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Professor Ralph Martins AO

Chair in Aging & Alzheimers Disease

Staff Member Details
Telephone: +61 8 6304 5456
Facsimile: +61 8 6304 5851
Email: r.martins@ecu.edu.au
Campus: Joondalup  
Room: JO17.314  

Ralph is the Foundation Chair in Aging and Alzheimer's Disease within the School of Medical and Health Sciences.

Background

Professor Ralph Martins, Foundation Chair in Aging and Alzheimer’s Disease at Edith Cowan University, was appointed the Director of the Centre.  Ralph Martins graduated from University of Western Australia with a PhD in 1986. In 1987 he won a scholarship to Heidelberg University to work with Konrad Beyreuther. His collaborative seminal research involved isolating and characterising beta-amyloid and its precursor, the amyloid precursor protein (APP), which are now recognized as central to the pathogenesis of Alzheimer's disease.

He was the first to propose and demonstrate that the Alzheimer brain was under oxidative stress, which is now widely recognized by the Alzheimer research community. In 1989 he joined Professor Masters at Melbourne University where he was the first to isolate and characterize the molecular components of the neuropathological hallmarks of Alzheimer’s disease. This led to an international patent and formation of a spin-off company, Alzhyme Pty Ltd. In 2001 he won a Media Fellowship with the ABC and was the first Media Fellow to have his work on the Science Show. In 2002 he won a Biotechnology Innovation Fund grant, which was matched by commercial funding. He established the Sir James McCusker Alzheimer’s Research Unit at Hollywood Hospital, whose research is directed at the cause(s), and development of diagnostics and treatments. He received the UWA "Excellence in Teaching Award - Post Graduate Research" for 2002 and in 2003 was appointed Senior Editor, for the Journal of Alzheimer’s Disease and Editorial Board Member for Current Drug Targets CNS & Neurological Disease.

Edith Cowan University appointed him to the Inaugural Chair, Ageing and Alzheimer’s Disease in 2004. He has Adjunct Professorial positions and close ties with clinical academics with both the University of Western Australia and Thomas Jefferson University’s Farber Neurosciences Institute. He is instigator and director of the state government funded Centre of Excellence for Alzheimer’s Disease Research and Care composed of researchers from 4 universities, 3 hospitals and 2 healthcare providers.

  • 2004-2006: Professor – Inaugural Chair, Ageing and Alzheimer’s Disease, Edith Cowan University, Western Australia
  • 2004: Adjunct Professor School of Psychiatry & Clinical Neurosciences,University of Western Australia, Adjunct Professor, School of Biomedical Science
    Curtin University of Technology
  • 2001-2002: Associate Professor, Department of Psychiatry and Neurogenetics,University of Western Australia, Hollywood Private Hospital, Western Australia
  • 2001-2004: Professor on Staff, Research Centre and Community Services,Universitas Peila Harapan, Karawaci, Tangerang, Indonesia
  • 1998-2003: Adjunct Associate Professor, School of Biomedical Science,Curtin University
  • 1997-2001: Senior Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1997-1998:Adjunct Teaching Fellow, Curtin University, Western Australia
  • 1990-1997: Research Fellow in Surgery, Hollywood Private Hospital, University of Western Australia, Nedlands, Perth, Western Australia
  • 1989: Senior Research Officer, Department of Pathology, University of Melbourne
  • 1984-1988: Research Scientist, Department of Pathology, University of Western Australia
  • 1983-1988: Permanent Part-time Clinical Biochemist, Department of Pathology, King Edward Memorial Hospital for Women
  • 1980-1984: Tutor of 2nd and 3rd year   medical students in Biochemistry at the University of Western Australia
  • 1979-1983: Demonstrator of 2nd year Biochemistry

Professional Memberships

  • 1980-1997; 2000-2004: Australian Society for Biochemistry and Molecular Biology
  • 1982-1997: Australian Society for Medical Research
  • 1984-2002: Australian Neuroscience Society
  • 1984-1991: Australian Nutrition Foundation
  • 1991-2002: Surgical Research Society of Australasia
  • 1991-2004: Australian Association of Gerontology (WA)
  • 1992-2004: Alzheimer’s Association (WA)
  • 1996-2004: Society of Neuroscience (USA)
  • 2000-2004: The Australian Menopause Society
  • 2002-2004: Human Genetics Society of Australia
  • 2003-2004: European Society of Human Genetics Dementia & Neurodegenerative DISeases Group (DANDIS)

Research Areas and Interests

Ralph's current research interests are focused on understanding the mechanisms and factor(s) leading to the abnormal release and deposition of βA4 in Alzheimer's disease.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 1987.

