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Professor Simon Laws

Associate Dean and Director, Centre of Precision Health

Staff Member Details
Telephone: +61 8 6304 5128
Mobile: 0408 789 680
Email: s.laws@ecu.edu.au
Campus: Joondalup  
Room: JO21.513  
ORCID iD: https://orcid.org/0000-0002-4355-7082

Simon is the Associate Dean (Medical and Exercise Sciences) and Professor of Translational Genomics in the School of Medical and Health Sciences. He is Director of the Centre for Precision Health, an ECU Strategic Research Centre, and leads the Collaborative Genomics and Translation Group.

Background

  • Jan 2021 – present: Director, Centre for Precision Health, Edith Cowan University, Perth, Australia
  • Nov 2020 – present: Professor of Translational Genomics, Edith Cowan University, Perth, Australia
  • Nov 2011 – Nov 2020: Associate Professor, Edith Cowan University, Perth, Australia
  • Nov 2011 – Dec 2017: Deputy Chief Scientific Officer, Cooperative Research Centre (CRC) for Mental Health www.mentalhealthcrc.com.au
  • April 2009 – Nov 2011: Research Fellow, Edith Cowan University, Perth, Australia
  • Nov 2007 – Mar 2009: Research Fellow, Department of Psychiatrie und Psychotherapie, Neurogenetics Laboratory, Technische Universität München, Germany
  • Jan 2005 – Oct 2007: Post-Doctoral Research Fellow, Department of Psychiatrie und Psychotherapie, Neurogenetics Laboratory, Technische Universität München, Germany
  • Mar 2004 – Dec 2004: Post-Doctoral Research Fellow, McCusker Alzheimer’s Research Foundation, Perth, Australia
  • Jul 2003 – Mar 2004: Research Associate, Alzhyme Pty Ltd, Perth, Australia

Professional Associations

  • 2014 – present: Australasian Neuroscience Society (ANS)
  • 2013 – present: Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)
  • 2012 – present: Australian Society for Biochemistry and Molecular Biology (ASBMB)
  • 2011 – present: Australian Society for Medical Research (ASMR)

Awards and Recognition

Other

  • 2019 – Vice-Chancellor's Award for Excellence in Research

Research Areas and Interests

Professor Laws leads The Collaborative Genomics and Translation Group, part of the Centre for Precision Health, an Edith Cowan University Strategic Research Centre, which he is the inaugural Director of. His Translational Genomics research focuses on understanding the role of genomics primarily in human health, with a developing application to human performance.  This is undertaken from a Precision Health perspective, which utilises advanced biological technologies and analytical methodologies to improve health outcomes through the development of interventions (treatment/preventative strategies) tailored to an individual’s biological (e.g. genetic) profile, as well as their variable responses to their environment/lifestyle. Properly implemented, it has the potential to shift the focus of human health, and potentially, performance systems away from broad treatments/interventions towards improved individualised protection/prevention strategies for human health and performance.

The Human Health portfolio has two major research programs, which focus on:

Understanding the Genomic Architecture of Rates of Change in Alzheimer’s disease and other neurological disorders

  • Develop genetic/epigenetic risk profiles for rates of change of related phenotypes
  • Determine if peripheral methylation patterns track with changes in related phenotypes

Assessing the interaction of genomics and modifiable lifestyle factors and their combined impact on rates of change

  • Understanding the genetic basis of differential effects of lifestyle patterns/choices
  • Determine the impact of positive lifestyle choices on peripheral methylation patterns

The Human Performance portfolio currently focuses on developing an understanding of how genetics can be used for the optimisation of training for improved performance and injury prevention

Professor Laws also undertakes broader genetic and epigenetic collaborative research with scientists and industry partners in the Australian and International research community.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2003.
  • Bachelor of Science (Medical Science), Curtin University of Technology, 1999.

Research Outputs

Journal Articles

  • Brown, B., Frost, N., Rainey-Smith, S., Doecke, J., Markovic, S., Gordon, N., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Erickson, K., Peiffer, J. (2021). High intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial. Alzheimer's Research and Therapy, 13(Feb), Article number 33. https://doi.org/10.1186/s13195-021-00774-y.
  • Frost, N., Weinborn, M., Gignac, G., Rainey-Smith, S., Markovic, S., Gordon, N., Sohrabi, H., Laws, S., Martins, R., Peiffer, J., Brown, B. (2021). A Randomized Controlled Trial of High-Intensity Exercise and Executive Functioning in Cognitively Normal Older Adults. American Journal of Geriatric Psychiatry, 29(2), 129-140. https://doi.org/https://doi.org/10.1016/j.jagp.2020.06.015.
  • Van Der Krall, V., Truong, T., Burnham, S., Dore, V., Mulligan, R., Bozinovski, S., Lamb, F., Bourgeat, P., Fripp, J., Schultz, S., Lim, Y., Laws, S., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Maruff, P., Masters, C., Villemagne, V., Rowe, C. (2021). Association of β-amyloid level, clinical progression and longitudinal cognitive change in normal older individuals. Neurology, NA(NA), NA. https://doi.org/https://doi.org/10.1212/WNL.0000000000011222.

