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  • Dr Xingang Li

    Dr Xingang Li

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Dr Xingang Li

Xingang is a Postdoctoral Research Fellow in the School of Medical and Health Sciences, within the Suboptimal Health and Glycomics research group. He is also a research member of the Centre for Precision Health, an ECU Strategic Research Centre.

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2020.
  • Master of Medicine, China (excludes SARs and Taiwan), 2008.
  • Bachelor of Medicine, China (excludes SARs and Taiwan), 2001.

Research Outputs

2024

Journal Articles

  • Wu, Z., Jiang, Y., Guo, Z., Li, P., Zheng, Y., Wang, Y., Zhang, H., Balmer, L., Li, X., Tao, L., Zhang, Q., Gao, B., Guo, X. (2024). Remnant cholesterol traits and risk of stroke: A multivariable Mendelian randomization study. PNAS Nexus, 3(2), Article number pgae033. https://doi.org/10.1093/pnasnexus/pgae033.
  • Guo, Z., Zheng, Y., Geng, J., Wu, Z., Wei, T., Shan, G., Zhu, Y., Zheng, Y., Li, X. (2024). Unveiling the link between systemic inflammation markers and cognitive performance among older adults in the US: A population-based study using NHANES 2011–2014 data. Journal of Clinical Neuroscience, 119(2024), 45-51. https://doi.org/10.1016/j.jocn.2023.11.004.

2023

Journal Articles

  • Lan, Y., Chen, G., Wu, D., Ding, X., Huang, Z., Wang, X., Balmer, L., Li, X., Song, M., Wang, W., Wu, S., Chen, Y. (2023). Temporal relationship between atherogenic dyslipidemia and inflammation and their joint cumulative effect on type 2 diabetes onset: a longitudinal cohort study. BMC Medicine, 21(1), Article number 31. https://doi.org/10.1186/s12916-023-02729-6.
  • Yang, L., Yan, Y., Li, J., Zhou, C., Jin, J., Zhang, T., Wu, H., Li, X., Wang, W., Yuan, L., Zhang, X., Gao, J. (2023). (Tn5-) FISH-based imaging in the era of 3D/spatial genomics. Biophysics Reports, 9(1), 15-25. https://doi.org/10.52601/bpr.2023.220025.
  • Wang, Y., Guo, Z., Tian, Y., Cong, L., Zheng, Y., Wu, Z., Shan, G., Xia, Y., Zhu, Y., Li, X., Song, Y. (2023). MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor. BMC Cancer, 23(1), article number 959. https://doi.org/10.1186/s12885-023-11480-3.
  • Lan, Y., Wu, D., Cai, Z., Xu, Y., Ding, X., Wu, W., Lan, S., Chen, L., Guo, Z., Balmer, L., Li, X., Song, M., Wu, S., Gao, J., Wang, W., Chen, Y. (2023). Supra-additive effect of chronic inflammation and atherogenic dyslipidemia on developing type 2 diabetes among young adults: a prospective cohort study. Cardiovascular Diabetology, 22(1), Article number 181. https://doi.org/10.1186/s12933-023-01878-5.

2022

Journal Articles

  • Wang, H., Wang, Y., Li, X., Deng, X., Kong, Y., Wang, W., Zhou, Y. (2022). Machine learning of plasma metabolome identifies biomarker panels for metabolic syndrome: findings from the China Suboptimal Health Cohort. Cardiovascular Diabetology, 21(1), article number 288. https://doi.org/10.1186/s12933-022-01716-0.
  • Guo, Z., Meng, R., Zheng, Y., Li, X., Zhon, Z., Yu, L., Tang, Q., Zhao, Y., Garcia, M., Tan, Y., Song, M., Balmer, L., Wen, J., Hou, H., Tan, X., Wang, W. (2022). Translation and cross-cultural validation of a precision health tool, the Suboptimal Health Status Questionnaire-25, in Korean. Journal of Global Health, 12(1 October 2022), Article Number 04077. https://doi.org/10.7189/jogh.12.04077.
  • Zheng, Y., Guo, Z., Zhang, Y., Shang, J., Yu, L., Fu, P., Liu, Y., Li, X., Wang, H., Ren, L., Zhang, W., Hou, H., Tan, X., Wang, W. (2022). Rapid triage for ischemic stroke: a machine learning‑driven approach in the context of predictive, preventive and personalised medicine. EPMA Journal, 13(2), 285-298. https://doi.org/10.1007/s13167-022-00283-4.

2021

Journal Articles

  • Li, X., Wang, H., Zhu, Y., Cao, W., Song, M., Wang, Y., Hou, H., Lang, M., Guo, X., Tan, X., Han, J., Wang, W. (2021). Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues. Frontiers in Immunology, 12(3 November 2021), article number 741705. https://doi.org/10.3389/fimmu.2021.741705.
  • Wang, H., Tian, Q., Zhang, J., Liu, H., Zhang, J., Cao, W., Zhang, X., Li, X., Wu, L., Song, M., Kong, Y., Wang, W., Wang, Y. (2021). Blood transcriptome profiling as potential biomarkers of suboptimal health status: potential utility of novel biomarkers for predictive, preventive, and personalized medicine strategy. EPMA Journal, 12(2), 103-115. https://doi.org/10.1007/s13167-021-00238-1.
  • Yang, J., Chen, T., Zhu, Y., Bai, M., Li, X. (2021). Causal Inference Between Chronic Periodontitis and Chronic Kidney Disease: A Bidirectional Mendelian Randomization Analysis in a European Population. Frontiers in Genetics, 12(7 June 2021), Article number 676136. https://doi.org/10.3389/fgene.2021.676136.
  • Meng, X., Song, M., Vilaj, M., Štambuk , J., Dolikun, M., Zhang, J., Liu, D., Wang, H., Zhang, X., Zhang, J., Cao, W., Momčilović , A., Trbojević-Akmačić , I., Li, X., Zheng, D., Wu, L., Guo, X., Wang, Y., Lauc, G., Wang, W. (2021). Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese. Journal of Personalized Medicine, 11(7), Article number 614. https://doi.org/10.3390/jpm11070614.