Research

Recent Research Grants

  • The AUstralian-multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention (AU-ARROW) Study,  National Health and Medical Research Council,  MRFF International Clinical Trial Collaborations grant program,  2020 - 2024,  $1,411,151.
  • In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease,  National Foundation for Medical Research and Innovation,  NFMRI - Grant,  2020 - 2023,  $170,000.
  • In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease (AD),  CWEK Pty Ltd,  Industry Engagement Scholarship to support PhD projects,  2018 - 2023,  $32,500.
  • The Australian Dementia Network (ADNeT): Bringing together Australia’s dementia stakeholders,  National Health and Medical Research Council,  Boosting Dementia Research Grants Scheme,  2019 - 2023,  $529,896.
  • In vitro assessment to evaluate the potential effect of Gallic acid on Alzheimer’s disease,  Al Faris Food Industries Pvt. Ltd.,  Industry Engagement Scholarship to support MBR projects,  2018 - 2023,  $39,000.
  • AIBL: Agreement with Biogen for provision of AIBL Data and samples,  Florey Institute of Neuroscience and Mental Health,  Grant,  2016 - 2022,  $2,424,071.
  • A systems epidemiology approach to define metabolic and genomic determinants of Alzheimer's disease ,  National Health and Medical Research Council,  Project Grants,  2019 - 2022,  $458,851.
  • Improving sleep to promote healthy brain aging: an intervention study ,  Alzheimer's Association USA,  Alzheimer's Association Research Grant,  2019 - 2022,  $220,992.
  • Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort,  National Health and Medical Research Council,  Project Grants,  2017 - 2022,  $1,125,804.
  • Dominantly Inherited Alzheimer Network,  Washington University,  Grant,  2019 - 2021,  $380,000.
  • WA Memory Study (WAMS),  Australian Alzheimer's Research Foundation,  McCusker Alzheimer's Research Foundation - Grant,  2019 - 2021,  $236,746.
  • Medical and Health Research Infrastructure Fund 2019 (Round 23),  Department of Health WA,  Medical and Health Research Infrastructure,  2020 - 2021,  $122,964.
  • Sponsorship of Research Fellow (Kevin Taddei),  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2020,  $210,393.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22),  Department of Health WA,  Medical and Health Research Infrastructure,  2019 - 2020,  $150,771.
  • Sponsorship of Research Fellow (Kevin Taddei),  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2019,  $90,198.
  • Sponsorship of Research Fellow (Hamid Soharbi),  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2019,  $47,130.
  • Sponsorship Agreement Post-Doctoral Research Fellow,  Australian Alzheimer's Research Foundation,  Neuroscience Research Institute - Sponsorship,  2018 - 2019,  $94,922.
  • High-frequency ultrasound and photoacoustic imaging for Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2018 - 2019,  $631,198.
  • Genetic Linkages to mTOR pathway dysregulation and development of Alzheimers Disease,  CRC For Mental Health,  WES Study,  2015 - 2019,  $524,000.
  • Investigating underlying mechanisms linking Type 2 diabetes with Alzheimer's disease pathology,  National Health and Medical Research Council,  Project Grants,  2016 - 2019,  $100,000.
  • Dominantly Inherited Alzheimer Network,  Washington University,  Grant,  2009 - 2019,  $1,398,587.
  • 4.4B1 Novel Therapeutics for AD Testosterone Trial,  CRC For Mental Health,  CRC Grant,  2011 - 2018,  $1,068,045.
  • 4.6 - Biomarkers for Schizophrenia Sub-Types - Part A Neuroimaging, Part B Biomarker Discovery,  CRC For Mental Health,  CRC Grant,  2011 - 2018,  $1,202,364.
  • 4.1 Biomarkers for Early Diagnosis of AD and PD,  CRC For Mental Health,  CRC Grant,  2011 - 2018,  $7,524,765.
  • Developing a blood-based biomarker panel for Alzheimer's disease,  BrightFocus Foundation,  Alzheimer's Disease Research - Postdoctoral Fellowship Awards,  2015 - 2018,  $126,876.
  • Biomarkers and Early Intervention for Neurodegeneration,  CRC For Mental Health,  CRC Grant,  2012 - 2018,  $674,185.
  • The contribution of sleep factors to healthy cognitive ageing: A pilot sleep-specific cognitive behavioural intervention study,  Equity Trustees Limited,  Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation),  2017 - 2018,  $60,000.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20),  Department of Health WA,  Medical and Health Research Infrastructure,  2017 - 2018,  $158,564.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2015 (Round 19),  Department of Health WA,  Medical and Health Research Infrastructure,  2016 - 2017,  $193,336.
  • The effect of high-intensity exercise on Alzheimer’s disease-related gene expression,  Brain Foundation,  Research Gifts Program,  2017,  $39,875.
  • Head Injury and Testosterone (HIT),  Harry Perkins Institute of Medical Research,  Neurotrauma Research Program,  2013 - 2017,  $148,701.
  • Development and refinement of methods for early and specific diagnosis of Alzheimer's disease, quantification of rates of change in the pathological processes and determination of the resultant effects on cognition.,  Fil Foundation,  Grant,  2015 - 2017,  $417,506.
  • High resolution mass spectrometry for metabolomics and proteomics research,  Australian Research Council,  Grant - Linkage (Infrastructure),  2015 - 2016,  $1,450,000.
  • Mass Cytometry: A breakthrough in multidimensional systems biology,  Australian Research Council,  Grant - Linkage (Infrastructure),  2015 - 2016,  $1,081,489.
  • Use of coconut oil as a novel neuro protective agent for Alzheimer’s disease,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $9,203.
  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease,  National Health and Medical Research Council,  Project Grants,  2013 - 2016,  $536,949.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. ,  Hollywood Private Hospital Research Foundation,  Grant,  2013 - 2016,  $20,000.
  • The influence of exercise intensity on the prevention of cognitive decline in older adults,  Dementia Australia Research Foundation,  AADRF - Postdoctoral Fellowships,  2014 - 2016,  $238,034.
  • Exercise intensity and prevention of cognitive decline in older adults,  Edith Cowan University,  ECU Early Career Researcher Grant - 2015,  2015 - 2016,  $24,066.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2014 Round 18,  Department of Health WA,  Medical and Health Research Infrastructure,  2015 - 2016,  $230,341.
  • Continuation of the 15M S.A work & In vitro testing of the Phylomers,  Alzhyme Pty Ltd,  Grant,  2015,  $111,674.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease,  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2014 - 2015,  $12,555.
  • A study of the kinetics of biomarkers and their presumptive relationship with brain amyloid ,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Araclon Biotech ,  2014 - 2015,  $132,200.
  • Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease.,  Hollywood Private Hospital Research Foundation,  Grant,  2015,  $15,000.
  • Establishing a combined ocular and blood biomarker panel for Alzheimer’s disease.,  Australian National University,  ANU - Dementia CRC - Grant,  2014 - 2015,  $517,977.
  • Progressing the clinical neuropsychological phenotype of Alzheimer's disease.,  Florey Institute of Neuroscience and Mental Health,  Grant,  2014 - 2015,  $107,935.
  • Ocular Imaging Project NeuroVision Imaging,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  NeuroVision Imaging, LLC Grant,  2013 - 2015,  $152,999.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2013 (Round 17),  Department of Health WA,  Medical and Health Research Infrastructure,  2014 - 2015,  $186,666.
  • Personality dimensions and increased risk of late onset Alzheimer's disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014 - 2015,  $15,000.
  • CSIRO/Janssen AIBL Neuroscience Program,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Janssen Neuroscience Program,  2014 - 2015,  $231,018.
  • A Pilot Clinical Study to Evaluate the Potential of AMLAMAX™ (Emblica Officinalis) Extract on Raising HDL-Cholesterol Levels and Decreasing Plasma Amyloid beta (Aβ) Levels in a Perth Memory,  Hollywood Private Hospital Research Foundation,  Grant,  2010 - 2014,  $14,760.
  • Investigation of Biomarkers of Disease State in Alzheimer's Disease and Non-AD Dementias,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Merck Sharp and Dohme Corpe Grant,  2011 - 2014,  $265,000.
  • Western Australian Zebrafish Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $682,000.
  • An innovative approach to identify specific biomarkers for early diagnosis of Alzheimer's disease,  Australian National University,  ANU - Dementia CRC - Grant,  2013 - 2014,  $115,000.
  • Protective role of autophagy genes in Alzheimer’s disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014,  $10,000.
  • AIBL Carer Extension Study (ACES),  Florey Institute of Neuroscience and Mental Health,  Wyeth Caregiver Study,  2013 - 2014,  $87,840.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2012 Round 16,  Department of Health WA,  Medical and Health Research Infrastructure,  2013 - 2014,  $120,279.
  • Peripheral Clearance of Amyloid-beta (Aβ) using Novel Binding Peptides,  Alzhyme Pty Ltd,  Grant,  2011 - 2014,  $800,000.
  • Dementia Collaborative Research Council - Lipid Profiles in Alzheimer's Disease,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2014,  $90,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $494,615.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $352,524.
  • Developing a Zebrafish Model for Alzheimer's Disease,  The McCusker Foundation For Alzheimer`s Disease Research,  Scholarship,  2009 - 2013,  $75,000.
  • 'Deep Within My Soul': Recovering Memory in Bilingual Early Alzheimer's Patients,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2008 - 2013,  $84,302.
  • The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro,  National Health and Medical Research Council,  Grant,  2010 - 2013,  $409,650.
  • Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease,  National Health and Medical Research Council,  Grant,  2010 - 2013,  $529,125.
  • Evaluation of the Nutritional Extract Bio-Curcumax BCM-95 to Preserve Cognitive Functioning,  Arjuna Natural Extracts,  Grant,  2011 - 2013,  $90,641.
  • Alzheimers Disease Research - McCusker Foundation,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2004 - 2013,  $1,568,543.
  • Round 15 Medical and Health Research Infrastructure Fund (MHRIF) 2011,  Department of Health WA,  Medical and Health Research Infrastructure,  2012 - 2013,  $41,708.
  • Assess suitability of multiplexing,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2013,  $241,785.
  • Proteomics for discovery of novel biomarkers,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2013,  $117,075.
  • Initiating an Indo-Australian cooperation for early diagnosis and prediction in the aged population: Partnering the universities for a tactical approach to Alzheimer's disease and other neurodegenerative conditions,  Department of Foreign Affairs and Trade,  Australia-India Council,  2011 - 2013,  $4,000.
  • The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Science Industry Endowment Fund Agreement,  2010 - 2013,  $5,341,586.
  • Discovering Transcriptome and Cytome Biomarkers of Alzheimer's Disease in Isolated Buccal Cells,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  CSIRO - Scholarship,  2010 - 2013,  $21,000.
  • Evaluation of candidate biomarkers in platelets,  Australian National University,  ANU - Dementia CRC - Grant,  2011 - 2012,  $89,020.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.
  • Round 14 - Medical and health research infrastructure fund (MHRIF) 2010,  Department of Health WA,  Medical and Health Research Infrastructure,  2011 - 2012,  $42,757.
  • AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream),  Confidential,  Confidential,  2011 - 2012,  $95,238.
  • A high-throughput protein production and structure facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012,  $470,000.
  • Do Combinations of Nutritional Supplements Help in the Prevention of Alzheimer's disease,  National Health and Medical Research Council,  Special Call Complementary & Alternative Medicine,  2008 - 2011,  $484,675.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization,  Australian Research Council,  Grant - Linkage (Infrastructure),  2011,  $849,590.
  • Round 13 Medical and Health Research Infrastructure Fund,  Medical and Health Research Infrastructure Fund,  MHRIF - Grant,  2010 - 2011,  $36,150.
  • Analysis of Internal Brain Structures using Magnetic Resonance Image - Development of Collaboration with the Perth Neuroscience for Diagnosis of Neurodegenerative Diseases,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  CSIRO - Fellowship,  2008 - 2011,  $148,500.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 3 (ECUPO3) - Plasma IDE Measurement,  Department of Health,  Grant,  2010 - 2011,  $187,075.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant,  2010 - 2011,  $10,881.
  • Diets to Defy Dementia,  Council On The Ageing (WA) Inc,  Grant,  2010 - 2011,  $5,000.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2011,  $22,750.
  • Dementia Collaborative Research Centre (Round2): Early Diagnosis and Prevention - PROJECT 2 (ECUPO2) - Plasma apoE Measurement,  Department of Health,  Grant,  2010 - 2011,  $100,674.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid,  Centre of Excellence for Alzheimers Disease Research and Care,  Scholarship,  2006 - 2010,  $135,000.
  • Dementia Collaborative Research Centre: Prevention, Early Intervention and Risk Reduction,  Australian Research Council,  Grant - Centres of Excellence,  2007 - 2010,  $315,000.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2000 - 2010,  $322,262.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $400,278.
  • CRC for Mental Illness,  The Department of Industry, Innovation, Climate Change, Science, Research and Tertiary Education ,  CRC - Grant,  2010,  $4,950.
  • The role of APOE as a modulator in recovery from traumatic head injury,  Road Safety Council of WA,  Neurotrauma Research Program,  2007 - 2010,  $126,000.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2010,  $75,000.
  • Truncating presenilin mutations and their effects on gamma-secretase activity, tau and beta-catenin,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $138,344.
  • Centre of Excellence for Alzheimer's Disease Research and Care,  Department of Mines and Petroleum,  Centre of Excellence,  2005 - 2010,  $2,060,186.
  • Round 12 Medical and Health Research Infrastructure Fund,  Department of Health WA,  Medical and Health Research Infrastructure,  2008 - 2010,  $24,648.
  • Round 11 of the Medical & Health Research Infrastructure Fund,  Department of Health WA,  Medical and Health Research Infrastructure,  2008 - 2010,  $16,645.
  • Detecting and preventing Alzheimer's Disease: Towards diet and lifestyle interventions,  Neurosciences Australia Ltd,  Flagship Collaboration Research Fund,  2006 - 2010,  $909,328.
  • Factors that Modulate Testosterone Action on Cognition,  Well Men Centres Pty Ltd,  Fellowship,  2008 - 2009,  $68,557.
  • Keeping the aged healthy, happy and independent through physical and cognitive exercise,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2009,  $446,100.
  • A Multidimensional Approach to Enhanced Diagnostics in Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $367,663.
  • Exercise Physiology,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $252,721.
  • Investigating beta amyloid clearance in vivo,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $207,655.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $193,372.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory,  Edith Cowan University,  Grant,  2007 - 2008,  $12,266.
  • MALDI Imaging and Protein Analysis Facility for WA,  Australian Research Council,  Grant - Linkage (Infrastructure),  2007 - 2008,  $915,000.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2008,  $25,000.
  • Novel peptides as inhibitors of human beta amyloid function (Stage 2),  Alzhyme Pty Ltd,  Grant,  2005 - 2007,  $120,384.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health and Medical Research Council,  Grant,  2005 - 2007,  $423,750.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice,  Hollywood Private Hospital,  Grant,  2006 - 2007,  $9,455.
  • Novel peptides as inhibitors of human beta amyloid function,  Alzhyme Pty Ltd,  Grant,  2005,  $22,264.
  • Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system,  Ramaciotti Foundation,  Grant,  2004 - 2005,  $49,000.
  • Biophysical tools for molecular interactions (Biacore),  Australian Research Council,  Grant - Linkage (Infrastructure),  2005,  $352,000.

Recent Publications (within the last five years)

Book Chapters

  • Shah, T., Martins, R., (2017), Synergistic effects of combined physical activity and brain training on neurological functions. Physical activity and the aging brain: Effects of exercise on neurological function, 175-184, United States, Elsevier, DOI: 10.1016/B978-0-12-805094-1.00017-4.

