Neurodegeneration, 7(1), art. no. 16. https://doi.org/10.1186/1750-1326-7-16.
  • Lim, YY., Ellis, KA., Harrington, K., Ames, D., Martins, R., Masters, CL., Rowe, C., Savage, G., Szoeke, C., Darby, D., Maruff, P. (2012). Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology, 34(4), 345-358. https://doi.org/10.1080/13803395.2011.643227.
  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R. (2012). Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456. https://doi.org/10.4236/health.2012.412A209.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R. (2012). Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325. https://doi.org/10.1001/archneurol.2012.1282.
  • Chetelat, G., Villemagne, V., Villain, N., Jones, G., Ellis, K., Ames, D., Martins, R., Masters, C., Rowe, C. (2012). Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition. Neurology, 78(7), 477-484. https://doi.org/10.1212/WNL.0b013e318246d67a.
  • Acosta, O., Fripp, J., Dore, V., Bourgeat, P., Favreau, JM., Chetelat, G., Rueda, A., Villemagne, VL., Szoeke, C., Ames, D., Ellis, K., Martins, R., Masters, CA., Rowe, CA., Bonner, E., Gris, F., Xiao, D., Raniga, P., Barra, V., Salvado, O. (2012). Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods, 205(1), 96-109. https://doi.org/10.1016/j.jneumeth.2011.12.011.
  • Morris, JC., Aisen, PS., Bateman, RJ., Benzinger, TL., Cairns, NJ., Fagan, AM., Ghetti, B., Goate, AM., Holtzman, DM., Klunk, WE., McDade, E., Marcus, DS., Martins, R., Masters, CL., Mayeux, R., Oliver, A., Quaid, K., Ringman, JM., Rossor, MN., Salloway, S., Schofield, PR., Selsor, NJ., Sperling, RA., Weiner, MW., Xiong, C., Moulder, KL., Buckles, VD. (2012). Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network. Clinical Investigation, 2(10), 975-984. https://doi.org/10.4155/cli.12.93.
  • Bateman, RJ., Xiong, C., Benzinger, TL., Fagan, AM., Goate, A., Fox, NC., Marcus, DS., Cairns, NJ., Xie, X., Blazey, TM., Holtzman, DM., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, PM., Ghetti, B., Klunk, WM., McDade, E., Martins, R., Masters, CM., Mayeux, R., Ringman, JM., Rossor, MM., Schofield, PM., Sperling, RM., Salloway, S., Morris, JM. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. New England Journal of Medicine, 367(9), 795-804. https://doi.org/10.1056/NEJMoa1202753.
  • Kirby, S., Gu, Y., Rainey-Smith, S., Keogh, JB., Clifton, PM., Mathieson, SL., Taddei, K., Mondal, A., Ward, V., Scarmeas, N., Barnes, M., Ellis, K., Head, R., Masters, C0., Ames, D., Macaulay, S0., Rowe, C0., Szoeke, C., Martins, R. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry, 2(2012), e164. https://doi.org/10.1038/tp.2012.91.
  • Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R. (2012). Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469. https://doi.org/10.3233/JAD-2011-110704.

Conference Publications

  • Dore, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Szoeke, C., Ellis, K., Martins, R., Villemagne, V., Masters, CL., Ames, D., Rowe, C0., Salvado, O. (2012). A surface based approach for cortical thickness comparison between PiB+ and PiB-healthy control subjects. Proceedings of SPIE: Medical Imaging 2012: Image Processing, 831413 (February 23, 2012) (831413-1to 831413-6). SPIE. https://doi.org/10.1117/12.911752.

Journal Articles

  • Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A. (2011). Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study.. Journal of Alzheimer's Disease, 27(4), 909-922. https://doi.org/10.3233/JAD-2011-110752.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390. https://doi.org/10.1016/j.neuropsychologia.2011.04.012.
  • Avdesh, ., Wong, P., Martins, R., Martin-Iverson, MT. (2011). Memory function in a mouse genetic model of Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 433-444. https://doi.org/10.3233/JAD-2011-101944.
  • McBride, SJ., Szoeke, CE., Good, NM., Ames, D., Martins, R., Masters, CL., Maruff, PT., Rowe, CC., Savage, G., Ellis, KA. (2011). A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia, 194(4), S12-S14.
  • Chetelat, G., Villemagne, VL., Pike, KE., Ellis, KA., Bourgeat, P., Jones, G., O'Keefe, GJ., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, CL., Rowe, CC. (2011). Independent contribution of temporal β-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain, 134(3), 798-807. https://doi.org/10.1093/brain/awq383.
  • Villemagne, VL., Pike, KE., Chetelat, G., Ellis, KA., Mulligan, RS., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., Martins, R., O'Keefe, G., Mathis, CA., Klunk, WE., Ames, D., Masters, CL., Rowe, CC. (2011). Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Annals of Neurology, 69(1), 181-192. https://doi.org/10.1002/ana.22248.
  • Newman, M., Verdile, G., Martins, R., Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352. https://doi.org/10.1016/j.bbadis.2010.09.012.
  • Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P. (2011). Association of plasma Aβ peptides with blood pressure in the elderly. PLoS One, 6(4), e18536. https://doi.org/10.1371/journal.pone.0018536.
  • Ellis, KA., Rowe, CC., Szoeke, CE., Villemagne, VL., Ames, D., Chetelat, G., Martins, R., Masters, CL., Fripp, J., Acosta, O., Raniga, P., Bourgeat, PT., Salvado, O. (2011). Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia, 194(4), S20-S23.
  • Mattsson, N., Andreasson, U., Persson, S., Arai, H., Batish, SD., Bernardini, S., Bocchio-Chiavetto, L., Blankenstein, MA., Carrillo, MC., Chalbot, S., Coart, E., Chiasserini, D., Cutler, N., Dahlfors, G., Duller, S., Fagan, AM., Forlenza, O., Frisone , GB., Galasko, D., Galimberti, D., Hampel, H., Handberg, A., Heneka, MT., Herskovits, AZ., Herukka , S., Holtzmann, DM., Humpel, C., Hyman, B., Iqbal, K., Jucker, M., Kaeser , S., Kaiser, E., Kapaki, E., Kidd, D., Kilvenyi, P., Knudsen, CS., Kummer, M., Lui, J., Llado, A., Lewczuk, P., Li, Q., Martins, R., Masters, C., McAuliffe, J., Mercken, M., Moghekar, A., Molinuevo, JL., Montine, TJ., Nowatzke, W., O'Brien, R., Otto, M., Paraskevas, GP., Parnetti, L., Petersen, RC., Prvulovic, D., De Reus, HP., Rissman, RA., Scarpini, E., Stefani, A., Soininen, H., Schroeder , J., Shaw, LM., Skinningsrud, A., Skrogstad, B., Spreer, A., Talib, L., Teunissen, C., Trojanowski, JQ., Tunami, H., Umek, RM., Van Broeck, B., Vanderstichele, H., Vecsei, L., Verbeek, M., Windisch, M., Zhang, J., Zetterberg, H., Blennow, K. (2011). The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers and Dementia, 7(4), 386-395. https://doi.org/10.1016/j.jalz.2011.05.2243.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R. (2011). Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels.. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322. https://doi.org/10.1159/000330812.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., Martins, R., Rowe, C., Szoeke, C., Ellis, K. (2011). Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. https://doi.org/10.1159/000325171.
  • Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R. (2011). Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098. https://doi.org/10.1212/WNL.0b013e318211c352.
  • Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R. (2011). The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605. https://doi.org/10.3233/JAD-2011-110584.

