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Dr Tenielle Porter

Research Fellow

Staff Member Details
Telephone: +61 8 6304 5685
Email: t.porter@ecu.edu.au
Campus: Joondalup  
Room: JO21.508  
ORCID iD: https://orcid.org/0000-0002-7887-6622

Tenielle is a Strategic Research Fellow and Deputy Lead of the Collaborative Genomics and Translation Group, within the School of Medical and Health Sciences. She is also the Deputy Neurobiology Stream Lead in the Centre for Precision Health, an ECU Strategic Research Centre. Tenielle’s research focuses on understanding the relationship between genetics, lifestyle and markers of Alzheimer’s disease. Specifically, she aims to identify genetic and epigenetic patterns predicting cognitive decline and brain changes during the development of Alzheimer’s disease, and how these relationships are influenced by a person’s lifestyle.

Current Teaching

  • SCH2235 Applied Microbiology
  • MMS2102 Medical Microbiology

Professional Associations

  • 2012 – Present: Australian Society for Medical Research (ASMR)
  • 2014 – Present: Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) - including membership of the Alliance of Women Alzheimer's Researchers (AWARE) and Biofluid Based Biomarkers Professional Interest Areas (PIA)

Awards and Recognition

  • 2019: BioinfoSummer MATHS Award ($4,000)
  • 2019: ECR Collaboration Scheme, Dementia Centre for Research Collaboration ($5,000)
  • 2016: Cooperative Research Centre Association Showcasing Early Career Researchers Finalist ($1,000)
  • 2016: ECU Joondalup 3 Minute Thesis Finalist

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2018.

Research Outputs

Journal Articles

  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.
  • Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R., Wright, M., Goate, A., Marcora, E., Huang, K., Porter, T., Laws, S., Sachdev, P., Mather, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Yengo, L., Yang, J., Wray, N., McRae, A., Visscher, P. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11(1), Article number 4799. https://doi.org/10.1038/s41467-020-18534-1.

Journal Articles

  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.

Journal Articles

  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211. https://doi.org/10.3233/JAD-180713.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.

Journal Articles

  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.

Research Projects

  • Defining genetic, epigenetic and transcriptomic profiles of progression in preclinical Alzheimer’s disease, Department of Health WA, Near Miss Merit Awards, 2020 ‑ 2022, $95,000.
  • Understanding the biology behind the benefits of physical activity in the elderly., Edith Cowan University, ECU Early Career Researcher Grant – 2020, 2020 ‑ 2021, $26,920.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy, The impact of the interaction between SITR1 and lifestyle factors on Alzheimer's Disease risk and related phenotypes
  • Doctor of Philosophy, Acute and chronic interference effect: Insights into the role of genetic variation
  • Doctor of Philosophy, Peripheral DNA methylation patterns, methylation age and alzheimer's disease risk and related phenotypes

Associate Supervisor

  • Master of Science (Medical Science), Dna methylation of the clusterin promoter: Associations with alzheimer's disease risk and related phenotypes
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