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  • Dr Tenielle Porter

    Dr Tenielle Porter

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Dr Tenielle Porter

Lecturer

Staff Member Details
Telephone: +61 8 6304 5685
Email: t.porter@ecu.edu.au
Campus: Joondalup  
Room: JO21.508  
ORCID iD: https://orcid.org/0000-0002-7887-6622

Tenielle is a Strategic Research Fellow and Deputy Lead of the Collaborative Genomics and Translation Group, within the School of Medical and Health Sciences. She is also the Deputy Neurological conditions Program Lead in the Centre for Precision Health, an ECU Strategic Research Centre. Tenielle’s research focuses on understanding the relationship between genetics, lifestyle and markers of Alzheimer’s disease. Specifically, she aims to identify genetic and epigenetic patterns predicting cognitive decline and brain changes during the development of Alzheimer’s disease, and how these relationships are influenced by a person’s lifestyle.

Current Teaching

  • SCH2235 Applied Microbiology
  • MMS2102 Medical Microbiology

Professional Associations

  • 2012 – Present: Australian Society for Medical Research (ASMR)
  • 2014 – Present: Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) - including membership of the Alliance of Women Alzheimer's Researchers (AWARE) and Biofluid Based Biomarkers Professional Interest Areas (PIA)

Awards and Recognition

  • 2019: BioinfoSummer MATHS Award ($4,000)
  • 2019: ECR Collaboration Scheme, Dementia Centre for Research Collaboration ($5,000)
  • 2016: Cooperative Research Centre Association Showcasing Early Career Researchers Finalist ($1,000)
  • 2016: ECU Joondalup 3 Minute Thesis Finalist

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2018.

Research Outputs

2023

Journal Articles

  • Milicic, L., Porter, T., Vacher, M., Laws, S. (2023). Utility of DNA Methylation as a Biomarker in Ageing and Alzheimer’s Disease. Journal of Alzheimer's Disease Reports, 7(1), 475-503. https://doi.org/10.3233/ADR-220109.
  • Schäfer Hackenhaar, F., Josefsson, M., Nordin Adolfsson, A., Landfors, M., Kauppi, K., Porter, T., Milicic, L., Laws, S., Hultdin, M., Adolfsson, R., Degerman, S., Pudas, S. (2023). Sixteen-Year Longitudinal Evaluation of Blood-Based DNA Methylation Biomarkers for Early Prediction of Alzheimer's Disease. Journal of Alzheimer's Disease, 94(4), 1443-1464. https://doi.org/10.3233/JAD-230039.
  • Roberts, B., Laffoon, S., Roberts, A., Porter, T., Fowler, C., Masters, C., Dratz, E., Laws, S. (2023). Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study. Journal of Alzheimer's Disease Reports, 7(1), 165-172. https://doi.org/10.3233/ADR-220075.
  • Mehramiz, M., Porter, T., O'Brien, E., Rainey-Smith, S., Laws, S. (2023). A Potential Role for Sirtuin-1 in Alzheimer's Disease: Reviewing the Biological and Environmental Evidence. Journal of Alzheimer's Disease Reports, 7(1), 823-843. https://doi.org/10.3233/ADR-220088.

