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Professor Mel Ziman

Honorary Professor

Contact Information Email: m.ziman@ecu.edu.au,
Staff Member Details
Email: m.ziman@ecu.edu.au

 

Mel is a Professor in the School of Medical and Health Sciences, her areas of expertise include Melanoma and Huntington's disease. Mel is head of the ECU Melanoma Research Group.

Current Teaching

  • BSc Medical Science Honour Degree Coordination
  • Postgraduate Supervision

Background

  • 2013-present: Professor, School of Medical and Health Sciences, ECU
  • 2011-2013: Associate Professor, School of Medical Sciences, ECU
  • 2005-2010: Associate Professor, School of Exercise, Biomedical and Health Science, ECU
  • 2003-2005: Senior Lecturer, School of Exercise, Biomedical and Health Science, ECU
  • 2001-2003: Lecturer, School of Exercise, Biomedical and Health Science, ECU
  • 1996-2001: Senior Research Fellowship, School of Pathology and Laboratory Medicine, UWA

Professional Associations

  • Society for Melanoma Research, USA
  • ANZMTG
  • Australian Neuroscience Society,
  • Human Genetics Society of Australia,
  • Australian Society for Medical Research
  • Australian and New Zealand Society of Development and Cell Biology
  • Combined Biological Society
  • International Society of Differentiation (ISD)

Awards and Recognition

University and National Teaching Awards

  • 2012:UniJobs Lecturer of the Year Award for the Top 10 Lecturers at ECU in 2011
  • 2012:ECU award for Excellence in Postgraduate Supervision
  • 2011:VC Excellence Award for Engagement in Research
  • 2010:  VC Citation for excellence in development of a Teaching and Research Nexus
  • 2010: Citation for Outstanding Contribution to Student Learning – Australian Learning and Teaching
  • 2008: VC Citation for excellence in development of a Teaching and Research Nexus
  • 2008: Citation for Outstanding Contribution to Student Learning – Australian Learning and Teaching Council (Carrick)
  • 2008: ECU Certificate of excellence in Learning and Teaching – UTEI over 85
  • 2005: ECU award for Excellence in Postgraduate Supervision

Other

  • 2010 - 2016: NHMRC grant review panel member
  • 2009-2015: National OLT grant review panel member
  • 2015:   WAHTN Committee Member
  • 2014:Parliamentary Standing Committee on Health - Skin cancer in Australia
  • 2013:ASPIRE Professional Development Award, Perth Convention Bureau
  • 2012-  NHMRC Research Translation Faculty Member

Research Areas and Interests

  • The role of developmental genes in the proliferation, differentiation and migration of cells in the embryo and in disease processes such as cancer including Cutaneous Malignant Melanoma and neurodegenerative diseases including Huntington’s disease.
  • Characterisation of circulating cells in Melanoma
  • Multidisciplinary therapy and neurogenesis in Huntington’s disease.

Qualifications

  • Bachelor of Science Honours, South Africa.
  • Degree of Doctor of Philosophy, South Africa, 1983.