Journal Articles

  • Jacob, Y., Hart, N., Cochrane Wilkie, J., Spiteri, T., Laws, S., Jones, A., Rogalski, B., Kenna, J., Anderton, R. (2020). ACTN3 (R577X) genotype is associated with Australian Football League players. Journal of Strength and Conditioning Research, 2020(Article in press), 1-4. https://doi.org/10.1519/JSC.0000000000003458.
  • De Frutos, J., Cuesta, P., Ramírez-Toraño, F., Nebreda, A., Cuadrado-Soto, E., Peral-Suárez, A., Lopez-Sanz, D., Bruña, R., Marcos-De Pedro, S., Delgado-Losada, M., López-Sobaler, AM., Rodríguez-Rojo, IC., Barabash, A., Rodriguez, JM., Laws, S., Dolado, A., López-Higes, R., Brown, B., Maestú, F. (2020). Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Alzheimer's Research and Therapy, 12(1), Article number 113. https://doi.org/10.1186/s13195-020-00681-8.
  • Gaff, J., Pillay, P., Cherry, C., Laws, S., Price, P., Kamerman, P. (2020). The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans. Journal of the Neurological Sciences, 416(15 September 2020), Article number 116987. https://doi.org/10.1016/j.jns.2020.116987.
  • Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P., Doecke, J., Ames, D., Laws, S., Fowler, C., Rainey-Smith, S., Martins, R., Maruff, P., Villemagne, V., Masters, C., Rowe, C., Fripp, J., Salvado, O. (2020). Comorbidity of Cerebrovascular and Alzheimer’s Disease in Aging. Journal of Alzheimer's Disease, 78(1), 321-334. https://doi.org/10.3233/JAD-200419.
  • Safri, A., Gaff, J., Octaviana, F., Setiawan, D., Imran, D., Cherry, C., Laws, S., Price, P. (2020). Demographic and Genetic Associations With Markers of Small and Large Fiber Sensory Neuropathy in HIV Patients Treated Without Stavudine. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 85(5), 612-616. https://doi.org/10.1097/QAI.0000000000002503.
  • Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R. (2020). Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315. https://doi.org/10.3233/JAD-191304.
  • Gaff, J., Octaviana, F., Pillay, P., Mbenda, HG., Ariyanto, I., Gan, J., Cherry, C., Kamerman, P., Laws, S., Price, P. (2020). TNF-Block Genotypes Influence Susceptibility to HIV-Associated Sensory Neuropathy in Indonesians and South Africans. International Journal of Molecular Sciences, 21(2), Article number 380. https://doi.org/10.3390/ijms21020380.
  • Lim, Y., Laws, S., Perin, S., Pietrzak, R., Fowler, C., Masters, C., Maruff, P. (2020). BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease. Genes, Brain and Behavior, 2020(Article in press), Article number e12724. https://doi.org/https://doi.org/10.1111/gbb.12724.
  • Sohrabi, H., Goozee, K., Weinborn, M., Shen, K., Brown, B., Rainey-Smith, S., Salvado, O., Taddei, K., Bucks, R., Maruff, P., Laws, S., Lenzo, N., Laws, M., Deyoung, C., Speelman, C., Laske, C., Ames, D., Savage, G., Martins, R. (2020). Personality factors and cerebral glucose metabolism in community‑dwelling older adults. Brain Structure and Function, 225(5), 1511–1522. https://doi.org/10.1007/s00429-020-02071-0.
  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.
  • De Frutos-Lucas, J., Cuesta, P., López-Sanz, D., Peral-Suárez, A., Cuadrado-Soto, E., Ramírez-Toraño, F., Brown, B., Serrano, J., Laws, S., Rodriguez-Rojo, I., Verdejo-Román, J., Bruña, R., Delgado-Losada, M., Barabash, A., López-Sobaler, A., López-Higes, R., Marcos, A., Maestú, F. (2020). The relationship between physical activity, apolipoprotein e ϵ4 carriage, and brain health. Alzheimer's Research and Therapy, 12(1), Article number 48. https://doi.org/10.1186/s13195-020-00608-3.
  • Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R., Wright, M., Goate, A., Marcora, E., Huang, K., Porter, T., Laws, S., Sachdev, P., Mather, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Yengo, L., Yang, J., Wray, N., McRae, A., Visscher, P. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11(1), Article number 4799. https://doi.org/10.1038/s41467-020-18534-1.
  • De Frutos, J., Frost, N., Erikson, K., Serrano, JM., Maestú, F., Laws, S., Brown, B. (2020). Does APOE genotype moderate the relationship between physical activity, brain health and dementia risk? A systematic review. Ageing Research Reviews, 64(December 2020), Article number 101173. https://doi.org/10.1016/j.arr.2020.101173.
  • Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(1), Article number 5698. https://doi.org/https://doi.org/10.1038/s41467-020-19473-7.
  • Jayakody, D., Menegola, H., Yiannos, J., Goodman-Simpson, J., Friedland, P., Taddei, K., Laws, S., Weinborn, M., Martins, R., Sohrabi, H. (2020). The peripheral hearing and Central Auditory Processing skills of individuals with subjective memory complaints. Frontiers in Neuroscience, 14(21 August 2020), Article 888. https://doi.org/10.3389/fnins.2020.00888.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.