2022

Journal Articles

  • Krishnadas, N., Dore, V., Laws, S., Porter, T., Bozinovski, S., Villemagne, V., Rowe, C. (2022). Exploring discordant low amyloid-beta and high neocortical tau PET cases. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), article number e12326. https://doi.org/10.1002/dad2.12326.
  • Jiang, Y., Zhou, X., Wong, H., Ouyang, L., Ip, F., Chau, V., Lau, S., Wu, W., Wong, D., Seo, H., Fu, W., Lai, N., Chen, Y., Chen, Y., Tong, E., Mok, V., Kwok, T., Mok, K., Shaoi, M., Lehallier, B., Losada, P., O'Brien, E., Porter, T., Laws, S., Hardy, J., Wyss-Coray, T., Masters, C., Fu, A., Ip, N. (2022). An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature Aging, 2(7), 616-634. https://doi.org/10.1038/s43587-022-00241-9.
  • Cadby, G., Giles, C., Melton, P., Huynh, K., Mellett, N., Duong, T., Nguyen, A., Cinel, M., Smith, A., Olshansky, G., Wang, T., Brozynska, M., Inouye, M., McCarthy, N., Ariff, A., Hung, J., Hui, J., Beilby, J., Dube, M., Watts, G., Shah, S., Wray, N., Lim, F., Chatterjee, P., Martins, I., Laws, S., Porter, T., Vacher, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Taddei, K., Arnold, M., Kastenmuller, G., Nho, K., Saykin, A., Han, X., Kaddurah-Daouk, R., Martins, R., Blangero, J., Meikle, P., Moses, E. (2022). Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease. Nature Communications, 13(1), Article number 3124. https://doi.org/10.1038/s41467-022-30875-7.
  • Adewuyi, E., O'Brien, E., Nyholt, D., Porter, T., Laws, S. (2022). A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders. Communications Biology, 5(1), article number 691. https://doi.org/10.1038/s42003-022-03607-2.
  • Adewuyi, E., O'Brien, E., Porter, T., Laws, S. (2022). Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis. International Journal of Molecular Sciences, 23(24), Article number 16199. https://doi.org/https://doi.org/10.3390/ijms232416199.
  • Porter, T., Sim, M., Prince, R., Schousboe, JT., Bondonno, C., Lim, WH., Zhu, K., Kiel, DP., Hodgson, J., Laws, S., Lewis, J. (2022). Abdominal aortic calcification on lateral spine images captured during bone density testing and late-life dementia risk in older women: a prospective cohort study. The Lancet Regional Health - Western Pacific, 2022(Article in Press), 59p. https://doi.org/10.1016/j.lanwpc.2022.100502.
  • Vacher, M., Dore, V., Porter, T., Milicic, L., Villemagne, V., Bourgeat, P., Burnham, S., Cox, T., Masters, C., Rowe, C., Fripp, J., Doecke, J., Laws, S. (2022). Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease. BMC Genomics, 23(1), Article 401. https://doi.org/10.1186/s12864-022-08617-2.
  • Milicic, L., Vacher, M., Porter, T., Dore, V., Burnham, S., Bourgeat, P., Shishegar, R., Doecke, J., Armstrong, N., Tankard, R., Maruff, P., Masters, C., Rowe, C., Villemagne, V., Laws, S. (2022). Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. GeroScience, 44(3), 1807-1823. https://doi.org/10.1007/s11357-022-00558-8.
  • Vacher, M., Porter, T., Milicic, L., Bourgeat, P., Dore, V., Villemagne, V., Laws, S., Doecke, J. (2022). A Targeted Association Study of Blood-Brain Barrier Gene SNPs and Brain Atrophy. Journal of Alzheimer's Disease, 86(4), 1817-1829. https://doi.org/10.3233/JAD-210644.
  • Woodfield, A., Porter, T., Gilani, I., Noordin, S., Li, Q., Collins, S., Martins, R., Maruff, P., Masters, C., Rowe, C., Villemagne, V., Dore, V., Newsholme, P., Laws, S., Verdile, G. (2022). Insulin resistance, cognition and Alzheimer’s disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of Aging, 114(June 2022), 38-48. https://doi.org/10.1016/j.neurobiolaging.2022.03.004.
  • Mehramiz, M., Porter, T., Laws, S., Rainey-Smith, S. (2022). Sleep, Sirtuin 1 and Alzheimer’s disease: a review. Ageing Brain, 2(2022), article number 100050. https://doi.org/10.1016/j.nbas.2022.100050.
  • Woodfield, A., Gonzales, T., Helmerhorst, E., Laws, S., Newsholme, P., Porter, T., Verdile, G. (2022). Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease. International Journal of Molecular Sciences, 23(24), Article number 15811. https://doi.org/10.3390/ijms232415811.
  • Brown, B., De Frutos Lucas, J., Porter, T., Frost, N., Vacher, M., Peiffer, J., Laws, S. (2022). A new paradigm for the treatment of Alzheimer's disease: targeting vascular activation. Journal of Alzheimer's Disease, 40(3), 619-630. https://doi.org/10.3233/JAD-220114.