Book Chapters

  • Maczurek, A., Krautwald, M., Steele, M., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Munch, G. (2010). Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease. Micronutrients and Brain Health (133-148). Routledge.

Journal Articles

  • Chetelat, G., Villemagne, V., Bourgeat, P., Pike, K., Jones, G., Ames, D., Ellis, K., Szoeke, C., Martins, R., O'Keefe, G., Salvado, O., Masters, C., Rowe, C. (2010). Relationship between Atrophy and B-Amyloid Deposition in Alzheimer Disease. Annals of Neurology, 67(3), 317-324.
  • Jenner, A., Lim, F., Ng, M., Wenk, MR., Shui, G., Sharman, M., Gandy, S., Martins, R. (2010). The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2,ε3 and ε4 knock-in mice. Neuroscience, 169(1), 109-115. https://doi.org/10.1016/j.neuroscience.2010.04.026.
  • Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., Haroutunian, V., Fried, U., Ehrlich, M., Martins, R., Gandy, S. (2010). Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration, 5(1), Article No.1.
  • Chetelat, G., Villemagne, VL., Pike, KE., Baron, J., Bourgeat, P., Jones, G., Faux, NG., Ellis, K., Salvado, O., Szoeke, C., Martins, R., Ames, D., Masters, C., Rowe, C. (2010). Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain, 133(11), 3349-3358.
  • Sharman, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R. (2010). APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-ß42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409. https://doi.org/10.3233/JAD-2010-100141.
  • Barron, A., Verdile, G., Taddei, K., Bates, K., Martins, R. (2010). Effect of Chronic hCG Administration on Alzheimer's-Related Cognition and Aβ accumulation in PS1KI mice. Endocrinology, 151(11), 5380–5388.
  • Bharadwaj, P., Martins, R., Macreadie, I. (2010). Yeast as a model for studying Alzheimer's disease. F E M S Yeast Research, 10(8), 961–969.
  • Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R. (2010). Plasma amyloid-β as a biomarker in Alzheimer’s disease: the AIBL study of aging.. Journal of Alzheimer's Disease, 20(4), 1233-1242.
  • Rowe, C., Ellis, K., Rimajova, M., Bourgeat, P., Pike, KE., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., Price, R., Raniga, P., Robins, P., Acosta, O., Lenzo, N., Szoeke, C., Salvado, O., Head, R., Martins, R., Masters, C., Ames, D., Villemagne, VL. (2010). Amyloid imaging results, from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31(8), 1275-1283.
  • Rodrigues, M., Foster, J., Verdile, G., Joesbury, K., Prince, R., Devine, A., Mehta, P., Beilby, J., Martins, R. (2010). Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: Quod erat demonstrandum?. International Psychogeriatrics, 22(2), 332-335. https://doi.org/10.1017/S1041610209991190.
  • Frost, S., Martins, R., Kanagasingam, Y. (2010). Ocular biomarkers for early detection of Alzheimer's Disease. Journal of Alzheimer's Disease, 22(1), 1-16.
  • Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., Lardelli, M. (2010). A Zebrafish melanophore model of Amyloid β toxicity. Zebrafish, 7(2), 155-159.
  • Ford, A., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. (2010). Vitamins B12, B6, and folic acid for cognition in older men. Neurology, 75(17), 1540-1547. https://doi.org/10.1212/WNL.0b013e3181f962c4.
  • Bourgeat, P., Chetelat, G., Villemagne, V., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C., Ourselin, S., Ames, D., Ellis, KA., Martins, R., Masters, C., Rowe, C., Salvado, O. (2010). β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 74(2), 121-127.
  • Ellis, K., Rowe, C., Villemagne, V., Martins, R., Masters, C., Salvado, O., Szoeke, C., Ames, D. (2010). Addressing population aging and Alzheimer's disease through the Australian Imaging Biomarkers and Lifestyle study: Collaboration with the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's and Dementia, 6(3), 291-296.
  • Sharman, M., Shui, G., Fernandis, A., Lim, WL., Berger, T., Hone, E., Taddei, K., Martins, I., Ghiso, J., Buxbaum, JD., Gandy, S., Wenk, M., Martins, R. (2010). Profiling brain and plasma lipids in human APOE ε2, ε3 and ε4 knock-in mice using electrospray ionization mass spectrometry.. Journal of Alzheimer's Disease, 20(1), 105-111.
  • Peiffer, J., Galvao, D., Gibbs, Z., Smith, K., Turner, D., Foster, J., Martins, R., Newton, R. (2010). Strength and Functional Characteristics of Men and women 65 Years and Older. Rejuvenation Research, 13(1), 75-82.
  • Miklossy, J., Qing, H., Radenovic, A., Kis, A., Vileno, B., Laszlo, F., Miller, L., Martins, R., Waeber, G., Mooser, V., Bosman, F., Khalili, K., Darbinian, N., McGeer, P. (2010). Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging, 31(9), 1503-1515.

Book Chapters

  • Verdile, G., Martins, R. (2009). The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism.. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies (259-268). Cambridge University Press.
  • Verdile, G., Martins, R. (2009). Molecular Genetics of Alzheimer's Disease. Molecular Biology of Neuropsychiatric Disorders (229-276). Springer Verlag. https://doi.org/10.1007/978-3-540-85383-1_8.