Journal Articles

  • Marston, K., Brown, B., Rainey-Smith, S., Bird, S., Wijaya, L., Teo, S., Laws, S., Martins, R., Peiffer, J. (2019). Twelve weeks of resistance training does not influence peripheral levels of neurotrophic growth factors or homocysteine in healthy adults: a randomized‑controlled trial. European Journal of Applied Physiology, 119(10), 2167-2176. https://doi.org/10.1007/s00421-019-04202-w.
  • Marston, K., Peiffer, J., Rainey-Smith, S., Gordon, N., Teo, S., Laws, S., Sohrabi, H., Martins, R., Brown, B. (2019). Resistance training enhances delayed memory in healthy middle-aged and older adults: A randomised controlled trial. Journal of Science and Medicine in Sport, 22(11), 1226-1231. https://doi.org/10.1016/j.jsams.2019.06.013.
  • Gaff, J., Octaviana, F., Ariyanto, I., Cherry, C., Laws, S., Price, P. (2019). Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine. Journal of NeuroVirology, 25(6), 814-824. https://doi.org/10.1007/s13365-019-00771-w.
  • Baker, J., Pietrzak, R., Laws, S., Ames, D., Villemagne, V., Rowe, C., Masters, C., Maruff, P., Lim, YY. (2019). Visual Paired Associate Learning Deficits Associated With Elevated Beta-Amyloid in Cognitively Normal Older Adults. Neuropsychology, 33(7), 964-974. https://doi.org/10.1037/neu0000561.
  • Huq, A., Fransquet, P., Laws, S., Ryan, J., Sebra, R., Masters, C., Winship, I., James, P., Lacaze, P. (2019). Genetic resilience to Alzheimer’s disease in APOE ε4 homozygotes: A systematic review. Alzheimer's and Dementia, 15(12), 1612-1623. https://doi.org/10.1016/j.jalz.2019.05.011.
  • Brown, B., Castalanelli, N., Rainey-Smith, S., Doecke, J., Weinborn, M., Sohrabi, H., Laws, S., Martins, R., Peiffer, J. (2019). Influence of BDNF Val66Met on the relationship between cardiorespiratory fitness and memory in cognitively normal older adults. Behavioural Brain Research, 362(19 April 2019), 103-108. https://doi.org/10.1016/j.bbr.2019.01.013.
  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.
  • Sohrabi, H., Weinborn, M., Laske, C., Bates, K., Christensen, D., Taddei, K., Rainey-Smith, S., Brown, B., Kirby, S., Laws, S., Martins, G., Burnham, S., Bucks, R., Reisberg, B., Lautenschlager, N., Foster, J., Martins, R. (2019). Subjective memory complaints predict baseline but not future cognitive function over three years: results from the Western Australia Memory Study. International Psychogeriatrics, 31(4), 513-525. https://doi.org/10.1017/S1041610218001072.
  • Dang, C., Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., Rowe, C., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Masters, C., Maruff, P. (2019). Superior Memory Reduces 8-year Risk of Mild Cognitive Impairment and Dementia But Not Amyloid β-Associated Cognitive Decline in Older Adults. Archives of Clinical Neuropsychology, 34(5), 585-598. https://doi.org/10.1093/arclin/acy078.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Dang, C., Yassi, N., Harrington, K., Xia, Y., Lim, YY., Ames, D., Laws, S., Hickey, M., Rainey-Smith, S., Sohrabi, H., Doecke, J., Fripp, J., Salvado, O., Snyder, P., Weinborn, M., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2019). Rates of age- and amyloid B-associated cortical atrophy in older adults with superior memory performance. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11(December 2019), 566-575. https://doi.org/10.1016/j.dadm.2019.05.005.
  • Burnham, S., Coloma, P., Li, Q., Collins, S., Savage, G., Laws, S., Doecke, J., Maruff, P., Martins, R., Ames, D., Rowe, C., Masters, C., Villemagne, V. (2019). Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer’s Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study. The Journal of Prevention of Alzheimer's Disease, 6(4), 248-255. https://doi.org/10.14283/jpad.2019.25.
  • Russell, A., Kepka, A., Trbojevic-Akmacic, I., Ugrina, I., Song, M., Hui, J., Hunter, M., Laws, S., Lauc, G., Wang, W. (2019). Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans. Immunobiology, 224(1), 110-115. https://doi.org/10.1016/j.imbio.2018.10.002.

Book Chapters

  • Masters, C., Gu, B., Laws, S., Lim, YY., Roberts, B., Villemagne, VL., Beyreuther, K. (2018). Alzheimer's disease: Toward a quantitative biological approach in describing its natural history and underlying mechanisms. The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms (57-74). Academic Press.

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.
  • Fernando, B., Rainey-Smith, S., Kirby, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R. (2018). Associations of dietary protein and fiber intake with brain and blood amyloid-β. Journal of Alzheimer's Disease, 61(4), 1589-1598. https://doi.org/10.3233/JAD-170742.
  • Weinborn, M., Bucks, R., Sohrabi, H., Rainey-Smith, S., Brown, B., Kirby, S., Gozt, O., Christensen, D., Savage, G., Laws, S., Taddei, K., Maruff, P., Robertson, J., Ellis, K., Ames, D., Masters, C., Rowe, C., Martins, R. (2018). Trajectories of Irregular Word Reading Ability as a Proxy for Premorbid Intelligence in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Aging: A Longitudinal Study. Psychological Assessment, 30(10), 1308-1316. https://doi.org/10.1037/pas0000565.
  • Lim, YY., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., Rowe, C., Masters, C., Maruff, P. (2018). Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA Neurology, 75(4), 488-494. https://doi.org/10.1001/jamaneurol.2017.4325.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
  • Harrington, K., Schembri, A., Lim, YY., Dang, C., Ames, D., Hassenstab, J., Laws, S., Rainey-Smith, S., Robertson, J., Rowe, C., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Masters, C., Maruff, P. (2018). Estimates of age-related memory decline are inflated by unrecognized Alzheimer’s disease. Neurobiology of Aging, 70(Oct 2018), 170-179. https://doi.org/10.1016/j.neurobiolaging.2018.06.005.
  • Russell, A., Adua, E., Ugrina, I., Laws, S., Wang, W. (2018). Unravelling immunoglobulin G Fc N-glycosylation: A dynamic marker potentiating predictive, preventive and personalised medicine. International Journal of Molecular Sciences, 19(2), article no.390. https://doi.org/10.3390/ijms19020390.
  • Harrington, K., Dang, C., Lim, YY., Ames, D., Laws, S., Pietrzak, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Villemagne, V., Masters, C., Maruff, P. (2018). The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults. Intelligence, 70(Sept-Oct 2018), 22-29. https://doi.org/10.1016/j.intell.2018.07.004.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.
  • Brown, B., Rainey-Smith, S., Dore, V., Peiffer, J., Burnham, S., Laws, S., Taddei, K., Ames, D., Masters, C., Rowe, C., Martins, R., Villemagne, V. (2018). Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's Disease, 63(4), 1299-1305. https://doi.org/10.3233/JAD-170998.
  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211. https://doi.org/10.3233/JAD-180713.
  • Perin, S., Harrington, K., Lim, YY., Ellis, K., Ames, D., Pietrzak, R., Schembri, A., Rainey-Smith, S., Salvado, O., Laws, S., Martins, R., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2018). Amyloid burden and incident depressive symptoms in preclinical Alzheimer’s disease. Journal of Affective Disorders, 229(15 March 2018), 269-274. https://doi.org/10.1016/j.jad.2017.12.101.
  • Doecke, J., Rembach, A., Villemagne, V., Varghesi, S., Rainey-Smith, S., Sarros, S., Evered, L., Fowler, C., Pertile, K., Rumble, R., Trounson, B., Taddei, K., Laws, S., Macaulay, SL., Bush, A., Ellis, K., Martins, R., Ames, D., Silbert, B., Vanderstichele, H., Masters, C., Darby, D., Li, Q., Collins, S. (2018). Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms. Journal of Alzheimer's Disease, 61(1), 169-183. https://doi.org/10.3233/JAD-170128.
  • Holmes, SE., Esterlis, I., Mazure, CM., Lim, YY., Ames, D., Rainey-Smith, S., Fowler, C., Ellis, K., Martins, R., Salvado, O., Doré, V., Villemagne, VL., Rowe, CC., Laws, S., Masters, CL., Pietrzak, RH., Maruff, P. (2018). Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study. International Journal of Geriatric Psychiatry, 33(2), 405-413. https://doi.org/10.1002/gps.4761.
  • Rainey-Smith, S., Gu, Y., Kirby, S., Doecke, J., Villemagne, V., Brown, B., Taddei, K., Laws, S., Sohrabi, H., Weinborn, M., Ames, D., Fowler, C., Macaulay, SL., Maruff, P., Masters, C., Salvado, O., Rowe, C., Scarmeas, N., Martins, R. (2018). Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Translational Psychiatry, 8(1), 238-244. https://doi.org/10.1038/s41398-018-0293-5.
  • Dang, C., Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Yassi, N., Hickey, M., Rainey-Smith, S., Robertson, J., Sohrabi, H., Salvado, O., Weinborn, M., Villemagne, V., Rowe, C., Masters, C., Maruff, P. (2018). Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 65(4), 1313-1325. https://doi.org/10.3233/JAD-180507.

