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  • Dr Joel P.A. Gummer

    Dr Joel P.A. Gummer

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  • ResearchGate Profile
    https://www.researchgate.net/profile/Joel_Gummer
  • ResearchGate Profile

Dr Joel P.A. Gummer

Adjunct Senior Lecturer

Staff Member Details
Email: j.gummer@ecu.edu.au
ORCID iD: https://orcid.org/0000-0002-3609-3398

Joel is a Post Doctoral Research Fellow, jointly appointed between ECU’s School of Science and the ChemCentre.

Background

Joel specialises in the use of mass spectrometry-based platforms for characterising the metabolomes and proteomes of biological systems. Joel is jointly appointed with the ChemCentre, Western Australia’s premier chemical science facility, within the Forensic Proteomics team, and holds honourary appointments with the School of Surgery at the University of Western Australia and Curtin University. Joel was the former National Head of Analytics for Metabolomics Australia, based as Murdoch University, and Affiliate Academic with the Lee Kong Chian School of Medicine at the Nanyang Technological University (NTU) of Singapore. More recently, Joel helped establish the Australian National Phenome Centre and held a position of Analytical Specialist.

Professional Memberships

  • 2020 - Australasian Proteomics Society, APS (Member)
  • 2019 - Accelerating Australia (MTPConnect), WA (Sub-Committee Member)
  • 2018-19 – Metabolomics Australia (National Head of Analytics)
  • 2015-18 – International Metabolomics Society (Member)
  • 2015-18 – American Society for Mass Spectrometry, ASMS (Member)
  • 2010 - Australian and New Zealand Society for Mass Spectrometry, ANZSMS (Member)

Research Areas and Interests

  • Proteomics
  • Peptidomics
  • Metabolomics
  • Mass Spectrometry
  • Chromatography
  • Iron Metabolism
  • Systems Biology
  • Disease mechanisms
  • Conservation Biology
  • Commercialisation

Qualifications

  • Doctor of Philosophy, Murdoch University, 2012.

Research Outputs

2023

Journal Articles

  • Claus, MA., Smart, L., Raisis, AL., Sharp, CR., Abraham, S., Gummer, J., Mead, MK., Bradley, DL., Van Swelm, R., Wiegerinck, ET., Litton, E. (2023). Effect Of Deferoxamine On Post-Transfusion Iron, Inflammation, And In Vitro Microbial Growth In A Canine Hemorrhagic Shock Model: A Randomized Controlled Blinded Pilot Study. Veterinary Sciences, 10(2), article number 121. https://doi.org/10.3390/vetsci10020121.

2022

Journal Articles

  • Orozco Morales, ML., Rinaldi, CA., De Jong, E., Lansley, SM., Gummer, J., Olasz, B., Nambiar, S., Hope, DE., Casey, TH., Lee, YC., Leslie, C., Nealon, G., Shackleford, DM., Powell, AK., Grimaldi, M., Balaguer, P., Zemek, RM., Bosco, A., Piggott, MJ., Alice, V., Lake, RA., Lesterhuis, WJ. (2022). PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective. iScience, 25(1), article number 103571. https://doi.org/10.1016/j.isci.2021.103571.

2021

Journal Articles

  • Scaccabarozzi, D., Dods, K., Le, TT., Gummer, J., Lussu, M., Milne, L., Campbell, T., Wafujian, B., Priddis, C. (2021). Factors driving the compositional diversity of Apis mellifera bee venom from a Corymbia calophylla (marri) ecosystem, Southwestern Australia. PLoS One, 16(6), Article number e0253838. https://doi.org/10.1371/journal.pone.0253838.
  • Nambiar, S., Kahn, N., Gummer, J. (2021). Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging by Freeze-Spot Deposition of the Matrix. Journal of the American Society for Mass Spectrometry, 32(7), 1829–1836. https://doi.org/10.1021/jasms.1c00063.
  • Nambiar, S., Tan, D., Clynick, B., Bong, S., Rawlinson, C., Gummer, J., Corte, T., Glaspole, I., Moodley, Y., Trengrove, R. (2021). Untargeted metabolomics of human plasma reveal lipid markers unique to chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Proteomics: Clinical Applications, 15(2-3), Article number 2000039. https://doi.org/10.1002/prca.202000039.