Journal Articles

  • Krishnaswamy, S., Verdile, G., Groth, D., Kanyenda, L., Martins, R. (2009). The structure and function of Alzheimer's gamma secretase enzyme complex. Critical Reviews in Clinical Laboratory Science, 46(5-6), 282-301.
  • Bharadwaj, P., Dubey, AK., Masters, CL., Martins, R., Macreadie, I. (2009). A β aggregation and possible implications in Alzheimer's disease pathogenesis. Journal of Cell and Molecular Medicine, 13(3), 412-421.
  • Pedrini, S., Thomas, C., Brautigam, H., Schmeidler, J., Ho, L., Fraser, P., Westaway, D., St George Hyslop, P., Martins, R., Buxbaum, D., Pasinetti, GM., Dickstein, DL., Hof, PR., Ehrlich, M., Gandy, S. (2009). Dietary composition modulates brain mass and solubilizable A levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration, 4(1), Article No. 40.
  • Foster, J., Verdile, G., Bates, K., Martins, R. (2009). Immunization in Alzheimer's disease: naive hope or realistic clinical potential. Molecular Psychiatry, 14(3), 239-251.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein eε4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79.
  • Ellis, K., Bush, A., Darby, D., De Fazio, D., Foster, J., Hudson, P., Lautenschlager, N., Lenzo, N., Martins, R., Maruff, P., Masters, C., Milner, A., Pike, K., Rowe, C., Savage, G., Szoeke, C., Taddei, K., Villemagne, V., Woodward, M., Ames, D., Aibl Research Group, T. (2009). The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease. International Psychogeriatrics, 21(4), 672-687.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R. (2009). Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142.
  • Barron, A., Cake, M., Verdile, G., Martins, R. (2009). Ovariectomy and 17β-Estradiol Replacement Do Not Alter beta-Amyloid Levels in Sheep Brain. Endocrinology, 150(7), 3228-3236.
  • De Silva, R., Disanayaka, S., De Zoysa, N., Sanjeewanie, N., Somaratne, S., Foster, J., Srikanth, S., Kathriarachchi, S., Martins, R. (2009). Norms for the mini-mental state examination from a sample of Sri Lankan older people. International Journal of Geriatric Psychiatry, 24(7), 666-670.
  • Chen, M., Martins, R., Lardelli, M. (2009). Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish embryos. Journal of Alzheimer's Disease, 18(2), 305-317.
  • Drummond, E., Harvey, AR., Martins, R. (2009). Androgens and Alzheimer's Disease. Current Opinion in Endocrinology, Diabetes and Obesity, 16(3), 254-259.
  • Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R. (2009). Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R. (2009). Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-β Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318.
  • Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., Martins, R. (2009). Clearance mechanisms of Alzheimer’s amyloid-β peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry, 14(5), 469-486.
  • Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., Lardelli, M. (2009). Independent an cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 315(16), 2791-2801.
  • Hata, S., Fujishige, S., Araki, Y., Kato, N., Araseki, M., Nishimura, M., Hartmann, D., Saftig, P., Fahrenholz, F., Taniguchi, M., Urakami, K., Akatsu, H., Martins, R., Yamamoto, K., Maeda, M., Yamamoto, T., Nakaya, T., Gandy, S., Suzuki, T. (2009). Alcadein Cleavages by Amyloid β -Precursor Protein (APP) α -and γ -Secretases Generate Small Peptides, p3-Alcs, Indicating Alzhiemer Disease-related γ -Secretase Dysfunction. The Journal of Biological Chemistry, 284(52), 36024-36033.

Journal Articles

  • Maczurek, A., Hager, K., Kenklies, M., Sharman, M., Martins, R., Engel, J., Carlson, D., Muench, G. (2008). Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Advanced Drug Delivery Reviews, 60(13-14), 1463-1470. https://doi.org/10.1016/j.addr.2008.04.015.
  • Urosevic, N., Martins, R. (2008). Infection and Alzheimer's Disease: The APOE epsilon 4 Connection and Lipid Metabolism. Journal of Alzheimer's Disease, 13(4), 421-435.
  • Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R. (2008). Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274.
  • Foster, J., Sohrabi, H., Verdile, G., Martins, R. (2008). Research Criteria for the Diagnosis of Alzheimer'S Disease: Genetic Risk Factors, Blood Biomarkers and Olfactory Dysfunction. International Psychogeriatrics, 20(4), 853-855.
  • Verdile, G., Yeap, B., Clarnette, R., Dhaliwal, S., Burkhart, M., Chubb, SA., De Ruyck, K., Rodrigues, M., Mehta, PD., Foster, J., Bruce, D., Martins, R. (2008). Luteinizing Hormone Levels are Positively Correlated with Plasma Amyloid-beta Protein Levels in Elderly Men. Journal of Alzheimer's Disease, 14(2), 201-208.
  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R. (2008). Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Martins, G., Howard, M., De Ruyck, K., Bates, K., Dhaliwal, S., Verdile, G., Carruthers, M., Martins, R. (2008). Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137.
  • Flicker, L., Martins, R., Thomas, J., Acres, J., Taddei, K., Vasikaran, S., Norman, P., Jamrozik, K., Almeida, O. (2008). B-Vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging, 29(2), 303-305. https://doi.org/10.1016/j.neurobiolaging.2006.10.007.
  • Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Sleptsova - Fredrich, I., Martins, R., Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412. https://doi.org/10.1093/hmg/ddm317.
  • Rimajova, M., Lenzo, N., Wu, J., Bates, K., Campbell, A., Dhaliwald, SS., McCarthy, M., Rodrigues, M., Paton, A., Rowe, C., Foster, J., Martins, R. (2008). Fluoro-2-deoxy-D-glucose (FDG)-PET in APOE epsilon 4 carriers in the Australian population. Journal of Alzheimer's disease, 13(2), 137-146.
  • Gnjec, A., D'costa, K., Laws, S., Hedley, R., Balakrishnan, K., Taddei, K., Martins, G., Paton, A., Verdile, G., Gandy, S., Broe, A., Brooks, W., Bennett, H., Piguet, O., Price, P., Miklossy, J., Hallmayer, J., McGeer, P., Martins, R. (2008). Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation, 5(36), 1-10. https://doi.org/10.1186/1742-2094-5-36.