Journal Articles

  • Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P., Doecke, J., Ames, D., Laws, S., Fowler, C., Rainey-Smith, S., Martins, R., Maruff, P., Villemagne, V., Masters, C., Rowe, C., Fripp, J., Salvado, O., (2020), Comorbidity of Cerebrovascular and Alzheimer’s Disease in Aging. Journal of Alzheimer's Disease, In Press(Sept), 1-14, Netherlands, IOS Press, DOI: 10.3233/JAD-200419.
  • Bharadwaj, P., Martins, R., (2020), Autophagy modulates Aβ accumulation and formation of aggregates in yeast. Molecular and Cellular Neuroscience, 104(April 2020), Article 103466, DOI: 10.1016/j.mcn.2020.103466.
  • Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P., (2020), Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(Nov), Article number 5698, DOI: https://doi.org/10.1038/s41467-020-19473-7.
  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Martins, R., Peiffer, J., (2020), An intense, but ecologically valid, resistance exercise session does not alter growth factors associated with cognitive health. Journal of Aging and Physical Activity, 28(4), 605-612, DOI: 10.1123/japa.2019-0100.
  • Frost, N., Weinborn, M., Gignac, G., Rainey-Smith, S., Markovic, S., Gordon, N., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., Brown, B., (2020), A Randomized Controlled Trial of High-Intensity Exercise and Executive Functioning in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, Online(June), 12p., DOI: https://doi.org/10.1016/j.jagp.2020.06.015.
  • Dhiman, K., Gupta, V., Villemagne, V., Eratne, D., Graham, P., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Bush, A., Rowe, C., Masters, C., Ames, D., Hone, E., Blennow, K., Zetterberg, H., Martins, R., (2020), Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer’s disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 12(1), Article number e12005, DOI: 10.1002/dad2.12005.
  • Arnold, M., Nho, K., Kueder-Paisley, A., Massaro, T., Huynh, K., Brauner, B., Mahmoudian Dehkordi, S., Louie, G., Moseley, M., Thompson, JW., St John-Williams, L., Tenenbaum, J., Blach, C., Chang, R., Brinton, R., Baillie, R., Han, X., Trojanowski, J., Shaw, L., Martins, R., Weiner, M., Trushina, E., Toledo, J., Meikle, P., Bennett, D., Krumsiek, J., Murali Doraiswamy, P., Saykin, A., Kaddurah-Daok, R., Kastenmuller, G., (2020), Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome. Nature Communications, 11(1), Article number 1148, DOI: 10.1038/s41467-020-14959-w.
  • Thota, R., Rosato, J., Burrows, T., Dias, C., Abbott, K., Martins, R., Garg, M., (2020), Docosahexaenoic acid-rich fish oil supplementation reduces kinase associated with insulin resistance in overweight and obese midlife adults. Nutrients, 12(6), Article 1612, DOI: 10.3390/nu12061612.
  • Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Shen, K., Asih, P., Dave, P., Pedrini, S., Ashton, N., Hye, A., Taddei, K., Lovejoy, D., Zetterberg, H., Blennow, K., Martins, R., (2020), Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(2020), 291-301, Netherlands, IOS Press, DOI: 10.3233/JAD-200162.
  • Jayakody, D., Menegola, H., Yiannos, J., Goodman-Simpson, J., Friedland, P., Taddei, K., Laws, S., Weinborn, M., Martins, R., Sohrabi, H., (2020), The peripheral hearing and Central Auditory Processing skills of individuals with subjective memory complaints. Frontiers in Neuroscience, 14(August), Article 888, DOI: 10.3389/fnins.2020.00888.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R., (2020), Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744, Netherlands, IOS Press, DOI: 10.3233/JAD-200291.
  • Chatterjee, P., Fernando, M., Fernando, B., Dias, C., Shah, T., Silva, R., Williams, S., Pedrini, S., Hillebrandt, H., Goozee, K., Barin, E., Sohrabi, H., Garg, M., Cunnane, S., Martins, R., (2020), Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development, 186(March 2020), Article number 111209, DOI: 10.1016/j.mad.2020.111209.
  • Brini, S., Sohrabi, H., Hebert, J., Forrest, M., Laine, M., Hamalainen, H., Karrasch, M., Peiffer, J., Martins, R., Fairchild, T., (2020), Bilingualism Is Associated with a Delayed Onset of Dementia but Not with a Lower Risk of Developing it: a Systematic Review with Meta-Analyses. Neuropsychology Review, 30(March 2020), 24 p., DOI: 10.1007/s11065-020-09426-8.
  • Lai, M., Ames, D., Cox, K., Ellis, K., Sharman, M., Hepworth, G., Desmond, P., Cyarto, E., Szoeke, C., Martins, R., Masters, C., Lautenschlager, N., (2020), Association between cognitive function and clustered cardiovascular risk of metabolic syndrome in older adults at risk of cognitive decline. Journal of Nutrition, Health and Aging, 24(3), 300-304, DOI: 10.1007/s12603-020-1333-4.
  • Aschenbrenner, A., James, B., McDade, E., Wang, G., Lim, YY., Benzinger, T., Cruchaga, C., Goate, A., Xiong, C., Perrin, R., Buckles, V., Allegri, R., Berman, S., Chhatwal, J., Fagan, A., Farlow, M., O'Connor, A., Ghetti, B., Graff-Radford, N., Goldman, J., Gräber, S., Karch, C., Lee, J., Levin, J., Martins, R., Masters, C., Mori, H., Noble, J., Salloway, S., Schofield, P., Morris, J., Bateman, R., Hassenstab, J., (2020), Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's and Dementia, 16(1), 219-228, United States, Elsevier Science Inc., DOI: 10.1002/alz.12010.
  • Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D., (2020), Aggregation of Abnormal Memory Scores and Risk of Incident Alzheimer’s Disease Dementia: A Measure of Objective Memory Impairment in Amnestic Mild Cognitive Impairment. Journal of the International Neuropsychological Society, Online(Aug), 12p., DOI: 10.1017/S135561772000079X.
  • Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R., (2020), Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733, Netherlands, IOS Press, DOI: 10.3233/JAD-191033.
  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V., (2020), Impact of APOE-ε4 carriage on the onset and rates of neocortical A-β amyloid deposition. Neurobiology of Aging, 95(2020), 46-55, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2020.06.001.
  • Shen, K., Welton, T., Lyon, M., McCorkindale, A., Sutherland, G., Burnham, S., Fripp, J., Martins, R., Grieve, S., (2020), Structural core of the executive control network: A high angular resolution diffusion MRI study. Human Brain Mapping, 41(5), 1226-1236, DOI: 10.1002/hbm.24870.
  • Krishnan, S., Shrestha, Y., Jayatunga, P., Rea, S., Martins, R., Bharadwaj, P., (2020), Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease. International Journal of Molecular Sciences, 21(18), Article 6739, DOI: 10.3390/ijms21186739.
  • Siddiqui, M., Francois, M., Rainey-Smith, S., Martins, R., Masters, C., Ames, D., Rowe, C., Macaulay, L., Fenech, M., Leifert, W., (2020), Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer’s Disease in the AIBL Study of Ageing. Life, 10(8), Article 141, DOI: 10.3390/life10080141.
  • Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P., (2020), Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356, DOI: 10.1038/s41598-020-66602-9.
  • Lim, B., Fowler, C., Li, Q., Rowe, C., Dhiman, K., Gupta, V., Masters, C., Doecke, J., Martins, R., Collins, S., Diamandi, E., (2020), Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Aβ load and cerebrospinal fluid Aβ in a pilot study of Alzheimer’s disease. Neuroscience Letters, 731(13 July 2020), Article number 135078, DOI: 10.1016/j.neulet.2020.135078.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R., (2020), Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, epub ahead of print(2020), 14p., United Kingdom, Wiley-Blackwell Publishing Ltd, DOI: 10.1111/jnc.15128.
  • Jayakody, D., Tarawneh, H., Menegola, H., Yiannos, J., Friedland, P., Wilson, W., Martins, R., Sohrabi, H., (2020), Systematic review protocol for assessing central auditory functions of Alzheimer’s disease and its preclinical stages. BMJ Open, 10(2020), e033342, DOI: 10.1136/bmjopen-2019-033342.
  • Lai, M., Sharman, M., Ames, D., Ellis, K., Cox, K., Hepworth, G., Desmond, P., Cyarto, E., Martins, R., Masters, C., Lautenschlager, N., (2020), Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration. Journal of Alzheimer's Disease, 74(1), 163-171, Netherlands, IOS Press, DOI: 10.3233/JAD-190953.
  • Yassi, N., Hilal, S., Xia, Y., Lim, YY., Watson, R., Kuijf, H., Fowler, C., Yates, P., Maruff, P., Martins, R., Ames, D., Chen, C., Rowe, C., Villemagne, V., Salvado, O., Desmond, P., Masters, C., (2020), Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease. Journal of Alzheimer's Disease, 73(3), 897-907, Netherlands, IOS Press, DOI: 10.3233/JAD-191028.
  • Thota, R., Rosato, J., Dias, C., Burrows, T., Martins, R., Garg, M., (2020), Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease. Nutrients, 12(4), Article number 1032, DOI: 10.3390/nu12041032.
  • Bharadwaj, P., Martins, R., (2020), A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast. Neural Regeneration Research, 15(10), 1931-1936, DOI: 10.4103/1673-5374.280318.
  • Tarawneh, H., Mulders, W., Sohrabi, H., Martins, R., Jayakody, D., (2020), Auditory electrophysiological assessments of Alzheimer’s disease and preclinical stages: protocol for a systematic review and meta-analysis. BMJ Open, 10(2020), e033308, DOI: 10.1136/bmjopen-2019-033308.
  • Bharadwaj, P., Martins, R., (2020), PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-B Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease, 74(2), 441-448, Netherlands, IOS Press, DOI: 10.3233/JAD-190948.
  • Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R., (2020), Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315, Netherlands, IOS Press, DOI: 10.3233/JAD-191304.
  • Barthelemy, N., Li, Y., Joseph-Marthurin, N., Gordon, B., Hassenstab, J., Benzinger, T., Buckles, V., Fagan, A., Perrin, R., Goate, A., Morris, J., Karch, C., Xiong, C., Allegri, R., Mendez, P., Berman, S., Ikeuchi, T., Mori, H., Shimada, H., Shoji, M., Suzuki, K., Noble, J., Farlow, M., Chhatwal, J., Graff-Radford, N., Salloway, S., Schofield, P., Masters, C., Martins, R., O'Connor, A., Fox, N., Levin, J., Jucker, M., Gabelle, A., Lehmann, S., Sato, C., Bateman, R., McDade, E., (2020), A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine, 26(3), 398-407, DOI: 10.1038/s41591-020-0781-z.
  • Ashraf, A., Ashton, N., Chatterjee, P., Goozee, K., Shen, K., Fripp, J., Ames, D., Rowe, C., Masters, C., Villemagne, V., Hye, A., Martins, R., So, P., (2020), Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer’s disease pathology. Alzheimer's Research and Therapy, 12(June 2020), Article number 72, United Kingdom, DOI: 10.1186/s13195-020-00634-1.
  • Doecke, J., Ward, L., Burnham, S., Villemagne, V., Li, Q., Collins, S., Fowler, C., Manuilova, E., Widmann, M., Rainey-Smith, S., Martins, R., Masters, C., (2020), Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid- PET imaging. Alzheimer's Research and Therapy, 12(March 2020), Article number 36, DOI: 10.1186/s13195-020-00595-5.
  • Sohrabi, H., Goozee, K., Weinborn, M., Shen, K., Brown, B., Rainey-Smith, S., Salvado, O., Taddei, K., Bucks, R., Maruff, P., Laws, S., Lenzo, N., Laws, M., Deyoung, C., Speelman, C., Laske, C., Ames, D., Savage, G., Martins, R., (2020), Personality factors and cerebral glucose metabolism in community‑dwelling older adults. Brain Structure and Function, 225(5), 1511–1522, DOI: 10.1007/s00429-020-02071-0.
  • Tripathi, T., Kalita, P., Martins, R., Bharadwaj, P., (2019), Autophagy promotes memory function. ACS Chemical Neuroscience, 10(8), 3337-3339, DOI: 10.1021/acschemneuro.9b00317.