2020

Journal Articles

  • Abbiss, H., Gummer, J., Francki, M., Trengove, RD. (2020). Untargeted liquid chromatography-mass spectrometry-based metabolomics analysis of wheat grain. Journal of Visualized Experiments, March 2020(157), Article number e60851. https://doi.org/10.3791/60851.
  • Litton, E., Anstey, M., Broadhurst, D., Chapman, A., Currie, A., Ferrier, J., Gummer, J., Higgins, A., Lim, J., Manning, L., Myers, E., Orr, K., Palermo, A., Paparini, A., Pellicano, S., Raby, E., Rammohan, A., Regli, A., Richter, B., Salman, S., Strunk, T., Waterson, S., Wibrow, B., Wood, F. (2020). Study protocol for the safety and efficacy of probiotic therapy on days alive and out of hospital in adult ICU patients: the multicentre, randomised, placebo-controlled Restoration Of gut microflora in Critical Illness Trial (ROCIT). BMJ Open, 10(6), Article number e035930. https://doi.org/10.1136/bmjopen-2019-035930.

2019

Journal Articles

  • Lawler, N., Abbiss, C., Gummer, J., Broadhurst, D., Govus, A., Fairchild, T., Thompson, K., Garvican-Lewis, L., Gore, C., Maker, G., Trengove, R., Peiffer, J. (2019). Characterizing the plasma metabolome during 14 days of live-high, train-low simulated altitude: A metabolomic approach. Experimental Physiology, 104(1), 81-92. https://doi.org/10.1113/EP087159.
  • Abbiss, H., Maker, GL., Gummer, J., Rawlinson, C., Musk, GC., Fleming, PA., Phillips, JK., Boyce, M., Trengove, RD. (2019). Untargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1118-1119(15 June 2019), 25-32. https://doi.org/10.1016/j.jchromb.2019.04.021.
  • Mead, MK., Claus, M., Litton, E., Smart, L., Raisis, A., Rossi, G., Trengrove, RD., Gummer, J. (2019). Identification of the Canidae iron regulatory hormone hepcidin. Scientific Reports, 9(1), Article number 19400. https://doi.org/10.1038/s41598-019-55009-w.
  • Claytor, S., Gummer, J., Groagan, L., Skerratt, L., Webb, R., Brannelly, L., Berger, L., Roberts, A. (2019). Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin. Cellular Microbiology, 21(10), Article number e13089. https://doi.org/10.1111/cmi.13089.

2018

Journal Articles

  • Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S. (2018). Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study. Journal of Intensive Care, 6(1), Article no.60. https://doi.org/10.1186/s40560-018-0328-2.
  • Grogan, L., Skerratt, L., Berger, L., Cashins, S., Trengove, R., Gummer, J. (2018). Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways. Scientific Reports, 8(1), Article number 8188. https://doi.org/10.1038/s41598-018-26427-z.
  • Grogan, L., Mulvenna, J., Gummer, J., Scheele, B., Berger, L., Cashins, S., McFadden, M., Harlow, P., Hunter, D., Trengove, R., Skerratt, L. (2018). Survival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis. Scientific Data, 5(6 March 2018), Article number 180033. https://doi.org/10.1038/sdata.2018.33.
  • Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Stuart, K., Subramaniam, VN., Jeffrey, G., St Pierre, T., House, M., Gummer, J., Trengove, R., Olynyk, J., Crawford, D., Adams, L. (2018). Hepatic iron concentration correlates with insulin sensitivity in non-alcoholic fatty liver disease. Hepatology Communications, 2(6), 644-653. https://doi.org/10.1002/hep4.1190.