Journal Articles

  • Villemagne, V., Doré, V., Bourgeat, P., Burnham, S., Laws, S., Salvado, O., Masters, C., Rowe, C. (2017). Aβ-amyloid and Tau Imaging in Dementia. Seminars in Nuclear Medicine, 47(1), 75-88. https://doi.org/10.1053/j.semnuclmed.2016.09.006.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.
  • Harrington, K., Lim, YY., Ames, D., Hassenstab, J., Laws, S., Martins, R., Rainey-Smith, S., Robertson, J., Rowe, C., Salvado, O., Dore, V., Villemagne, V., Snyder, P., Masters, C., Maruff, P. (2017). Amyloid β–associated cognitive decline in the absence of clinical disease progression and systemic illness. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(1), 156-164. https://doi.org/10.1016/j.dadm.2017.05.006.
  • Lim, YY., Williamson, R., Laws, S., Villemagne, V., Bourgeat, P., Fowler, C., Rainey-Smith, S., Salvado, O., Martins, R., Rowe, C., Masters, C., Maruff, P. (2017). Effect of APOE genotype on amyloid deposition, brain volume, and memory in cognitively normal older individuals. Journal of Alzheimer's Disease, 58(4), 1293-1302. https://doi.org/10.3233/JAD-170072.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Brown, B., Rainey-Smith, S., Castalanelli, N., Gordon, N., Markovic, S., Sohrabi, H., Weinborn, M., Laws, S., Doecke, J., Shen, K., Martins, R., Peiffer, JJ. (2017). Study protocol of the Intense Physical Activity and Cognition study: The effect of high-intensity exercise training on cognitive function in older adults. Alzheimer's and Dementia, 3(4), 562-570. https://doi.org/10.1016/j.trci.2017.09.003.
  • Cardoso, B., Hare, D., Lind, M., McLean, C., Volitakis, I., Laws, S., Masters, C., Bush, A., Roberts, B. (2017). The APOE ε4 Allele is associated with lower selenium levels in the brain: Implications for Alzheimer’s disease. ACS Chemical Neuroscience, 8(7), 1459-1464. https://doi.org/10.1021/acschemneuro.7b00014.

Journal Articles

  • Lim, Y., Laws, S., Villemagne, V., Pietrzak, R., Porter, T., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Martins, R., Salvado, O., Bourgeat, P., Rowe, C., Masters, C., Maruff, P. (2016). Aβ-related memory decline in APOE ε4 non-carriers: Implications for Alzheimer’s disease. Neurology, 86(17), 1635-1642. https://doi.org/10.1212/WNL.0000000000002604.
  • Kirby, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R. (2016). Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672. https://doi.org/10.3233/JAD-151084.
  • Lim, YY., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., Salvado, O., Rowe, C., Masters, C., Maruff, P. (2016). Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia. Journal of Molecular Neuroscience, 60(3), 362-370. https://doi.org/10.1007/s12031-016-0822-8.
  • Brown, B., Rainey-Smith, S., Villemagne, V., Weinborn, M., Bucks, R., Sohrabi, H., Laws, S., Taddei, K., Macaulay, SL., Ames, D., Fowler, C., Maruff, P., Masters, C., Rowe, C., Martins, R. (2016). The relationship between sleep quality and brain amyloid burden. Sleep, 39(5), 1063-1068. https://doi.org/10.5665/sleep.5756.
  • Holmes, S., Esterlis, I., Mazure, C., Lim, YY., Ames, D., Rainey-Smith, S., Martins, R., Salvado, O., Dore, V., Villemagne, V., Rowe, C., Laws, S., Masters, C., Maruff, P., Pietrzak, R. (2016). β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195. https://doi.org/10.1016/j.jagp.2016.08.007.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.
  • Burnham, S., Rowe, C., Baker, D., Bush, A., Doecke, JD., Faux, N., Laws, S., Martins, R., Maruff, P., Macaulay, S., Rainey-Smith, S., Savage, G., Ames, D., Masters, C., Wilson, W., Villemagne, V. (2016). Predicting Alzheimer disease from a blood-based biomarker profile. Neurology, 87(11), 1093-1101. https://doi.org/10.1212/WNL.0000000000003094.
  • Burnham, S., Bourgeat, P., Dore, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R., Masters, C., Rowe, C., Villemagne, V. (2016). Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study. Lancet Neurology, 15(10), 1044-1053. https://doi.org/10.1016/S1474-4422(16)30125-9.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.