  • Tan, J., Iyer, K., Tang, A., Jamil, A., Martins, R., Sohrabi, H., Nitsche, M., Hinder, M., Fujiyama, H., (2019), Modulating functional connectivity with non-invasive brain stimulation for the investigation and alleviation of age-associated declines in response inhibition: A narrative review. NeuroImage, 185(15 January 2019), 490-512, DOI: 10.1016/j.neuroimage.2018.10.044.
  • Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C., Jacobs, K., Ashton, N., Hye, A., Pedrini, S., Sohrabi, H., Shah, T., Asih, P., Dave, P., Shen, K., Taddei, K., Lovejoy, D., Guillemin, G., Blennow, K., Martins, R., (2019), Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease. Journal of Neuroinflammation, 16(2019), Article number 186, DOI: 10.1186/s12974-019-1567-4.
  • Frost, N., Weinborn, M., Gignac, G., Markovic, S., Rainey-Smith, S., Sohrabi, H., Martins, R., Peiffer, J., Brown, B., (2019), Higher cardiorespiratory fitness is associated with better verbal generativity in community-dwelling older adults. Journal of Aging and Physical Activity, 27(5), 703-710, DOI: 10.1123/japa.2018-0382.
  • Moshfegh, A., Javadzadegan, A., Mohammadi, M., Ravipudi, L., Cheng, S., Martins, R., (2019), Development of an innovative technology to segment luminal borders of intravascular ultrasound image sequences in a fully automated manner. Computers in Biology and Medicine, 108(May 2019), 111-121, DOI: 10.1016/j.compbiomed.2019.03.008.
  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S., (2019), Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069, DOI: 10.1038/s41598-019-53604-5.
  • Jacobs, K., Lim, C., Blennow, K., Zetterberg, H., Chatterjee, P., Martins, R., Brew, B., Guillemin, G., Lovejoy, D., (2019), Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer’s disease and relationship to amyloid-b and tau. Neurobiology of Aging, 80(August 2019), 11-20, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2019.03.015.
  • Babulal, G., Quiroz, Y., Albensi, B., Arenaza-Urquijo, E., Astell, A., Babiloni, C., Bahar-Fuchs, A., Bell, J., Bowman, G., Brickman, A., Chetelat, G., Ciro, C., Cohen, A., Dilworth-Anderson, P., Dodge, H., Dreux, S., Edland, S., Esbensen, A., Evered, L., Ewers, M., Fargo, K., Fortea, J., Gonzalez, H., Gustafson, D., Head, E., Hendrix, J., Hofer, S., Johnson, L., Jutten, R., Kilborn, K., Lanctot, K., Manly, J., Martins, R., Mielke, M., Morris, M., Murray, M., Oh, E., Parra, M., Rissman, R., Roe, C., Santos, O., Scarmeas, N., Schneider, L., Schupf, N., Sikkes, S., Snyder, H., Sohrabi, H., Stern, Y., Strydom, A., Tang, Y., Terrera, G., Teunissen, C., Van Lent, DM., Weinborn, M., Wesselman, L., Wilcock, D., Zetterberg, H., O’bryant, S., (2019), Perspectives on ethnic and racial disparities in Alzheimer’s disease and related dementias: Update and areas of immediate need. Alzheimer's and Dementia, 15(2), 292-312, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2018.09.009.
  • Nasef, N., Loveday, S., Golding, M., Martins, R., Shah, T., Clarke, M., Coad, J., Moughan, P., Garg, M., Singh, H., (2019), Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans. Food and Function, 10(8), 4584-4592, DOI: 10.1039/c9fo01063g.
  • Schultz, A., Kloet, R., Sohrabi, H., Van Der Weerd, L., Van Rooden, S., Wermer, M., Moursel, L., Yaqub, M., Van Berckel, B., Chatterjee, P., Kirby, S., Taddei, K., Fagan, A., Benzinger, T., Morris, J., Sperling, R., Johnson, K., Bateman, R., Gurol, ME., Van Buchem, M., Martins, R., Chhatwal, J., Greenberg, S., (2019), Amyloid Imaging of Dutch-Type Hereditary Cerebral Amyloid Angiopathy Carriers. Annals of Neurology, 86(4), 616-625, DOI: 10.1002/ana.25560.
  • Tan, S., Sohrabi, H., Weinborn, M., Tegg, M., Bucks, R., Taddei, K., Carruthers, M., Martins, R., (2019), Effects of Testosterone Supplementation on Separate Cognitive Domains in Cognitively Healthy Older Men: A Meta-analysis of Current Randomized Clinical Trials. American Journal of Geriatric Psychiatry, 27(11), 1232-1246, DOI: 10.1016/j.jagp.2019.05.008.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A., (2019), A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220, DOI: 10.1126/sciadv.aau7220.
  • Burnham, S., Coloma, P., Li, Q., Collins, S., Savage, G., Laws, S., Doecke, J., Maruff, P., Martins, R., Ames, D., Rowe, C., Masters, C., Villemagne, V., (2019), Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer’s Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study. The Journal of Prevention of Alzheimer's Disease, 6(4), 248-255, DOI: 10.14283/jpad.2019.25.
  • Sharman, M., Gyengesi, E., Liang, H., Chatterjee, P., Karl, T., Li, Q., Wenk, M., Halliwell, B., Martins, R., Munch, G., (2019), Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?. Neurobiology of Disease, 124(April 2019), 505-519, DOI: 10.1016/j.nbd.2018.11.026.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2019), Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2018.12.014.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2019), COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152, DOI: 10.1016/j.ibror.2019.05.001.
  • Marston, K., Peiffer, J., Rainey-Smith, S., Gordon, N., Teo, S., Laws, S., Sohrabi, H., Martins, R., Brown, B., (2019), Resistance training enhances delayed memory in healthy middle-aged and older adults: A randomised controlled trial. Journal of Science and Medicine in Sport, 22(11), 1226-1231, DOI: 10.1016/j.jsams.2019.06.013.
  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T., (2019), Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(2019), 740-750, DOI: https://doi.org/10.1016/j.trci.2019.09.015.
  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Laws, S., Martins, R., Peiffer, J., (2019), Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized‑controlled trial. European Journal of Applied Physiology, 119(10), 2167-2176, Germany, Springer, DOI: 10.1007/s00421-019-04202-w.
  • Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., Bharadwaj, P., (2019), Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24(18), Article 3372, DOI: 10.3390/molecules24183372.
  • Dube, U., Del-Aguila, J., Li, Z., Budde, J., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M., Farias, F., Norton, J., Gentsch, J., Wang, F., Allegri, R., Amtashar, F., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Buck, J., Buckles, V., Chea, S., Chrem, P., Chui, H., Cinco, J., Clifford, J., D’mello, M., Donahue, T., Douglas, J., Edigo, N., Erekin-Taner, N., Fagan, A., Farlow, M., Farrar, A., Feldman, H., Flynn, G., Fox, N., Franklin, E., Fujii, H., Gant, C., Kirby, S., Ghetti, B., Goate, A., Goldman, J., Gordon, B., Gray, J., Gurney, J., Hassenstab, J., Hirohara, M., Holtzman, D., Hornbeck, R., Dibari, S., Ikeuchi, T., Ikonomovic, S., Jerome, G., Jucker, M., Kasuga, K., Kawarabayashi, T., Klunk, W., Koeppe, R., Kuder-Buletta, E., Laske, C., Levin, J., Marcus, D., Martins, R., Mason, N., Maue-Dreyfus, D., McDade, E., Montoya, L., Mori, H., Nagamatsu, A., Neimeyer, K., Noble, J., Perrin, R., Raichle, M., Ringman, J., Roh, J., Schofield, P., Shimada, H., Shiroto, T., Shoji, M., Sigurdson, W., Sohrabi, H., Sparks, P., Suzuki, K., Swisher, L., Taddei, K., Wang, J., Wang, P., Weiner, M., Wolfsberger, M., Xiong, C., Xu, X., Salloway, S., Masters, C., Lee, J., Graff-Radford, N., Chhatwal, J., Bateman, R., Morris, J., Karch, C., Harari, O., Cruchaga, C., (2019), An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nature Neuroscience, 22(11), 1903-1912, DOI: 10.1038/s41593-019-0501-5.
  • Chatterjee, P., Elmi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Pedrini, S., Shen, K., Asih, P., Dave, P., Taddei, K., Vanderstichele, H., Zetterberg, H., Blennow, K., Martins, R., (2019), Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 71(3), 775-783, Netherlands, IOS Press, DOI: 10.3233/JAD-190533.
  • Brown, B., Castalanelli, N., Rainey-Smith, S., Doecke, J., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., (2019), Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. Behavioural Brain Research, 362(19 April 2019), 103-108, DOI: 10.1016/j.bbr.2019.01.013.
  • Sohrabi, H., Weinborn, M., Laske, C., Bates, K., Christensen, D., Taddei, K., Rainey-Smith, S., Brown, B., Kirby, S., Laws, S., Martins, G., Burnham, S., Bucks, R., Reisberg, B., Lautenschlager, N., Foster, J., Martins, R., (2019), Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, 31(4), 513-525, Cambridge University Press, DOI: 10.1017/S1041610218001072.
  • Dhiman, K., Blennow, K., Zetterberg, H., Martins, R., Gupta, V., (2019), Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis. Cellular and Molecular Life Sciences, 76(10), 1833-1863, DOI: 10.1007/s00018-019-03040-5.
  • Fine, L., Weinborn, M., Ng, A., Loft, S., Li, Y., Hodgson, E., Parker, D., Rainey-Smith, S., Sohrabi, H., Brown, B., Martins, R., Bucks, R., (2019), Sleep disruption explains age-related prospective memory deficits: implications for cognitive aging and intervention. Aging, Neuropsychology and Cognition: A Journal on Normal and Dysfunctional Development, 26(4), 621-636, Routledge, DOI: 10.1080/13825585.2018.1513449.
  • Chhatwal, J., Schultz, A., Johnson, K., Hedden, T., James, S., Benzinger, T., Jack, C., Ances, B., Ringman, J., Marcus, D., Ghetti, B., Farlow, M., Danek, A., Levin, J., Yakushev, I., Laske, C., Koeppe, R., Galasko, D., Xiong, C., Masters, C., Schofield, P., Kinnunen, K., Salloway, S., Martins, R., McDade, E., Cairns, N., Buckles, V., Morris, J., Bateman, R., Sperling, R., (2018), Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing. Brain: a journal of neurology, 141(5), 1486-1500, United Kingdom, Oxford University Press, DOI: 10.1093/brain/awy053.
  • Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V., (2018), Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's Disease, 63(4), 1299-1305, Netherlands, IOS Press, DOI: 10.3233/JAD-170998.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S., (2018), Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41398-018-0094-x.
  • Rainey-Smith, S., Gu, Y., Kirby, S., Doecke, J., Villemagne, V., Brown, B., Taddei, K., Laws, S., Sohrabi, H., Weinborn, M., Ames, D., Fowler, C., Macaulay, SL., Maruff, P., Masters, C., Salvado, O., Rowe, C., Scarmeas, N., Martins, R., (2018), Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(1), 238-244, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41398-018-0293-5.
  • Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Manyan, C., Taddei, K., Ayton, S., Garg, M., Kwok, J., Bush, A., Chung, R., Magnussen, J., Martins, R., (2018), Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load. Molecular Psychiatry, 23(8), 1807-1812, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2017.146.
  • Perin, S., Harrington, K., Lim, YY., Ellis, K., Ames, D., Pietrzak, R., Schembri, A., Rainey-Smith, S., Salvado, O., Laws, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Maruff, P., (2018), Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. Journal of Affective Disorders, 229(15 March 2018), 269-274, Netherlands, Elsevier, DOI: 10.1016/j.jad.2017.12.101.
  • Nakamura, A., Kaneko, N., Villemagne, V., Kato, T., Doecke, J., Dore, V., Fowler, C., Li, Q., Martins, R., Rowe, C., Tomita, T., Matsuzaki, K., Ishii, K., Ishii, K., Arahata, Y., Iwamoto, S., Ito, K., Tanaka, K., Masters, C., Yanagisawa, K., (2018), High performance plasma amyloid-β biomarkers for Alzheimer’s disease. Nature, 554(7691), 249-254, United Kingdom, Nature Publishing Group, DOI: 10.1038/nature25456.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-20513-y.
  • Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Fox, N., Levin, J., Danek, A., Voglein, J., Salloway, S., Xiong, C., Benzingers, T., Buckless, V., Masters, C., Sperling, R., Bateman, R., Morriss, J., Laske, C., (2018), Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's and Dementia, 14(11), 1427-1437, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2018.06.3059.
  • Chatterjee, P., Goozee, K., Lim, CK., James, I., Shen, K., Jacobs, K., Sohrabi, H., Shah, T., Asih, P., Dave, P., Manyan, C., Taddei, K., Lovejoy, D., Chung, R., Guillemin, G., Martins, R., (2018), Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-B load: A pilot study. Scientific Reports, 8(2018), Article no. 8008, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-25968-7.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S., (2018), Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20, United States, Elsevier, DOI: 10.1016/j.pmip.2018.03.001.
  • Doecke, J., Rembach, A., Villemagne, V., Varghesi, S., Rainey-Smith, S., Sarros, S., Evered, L., Fowler, C., Pertile, K., Rumble, R., Trounson, B., Taddei, K., Laws, S., Macaulay, SL., Bush, A., Ellis, K., Martins, R., Ames, D., Silbert, B., Vanderstichele, H., Masters, C., Darby, D., Li, Q., Collins, S., (2018), Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms. Journal of Alzheimer's Disease, 61(1), 169-183, Netherlands, IOS Press, DOI: 10.3233/JAD-170128.
  • Bradfield, N., Ellis, K., Savage, G., Maruff, P., Burnham, S., Darby, D., Lautenschlager, N., Martins, R., Masters, C., Rainey-Smith, S., Robertson, J., Rowe, C., Woodward, M., Ames, D., (2018), Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years. Alzheimer Disease and Associated Disorders, 32(3), 190-196, United States, Lippincott Williams & Wilkins, DOI: 10.1097/WAD.0000000000000252.
  • Chatterjee, P., Goozee, K., Sohrabi, H., Shen, K., Shah, T., Asih, P., Dave, P., Man Yan, C., Taddei, K., Chung, R., Zetterberg, H., Blennow, K., Martins, R., (2018), Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants. Journal of Alzheimer's Disease, 63(2), 479-487, Netherlands, IOS Press, DOI: 10.3233/JAD-180025.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • Fernando, B., Rainey-Smith, S., Kirby, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R., (2018), Associations of dietary protein and fiber intake with brain and blood amyloid-β. Journal of Alzheimer's Disease, 61(4), 1589-1598, Netherlands, IOS Press, DOI: 10.3233/JAD-170742.
  • Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Gozt, O., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R., (2018), Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study. Psychological Assessment, 30(10), 1308-1316, United States, American Psychological Association, DOI: 10.1037/pas0000565.
  • Khan, I., Krishnaswamy, S., Sabale, M., Groth, D., Wijaya, L., Morici, M., Berger, I., Schaffitzel, C., Fraser, P., Martins, R., Verdile, G., (2018), Efficient production of a mature and functional gamma secretase protease. Scientific Reports, 8(1), Article no. 12834, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-30788-w.
  • Lee, S., Zimmerman, M., Narkhede, A., Nasrabady, S., Tosto, G., Meier, I., Benzinger, T., Marcus, D., Fagan, A., Fox, N., Cairns, N., Holtzmann, D., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, A., Masters, C., Ringman, J., Forster, S., Schofield, P., Sperling, R., Johnson, K., Chhatwal, J., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, J., Mayeux, R., Brickman, A., (2018), White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One, 13(5), Article number e0195838, United States, Public Libary of Science, DOI: 10.1371/journal.pone.0195838.
  • Holmes, SE., Esterlis, I., Mazure, CM., Lim, YY., Ames, D., Rainey-Smith, S., Fowler, C., Ellis, K., Martins, R., Salvado, O., Doré, V., Villemagne, VL., Rowe, CC., Laws, S., Masters, CL., Pietrzak, RH., Maruff, P., (2018), Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study. International Journal of Geriatric Psychiatry, 33(2), 405-413, DOI: 10.1002/gps.4761.
  • Brini, S., Sohrabi, H., Peiffer, J., Karrasch, M., Hamalainen, H., Martins, R., Fairchild, TJ., (2018), Physical activity in preventing Alzheimer's disease and cognitive decline: A narrative review. Sports Medicine, 48(1), 29-44, Auckland, New Zealand, Adis international Ltd, DOI: 10.1007/s40279-017-0787-y.
  • McCabe, K., Woods, S., Weinborn, M., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Taddei, K., Martins, R., (2018), Personality characteristics are independently associated with prospective memory in the laboratory, and in daily Life, among older adults. Journal of Research in Personality, 76(Oct 2018), 32-37, United States, Academic Press, DOI: 10.1016/j.jrp.2018.06.006.
  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2018.00423.
  • Elaskalani, O., Khan, I., Morici, M., Matthysen, C., Sabale, M., Martins, R., Verdile, G., Metharom, P., (2018), Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. Platelets (London), 29(4), 415-420, London, Taylor & Francis Group, DOI: 10.1080/09537104.2017.1401057.
  • Jayakody, D., Friedland, P., Martins, R., Sohrabi, H., (2018), Impact of aging on the auditory system and related cognitive functions: A narrative review. Frontiers in Neuroscience, 12(MAR), Article no.125, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnins.2018.00125.
  • Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R., (2018), Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651, Netherlands, Elsevier, DOI: 10.1016/j.bbamem.2018.03.015.
  • Kinnunen, KM., Cash, DM., Poole, T., Frost, C., Benzinger, TL., Ahsan, RL., Leung, KK., Cardoso, ML., Modat, M., Malone, IB., Morris, JC., Bateman, RJ., Marcus, DS., Goate, A., Salloway, SP., Correia, S., Sperling, RA., Chhatwal, J., Mayeux, R., Brickman, A., Martins, R., Farlow, M., Ghetti, B., Saykin, A., Jack, C., Schofield, P., McDade, E., Weiner, M., Ringman, J., Thompson, P., Masters, C., Rowe, C., Rossor, M., Ourselin, S., Fox, N., (2018), Presymptomatic atrophy in autosomal dominant Alzheimer’s disease: A serial magnetic resonance imaging study. Alzheimer's and Dementia, 14(1), 43-53, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2017.06.2268.
  • Lan, J., Galindo, A., Doecke, J., Fowler, C., Martins, R., Rainey-Smith, S., Cominetti, O., Dayon, L., (2018), Systematic Evaluation of the Use of Human Plasma and Serum for Mass-Spectrometry-Based Shotgun Proteomics. Journal of Proteome Research, 17(4), 1426-1435, United States, American Chemical Society, DOI: 10.1021/acs.jproteome.7b00788.
  • Jayakody, D., Friedland, PL., Eikelboom, RH., Martins, R., Sohrabi, H., (2018), A novel study on association between untreated hearing loss and cognitive functions of older adults: Baseline non-verbal cognitive assessment results. Clinical Otolaryngology, 43(1), 182-191, DOI: 10.1111/coa.12937.
  • Lim, YY., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., Rowe, C., Masters, C., Maruff, P., (2018), Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA Neurology, 75(4), 488-494, United States, American Medical Association, DOI: 10.1001/jamaneurol.2017.4325.
  • Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., Martins, R., (2017), Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252, Taylor and Francis Ltd, DOI: 10.1080/00207454.2016.1182527.
  • Peters, K., Davis, W., Taddei, K., Martins, R., Masters, C., Davis, T., Bruce, D., (2017), Plasma amyloid-β Peptides in Type 2 Diabetes: A matched case-control study. Journal of Alzheimer's Disease, 56(3), 1127-1133, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161050.
  • Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Martins, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Dore, V., Villemagne, V., Snyder, P., Masters, C., Maruff, P., (2017), Amyloid β–associated cognitive decline in the absence of clinical disease progression and systemic illness. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(1), 156-164, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.05.006.
  • Lim, YY., Williamson, R., Laws, S., Villemagne, V., Bourgeat, P., Fowler, C., Rainey-Smith, S., Salvado, O., Martins, R., Rowe, C., Masters, C., Maruff, P., (2017), Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. Journal of Alzheimer's Disease, 58(4), 1293-1302, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-170072.
  • Mirmosayyeb, O., Tanhaei, A., Sohrabi, H., Martins, R., Tanhaei, M., Najafi, MA., Safaei, A., Meamar, R., (2017), Possible role of common spices as a preventive and therapeutic agent for Alzheimer's disease. International Journal of Preventive Medicine, 8(1), article no. 5, Maharastra, India, Medknow Publications and Media, DOI: 10.4103/2008-7802.199640.
  • Muller, S., Preische, O., Sohrabi, H., Graber, S., Jucker, M., Dietzsch, J., Ringman, J., Martins, R., McDade, E., Schofield, P., Ghetti, B., Rossor, M., Graff-Radford, N., Levin, J., Galasko, D., Quaid, K., Salloway, S., Xiong, C., Benzinger, T., Buckles, V., Masters, C., Sperling, R., Bateman, R., Morris, J., Laske, C., (2017), Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer’s disease. Scientific Reports, 7(1), Article number 1225, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-01327-w.
  • O'Bryan, S., Mielke, M., Rissman, R., Lista, S., Vanderstichele, H., Zetterberg, H., Lewczuk, P., Posner, H., Hall, J., Johnson, L., Fong, Y., Luthman, J., Jeromin, A., Batrla-Utermann, R., Villarreal, A., Britton, G., Snyder, P., Henriksen, K., Grammas, P., Gupta, V., Martins, R., Hampel, H., (2017), Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimer's and Dementia, 13(1), 45-58, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2016.09.014.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R., (2017), A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057, DOI: 10.1038/s41598-017-14020-9.
  • Harrington, K., Gould, E., Lim, Y., Ames, D., Pietrzak, R., Rembach, A., Rainey-Smith, S., Martins, R., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Maruff, P., (2017), Amyloid burden and incident depressive symptoms in cognitively normal older adults. International Journal of Geriatric Psychiatry, 32(4), 455-463, John Wiley & Sons, DOI: 10.1002/gps.4489.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R., (2017), Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72, United States, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.04.003.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P., (2017), APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422, Netherlands, IOS Press, DOI: 10.3233/JAD-161019.
  • Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R., (2017), Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80, Springer, DOI: 10.1007/s11065-016-9338-9.
  • Fernando, B., Somaratne, G., Goozee, K., Williams, S., Singh, H., Martins, R., (2017), Diabetes and Alzheimer's disease: Can tea phytochemicals play a role in prevention?. Journal of Alzheimer's Disease, 59(2), 481-501, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161200.
  • Kirby, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R., (2017), Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161158.
  • Cerin, E., Rainey-Smith, S., Ames, D., Lautenschlager, N., Macaulay, S., Fowler, C., Robertson, J., Rowe, C., Maruff, P., Martins, R., Masters, C., Ellis, K., (2017), Associations of neighbourhood environment with brain imaging outcomes in the AIBL cohort. Alzheimer's and Dementia, 13(4), 388-398, United States, Elsevier, DOI: 10.1016/j.jalz.2016.06.2364.
  • Shah, T., Gupta, S., Chatterjee, P., Campbell, M., Martins, R., (2017), Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease. Molecular Psychiatry, 22(3), 353-363, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2016.251.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P., (2017), Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52, DOI: 10.1016/j.bpsc.2016.08.006.