2017

Journal Articles

  • Gummer, J., Trengove, R., Pascoe, EM., Badve, SV., Cass, A., Clarke, P., McDonald, SP., Morrish, AT., Pedagogos, E., Perkovic, V., Reidlinger, D., Scaria, A., Walker, R., Vergara, LA., Hawley, CM., Johnson, DW., Olynyk, J., Ferrari, P. (2017). Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. Nephrology, 22(7), 548-554. https://doi.org/10.1111/nep.12815.

2016

Journal Articles

  • Ironman Investigators, T., Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S., Anzics Clinical Trials Group, T. (2016). Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial: A randomized trial of IV iron in critical illness. Intensive Care Medicine, 42(11), 1715-1722. https://doi.org/10.1007/s00134-016-4465-6.
  • Van Rijnsoever, M., Galhenage, S., Mollison, L., Gummer, J., Trengove, R., Olynyk, J. (2016). Dysregulated erythropoietin, hepcidin, and bone marrow iron metabolism contribute to interferon-induced anemia in hepatitis C. Journal of Interferon and Cytokine Research, 36(11), 630-634. https://doi.org/10.1089/jir.2016.0043.
  • Francki, M., Hayton, S., Gummer, J., Rawlinson, C., Trengove, R. (2016). Metabolomic profiling and genomic analysis of wheat aneuploid lines to identify genes controlling biochemical pathways in mature grain. Plant Biotechnology Journal, 14(2), 649-660. https://doi.org/10.1111/pbi.12410.

2015

Journal Articles

  • Rawlinson, C., Kamphuis, L., Gummer, J., Singh, K., Trengove, R. (2015). A rapid method for profiling of volatile and semi-volatile phytohormones using methyl chloroformate derivatisation and GC-MS. Metabolomics, 11(6), 1922-1933. https://doi.org/10.1007/s11306-015-0837-0.

2012

Journal Articles

  • Abbiss, H., Maker, GL., Gummer, J., Sharman, M., Phillips, JK., Boyce, M., Trengove, RD. (2012). Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease. Nephrology, 17(2), 104-110. https://doi.org/10.1111/j.1440-1797.2011.01532.x.

Research Projects

  • Development of a Routine Forensic Process for Individual Identification using Genetically Variant Peptides in Human Hair Evidence , Chemistry Centre WA T/A ChemCentre, Top Up Scholarship, 2022 ‑ 2026, $52,500.
  • Characterisation of genetically variant proteins using high-resolution mass spectrometry for taxonomic assignment of biological evidence in the forensic setting , Chemistry Centre WA T/A ChemCentre, Scholarships to support Industry Engagement PhD Projects, 2022 ‑ 2026, $105,000.
  • Innate Defence Regulator Peptide for Protecting the Preterm Infant from Postnatal Sepsis, National Health and Medical Research Council, Ideas grants, 2020 ‑ 2023, $74,920.
  • Creating a new Forensic Capability in Protein-Based Identification, Australia New Zealand Policing Advisory Agency (ANZPAA), ANZPAA NIFS Research and Innovation Program, 2022 ‑ 2023, $21,000.

Research Student Supervision

Current Supervisions

Associate Supervisor

  • Master of Medical and Health Science by Research, Preservation of Genetically Variant Peptides in the pursuit of DNA evidence

Adjunct Supervisor

  • Doctor of Philosophy, Characterisation of genetically variant proteins using high-resolution mass spectrometry for taxonomic assignment of biological evidence in the forensic setting

Completed Supervisions

Associate Supervisor

  • Developing an improved laboratory diagnostic test for early detection of sepsis in dogs
  • Towards the identification of metabolite markers of nipple pain and inflammation in human milk
  • Unravelling the Lipidome of Idiopathic Pulmonary Fibrosis and its Spatial Distribution using High Resolution Mass Spectrometry
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