Journal Articles

  • McRae, A., Martins, R., Fonte, J., Kraftsik, R., Hirt, L., Miklossy, J. (2007). Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: A putative marker of an ongoing inflammatory process. Experimental Gerontology, 42(4), 355-363.
  • Fuller, S., Tan, R., Martins, R. (2007). Androgens in the Etiology of Alzheimer's Disease in Aging Men and Possible Therapeutic Interventions. Journal of Alzheimer's disease, 12(2), 129-142.
  • Bates, K., Martins, R., Harvey, A. (2007). Oxidative Stress in a Rat Model of Chronic Gliosis. Neurobiology of Aging, 28(7), 995-1008.
  • Verdile, G., Gandy, S., Martins, R. (2007). The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer's Beta Amyloid. Neurochemical Research, 32(4-5), 609-623.

Journal Articles

  • Barron, A., Verdile, G., Martins, R. (2006). The Role of Gonadotropins in Alzheimer's Disease. Endocrine, 9(2), 257-269.
  • Burkhardt, M., Foster, J., Clarnette, RM., Chubb, P., Bruce, D., Drummond, P., Martins, R., Yeap, B. (2006). Interaction between Testosterone and Apolipoprotein E epsilon4 Status on Cognition in Healthy Older Men. Journal of Clinical Endocrinology & Metabolism, 91(3), 1168-1172.
  • Miklossy, J., Kis, A., Radenovic, A., Miller, L., Forro, L., Martins, R., Reiss, K., Darbinian, N., Darekar, P., Mihaly, L., Khalili, K. (2006). Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiology of Aging, 27(2), 228-236.
  • House, M., St Pierre, T., Foster, J., Martins, R., Clarnette, RM. (2006). Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss. American Journal of Neuroradiology, 27(2), 430-439.
  • Pickering-Brown, S., Baker, M., Gass, J., Boeve, B., Loy, C., Brooks, W., Mackenzie, I., Martins, R., Kwok, J., Halliday, G., Kril, J., Schofield, P., Mann, D., Hutton, M. (2006). Mutations in progranulin explain atypical phenotypes with variants in MAPT. Brain: a Journal of Neurology, 129(11), 3124-3126.
  • Riemenschneider, M., Konta, L., Friedrich, P., Schwarz, S., Taddei, K., Neff, F., Padovani, A., Kolsch, H., Laws, S., Klopp, N., Bickeboller, H., Wagenpfeil, S., Mueller, J., Rosenberger, A., Diehl-Schmid, J., Archetti, S., Lautenschlager, N., Borroni, B., Muller, U., Illig, T., Heun, R., Egensperger, R., Schlegel, J., Forstl, H., Martins, R., Kurz, A. (2006). A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease. Human Molecular Genetics, 15(16), 2446-2456.
  • Martins, I., Hone, E., Foster, J., Sunram-Lea, S., Gnjec, A., Fuller, S., Nolan, DA., Gandy, S., Martins, R. (2006). Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry, 11(8), 721-736.
  • Butterfield, A., Gnjec, A., Poon, H., Castegna, A., Pierce, W., Klein, JB., Martins, R. (2006). Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment. Journal of Alzheimer's disease, 10(4), 391-397.
  • Barron, A., Fuller, S., Verdile, G., Martins, R. (2006). Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling, 8(11), 2047-2059.
  • Burkhardt, M., Foster, J., Clarnette, R., Chubb, P., Bruce, D., Drummond, P., Martins, R., Yeap, B. (2006). Interaction between Testosterone and Apolipoprotein E4 Status on Cognition in Healthy Older Men. Journal of Clinical Endocrinology and Metabolism, 9(13), 116-1172.
  • Barron, A., Verdile, G., Martins, R. (2006). Gonadotropins: potential targets for preventative and therapeutic interventions in Alzheimer's Disease. Future Neurology, 1(2), 189-202.

Journal Articles

  • Lautenschlager, N., Wu, J., Laws, S., Almeida, O., Clarnette, R., Joesbury, K., Wagenpfeil, S., Martins, G., Paton, A., Gandy, S., Forstl, H., Martins, R. (2005). Neurological soft signs are associated with APOE genotype, age and cognitive performance. Journal of Alzheimer's disease, 7(1), 325-330.
  • Laws, S., Perneczky, R., Wagenpfeil, S., Muller, U., Forstl, H., Martins, R., Kurz, A., Riemenschneider, M. (2005). TNF Polymorphisms in Alzheimer Disease and Functional Implications on CSF Beta-Amyloid Levels. Human Mutation, 26(1), 29-35.
  • Lautenschlager, N., Martins, R. (2005). Common versus uncommon causes of dementia. International Psychogeriatics, 17(1), S27-S34.
  • Balakrishnan, K., Verdile, G., Mehta, P., Beilby, J., Nolan, DA., Galvao, D., Newton, R., Gandy, S., Martins, R. (2005). Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's disease, 8(3), 269-282.
  • Hone, E., Martins, I., Jeoung, M., Ji, T., Gandy, S., Martins, R. (2005). Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. Journal of Alzheimer's disease, 7(4), 303-314.
  • James, V., Richardson, J., Robertson, T., Papadimitriou, J., Dutton, N., Maley, M., Berstein, L., Lantseva, O., Martins, R. (2005). Fibre diffraction of hair can provide a screening test for Alzheimer's Disease: a human and animal model study. Medical Science Monitor, 11(2), 53-57.
  • Bates, K., Harvey, AR., Carruthers, M., Martins, R. (2005). Androgens, andropause and neurodegeneration: Exploring the link between steroidogenesis, androgens and Alzheimer's disease. CMLS Cellular and Molecular Life Sciences, 62(3), 281-292.