  • Golzan, SM., Goozee, K., Georgevsky, D., Avolio, A., Chatterjee, P., Shen, K., Gupta, V., Chung, R., Savage, G., Orr, C., Martins, R., Graham, S., (2017), Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease. Alzheimer's Research and Therapy, 9(1), Article number 13, London, United Kingdom, BioMed Central Ltd, DOI: 10.1186/s13195-017-0239-9.
  • Goozee, K., Chatterjee, P., James, I., Shen, K., Sohrabi, H., Asih, P., Dave, P., Ball, B., Manyan, C., Taddei, K., Chung, R., Garg, M., Martins, R., (2017), Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease. Scientific Reports, 7(1), Article number 676, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-00751-2.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P., (2017), BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S1041610217001284.
  • Cardoso, B., Hare, D., Bush, A., Li, Q., Fowler, C., Masters, C., Martins, R., Ganio, K., Lothian, A., Mukherjee, S., Kapp, E., Roberts, B., (2017), Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). Journal of Alzheimer's Disease, 57(1), 183-193, Netherlands, IOS Press, DOI: 10.3233/JAD-160622.
  • Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, JJ., (2017), Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia, 3(4), 562-570, United States, Elsevier Science Inc., DOI: 10.1016/j.trci.2017.09.003.
  • Brown, B., Sohrabi, H., Taddei, K., Kirby, S., Rainey-Smith, S., Peiffer, J., Xiong, C., Fagan, A., Benzinger, T., Buckles, V., Erickson, K., Clarnette, R., Shah, T., Masters, C., Weiner, M., Cairns, N., Rossor, M., Graff-Radford, N., Salloway, S., Voglein, J., Laske, C., Noble, J., Schofield, P., Bateman, R., Morris, J., Martins, R., (2017), Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer’s disease. Alzheimer's and Dementia, 13(11), 1197-1206, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2017.03.008.
  • Huynh, K., Martins, R., Meikle, P., (2017), Lipidomic profiles in Diabetes and Dementia. Journal of Alzheimer's Disease, 59(2), 433-444, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161215.
  • Marston, K., Newton, M., Brown, B., Rainey-Smith, S., Bird, S., Martins, R., Peiffer, J., (2017), Intense resistance exercise increases peripheral brain-derived neurotrophic factor. Journal of Science and Medicine in Sport, 20(10), 899-903, Chatswood, NSW, Elsevier Australia, DOI: 10.1016/j.jsams.2017.03.015.
  • Frost, S., Bhuiyan, A., Offerman, D., Doecke, J., Macaulay, S., Sohrabi, H., Ames, D., Masters, C., Martins, R., Kanagasingam, Y., (2017), Modulation of retinal arteriolar central reflection by APOE genotype. Current Alzheimer Research, 14(9), 916-923, Bentham Science Publishers B.V., DOI: 10.2174/1567205014666170309115016.
  • Frost, S., Robinson, L., Rowe, C., Ames, D., Masters, C., Taddei, K., Rainey-Smith, S., Martins, R., Kanagasingam, Y., (2017), Evaluation of cholinergic deficiency in preclinical Alzheimer's disease using pupillometry. Journal of Ophthalmology, 2017(August 2017), Article no. 7935406, New York, USA, Hindawi Ltd., DOI: 10.1155/2017/7935406.
  • Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK., (2017), Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685, Lonon, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-12858-7.
  • Jayakody, D., Friedland, P., Nel, E., Martins, R., Atlas, M., Sohrabi, H., (2017), Impact of cochlear implantation on cognitive function of older adults: Pilot test results. Otology and Neurotology: an international forum, 38(8), e289-e295, Philadelphia, USA, Lippincott Williams & Wilkins, DOI: 10.1097/MAO.0000000000001502.
  • Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R., (2017), Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161259.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G., (2017), Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-09577-4.
  • Frost, S., Guymer, R., Aung, K., Macaulay, S., Sohrabi, H., Bourgeat, P., Salvado, O., Rowe, C., Ames, D., Masters, C., Martins, R., Kanagasingam, Y., (2016), Alzheimer's disease and the early signs of age-related macular degeneration. Current Alzheimer Research, 13(11), 1259-1266, Bussum, Netherlands, Bentham Science Publishers Ltd., DOI: 10.2174/1567205013666160603003800.
  • Tang, M., Ryman, DC., McDade, E., Jasielec, MS., Buckles, VD., Cairns, NJ., Fagan, AM., Goate, A., Marcus, DS., Xiong, C., Allegri, RF., Chhatwal, JP., Danek, A., Farlow, MR., Fox, NC., Ghetti, B., Graff-Radford, NR., Laske, C., Martins, R., Masters, CL., Mayeux, RP., Ringman, JM., Rossor, MN., Salloway, SP., Schofield, PR., Morris, JC., Bateman, RJ., (2016), Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet Neurology, 15(13), 1317-1325, Lancet Publishing Group, DOI: 10.1016/S1474-4422(16)30229-0.
  • Lee, S., Viqar, F., Zimmerman, ME., Narkhede, A., Tosto, G., Benzinger, T., Marcus, DS., Fagan, A., Goate, A., Fox, N., Cairns, N., Holtzman, DM., Buckles, V., Ghetti, B., McDade, E., Martins, R., Saykin, AJ., Masters, C., Ringman, JM., Ryan, NS., Forster, S., Laske, C., Schofield, PR., Sperling, RA., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R., Morris, JC., Mayeux, R., Brickman, A., (2016), White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. Annals of Neurology, 79(6), 929-939, John Wiley and Sons Inc., DOI: 10.1002/ana.24647.
  • Kirby, S., Rainey-Smith, S., Martins, R., (2016), Diet and Inflammation in Alzheimer's Disease and Related Chronic Diseases: A Review. Journal of Alzheimer's Disease, 50(2), 301-334, Netherlands, IOS Press, DOI: 10.3233/JAD-150765.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R., (2016), Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559, Bethesda, USA, American Society for Biochemistry and Molecular Biology, Inc., DOI: 10.1074/jbc.M115.679993.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2016), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515004687.
  • Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P., (2016), Aβ-related memory decline in APOE ε4 non-carriers: Implications for Alzheimer’s disease. Neurology, 86(17), 1635-1642, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000002604.
  • Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V., (2016), Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, 15(10), 1044-1053, London, UK, Lancet Publishing Group, DOI: 10.1016/S1474-4422(16)30125-9.
  • Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R., (2016), The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068, Westchester, USA, Associated Professional Sleep Societies,LLC, DOI: 10.5665/sleep.5756.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894, Netherlands, IOS Press, DOI: 10.3233/JAD-150948.
  • Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R., (2016), Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. The British Journal of Nutrition: an international journal of nutritional science, 115(12), 2106-2113, Cambridge University Press, DOI: 10.1017/S0007114516001203.
  • Zwan, MD., Villemagne, VL., Doré, V., Buckley, R., Bourgeat, P., Veljanoski, R., Salvado, O., Williams, R., Margison, L., Rembach, A., Macaulay, SL., Martins, R., Ames, D., Van Der Flier, WM., Ellis, KA., Scheltens, P., Masters, C., Rowe, C., (2016), Subjective memory complaints in APOE e4 carriers are associated with high Amyloid-ß Burden. Journal of Alzheimer's Disease, 49(4), 1115-1122, Netherlands, IOS Press, DOI: 10.3233/JAD-150446.
  • Lim, YY., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., Salvado, O., Rowe, C., Masters, C., Maruff, P., (2016), Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, 60(3), 362-370, Springer New York LLC, DOI: 10.1007/s12031-016-0822-8.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G., (2016), The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905, Netherlands, IOS Press, DOI: 10.3233/JAD-150790.
  • Muenchhoff, J., Poljak, A., Thalamuthu, A., Gupta, V., Chatterjee, P., Raffery, M., Masters, C., Morris, J., Bateman, J., Fagan, A., Martins, R., Sachdev, P., (2016), Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease. Scientific Reports, 6(2016), Article no. 29078, Nature Publishing Group, DOI: 10.1038/srep29078.
  • Gupta, V., Gupta, V., Chitranshi, N., Gangoda, S., Vander Wall, R., Abbasi, M., Golzan, M., Dheer, Y., Shah, T., Avolio, A., Chung, R., Martins, R., Graham, S., (2016), One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina. Cellular and Molecular Life Sciences, 73(22), 4279-4297, Birkhauser Verlag AG, DOI: 10.1007/s00018-016-2295-x.
  • O'Bryant, S., Lista, S., Rissman, R., Edwards, M., Zhang, F., Hall, J., Zetterberg, H., Lovestone, S., Gupta, V., Graff-Radford, N., Martins, R., Jeromin, A., Waring, S., Oh, E., Kling, M., Baker, L., Hampel, H., (2016), Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 27-34, Elsevier, DOI: 10.1016/j.dadm.2015.12.003.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.12.001.
  • Holmes, S., Esterlis, I., Mazure, C., Lim, YY., Ames, D., Rainey-Smith, S., Martins, R., Salvado, O., Dore, V., Villemagne, V., Rowe, C., Laws, S., Masters, C., Maruff, P., Pietrzak, R., (2016), β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195, Elsevier B.V., DOI: 10.1016/j.jagp.2016.08.007.
  • Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R., (2016), The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343, Bentham Science Publishers B.V., DOI: 10.2174/1871527315666151110125704.
  • Francois, M., Fenech, M., Thomas, P., Hor, M., Rembach, A., Martins, R., Rainey-Smith, S., Masters, C., Ames, D., Rowe, C., Macaulay, S., Hill, A., Leifert, W., (2016), High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. Current Alzheimer Research, 13(7), 787-799, DOI: 10.2174/1567205013666160315112151.
  • Buckley, R., Maruff, P., Ames, D., Bourgeat, P., Martins, R., Masters, C., Rainey-Smith, S., Lautenschlager, N., Rowe, C., Savage, G., Villemagne, V., Ellis, K., (2016), Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease. Alzheimer's and Dementia, 12(7), 796-804, United States, Elsevier, DOI: 10.1016/j.jalz.2015.12.013.
  • Kirby, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R., (2016), Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672, Netherlands, IOS Press, DOI: 10.3233/JAD-151084.
  • Lim, YY., Snyder, PJ., Pietrzak, RH., Ukiqi, A., Villemagne, VL., Ames, D., Salvado, O., Bourgeat, P., Martins, R., Masters, CL., Rowe, CC., Maruff, P., (2016), Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 2(2016), 19-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.11.003.
  • Warrier, S., Marimuthu, R., Sekhar, S., Bhuvanalakshmi, G., Arfuso, F., Das, AK., Bhonde, R., Martins, R., Dharmarajan, A., (2016), SFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease. International Journal of Biochemistry and Cell Biology, 75(June 2016), 104-111, Elsevier Ltd, DOI: 10.1016/j.biocel.2016.04.002.
  • Hare, DJ., Faux, NG., Roberts, BR., Volitakis, I., Martins, R., Bush, AI., (2016), Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Metallomics, 8(6), 628-632, Royal Society of Chemistry, DOI: 10.1039/c6mt00019c.
  • Burnham, S., Rowe, C., Baker, D., Bush, A., Doecke, JD., Faux, N., Laws, S., Martins, R., Maruff, P., Macaulay, S., Rainey-Smith, S., Savage, G., Ames, D., Masters, C., Wilson, W., Villemagne, V., (2016), Predicting Alzheimer disease from a blood-based biomarker profile. Neurology, 87(11), 1093-1101, Lippincott Williams and Wilkins, DOI: 10.1212/WNL.0000000000003094.