Journal Articles

  • Pietrzak, RH., Lim, YY., Ames, D., Harrington, K., Restrepo, C., Martins, R., Rembach, A., Laws, S., Masters, CL., Villemagne, VL., Rowe, CC., Maruff, P. (2015). Trajectories of memory decline in preclinical Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Neurobiology of Aging, 36(3), 1231-1238. https://doi.org/10.1016/j.neurobiolaging.2014.12.015.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R. (2015). Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16. https://doi.org/10.3389/fnagi.2015.00016.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.
  • Li, Q., Villemagne, V., Doecke, J., Rembach, A., Sarros, S., Varghese, S., McGlade, A., Laughton, K., Pertile, K., Fowler, C., Rumble, R., Trounson, B., Taddei, K., Rainey-Smith, S., Laws, S., Robertson, J., Evered, L., Silbert, B., Ellis, K., Rowe, C., Macaulay, S., Darby, D., Martins, R., Ames, D., Masters, C., Collins, S. (2015). Alzheimer’s Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Alzheimer's Disease, 48(1), 175-187. https://doi.org/10.3233/JAD-150247.
  • Gu, B., Field, J., Duterte, S., Ou, A., Kilpatrick, T., Lechner-Scott, J., Scott, R., Lea, R., Taylor, B., Stankovich, J., Butzkueven, H., Gresle, M., Laws, S., Petrou, S., Hoffjan, S., Akkad, D., Graham, C., Hawkins, S., Glaser, A., Bedri, S., Hillert, J., Matute, C., Antiguedad, A., Wiley, J. (2015). A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis. Human Molecular Genetics, 24(19), 5644-54. https://doi.org/10.1093/hmg/ddv278.
  • Thai, C., Lim, YY., Villemagne, VL., Laws, S., Ames, D., Ellis, KA., Rainey-Smith, S., Martins, R., Masters, CL., Rowe, CC., Maruff, P. (2015). Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease is Dependent on APOE ε4 and is Detectable over 18-Months. PLoS One, 10(10), Article number e0139082. https://doi.org/10.1371/journal.pone.0139082.
  • Rembach, A., Evered, L., Li, Q., Nash, T., Vidaurre, L., Fowler, CJ., Pertile, KK., Rumble, RL., Trounson, BO., Maher, S., Mooney, F., Farrow, M., Taddei, K., Rainey-Smith, S., Laws, S., Macaulay, SL., Wilson, W., Darby, DG., Martins, R., Ames, D., Collins, S., Silbert, B., Masters, CL., Doecke, JD. (2015). Alzheimer's Disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology. Alzheimer's Research and Therapy, 7(2015), Article number 71. https://doi.org/10.1186/s13195-015-0157-7.
  • Lim, YY., Villemagne, VL., Laws, S., Pietrzak, RH., Snyder, PJ., Ames, D., Ellis, KA., Harrington, K., Rembach, A., Martins, R., Rowe, CC., Masters, CL., Maruff, P. (2015). APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Molecular Psychiatry, 20(11), 1322-1328. https://doi.org/10.1038/mp.2014.123.

Journal Articles

  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R. (2014). Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75. https://doi.org/10.1038/mp.2012.147.
  • Rembach, A., Faux, N., Watt, A., Pertile, K., Rumble, R., Trounson, B., Fowler, C., Roberts, B., Perez, K., Li, Q., Laws, S., Taddei, K., Rainey-Smith, S., Robertson, J., Vandijck, M., Vanderstichele, H., Barnham, K., Ellis, K., Szoeke, C., Macaulay, L., Rowe, C., Villemagne, V., Ames, D., Martins, R., Bush, A., Masters, C. (2014). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia, 10(1), 53-61. https://doi.org/10.1016/j.jalz.2012.12.006.
  • Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S. (2014). Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546. https://doi.org/10.3233/JAD-131442.
  • Burnham, S., Faux, N., Wilson, W., Laws, S., Ames, D., Bedo, J., Bush, A., Doecke, J., Ellis, K., Head, R., Jones, G., Kiiveri, H., Martins, R., Rembach, A., Rowe, C., Salvado, O., Macaulay, SL., Masters, C., Villemagne, V. (2014). A blood-based predictor for neocortical A-beta burden in Alzheimer's disease: results from the AIBL study. Molecular Psychiatry, 19(2014), 519-526. https://doi.org/10.1038/mp.2013.40.
  • Brown, B., Bourgeat, P., Peiffer, J., Burnham, S., Laws, S., Rainey-Smith, S., Bartres-Faz, D., Villemagne, V., Taddei, K., Rembach, A., Bush, A., Ellis, K., Macaulay, SL., Rowe, C., Ames, D., Masters, C., Maruff, P., Martins, R. (2014). Influence of BDNF Val66Met on the relationship between physical activity and brain volume. Neurology, 83(15), 1345-52. https://doi.org/10.1212/WNL.0000000000000867.
  • Villemagne, V., Dore, V., Yates, P., Brown, B., Mulligan, R., Bourgeat, P., Veljanoski, R., Rainey-Smith, S., Ong, K., Rembach, A., Williams, R., Burnham, S., Laws, S., Salvado, O., Taddei, K., Macaulay, SL., Martins, R., Ames, D., Masters, C., Rowe, C. (2014). En Attendant Centiloid. Advances in Research, 2(12), 723-729. https://doi.org/10.9734/AIR/2014/11599.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Bush, A., Martins, R., Masters, C., Rowe, C., Maruff, P. (2014). Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer’s disease: A preliminary study. PLoS One, 9(1), Article no. e86498. https://doi.org/10.1371/journal.pone.0086498.

Journal Articles

  • Brown, B., Peiffer, J., Taddei, K., Lui, J., Laws, S., Gupta, V., Taddei, T., Ward, V., Rodrigues, M., Burnham, S., Rainey-Smith, S., Villemagne, V., Bush, A., Ellis, K., Masters, C., Ames, D., Macaulay, L., Szoeke, C., Rowe, C., Martins, R. (2013). Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry, 18(8), 875-881. https://doi.org/10.1038/mp.2012.107.
  • Lim, YY., Villemagne, V., Laws, S., Ames, D., Pietrzak, R., Ellis, K., Harrington, K., Bourgeat, P., Salvado, O., Darby, D., Snyder, P., Bush, A., Martins, R., Masters, C., Rowe, C., Nathan, P., Maruff, P. (2013). BDNF Val66Met, Abeta amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of Aging, 34(11), 2457-2464. https://doi.org/10.1016/j.neurobiolaging.2013.05.006.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R. (2013). The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920. https://doi.org/10.4236/health.2013.55121.
  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G. (2013). The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235. https://doi.org/10.1371/journal.pone.0066235.