2021

Journal Articles

  • Tan, S., Porter, T., Bucks, R., Weinborn, M., Milicic, L., Brown, A., Rainey-Smith, S., Taddei, K., Ames, D., Masters, C., Maruff, P., Savage, G., Rowe, C., Villemagne, V., Brown, B., Sohrabi, H., Laws, S., Martins, R. (2021). Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition. Hormones and Behaviour, 131(May 2021), Article number 104966. https://doi.org/10.1016/j.yhbeh.2021.104966.
  • Belloy, M., Eger, S., Le Guen, Y., Napolioni, V., Deters, K., Yang, H., Scelsi, M., Porter, T., James, S., Wong, A., Schott, J., Sperling, R., Laws, S., Mormino, E., He, Z., Han, S., Altmann, A., Greicius, M. (2021). KL*VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE*4 carriers. Neurobiology of Aging, 101(May 2021), 123-129. https://doi.org/10.1016/j.neurobiolaging.2021.01.008.
  • Moussavi Nik, S., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., Eccles, M., Woodfield, A., Groth, D., Dore, V., Villemagne, V., Masters, C., Martins, R., Laws, S., Lardelli, M., Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 Transcript to Alzheimer's disease and neurodegeneration. Journal of Alzheimer's Disease, 80(4), 1479-1489. https://doi.org/10.3233/jad-201133.
  • Fowler, C., Rainey-Smith, S., Bird, S., Bomke, J., Bourgeat, P., Brown, B., Burnham, S., Bush, A., Chadunow, C., Collins, S., Doecke, J., Dore, V., Ellis, K., Evered, L., Fazlollahi, A., Fripp, J., Kirby, S., Gibson, S., Grenfell, R., Harrison, E., Head, R., Jin, L., Kamer, A., Lamb, F., Lautenschlager, N., Laws, S., Li, Q., Lim, L., Lim, Yy., Louey, A., Macaulay, L., Mackintosh, L., Martins, R., Maruff, P., Masters, C., McBride, S., Milicic, L., Peretti, M., Pertile, K., Porter, T., Radler, M., Rembach, A., Robertson, J., Rodriguez, M., Rowe, C., Rumble, R., Salvado, O., Savage, G., Silbert, B., Soh, M., Sohrabi, H., Taddei, K., Taddei, T., Thai, C., Trounson, B., Tyrell, R., Vacher, M., Varghese, S., Villemagne, V., Weinborn, M., Woodward, M., Xia, Y., Ames, D. (2021). Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer's disease. Journal of Alzheimer's Disease Reports, 5(1), 443-468. https://doi.org/10.3233/ADR-210005.
  • Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., Jackaman, C., Villemagne, V., Munyard, K., Laws, S., Verdile, G., Groth, D. (2021). Chronic stress and Alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. Biological Reviews, 96(5), 2209-2228. https://doi.org/10.1111/brv.12750.
  • Fernandez, S., Burnham, S., Milicic, L., Savage, G., Maruff, P., Peretti, M., Sohrabi, H., Lam, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Porter, T., Laws, S. (2021). SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults. Journal of Alzheimer's Disease Reports, 5(1), 111-120. https://doi.org/10.3233/ADR-200246.
  • Cruickshank, T., Porter, T., Laws, S., Ziman, M., Bartlett, D. (2021). Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease. Scientific Reports, 11(December 2021), Article number 5464. https://doi.org/10.1038/s41598-021-84726-4.

2020

Journal Articles

  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.
  • Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R., Wright, M., Goate, A., Marcora, E., Huang, K., Porter, T., Laws, S., Sachdev, P., Mather, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Yengo, L., Yang, J., Wray, N., McRae, A., Visscher, P. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11(1), Article number 4799. https://doi.org/10.1038/s41467-020-18534-1.

2019

Journal Articles

  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.

2018

Journal Articles

  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211. https://doi.org/10.3233/JAD-180713.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.

2017

Journal Articles

  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.

Research Projects

  • The interaction of genetic and lifestyle factors affecting progression in neurodegenerative disorders, Department of Health WA, Near Miss Merit Awards, 2021 ‑ 2023, $74,000.
  • Defining genetic, epigenetic and transcriptomic profiles of progression in preclinical Alzheimer’s disease, Department of Health WA, Near Miss Merit Awards, 2020 ‑ 2022, $95,000.
  • Understanding the biology behind the benefits of physical activity in the elderly., Edith Cowan University, ECU Early Career Researcher Grant – 2020, 2020 ‑ 2021, $26,920.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Master of Medical and Health Science by Research, Investigating relationships between genetic variation in a metabolic clearance pathway, physical activity, and Alzheimer's Disease
  • Doctor of Philosophy, Modelling Alzheimer’s disease trajectories as a function of genetic factors and mapping relevant biological pathways
  • Master of Medical and Health Science by Research, Investigating the genetic relationship between Alzheimer's disease and physical activity.

Co-principal Supervisor

  • Doctor of Philosophy, Assessing the genetic relationship between Alzheimer's disease and inflammatory and autoimmune-related traits to identify potential drug targets.

Associate Supervisor

  • Doctor of Philosophy, Acute and chronic interference effect: Insights into the role of genetic variation

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Peripheral DNA methylation patterns, methylation age and Alzheimer's disease risk and related phenotypes
  • Master of Science (Medical Science), Dna methylation of the clusterin promoter: Associations with alzheimer's disease risk and related phenotypes
  • Doctor of Philosophy, The impact of the interaction between SIRT1 and lifestyle factors on Alzheimer’s disease risk and related phenotypes
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