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Dr Armaghan Shafaei Darestani

Research Fellow

Staff Member Details
Mobile: 0468 464 626
Campus: Joondalup  
Room: JO19.364  

Armaghan is a Research Fellow with the Centre of Integrative Metabolomics & Computational Biology (CIMCB) in the School of Science.

Current Teaching

  • SCC2211 Organic Chemistry
  • SCC3201 Analytical Chemistry


Armaghan Shafaei received her PhD in Pharmaceutical Chemistry. Her PhD research focused on applying analytical chemistry to investigate bioactivity, safety and efficacy of medicinal plants for treating different diseases such as hypertension, cancer, obesity and uterine fibroid. During her Endeavour Postdoctoral Fellowship (awarded by the Australian Government Department of Education and Training) she linked the analytical research with metabolomic, nutrition and epidemiology expertise. In particular, she developed targeted assays using liquid chromatography-mass spectrometry (LC-MS) techniques for identification and quantification of different metabolites in human plasma and urine samples to support dietary intervention studies. More recently, as a Postdoctoral Fellow at Norwegian University of Science and Technology (NTNU), her research foci were on the development of a suite of targeted and non-targeted Metabolomics and Proteomics methods, applicable to a range of biological model systems (prokaryotic and eukaryotic) for deep phenotyping of model systems.

Professional Memberships

  • 2010 - Malaysian Natural Product Society, MNPS (Member)
  • 2020 – International Metabolomics Society

Awards and Recognition

National and International Awards

  • 2018 - Endeavour Postdoctoral Research Fellowship (Australian Government Department of Education and Training)
  • 2014 - Gold medal for the invention of an anti-hypertension medicine based on local plants in the 25th international invention, innovation & technology exhibition (ITEX 2014), Kuala Lumpur, Malaysia
  • PhD Research Fellowship (University of Science Malaysia)

National and International Research Positions

  • 2019 – Postdoctoral Fellow, held at Norwegian University of Science and Technology (Trondheim, Norway)
  • 2018 – Postdoctoral Research Fellow, held at the University of Western Australia and Edith Cowan University (Australia)

Research Areas and Interests

  • Analytical chemistry
  • Nutritional metabolomics
  • Clinical and biomedical metabolomics


  • Doctor of Philosophy, Malaysia, 2017.

Recent Publications (within the last five years)