Journal Articles

  • Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K., Kakulas, B., Mehta, P., Milward, E., Tan, N., Lareu, R., Lim, D., Dharmarajan, A., Martins, R. (2004). Protein markers for alzheimer disease in the frontal cortex and cerebellum. Neurology, 63(8), 1385-1392.
  • Martins, R., Hallmayer, J. (2004). Age at onset: Important marker of genetic heterogeneity in alzheimer's disease. The pharmacogenomics journal, 4(n/a), 138-140.
  • Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: Still a cause of everything or the only one who got caught?. Pharmacological research, 50(4), 397-409.
  • Almeida, O., Waterreus, A., Spry, N., Flicker, L., Martins, R. (2004). One Year Follow-up Study of the Association between Chemical Castration, Sex Hormones, Beta-Amyloid, Memory and Depression in Men. Psychoneuroendocrinology, 29(8), 1071-1081.
  • Burkhardt, M., Foster, J., Martins, R. (2004). The significance of age-related androgen depletion in cognitive impairment: A review. Brain impairment, 5(2), 166-176.
  • Flicker, L., Martins, R., Thomas, J., Acres, J., Taddei, K., Norman, P., Jamrozik, K., Almeida, O. (2004). Homocysteine, Alzheimer genes and proteins, and measures of cognition and depression in older men. Journal of Alzheimer's disease, 6(3), 329-336.
  • Bowen, R., Verdile, G., Liu, T., Parlow, A., Perry, G., Smith, M., Martins, R., Atwood, C. (2004). Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-Beta precursor protein and amyloid-Beta deposition. The journal of biological chemistry, 279(19), 20539-20545.
  • Pocernich, C., Sultana, R., Hone, E., Turchan, J., Martins, R., Calabrese, V., Nath, A., Butterfield, D. (2004). Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes. Neuroscience Research, 77(4), 532-539.
  • Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?. Pharmacological Research, 50(4), 397-409.
  • Verdile, G., Groth, D., Matthews, P., St Geroge Hyslop, P., Fraser, P., Ramabhadran, T., Kwok, J., Schofeild, P., Carter, T., Gandy, S., Martins, R. (2004). Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular psychiatry, 9(6), 594-602.
  • Sweeney, D., Martins, R., Levine III, H., Smith, J., Gandy, S. (2004). Similar promotion of Abeta 1-42 fibrillogenesis by native apolipoprotein E epsilon3 and epsilon4 isoforms. Journal of Neuroinflammation, 1(15), 1-4. https://doi.org/10.1186/1742-2094-1-15.
  • Carter, T., Verdile, G., Groth, D., Bogush, A., Thomas, S., Shen, P., Fraser, P., Matthews, P., Nixon, R., Ehrlich, M., Kwok, J., St-George Hyslop, P., Schofeild, P., Li, Y., Yang, A., Martins, R., Gandy, S. (2004). Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer disease and associated disorders, 18(4), 261-263.
  • Stanford, P., Brooks, W., Teber, E., Hallupp, M., McLean, C., Halliday, G., Martins, R. (2004). Frequency of Tau Mutations in Familial and Sporadic Frontotemporal Dementia and other Tauopathies. Journal of Neurology, 251(9), 1098-1104.
  • Burkhardt, M., Foster, J., Laws, S., Baker, L., Craft, S., Gandy, S., Stuckey, B., Clarnette, R., Nolan, D., Hewson-Bower, B., Martins, R. (2004). Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. Journal of Alzheimer's Disease, 6(3), 221-228.
  • Liu, T., Perry, G., Chan, H., Verdile, G., Martins, R., Smith, M., Atwood, C. (2004). Amyloid-b-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Journal of Neurochemistry, 88(3), 554-563.
  • Yao, J., Petanceska, S., Montine, T., Holtzman, D., Schmidt, S., Parker, C., Callahan, M., Lipinski, W., Bisgaier, C., Turner, B., Nixon, R., Martins, R., Ouimet, C., Smith, J., Davies, P., Laska, E., Ehrlich, M., Walker, L., Mathews, P., Gandy, S. (2004). Aging, gender and APOE isotype modulate metabolism of Alzheimer's ABeta peptides and F2-isoprostanes in the absence of detectable amyloid deposits. The journal of neurochemistry, 90(4), 1011-1018. https://doi.org/10.1111/j.1471-4159.2004.02532.x.
  • Burkhardt, M., Foster, J., Martins, R. (2004). The significance of age-related androgen depletion in cognitive impairment: A review. Brain impairment, 5(2), 166-176.

Book Chapters

  • Verdile, G., Gandy, S., Fraser, P., Atwood, C., Martins, R. (2003). The Presenilins and their Role in Amyloid-β Generation Production. Focus on Alzheimer’s Disease Research (167-210). Nova Science Publishers.

Journal Articles

  • Dean, B., Laws, S., Hone, E., Taddei, K., Scarr, E., Thomas, E., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry, 54(6), 616-622.
  • Christen-Zaech, S., Kraftsik, R., Pillevuit, O., Kiraly, M., Martins, R., Miklossy, J. (2003). Early olfactory involvement in Alzheimer's disease. Canadian Journal of Neurological Sciences, 30(1), 20-25.
  • Veurink, G., Liu, D., Taddei, K., Perry, G., Smith, MA., Robertson, T., Hone, E., Groth, D., Atwood, CS., Martins, R. (2003). Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radical Biology and Medicine, 34(8), 1070-1077.
  • Veurink, G., Fuller, S., Atwood, C., Martins, R. (2003). Genetics, Lifestyle and the Roles of Amyloid beta and Oxidative Stress in Alzheimer's Disease. Annals of Human Biology, 30(6), 639-667.
  • Atwood, C., Obrenovich, M., Liu, T., Chan, H., Perry, G., Smith, M., Martins, R. (2003). Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta. Brain Research Reviews, 43(1), 1-16.
  • Thomas, E., Laws, S., Sutcliffe, J., Harper, C., Dean, B., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological Psychiatry, 54(2), 136-141.
  • Miklossy, J., Taddei, K., Suva, D., Verdile, G., Fonte, J., Fisher, C., Gnjec, A., Ghika, J., Suard, F., Mehta, P., McLean, C., Masters, C., Brooks, W., Martins, R. (2003). Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging, 24(5), 655-662.
  • Sumioka, A., Imoto, S., Martins, R., Kirino, Y., Suzuki, T. (2003). XB51 isopforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Biochemical Journal, 374(n/a), 261-268.
  • Stanford, P., Shepherd, C., Halliday, G., Brooks, W., Schofield, PW., Brodaty, H., Martins, R., Kwok, J., Schofield, PR. (2003). Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain, 126(4), 814-826.
  • Laws, S., Hone, E., Gandy, S., Martins, R. (2003). Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of Neurochemistry, 84(6), 1215-1236.
  • Gandy, S., Martins, R., Buxbaum, JD. (2003). Molecular and Cellular Basis for Anti-Amyloid Therapy in Alzheimer Disease. Alzheimer Disease and Associated Disorders, 17(4), 259-266.
  • Lim, D., Flicker, L., Dharmarajan, A., Martins, R. (2003). Can Testosterone Replacement Decrease the Memory Problem of Old Age?. Medical Hypotheses, 60(6), 893-896.
  • Gillet, M., Martins, R., Clarnette, R., Chubb, P., Bruce, D., Yeap, B. (2003). Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia.. Journal of Alzheimer's Disease, 5(4), 267-269.
  • Hone, E., Martins, I., Fonte, J., Martins, R. (2003). Apolipoprotein E influences amyloid-beta clearance from the murine periphery. Journal of Alzheimer's Disease, 5(1), 1-8.