  • Kirby, S., Rainey-Smith, S., Macaulay, SL., Taddei, K., Rembach, A., Maruff, P., Ellis, K., Masters, C., Rowe, C., Ames, D., Keogh, J., Martins, R., (2015), Comparative analysis of the Cancer Council of Victoria and the online Commonwealth Scientific and Industrial Research Organisation FFQ. The British Journal of Nutrition: an international journal of nutritional science, 114(10), 1683-1693, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515003335.
  • Lim, YY., Villemagne, VL., Pietrzak, RH., Ames, D., Ellis, KA., Harrington, K., Snyder, PJ., Martins, R., Masters, CL., Rowe, CC., Maruff, P., (2015), APOE e4 moderates amyloid-related memory decline in preclinical Alzheimer's disease. Neurobiology of Aging, 36(3), 1239-1244, Pennsylvania, United States, Elsevier Inc., DOI: 10.1016/j.neurobiolaging.2014.12.008.
  • Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R., (2015), Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586, Bussum, Netherlands, Bentham Science Publishers B.V..
  • Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R., (2015), Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164, Bussum, Netherlands, Bentham Science Publishers, DOI: 10.2174/1567205012666150204125732.
  • Verdile, G., Fuller, SJ., Martins, R., (2015), The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38, Maryland Heights, USA, Academic Press Inc., DOI: 10.1016/j.nbd.2015.04.008.
  • O'Bryant, SE., Gupta, V., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C., Soares, H., Lovestone, S., Hampel, H., Montine, T., Blennow, K., Foroud, T., Carrillo, M., Graff-Radford, N., Laske, C., Breteler, M., Shaw, L., Trojanowski, J., Schupf, N., Rissman, R., Fagan, A., Oberoi, P., Umek, R., Weiner, M., Grammas, P., Posner, H., Martins, R., (2015), Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's and Dementia, 11(5), 549-560, United States, Elsevier Inc., DOI: 10.1016/j.jalz.2014.08.099.
  • Burnham, SC., Raghavan, N., Wilson, W., Baker, D., Ropacki, MT., Novak, G., Ames, D., Ellis, K., Martins, R., Maruff, P., Masters, CL., Romano, G., Rowe, CC., Savage, G., Macaulay, SL., Narayan, V., (2015), Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study. Journal of Alzheimer's Disease, 46(4), 1079-1089, Netherlands, IOS Press, DOI: 10.3233/JAD-143015.
  • Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R., (2015), The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90, Elsevier, DOI: 10.1016/j.yhbeh.2015.05.020.
  • Leifert, WR., Nguyen, T., Rembach, A., Martins, R., Rainey-Smith, S., Masters, CL., Ames, D., Rowe, CC., Macaulay, SL., François, M., Fenech, MF., (2015), Buccal Cell Cytokeratin 14 Correlates with Multiple Blood Biomarkers of Alzheimer's Disease Risk. Journal of Alzheimer's Disease, 48(2), 443-452, Netherlands, IOS Press, DOI: 10.3233/JAD-150330.
  • Pietrzak, RH., Lim, YY., Ames, D., Harrington, K., Restrepo, C., Martins, R., Rembach, A., Laws, S., Masters, CL., Villemagne, VL., Rowe, CC., Maruff, P., (2015), Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Neurobiology of Aging, 36(3), 1231-1238, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2014.12.015.
  • Buckley, R., Saling, M., Ellis, K., Rowe, C., Maruff, P., Macaulay, LS., Martins, R., Masters, C., Savage, G., Rainey-Smith, S., Rembach, A., Ames, D., (2015), Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment. Age and Ageing, 44(6), 1012-1019, Oxford University Press, DOI: 10.1093/ageing/afv136.
  • Narlawar, R., Werry, EL., Scarf, AM., Hanani, R., Chua, SW., King, VA., Barron, ML., Martins, R., Ittner, LM., Rendina, LM., Kassiou, M., (2015), First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO). Journal of Medicinal Chemistry, 58(21), 8743-8749, American Chemical Society, DOI: 10.1021/acs.jmedchem.5b01288.
  • Albrecht, MA., Szoeke, C., Maruff, P., Savage, G., Lautenschlager, NT., Ellis, KA., Taddei, K., Martins, R., Masters, CL., Ames, D., Foster, JK., (2015), Longitudinal cognitive decline in the AIBL cohort: The role of APOE e4 status. Neuropsychologia, 75(2015), 411-419, Elsevier, DOI: 10.1016/j.neuropsychologia.2015.06.008.
  • Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M., (2015), Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678, United Kingdom, Oxford University Press, DOI: 10.1093/hmg/ddv110.
  • Sutton, T., Sohrabi, H., Rainey-Smith, S., Bird, S., Weinborn, M., Martins, R., (2015), The role of APOE-ε4 and beta amyloid in the differential rate of recovery from ECT: a review. Translational Psychiatry, 5(e539), 1-8, London, UK, Nature Publishing Group, DOI: 10.1038/tp.2015.39.
  • Leifert, WR., Tuli, JF., François, M., Nguyen, T., Rembach, A., Rumble, RL., Rainey-Smith, S., Martins, R., Fenech, MF., (2015), Buccal cell cytokeratin 14 identifies mild cognitive impairment and alzheimer’s disease in the AIBL study of aging. Current Alzheimer Research, 12(3), 233-241, Bentham Science Publishers.
  • Cysique, LA., Hewitt, T., Croitoru-Lamoury, J., Taddei, K., Martins, R., Chew, CS., Davies, NN., Price, P., Brew, BJ., (2015), APOE e4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals - A cross-sectional observational study. BMC Neurology, 15(1), Article no. 51, BioMed Central Ltd., DOI: 10.1186/s12883-015-0298-0.
  • Rembach, A., Stingo, FC., Peterson, C., Vannucci, M., Do, K., Wilson, WJ., Macaulay, SL., Ryan, TM., Martins, R., Ames, D., Masters, CL., Doecke, JD., (2015), Bayesian graphical network analyses reveal complex biological interactions specific to Alzheimer's disease. Journal of Alzheimer's Disease, 44(3), 917-925, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-141497.
  • Laske, C., Sohrabi, H., Frost, S., Lopez-De-Ipina, K., Garrard, P., Buscema, M., Dauwels, J., Soekadar, S., Mueller, S., Linnemann, C., Bridenbaugh, S., Kanagasingam, Y., Martins, R., O’bryant, S., (2015), Innovative diagnostic tools for early detection of Alzheimer’s disease. Alzheimer's and Dementia, 11(5), 561-578, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2014.06.004.
  • Hollands, S., Lim, Y., Buckley, R., Pietrzak, R., Snyder, P., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P., (2015), Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults. Journal of Alzheimer's Disease, 43(2), 677-686, Netherlands, IOS Press, DOI: 10.3233/JAD-140678.
  • Johnson, L., Sohrabi, H., Hall, J., Taddei, K., Edwards, M., O'Bryant, S., Martins, R., (2015), A depressive endophenotype of poorer cognition among cognitively healthy community-dwelling adults: results from the Western Australia memory study. International Journal of Geriatric Psychiatry, 30(8), 881-886, Wiley, DOI: 10.1002/gps.4231.
  • Laske, C., Sohrabi, H., Jasielec, MS., Muller, S., Koehler, N., Graber, S., Forster, S., Drzezga, A., Mueller-Sarnowski, F., Danek, A., Jucker, M., Bateman, R., Buckles, V., Saykin, A., Martins, R., Morris, J., (2015), Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer’s Disease: Results of the DIAN Study. BioMed Research International, 2015(2015), Article no. 828120, New York, USA, Hindawi Publishing Corporation, DOI: 10.1155/2015/828120.
  • Pietrzak, R., Lim, YY., Neumeister, A., Ames, D., Ellis, K., Harrington, K., Lautenschlager, N., Restrepo, C., Martins, R., Masters, C., Villemagne, V., Rowe, C., Maruff, P., (2015), Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease A Multicenter, Prospective Cohort Study. JAMA Psychiatry, 72(3), 284-291, United States, American Medical Association, DOI: 10.1001/jamapsychiatry.2014.2476.
  • Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA., (2015), Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48, Elsevier, DOI: 10.1016/j.nbd.2015.06.016.
  • Kirby, S., Rainey-Smith, S., Barnes, M., Sohrabi, H., Weinborn, M., Lim, Y., Harrington, K., Taddei, K., Gu, Y., Rembach, A., Szoeke, C., Ellis, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Keogh, J., Scarmeas, N., Martins, R., (2015), Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry, 20(7), 860-866, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2014.79.
  • Wang, F., Gordon, BA., Ryman, DC., Ma, S., Xiong, C., Hassenstab, J., Goate, A., Fagan, AM., Cairns, NJ., Marcus, DS., McDade, E., Ringman, JM., Graff-Radford, NR., Ghetti, B., Farlow, MR., Sperling, R., Salloway, S., Schofield, PR., Masters, CL., Martins, R., Rossor, MN., Jucker, M., Danek, A., Forster, S., Lane, CA., Morris, JC., Benzinger, TL., Bateman, RJ., (2015), Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology, 85(9), 790-798, Philadelphia, Pennsylvania, United States, Lippincott Williams & Wilkins, DOI: 10.1212/WNL.0000000000001903.
  • Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P., (2015), Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease is Dependent on APOE ε4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082, San Francisco, California, United States, Public Library of Science, DOI: 10.1371/journal.pone.0139082.
  • Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD., (2015), Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71, London, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0157-7.
  • Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S., (2015), Alzheimer’s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-150247.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16, Lausanne, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2015.00016.
  • Bourgeat, P., Villemagne, V., Dore, V., Brown, B., Macaulay, SL., Martins, R., Masters, C., Ames, D., Ellis, K., Rowe, C., Salvado, O., Fripp, J., (2015), Comparison of MR-less PiB SUVR quantification methods. Neurobiology of Aging, 36(S1), S159-S166, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2014.04.033.
  • Cheng, L., Doecke, J., Sharples, RA., Villemagne, VL., Fowler, CJ., Rembach, A., Martins, R., Rowe, CC., Macaulay, SL., Masters, CL., Hill, AF., (2015), Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Molecular Psychiatry, 20(10), 1188-1196, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2014.127.
  • Ying Lim, Y., Pietrzak, RH., Bourgeat, P., Ames, D., Ellis, KA., Rembach, A., Harrington, K., Salvado, O., Martins, R., Snyder, PJ., Masters, C., Rowe, CC., Villemagne, VL., Maruff, P., (2015), Relationships between performance on the cogstate brief battery, neurodegeneration, and aβ accumulation in cognitively normal older adults and adults with MCI. Archives of Clinical Neuropsychology, 30(1), 49-58, Oxford, United Kingdom, Oxford University Press, DOI: 10.1093/arclin/acu068.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0105-6.
  • Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R., (2015), The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515001452.
  • Lim, YY., Villemagne, VL., Laws, S., Pietrzak, RH., Snyder, PJ., Ames, D., Ellis, KA., Harrington, K., Rembach, A., Martins, R., Rowe, CC., Masters, CL., Maruff, P., (2015), APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Molecular Psychiatry, 20(11), 1322-1328, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2014.123.
  • Buckley, RF., Ellis, KA., Ames, D., Rowe, CC., Lautenschlager, NT., Maruff, P., Villemagne, V., Macaulay, SL., Szoeke, C., Martins, R., Masters, CL., Savage, G., Rainey-Smith, S., Rembach, A., Saling, MM., (2015), Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology, 29(4), 571-581, Washington DC, United States, American Psychological Association, DOI: 10.1037/neu0000156.
  • Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P., (2015), Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation, 6(2015), Article No. 105828, New York, USA, Hindawi Publishing Corporation, DOI: 10.1155/2015/105828.