Journal Articles

  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R. (2012). Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056. https://doi.org/10.1016/j.neurobiolaging.2010.09.003.
  • Guo, LH., Westerteicher, C., Wang, X., Kratzer, M., Tsolakidou, A., Jiang, M., Grimmer, T., Laws, S., Alexopoulos, P., Bujo, H., Kurz, A., Perneczky, R. (2012). SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience, 262(6), 529-534. https://doi.org/10.1007/s00406-012-0295-x.
  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R. (2012). Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456. https://doi.org/10.4236/health.2012.412A209.
  • Doecke, J., Laws, S., Faux, N., Wilson, W., Burnham, S., Lam, P., Mondal, A., Bedo, J., Bush, A., Brown, B., De Ruyck, K., Ellis, K., Fowler, C., Gupta, V., Head, R., Macaulay, SL., Pertile, K., Rowe, C., Rembach, A., Rodrigues, M., Rumble, R., Szoeke, C., Taddei, K., Taddei, T., Trounson, B., Ames, D., Masters, C., Martins, R. (2012). Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease. Archives of Neurology, 69(10), 1318-1325. https://doi.org/10.1001/archneurol.2012.1282.
  • Sohrabi, H., Bates, K., Weinborn, M., Johnston, A., Bahramian, A., Taddei, K., Laws, S., Rodrigues, M., Morici, M., Howard, M., Martins, G., Mackay-Sim, A., Gandy, S., Martins, R. (2012). Olfactory discrimination predicts cognitive decline amongst community-dwelling older adults. Translational Psychiatry, 2(2012), art. no. e118. https://doi.org/10.1038/tp.2012.43.

Journal Articles

  • Faux, NG., Ellis, KA., Porter, L., Fowler, CJ., Laws, S., Martins, R., Pertile, K., Rembach, A., Rowe, CC., Rumble, RL., Szoeke, C., Taddei, K., Taddei, T., Trounson, BO., Villemagne, VL., Ward, V., Ames, D., Masters, CL., Bush, A. (2011). Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study.. Journal of Alzheimer's Disease, 27(4), 909-922. https://doi.org/10.3233/JAD-2011-110752.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390. https://doi.org/10.1016/j.neuropsychologia.2011.04.012.
  • Laws, S., Eckart, K., Freidrich, P., Kurz, A., Forstl, H., Riemenschneider, M. (2011). Lack of evidence to support the association of polymorphisms within the α and β secretase genes (ADAM10/BACE1) with Alzheimer's disease. Neurobiology of Aging, 32(3), 541-543. https://doi.org/10.1016/j.neurobiolaging.2009.02.023.
  • Freidrich, P., Feulner, T., Laws, S., Eckart, K., Perneczky, R., Kurz, A., Forstl, H., Riemenschneider, M. (2011). No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. Neurobiology of Aging, 32(3), 544-545. https://doi.org/10.1016/j.neurobiolaging.2009.03.007.
  • Lambert, J., Dallongeville, J., Ellis, KA., Schraen-Maschke, S., Lui, J., Laws, S., Dumont, J., Richard, F., Cottel, D., Berr, C., Ames, D., Masters, CL., Rowe, CC., Szoeke, C., Tzourio, C., Dartigues, J., Buee, L., Martins, R., Amouyel, P. (2011). Association of plasma Aβ peptides with blood pressure in the elderly. PLoS One, 6(4), e18536. https://doi.org/10.1371/journal.pone.0018536.
  • Gupta, V., Laws, S., Villemagne, V., Ames, D., Bush, A., Ellis, K., Lui, J., Masters, C., Rowe, C., Szoeke, C., Taddei, K., Martins, R. (2011). Plasma apolipoprotein e and Alzheimer disease risk: The AIBL study of aging. Neurology, 76(12), 1091-1098. https://doi.org/10.1212/WNL.0b013e318211c352.

Journal Articles

  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, TU., Forstl, H., Reimenschneider, M. (2010). No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, 31(12), 2192-2193.
  • Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Riehle, C., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Forstl, H., Kurz, A., Reimenschneider, M. (2010). Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, 15(7), 756–766.
  • Lui, J., Laws, S., Li, Q., Villemagne, V., Ames, D., Brown, B., Bush, A., De Ruyck, K., Dromey, J., Ellis, K., Faux, N., Foster, J., Fowler, C., Gupta, V., Hudson, P., Laughton, K., Masters, C., Pertile, K., Rembach, A., Rimajova, M., Rodrigues, M., Rowe, C., Rumble, R., Szoecke, C., Taddei, K., Taddei, T., Trounson, B., Ward, V., Martins, R. (2010). Plasma amyloid-β as a biomarker in Alzheimer’s disease: the AIBL study of aging.. Journal of Alzheimer's Disease, 20(4), 1233-1242.