Research Projects

  • The AUstralian-multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention (AU-ARROW) Study, National Health and Medical Research Council, MRFF International Clinical Trial Collaborations grant program, 2020 ‑ 2024, $1,411,151.
  • In vitro assessment to evaluate the potential effect of Gallic acid on Alzheimer’s disease, Al Faris Food Industries Pvt. Ltd., Scholarships to Support Industry Engagement MBR Projects, 2018 ‑ 2023, $39,000.
  • The Australian Dementia Network (ADNeT): Bringing together Australia’s dementia stakeholders, National Health and Medical Research Council, Boosting Dementia Research Grants Scheme, 2019 ‑ 2023, $915,620.
  • In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease, National Foundation for Medical Research and Innovation, NFMRI - Grant, 2020 ‑ 2023, $170,000.
  • In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease (AD), CWEK Pty Ltd, Scholarships to Support Industry Engagement PhD Projects, 2018 ‑ 2023, $32,500.
  • AIBL: Agreement with Biogen for provision of AIBL Data and samples, Florey Institute of Neuroscience and Mental Health, Grant, 2016 ‑ 2022, $3,108,475.
  • Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort, National Health and Medical Research Council, Project Grants, 2017 ‑ 2022, $1,125,804.
  • A systems epidemiology approach to define metabolic and genomic determinants of Alzheimer's disease , National Health and Medical Research Council, Project Grants, 2019 ‑ 2022, $305,290.
  • Improving sleep to promote healthy brain aging: an intervention study , Alzheimer's Association USA, Alzheimer's Association Research Grant, 2019 ‑ 2022, $220,992.
  • Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2021, $190,000.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Dominantly Inherited Alzheimer Network, Washington University, Grant, 2019 ‑ 2021, $380,000.
  • Medical and Health Research Infrastructure Fund 2019 (Round 23), Department of Health WA, Medical and Health Research Infrastructure, 2020 ‑ 2021, $122,964.
  • WA Memory Study (WAMS), Australian Alzheimer's Research Foundation, McCusker Alzheimer's Research Foundation - Grant, 2019 ‑ 2021, $296,746.
  • Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2020, $210,393.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22), Department of Health WA, Medical and Health Research Infrastructure, 2019 ‑ 2020, $150,771.
  • Sponsorship of Research Fellow (Hamid Soharbi), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2019, $47,130.
  • Dominantly Inherited Alzheimer Network, Washington University, Grant, 2009 ‑ 2019, $1,398,587.
  • Sponsorship of Research Fellow (Kevin Taddei), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2019, $90,198.
  • Sponsorship Agreement Post-Doctoral Research Fellow, Australian Alzheimer's Research Foundation, Neuroscience Research Institute - Sponsorship, 2018 ‑ 2019, $94,922.
  • Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer's disease pathology, National Health and Medical Research Council, Project Grants, 2016 ‑ 2019, $100,000.
  • High-frequency ultrasound and photoacoustic imaging for Western Australia, Australian Research Council, Grant - Linkage (Infrastructure), 2018 ‑ 2019, $621,198.
  • Genetic Linkages to mTOR pathway dysregulation and development of Alzheimers Disease, CRC For Mental Health, WES Study, 2015 ‑ 2019, $524,000.
  • Biomarkers and Early Intervention for Neurodegeneration, CRC For Mental Health, CRC Grant, 2012 ‑ 2018, $674,185.
  • 4.1 Biomarkers for Early Diagnosis of AD and PD, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $7,524,765.
  • Developing a blood-based biomarker panel for Alzheimer's disease, BrightFocus Foundation, Alzheimer's Disease Research - Postdoctoral Fellowship Awards, 2015 ‑ 2018, $126,876.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20), Department of Health WA, Medical and Health Research Infrastructure, 2017 ‑ 2018, $158,564.
  • 4.6 - Biomarkers for Schizophrenia Sub-Types - Part A Neuroimaging, Part B Biomarker Discovery, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $1,202,364.
  • 4.4B1 Novel Therapeutics for AD Testosterone Trial, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $1,068,045.
  • The contribution of sleep factors to healthy cognitive ageing: A pilot sleep-specific cognitive behavioural intervention study, Equity Trustees Limited, Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation), 2017 ‑ 2018, $60,000.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2015 (Round 19), Department of Health WA, Medical and Health Research Infrastructure, 2016 ‑ 2017, $193,336.
  • The effect of high-intensity exercise on Alzheimer’s disease-related gene expression, Brain Foundation, Research Gifts Program, 2017, $39,875.
  • Head Injury and Testosterone (HIT), Harry Perkins Institute of Medical Research, Neurotrauma Research Program, 2013 ‑ 2017, $148,701.
  • Development and refinement of methods for early and specific diagnosis of Alzheimer's disease, quantification of rates of change in the pathological processes and determination of the resultant effects on cognition., Fil Foundation, Grant, 2015 ‑ 2017, $417,506.
  • High resolution mass spectrometry for metabolomics and proteomics research, Australian Research Council, Grant - Linkage (Infrastructure), 2015 ‑ 2016, $1,140,000.
  • Mass Cytometry: A breakthrough in multidimensional systems biology, Australian Research Council, Grant - Linkage (Infrastructure), 2015 ‑ 2016, $1,081,489.
  • Use of coconut oil as a novel neuro protective agent for Alzheimer’s disease, Edith Cowan University, School of Medical and Health Sciences Research Grant Scheme 2016, 2016, $9,203.
  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease, National Health and Medical Research Council, Project Grants, 2013 ‑ 2016, $536,949.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. , Hollywood Private Hospital Research Foundation, Grant, 2013 ‑ 2016, $20,000.
  • The influence of exercise intensity on the prevention of cognitive decline in older adults, Dementia Australia Research Foundation, AADRF - Postdoctoral Fellowships, 2014 ‑ 2016, $214,900.
  • Exercise intensity and prevention of cognitive decline in older adults, Edith Cowan University, ECU Early Career Researcher Grant - 2015, 2015 ‑ 2016, $24,066.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2014 Round 18, Department of Health WA, Medical and Health Research Infrastructure, 2015 ‑ 2016, $230,341.
  • Continuation of the 15M S.A work & In vitro testing of the Phylomers, Alzhyme Pty Ltd, Grant, 2015, $103,875.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2014 ‑ 2015, $12,555.
  • A study of the kinetics of biomarkers and their presumptive relationship with brain amyloid , Commonwealth Scientific and Industrial Research Organisation (CSIRO), Araclon Biotech , 2014 ‑ 2015, $132,200.
  • Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease., Hollywood Private Hospital Research Foundation, Grant, 2015, $15,000.
  • Establishing a combined ocular and blood biomarker panel for Alzheimer’s disease., Australian National University, ANU - Dementia CRC - Grant, 2014 ‑ 2015, $517,977.
  • Progressing the clinical neuropsychological phenotype of Alzheimer's disease., Florey Institute of Neuroscience and Mental Health, Grant, 2014 ‑ 2015, $85,000.
  • Ocular Imaging Project NeuroVision Imaging, Commonwealth Scientific and Industrial Research Organisation (CSIRO), NeuroVision Imaging, LLC Grant, 2013 ‑ 2015, $152,999.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2013 (Round 17), Department of Health WA, Medical and Health Research Infrastructure, 2014 ‑ 2015, $186,666.
  • Personality dimensions and increased risk of late onset Alzheimer's disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014 ‑ 2015, $15,000.
  • CSIRO/Janssen AIBL Neuroscience Program, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Janssen Neuroscience Program, 2014 ‑ 2015, $200,000.
  • A Pilot Clinical Study to Evaluate the Potential of AMLAMAX™ (Emblica Officinalis) Extract on Raising HDL-Cholesterol Levels and Decreasing Plasma Amyloid beta (Aβ) Levels in a Perth Memory, Hollywood Private Hospital Research Foundation, Grant, 2010 ‑ 2014, $14,760.
  • Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Merck Sharp and Dohme Corpe Grant, 2011 ‑ 2014, $265,000.