2020

Book Chapters

  • Wang, L., Li, X., Tang, D., Wang, W. (2020). DNA methylation. Genome Plasticity in Health and Disease (93-108). Academic Press. https://doi.org/10.1016/B978-0-12-817819-5.00007-3.
  • Li, X., Wang, L., Tan, X., Wang, W. (2020). Genome plasticity and endocrine diseases. Genome Plasticity in Health and Disease (211-235). Academic Press.

Journal Articles

  • Wang, H., Tian, Q., Zhang, J., Liu, H., Zhang, X., Cao, W., Zhang, J., Anto, E., Li, X., Wang, X., Liu, D., Zheng, Y., Guo, Z., Wu, L., Song, M., Wang, Y., Wang, W. (2020). Population-based case-control study revealed metabolomic biomarkers of suboptimal health status in Chinese population—potential utility for innovative approach by predictive, preventive, and personalized medicine. EPMA Journal, 11(2), 147-160. https://doi.org/10.1007/s13167-020-00200-7.

2019

Journal Articles

  • Cao, F., Li, X., Yang, Y., Fang, H., Qu, H., Chang, N., Ma, Q., Cao, W., Zhou, J., Wang, W. (2019). Toward Candidate Proteomic Biomarkers in Clinical Monitoring of Acute Promyelocytic Leukemia Treatment with Arsenic Trioxide. OMICS: A Journal of Integrative Biology, 23(2), 119-130. https://doi.org/10.1089/omi.2018.0178.
  • Li, X., Wang, H., Russell, A., Cao, W., Wang, X., Ge, S., Zheng, Y., Guo, Z., Hou, H., Song, M., Yu, X., Wang, Y., Hunter, M., Roberts, P., Lauc, G., Wang, W. (2019). Type 2 Diabetes Mellitus is Associated with the Immunoglobulin G N-Glycome through Putative Proinflammatory Mechanisms in an Australian Population. OMICS: A Journal of Integrative Biology, 23(12), 631-639. https://doi.org/10.1089/omi.2019.0075.
  • Wang, H., Li, X., Wang, X., Liu, D., Zhang, X., Cao, W., Zheng, Y., Guo, Z., Li, D., Xing, W., Hou, H., Wu, L., Song, M., Zhong, Z., Wang, Y., Tan, X., Lauc, G., Wang, W. (2019). Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N-Glycans in a Chinese Han Population. OMICS: A Journal of Integrative Biology, 23(12), 649-659. https://doi.org/10.1089/omi.2019.0099.

2018

Journal Articles

  • Ma, Q., Adua, E., Boyce, M., Li, X., Ji, G., Wang, W. (2018). IMass time: The future, in future!. OMICS: A Journal of Integrative Biology, 22(11), 679-695. https://doi.org/10.1089/omi.2018.0162.

Research Projects

  • B Cell Regulation of Immunoglobulin G N-Glycosylation in Crohn's Disease, Department of Health WA, WA Near-miss Awards: Emerging Leaders Program, 2024 ‑ 2025, $100,000.
  • Developing a tool to predict the likely occurrence of stroke, Edith Cowan University, Early-Mid Career Researcher Grant Scheme 2022 (Stream 1), 2023 ‑ 2024, $39,571.
  • Exploring the Potential for Intervening the Rise in the Prevalence of Chronic Disease in South-West Australia, WA Primary Health Alliance, Grant, 2017 ‑ 2018, $18,954.

Research Student Supervision

Current Supervisions

Associate Supervisor

  • Doctor of Philosophy, Investigating the Role of IgG N-glycosylation in Diagnosis and Disease Activity of Axial Spondyloarthritis
  • Doctor of Philosophy, Exploring the Impact of Uterine Fibroids on Hypertension through Hypoxia-Inducible Factor-1 alpha-Medicated Regulation of Endothelin-1 and Soluble Fms-like Tyrosine Kinase 1 in Hypoxic Leiomyoma Smooth Muscle Cells
  • Doctor of Philosophy, Development and External Validation of a Novel Prognostic Model for Aortic-related Adverse Events after Endovascular Repair in Patients with Type B Aortic Dissection
  • Doctor of Philosophy, Data mining for dementia prevention using mobile phone applications (the PRODEMOS study) in China: A multicentre randomised controlled effectiveness-implementation trial
  • Doctor of Philosophy, Unravelling Type 2 Diabetes Biomarkers Through Advance Single-Cell RNA Sequencing and N-Glycome Profiling.
  • Doctor of Philosophy, Exploring Moderator and Mediator Effects of Suboptimal Health Status and Multi-omics Signatures for Metabolic Syndrome: A Nested Case-Control Study and Post-GWAS Integrative Analysis

Assistant Supervisor

  • Doctor of Philosophy, Inflammation, metabolic disorders and incident type 2 diabetes

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Artificial intelligence-assisted prediction, feature, selection, and multi-omics integration in exploing the interaction between IgG N-glycome and transcriptome and constructing the ageing clock
  • Doctor of Philosophy, The role of CD147 N-glycosylation and IgG N-glycosylation in the inflammatory modulation of atherogenesis
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