Journal Articles

  • Diehl-Schmid, J., Neumann, M., Laws, S., Perneczky, R., Grimmer, T., Danek, A., Kurz, A., Riemenschneider, M., Förstl, H. (2009). Frontotemporale Lobärdegenerationen. Fortschritte der Neurologie, Psychiatrie, 77(5), 295-304.
  • Danek, A., Diehl-Schmid, J., Grimmer, T., Laws, S., Neumann, M., Perneczky, R., Riemenschneider, M., Kurz, A., Förstl, H. (2009). Frontotemporale Lobärdegenerationen, Teil 1: Diagnose und Therapie. Fortschritte der Neurologie-Psychiatrie, 77(3), 169-176.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Laws, S., Lautenschlager, N., Dhaliwal, S., Johnston, A., Mackay-Sim, A., Gandy, S., Foster, J., Martins, R. (2009). Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's disease, 17(1), 135-142.
  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Förstl, H., Riemenschneider, M. (2009). Lack of evidence to support the association of polymorphisms within the α and β secretase genes (ADAM10/BACE1) with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a. https://doi.org/10.1016/j.neurobiolaging.2009.02.023.
  • Sohrabi, H., Bates, K., Rodrigues, M., Taddei, K., Martins, G., Laws, S., Lautenschlager, N., Dhaliwal, S., Foster, J., Martins, R. (2009). The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein eε4 carriers and non-carriers. Journal of Alzheimer's disease, 17(1), 69-79.
  • Feulner, T., Laws, S., Friedrich, P., Wagenpfeil, S., Wurst, S., Kuhn, K., Krawczak, M., Schreiber, S., Nikolaus, S., Förstl, H., Kurz, A., Riemenschneider, M. (2009). Examination of the current top candidate genes for AD in a genome-wide association study. Molecular Psychiatry, n/a(n/a), n/a.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R. (2009). Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-β Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318.
  • Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Schoepfer-Wendels, A., Mueller, J., Konta, L., Laws, S., Kurz, A., Förstl, H., Riemenschneider, M. (2009). No Association of Common VCP Variants With Sporadic Frontotemporal Dementia. Neurobiology of Aging, 30(2), 333-335.
  • Friedrich, P., Feulner, T., Laws, S., Eckart, K., Perneczky, R., Kurz, A., Förstl, H., Riemenschneider, M. (2009). No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a.
  • Laws, S., Eckart, K., Friedrich, P., Eisele, T., Kurz, A., Förstl, H., Riemenschneider, M. (2009). No association of lipase C polymorphisms with Alzheimer's disease. Neurobiology of Aging, n/a(n/a), n/a.

Journal Articles

  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R. (2008). Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages.
  • Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R. (2008). Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274.
  • Laws, S., Friedrich, P., Diehl-Schmid, J., Muller, J., Ibach, B., Bauml, J., Eisele, T., Forstl, H., Kurz, A., Riemenschneider, M. (2008). Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. Neurobiology of Aging, 29(8), 1276-1278. https://doi.org/10.1016/j.neurobiolaging.2007.02.019.

Journal Articles

  • Riemenschneider, M., Schoepfer-Wendels, A., Friedrich, P., Konta, L., Laws, S., Mueller, J., Kurz, A., Förstl, H. (2007). No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease. Neurobiology of Aging, 28(6), 883-884.
  • Laws, S., Pernecky, R., Drzezga, A., Diehl-Schmid, J., Ibach, B., Bäuml, J., Eisele, T., Förstl, H., Kurz, A., Riemenschneider, M. (2007). Association of the tau haplotype H2 with age at onset and functional alterations of glucose utilization in frontotemporal dementia. American Journal of Psychiatry, 164(10), 1577-1584.
  • Schumacher, A., Friedrich, P., Diehl-Schmid, J., Ibach, B., Eisele, T., Laws, S., Förstl, H., Kurz, A., Riemenschneider, M. (2007). No association of chromatin-modifying protein 2B with sporadic frontotemporal dementia. Neurobiology of Aging, 28(11), 1789-1790.
  • Mueller, J., Riemenschneider, M., Schoepfer-Wendels, A., Gohlke, H., Konta, L., Friedrich, P., Illig, T., Laws, S., Förstl, H., Kurz, A. (2007). Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures. Neurobiology of Aging, 28(5), 727-734.
  • Laws, S., Friedrich, P., Diehl-Schmid, J., Mueller, J., Eisele, T., Bäuml, J., Förstl, H., Kurz, A., Riemenschneider, M. (2007). Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease. Molecular Psychiatry, 12(5), 510-517.

Journal Articles

  • Riemenschneider, M., Blennow, K., Wagenpfeil, S., Andreasen, N., Prince, J., Laws, S., Förstl, H., Kurz, A. (2006). The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease. Human Mutation, 27(6), 532-537.
  • Gohlke, H., Illig, T., Klopp, N., Wagenpfeil, S., Konta, L., Laws, S., Kurz, A., Riemenschneider, M. (2006). Association study between the D10S1423 microsatellite marker and Alzheimer's disease. Neurobiology of Aging, 27(5), 776e1-776e3.

Journal Articles

  • Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?. Pharmacological Research, 50(4), 397-409.
  • Burkhardt, M., Foster, J., Laws, S., Baker, L., Craft, S., Gandy, S., Stuckey, B., Clarnette, R., Nolan, D., Hewson-Bower, B., Martins, R. (2004). Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. Journal of Alzheimer's Disease, 6(3), 221-228.

Journal Articles

  • Laws, S., Hone, E., Gandy, S., Martins, R. (2003). Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of Neurochemistry, 84(6), 1215-1236.
  • Dean, B., Laws, S., Hone, E., Taddei, K., Scarr, E., Thomas, E., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry, 54(6), 616-622.
  • Thomas, E., Laws, S., Sutcliffe, J., Harper, C., Dean, B., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological Psychiatry, 54(2), 136-141.