  • Western Australian Zebrafish Facility, Australian Research Council, Grant - Linkage (Infrastructure), 2014, $620,000.
  • An innovative approach to identify specific biomarkers for early diagnosis of Alzheimer's disease, Australian National University, ANU - Dementia CRC - Grant, 2013 ‑ 2014, $115,000.
  • Protective role of autophagy genes in Alzheimer’s disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014, $10,000.
  • AIBL Carer Extension Study (ACES), Florey Institute of Neuroscience and Mental Health, Wyeth Caregiver Study, 2013 ‑ 2014, $78,396.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2012 Round 16, Department of Health WA, Medical and Health Research Infrastructure, 2013 ‑ 2014, $120,279.
  • Peripheral Clearance of Amyloid-beta (Aβ) using Novel Binding Peptides, Alzhyme Pty Ltd, Grant, 2011 ‑ 2014, $600,000.
  • Dementia Collaborative Research Council - Lipid Profiles in Alzheimer's Disease, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2014, $90,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $494,615.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $352,524.
  • Developing a Zebrafish Model for Alzheimer's Disease, The McCusker Foundation For Alzheimer`s Disease Research, Scholarship, 2009 ‑ 2013, $75,000.
  • 'Deep Within My Soul': Recovering Memory in Bilingual Early Alzheimer's Patients, Edith Cowan University, ECU Industry Collaboration - Grant, 2008 ‑ 2013, $25,282.
  • The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $409,650.
  • Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $529,125.
  • Evaluation of the Nutritional Extract Bio-Curcumax BCM-95 to Preserve Cognitive Functioning, Arjuna Natural Extracts, Grant, 2011 ‑ 2013, $90,641.
  • Alzheimers Disease Research - McCusker Foundation, The McCusker Foundation For Alzheimer`s Disease Research, Grant, 2004 ‑ 2013, $1,568,543.
  • Round 15 Medical and Health Research Infrastructure Fund (MHRIF) 2011, Department of Health WA, Medical and Health Research Infrastructure, 2012 ‑ 2013, $41,708.
  • Assess suitability of multiplexing, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2013, $198,755.
  • Proteomics for discovery of novel biomarkers, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2013, $74,045.
  • Initiating an Indo-Australian cooperation for early diagnosis and prediction in the aged population: Partnering the universities for a tactical approach to Alzheimer's disease and other neurodegenerative conditions, Department of Foreign Affairs and Trade, Australia-India Council, 2011 ‑ 2013, $4,000.
  • The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Science Industry Endowment Fund Agreement, 2010 ‑ 2013, $2,013,000.
  • Discovering Transcriptome and Cytome Biomarkers of Alzheimer's Disease in Isolated Buccal Cells, Commonwealth Scientific and Industrial Research Organisation (CSIRO), CSIRO - Scholarship, 2010 ‑ 2013, $21,000.
  • Evaluation of candidate biomarkers in platelets, Australian National University, ANU - Dementia CRC - Grant, 2011 ‑ 2012, $67,990.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research, National Health and Medical Research Council, Equipment Grant 2011, 2011 ‑ 2012, $10,927.
  • Round 14 - Medical and health research infrastructure fund (MHRIF) 2010, Department of Health WA, Medical and Health Research Infrastructure, 2011 ‑ 2012, $42,757.
  • AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream), Confidential, Confidential, 2011 ‑ 2012, $95,238.
  • A high-throughput protein production and structure facility, Australian Research Council, Grant - Linkage (Infrastructure), 2012, $470,000.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease, National Health and Medical Research Council, Special Call Complementary & Alternative Medicine, 2008 ‑ 2011, $484,675.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization, Australian Research Council, Grant - Linkage (Infrastructure), 2011, $849,590.
  • Round 13 Medical and Health Research Infrastructure Fund, Medical and Health Research Infrastructure Fund, MHRIF - Grant, 2010 ‑ 2011, $36,150.
  • Analysis of Internal Brain Structures using Magnetic Resonance Image - Development of Collaboration with the Perth Neuroscience for Diagnosis of Neurodegenerative Diseases, Commonwealth Scientific and Industrial Research Organisation (CSIRO), CSIRO - Fellowship, 2008 ‑ 2011, $148,500.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 3 (ECUPO3) - Plasma IDE Measurement, Department of Health, Grant, 2010 ‑ 2011, $187,075.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research, National Health and Medical Research Council, Equipment Grant, 2010 ‑ 2011, $10,881.
  • Diets to Defy Dementia, Council On The Ageing (WA) Inc, Grant, 2010 ‑ 2011, $5,000.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro, Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2011, $22,750.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 2 (ECUPO2) - Plasma apoE Measurement, Department of Health, Grant, 2010 ‑ 2011, $100,674.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid, Centre of Excellence for Alzheimers Disease Research and Care, Scholarship, 2006 ‑ 2010, $135,000.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction, Australian Research Council, Grant - Centres of Excellence, 2007 ‑ 2010, $315,000.
  • McCusker Therapeutic Research - Clinical trial, The McCusker Foundation For Alzheimer`s Disease Research, Grant, 2000 ‑ 2010, $322,262.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid, National Health and Medical Research Council, Project Grants, 2007 ‑ 2010, $400,278.
  • CRC for Mental Illness, The Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education , CRC - Grant, 2010, $4,950.
  • The role of APOE as a modulator in recovery from traumatic head injury, Road Safety Council of WA, Neurotrauma Research Program, 2007 ‑ 2010, $126,000.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB), Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2010, $75,000.
  • Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin, National Health and Medical Research Council, Project Grants, 2007 ‑ 2010, $138,344.
  • Centre of Excellence for Alzheimer's Disease Research and Care, Department of Mines and Petroleum, Centre of Excellence, 2005 ‑ 2010, $2,060,186.
  • Round 12 Medical and Health Research Infrastructure Fund, Department of Health WA, Medical and Health Research Infrastructure, 2008 ‑ 2010, $24,648.
  • Round 11 of the Medical & Health Research Infrastructure Fund, Department of Health WA, Medical and Health Research Infrastructure, 2008 ‑ 2010, $16,645.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions, Neurosciences Australia Ltd, Flagship Collaboration Research Fund, 2007 ‑ 2010, $909,328.
  • Factors that Modulate Testosterone Action on Cognition, Well Men Centres Pty Ltd, Fellowship, 2008 ‑ 2009, $68,557.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise, J.O. and J.R. Wicking Trust, Grant, 2005 ‑ 2009, $446,100.
  • A Multidimensional Approach to Enhanced Diagnostics in Alzheimer's Disease, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $367,663.
  • Exercise Physiology, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $252,721.
  • Investigating beta amyloid clearance in vivo, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $207,655.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $193,372.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory, Edith Cowan University, Grant, 2007 ‑ 2008, $12,266.
  • MALDI Imaging and Protein Analysis Facility for WA, Australian Research Council, Grant - Linkage (Infrastructure), 2007 ‑ 2008, $915,000.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model, J.O. and J.R. Wicking Trust, Grant, 2005 ‑ 2008, $25,000.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2), Alzhyme Pty Ltd, Grant, 2005 ‑ 2007, $120,384.
  • Molecular & neuropsychological predictive markers of cognitive decline, National Health and Medical Research Council, Grant, 2005 ‑ 2007, $423,750.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice, Hollywood Private Hospital, Grant, 2006 ‑ 2007, $9,455.
  • Novel peptides as inhibitors of human beta amyloid function, Alzhyme Pty Ltd, Grant, 2005, $22,264.
  • Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system, Ramaciotti Foundation, Grant, 2004 ‑ 2005, $49,000.
  • Biophysical tools for molecular interactions (Biacore), Australian Research Council, Grant - Linkage (Infrastructure), 2005, $352,000.