Journal Articles

  • Shafaei Darestani, A., Rees, J., Christophersen, C., Devine, A., Broadhurst, D., Boyce, M., (2021), Extraction and quantitative determination of bile acids in feces. Analytica Chimica Acta, 1150(March), Article 338224, DOI: 10.1016/j.aca.2021.338224.
  • Jafaria, SF., Al-Suede, FS., Yehya, AH., Ahamed, MB., Shafaei Darestani, A., Asif, M., Tabana, YM., Majid, AM., Baharetha, HM., (2020), Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats. Biomedicine and Pharmacotherapy, 130(October 2020), Article number 110602, DOI:
  • Zakaria, N., Mohd, KS., Saeed, MA., Hassan, LE., Shafaei Darestani, A., Al-Suede, FS., Memon, AH., Ismail, Z., (2020), Anti-Uterine Fibroid Effect of Standardized Labisia Pumila Var. Alata Extracts In Vitro and in Human Uterine Fibroid Cancer Xenograft Model. Asian Pacific Journal of Cancer Prevention (APJCP), 21(4), 943-951, DOI: 10.31557/APJCP.2020.21.4.943.
  • Bondonno, C., Bondonno, N., Shinde, S., Shafaei Darestani, A., Boyce, M., Swinny, E., Jacob, S., Lacey, K., Woodman, R., Croft, K., Considine, M., Hodgson, J., (2020), Phenolic composition of 91 Australian apple varieties: towards understanding their health attributes. Food and Function, 11(8), 7115-7125, DOI: 10.1039/d0fo01130d.
  • Røst, LM., Shafaei Darestani, A., Fuchino, K., Bruheim, P., (2020), Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1144(1 May 2020), Article number 122078, DOI:
  • Muhammad, A., Yehya, AH., Dahham, SS., Mohamed, S., Shafaei Darestani, A., Oday Ezzatf, M., Abdul Majid, AS., Oon, CE., Abdul Majid, AM., (2019), Establishment of in vitro and in vivo anti-colon cancer efficacy of essential oils containing oleo-gum resin extract of Mesua ferrea. Biomedicine and Pharmacotherapy, 109(January 2019), 1620-1629, DOI:
  • Shafaei Darestani, A., Croft, K., Hodgson, J., Boyce, M., (2019), Simultaneous quantitative analysis of polyphenolic compounds in human plasma by liquid chromatography tandem mass spectrometry. Journal of Separation Science, 42(18), 2909-2921, DOI:
  • Le, TT., Shafaei Darestani, A., Genoni, A., Christophersen, C., Devine, A., Lo, J., Lyons-Wall, P., Boyce, M., (2019), Development and validation of a simple LC-MS/MS method for the simultaneous quantitative determination of trimethylamine-N-oxide and branched chain amino acids in human serum. Analytical and Bioanalytical Chemistry, 411(5), 1019–1028, DOI: 10.1007/s00216-018-1522-8.
  • Esmailli, K., Shafaei Darestani, A., Aisha, A., Al-Suede, F., Majid, A., Ismail, Z., (2019), Evaluation of in vitro cytotoxicity effect of Clinacanthus nutans (Brum. f.) Lindau standardized leaf extracts. Tropical Journal of Pharmaceutical Research , 18(11), 2341-2348, Nigeria , DOI: 10.4314/tjpr.v18i11.16.
  • Shafaei Darestani, A., A. Saeed, MA., R. Hami, MS., Ismail, Z., (2018), Application of High Performance Liquid Chromatography and Fourier-Transform Infrared Spectroscopy Techniques for Evaluating the Stability of Orthosiphon stamineus Ethanolic Extract and Its Nano Liposomes. Revista Brasileira de Farmacognosia, 28(6), 658-668, DOI: 10.1016/j.bjp.2018.07.005.
  • Shafaei Darestani, A., Ahmad Saeed, MA., Aisha, AF., Ismail, Z., (2017), Pharmacokinetics and Bioavailability of Orthosiphon stamineus Ethanolic Extract and its Nano Liposomes in Sprague Dawley Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 9(1), 199-206, DOI: 10.22159/ijpps.2017v9i1.12407.
  • Shafaei Darestani, A., Ab Halim, NH., Zakaria, N., Ismail, Z., (2017), Analysis of Free Amino Acids in Different Extracts of Orthosiphon stamineus Leaves by High-Performance Liquid Chromatography Combined with Solid-Phase Extraction. Pharmacognosy Magazine, 13(Suppl 3), S385-391, DOI: 10.4103/0973-1296.216337.
  • Asif, M., Shafaei Darestani, A., Abdul Majid, AS., Ezzat, MO., Dahham, SS., Ahamed, MB., Oon, CE., Abdul Majid, AM., (2017), Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways. Chinese Journal of Natural Medicines, 15(7), 505-514.
  • Farsi, E., Esmailli, K., Shafaei Darestani, A., Ahamed, MB., Abdul Majid, AS., Abdul Sattar, MZ., Abdul Majid, AM., (2016), Preclinical safety assessment and mutagenicity of the hydroethanolic extract of Syzygium campanulatum leaves. International Journal of Phytomedicine, 8(4), 514-524, DOI: 10.5138/09750185.1955.
  • Muhammad, A., Shafaei Darestani, A., Jafari, SF., Mohamed, SK., Ezzat, MO., Abdul Majid, AS., Oon, CE., Petersen, SH., Kono, K., Abdul Majid, AM., (2016), Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. Toxicology Letters, 257(22 August 2016), 84-96, DOI: 10.1016/j.toxlet.2016.05.027.
  • Shafaei Darestani, A., Sultan Khan, MS., Aisha , AF., Majid , AM., Hamdan, MR., Mordi , MN., Ismail, Z., (2016), Flavonoids-rich Orthosiphon stamineus Extract as New Candidate for Angiotensin I-Converting Enzyme Inhibition: A Molecular Docking Study. Molecules, 21(11), Article number 1500, DOI: 10.3390/molecules21111500.
  • Farsi, E., Esmailli, K., Shafaei Darestani, A., Moradi Khaniabadi, P., Al Hindi, B., Ahamed, MB., Sandai, D., Abdul Sattar, M., Ismail, Z., Abdul Majid, AM., Abdul Majid, AS., (2016), Mutagenicity and Preclinical Safety Assessment of The Aqueous Extract of Clinacanthus nutans Leaves. Drug and Chemical Toxicology: an international journal for rapid communication, 39(4), 461-473, DOI: 10.3109/01480545.2016.1157810.
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