Research Student Supervision

Principal Supervisor

  • Master of Science (Human Biology),  Plasma insulin-degrading enzyme: Characterisation and evaluation as a potential biomarker for alzheimer's disease.
  • Doctor of Philosophy,  Identifying gamma secretase enzyme domains responsible for the generation of alzheimer's beta amyloid protein.
  • Doctor of Philosophy,  Yeast as a model for studying ab aggregation, toxicity and clearance
  • Doctor of Philosophy,  Role of testosterone in prevention of alzheimer's disease.
  • Doctor of Philosophy,  Impact of nutrition on cognition and its association with blood and brain alzheimer disease related biomarkers
  • Master of Science (Human Biology),  The role of luteninizing hormone (lh) and human chorionic gonadotropin (hcg) in the aetiology of alzheimer's disease.
  • Doctor of Philosophy,  Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing alzheimer's risk
  • Doctor of Philosophy,  Investigating the impact of cd147 and its expression on neuordegeneration and alzheimer's disease ad
  • Doctor of Philosophy,  Discovery of new biomarkers of mild cognitive impairment and alzheimer's disease risk in buccal cells using laser scanning cytometry.
  • Doctor of Philosophy,  Identification of plasma lipid biomarkers in alzheimer's disease.
  • Doctor of Philosophy,  Pharmacological modulation of learning and memory in mice and zebrafish: Implications for alzheimers disease animal models.

Co-principal Supervisor

Associate Supervisor

  • Master of Science (Sports Science),  Effects of long-term participation in tennis on cognitive function in elderly individuals
  • Doctor of Philosophy,  Evolutionary approaches for feature selection in biological data
  • Doctor of Philosophy,  Comparing live to recorded music and stories using multiple psychoneuroendocrine and psychological measures
  • Doctor of Philosophy,  Utility of CSF Biomarkers for the Diagnosis, Prognosis and Assessment of Cognitive Decline in Alzheimer’s disease
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