Research Student Supervision

Principal Supervisor

  • Doctor of Philosophy, Role of the hdl subclasses in the modulation of beta amyloid oligomers in alzheimer's disease
  • Master of Medical and Health Science by Research, Investigating protective effects of grape seed extract (GSE) on amyloid beta induced mitochondrial and neuronal toxicity in an Alzheime's disease (AD) cell model
  • Doctor of Philosophy, In vitro assessment of potential effects of polyphenol extracts from sorghum on alzheimer's disease

Associate Supervisor

  • Doctor of Philosophy, Studying posttranslational modifications - a novel approach to blood-based protein biomarkers for alzheimer's disease

Principal Supervisor

  • Doctor of Philosophy, Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing alzheimer's risk
  • Doctor of Philosophy, Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer's disease
  • Doctor of Philosophy, Pharmacological modulation of learning and memory in mice and zebrafish: Implications for alzheimers disease animal models.
  • Master of Science (Human Biology), Plasma insulin-degrading enzyme: Characterisation and evaluation as a potential biomarker for alzheimer's disease.
  • Doctor of Philosophy, Identifying gamma secretase enzyme domains responsible for the generation of alzheimer's beta amyloid protein.
  • Doctor of Philosophy, Yeast as a model for studying ab aggregation, toxicity and clearance
  • Doctor of Philosophy, Role of testosterone in prevention of alzheimer's disease.
  • Doctor of Philosophy, Impact of nutrition on cognition and its association with blood and brain alzheimer disease related biomarkers
  • Doctor of Philosophy, Investigating the impact of cd147 and its expression on neuordegeneration and alzheimer's disease ad
  • Master of Science (Human Biology), The role of luteninizing hormone (lh) and human chorionic gonadotropin (hcg) in the aetiology of alzheimer's disease.
  • Doctor of Philosophy, Discovery of new biomarkers of mild cognitive impairment and alzheimer's disease risk in buccal cells using laser scanning cytometry.
  • Doctor of Philosophy, Identification of plasma lipid biomarkers in alzheimer's disease.

Associate Supervisor

  • Master of Science (Sports Science), Effects of long-term participation in tennis on cognitive function in elderly individuals
  • Doctor of Philosophy, Evolutionary approaches for feature selection in biological data
  • Doctor of Philosophy, Utility of CSF Biomarkers for the Diagnosis, Prognosis and Assessment of Cognitive Decline in Alzheimer’s disease
  • Doctor of Philosophy, Comparing live to recorded music and stories using multiple psychoneuroendocrine and psychological measures
Skip to top of page