Research Projects

  • Imaging, fluid and genetic markers of Alzheimer's disease, National Health and Medical Research Council, Ideas grants, 2021 ‑ 2025, $1,519,004.
  • Alzheimer's dementia and progression in international cohorts, National Institutes of Health, Grant, 2019 ‑ 2024, $199,422.
  • E-DADS: Early Detection of Alzheimer s Disease Subtypes, National Health and Medical Research Council, Boosting Dementia Research Grants Scheme, 2020 ‑ 2024, $422,617.
  • BRAIN-MEND: Biological Resource Analysis to Identify new mechanisms and phenotypes in Neurodegenerative Diseases, National Health and Medical Research Council, Boosting Dementia Research Grants Scheme, 2018 ‑ 2022, $58,362.
  • Investigating changes in DNA Methylation age in Alzheimer’s disease , Australian Alzheimer's Research Foundation, Scholarships to support Industry Engagement PhD Projects, 2019 ‑ 2022, $35,000.
  • Genetic contributions to Alzheimer’s Disease risk and progression in the AIBL cohort, Florey Institute of Neuroscience and Mental Health, Grant, 2021, $170,000.
  • Assessing the functional implication of genetic and epigenetic risk and resilience factors in Alzheimer's Disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2019 ‑ 2021, $140,000.
  • Investigating association between AiM variants of interest and Alzheimer phenotypes of clinical or scientific interest via targeted PheWAS using human data, Eisai Inc, Grant, 2020 ‑ 2021, $167,598.
  • Jump-starting the spinal cord with acute intermittent hypoxia: mediators of inter-individual variability in neuroplasticity , Perron Institute for Neurological and Translational Science, Neurotrauma Research Program, 2021, $94,163.
  • WA Memory Study (WAMS), Australian Alzheimer's Research Foundation, McCusker Alzheimer's Research Foundation - Grant, 2019 ‑ 2021, $236,746.
  • Medical and Health Research Infrastructure Fund 2019 (Round 23), Department of Health WA, Medical and Health Research Infrastructure, 2020 ‑ 2021, $20,497.
  • The feasibility and therapeutic utility of a 12-week telehealth delivered environmental enrichment program for young stroke survivors experiencing cognitive impairment, Perron Institute for Neurological and Translational Science, Neurotrauma Research Program, 2021, $84,600.
  • Genetic and lifestyle susceptibility and resilience factors affecting rates of change in preclinical Alzheimer's Disease, National Health and Medical Research Council, Project Grants, 2019 ‑ 2021, $940,788.
  • Develop a systematic profiling of neurological conditions that will facilitate personalised treatment and streamline service delivery, Multiple Sclerosis Society of Western Australia, MS WA - Research funding for social and applied research, 2019 ‑ 2021, $1,200,000.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22), Department of Health WA, Medical and Health Research Infrastructure, 2019 ‑ 2020, $37,037.
  • Genetic Linkages to mTOR pathway dysregulation and development of Alzheimers Disease, CRC For Mental Health, WES Study, 2015 ‑ 2019, $524,000.
  • 4.1 Biomarkers for Early Diagnosis of AD and PD, CRC For Mental Health, CRC Grant, 2011 ‑ 2018, $7,524,765.
  • Biomarkers and Early Intervention for Neurodegeneration, CRC For Mental Health, CRC Grant, 2012 ‑ 2018, $674,185.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20), Department of Health WA, Medical and Health Research Infrastructure, 2017 ‑ 2018, $18,077.
  • Impact of genetics on the effect that modifiable lifestyle factors have on rates of change in Alzheimers Disease, Equity Trustees Limited, Mason Foundation National Medical Program (funded by the J. J. Mason & H.S. Williams Memorial Foundation), 2016 ‑ 2017, $55,370.
  • Development and refinement of methods for early and specific diagnosis of Alzheimer's disease, quantification of rates of change in the pathological processes and determination of the resultant effects on cognition., Fil Foundation, Grant, 2015 ‑ 2017, $417,506.
  • The effect of high-intensity exercise on Alzheimer’s disease-related gene expression, Brain Foundation, Research Gifts Program, 2017, $39,875.
  • In vitro functional analysis of Alzheimer’s disease associated genetic variants, Department of Health WA, Near Miss Merit Awards, 2015 ‑ 2016, $75,000.
  • CRC for Mental Health - Neurogenerative disease: Genome-Wide Association Studies (GWAS) study , CRC For Mental Health, GWAS Study, 2014 ‑ 2016, $395,000.
  • Validation of genetic variants and their functional implications in Alzheimers Disease, ANZ Executors and Trustee Company Limited, Judith Jane Mason and Harold Stannett Williams Memorial Foundation - National Medical & Scientific Grants, 2014 ‑ 2015, $40,000.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $352,524.
  • Western Australian Zebrafish Facility, Australian Research Council, Grant - Linkage (Infrastructure), 2014, $620,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research, National Health and Medical Research Council, Equipment Grant 2011, 2011 ‑ 2012, $10,927.
  • NEW INDEPENDENT RESEARCHER INFRASTRUCTURE SUPPORT (NIRIS) AWARDS 2011, Medical and Health Research Infrastructure Council WA, New Independent Researcher Infrastructure Support (NIRIS), 2011 ‑ 2012, $10,000.
  • AIBL: Imaging and genetic study add-ons (ECU project: Genomic Studies - Candidate Gene Validation Stream), Confidential, Confidential, 2011 ‑ 2012, $95,238.
  • Molecular & neuropsychological predictive markers of cognitive decline, National Health and Medical Research Council, Grant, 2005 ‑ 2007, $423,750.

Research Student Supervision

Principal Supervisor

  • Doctor of Philosophy, The impact of the interaction between SITR1 and lifestyle factors on Alzheimer's Disease risk and related phenotypes
  • Master of Medical and Health Science by Research, Remote preterm birth prevention using salbutamol tocolysis within the royal flying doctor service Western operations aeromedical retrieval
  • Doctor of Philosophy, Peripheral DNA methylation patterns, methylation age and alzheimer's disease risk and related phenotypes

Associate Supervisor

  • Doctor of Philosophy, Acute and chronic interference effect: Insights into the role of genetic variation
  • Doctor of Philosophy, Genetic link to athletic performance and injury incidence in Australian football

Principal Supervisor

  • Doctor of Philosophy, PHYSICAL ACTIVITY AS A POTENTIAL PROTECTIVE FACTOR FOR PEOPLE AT INCREASED GENETIC RISK FOR ALZHEIMER’S DISEASE
  • Master of Science (Medical Science), Dna methylation of the clusterin promoter: Associations with alzheimer's disease risk and related phenotypes
  • Doctor of Philosophy, Genetic determinants of rates of cognitive decline in preclinical alzheimer's disease

Associate Supervisor

  • Master of Science (Human Biology), Plasma insulin-degrading enzyme: Characterisation and evaluation as a potential biomarker for alzheimer's disease.
  • Doctor of Philosophy, Evolutionary approaches for feature selection in biological data
  • Doctor of Philosophy, Quantifying the heterogeneity of the immunoglobulin g n-glycome in an ageing Australian population: The busselton health ageing study
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