Research

Recent Research Grants

  • ACRF Centre for Advanced Cancer Genomics,  Australian Cancer Research Foundation,  Cancer Research Grants,  2020 - 2028,  $2,277,000.
  • The development and evaluation of a novel multidisciplinary therapy coaching program for people with mild-to-moderate Huntington’s disease. ,  Perpetual Ltd,  IMPACT Philanthropy Application Program,  2018 - 2023,  $445,021.
  • Enabling Advanced Single Cell Cancer Genomics in Western Australia,  Cancer Research Trust,  The Grant,  2017 - 2022,  $305,925.
  • Circulating Melanoma Cells as Predictive Biomarkers of Response to Immune Checkpoint Blockade ,  Cancer Council of WA Inc,  Grant,  2020 - 2022,  $100,000.
  • The effect of cognitive and exercise training on Brain Atrophy and Cognitive Decline in Breast Cancer Patients Treated with Adjuvant Chemotherapy Agents,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2018 - 2021,  $49,966.
  • Medical and Health Research Infrastructure Fund 2019 (Round 23),  Department of Health WA,  Medical and Health Research Infrastructure,  2020 - 2021,  $17,743.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22),  Department of Health WA,  Medical and Health Research Infrastructure,  2019 - 2020,  $17,691.
  • Early Detection of Cancer Spread and Treatment of Ocular Melanoma,  Cancer Council of WA Inc,  PhD Top Up Scholarship,  2018 - 2020,  $30,000.
  • Liquid biopsy for personalised monitoring of melanoma patients ,  National Health and Medical Research Council,  Development Grants,  2017 - 2020,  $950,389.
  • Translation of "Liquid Biopsy" Research into Clinical Practice,  Western Australian Health Translation Network,  Early Career Fellowships,  2019 - 2020,  $478,955.
  • Single Cell Whole Transcriptome Sequencing of Melanoma Circulating Tumour Cells (CTCs): Unveiling Cell Diversity,  Tour de Cure,  Pioneering Cancer Research Grant,  2019,  $120,000.
  • Development of a Multiplex Test for the Early Diagnosis of Melanoma,  Tour de Cure,  Senior Research Grant,  2019,  $280,000.
  • Medical and Health Research Infrastructure Fund 2017 (Round 21),  Department of Health WA,  Medical and Health Research Infrastructure,  2018 - 2019,  $14,816.
  • High-frequency ultrasound and photoacoustic imaging for Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2018 - 2019,  $631,198.
  • A liquid biopsy to assist with staging of melanoma patients,  Perpetual Ltd,  IMPACT Philanthropy Application Program,  2017 - 2019,  $210,050.
  • Predictive significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA) and serum vascular endothelial growth factor (VEGF) in advanced melanoma patients treated with pembrolizumab,  Merck Sharp and Dohme (Australia) Pty Ltd,  Grant,  2016 - 2019,  $73,300.
  • Liquid Biopsy for Prognosis of Uveal Melanoma,  The Ophthalmic Research Institute of Australia,  ORIA - Grant,  2018,  $27,551.
  • Circulating Tumour DNA to Predict and Monitor Treatment Response and Detect Acquired Resistance in Patients with Metastatic Melanoma,  Ramaciotti Foundation,  Grant,  2015 - 2018,  $99,911.
  • A Blood Based ‘Liquid Biopsy’ to Improve Healthcare for Metastatic Melanoma Patients,  Department of Health WA,  SHRAC Research Translation Projects,  2016 - 2018,  $4,075,030.
  • Understanding the Role of Melanoma Exosomes in Intercellular Communication,  Cancer Council of WA Inc,  Collaborative Cancer Grant Scheme,  2017 - 2018,  $43,230.
  • Blood Based Biomarkers Predictive of Treatment Response in Melanoma,  Cancer Council of WA Inc,  Grant,  2016 - 2018,  $246,822.
  • Translation of the HEROs Program of Multidisciplinary Therapy for Patients with Huntington s Disease (HD) into community settings,  Edith Cowan University,  ECU Industry Collaboration Scheme - 2016 Open Round,  2017 - 2018,  $169,003.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20),  Department of Health WA,  Medical and Health Research Infrastructure,  2017 - 2018,  $13,910.
  • Genetic Analysis of Blood Markers for Prognosis in Patients with Uveal Melanoma,  University of Western Australia,  Raine Foundation Grant,  2016 - 2018,  $100,000.
  • Blood based biomarkers predictive of treatment efficacy in metastatic melanoma,  Spinnaker Health Research Foundation,  Collaborative Research Partnership Grants,  2017 - 2018,  $107,448.
  • Western Australia Single-Cell Isolation and Genomics Preparation Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2017,  $430,000.
  • The effect of multidisciplinary therapy on neurodegeneration and clinical decline in Huntington’s disease individuals before the onset of diagnosable symptoms.,  Edith Cowan University,  ECU Early Career Researcher Grant - 2016,  2016 - 2017,  $27,900.
  • Circulating Tumour Cells (CTCs) as biomarkers in metastatic melanoma,  Edith Cowan University,  ECU Early Career Researcher Grant - 2016,  2016 - 2017,  $30,000.
  • Gene expression profiling of circulating tumour cells (CTCs) isolated from metastatic melanoma patients using a microfluidic chip,  Cancer Council of WA Inc,  Grant - Early Career Investigator,  2016 - 2017,  $35,000.
  • A preliminary study investigating blood markers of response to treatment with immune system targeted therapy in advanced melanoma,  Cancer Council of WA Inc,  Grant - Early Career Investigator,  2015 - 2017,  $35,000.
  • Circulating Melanoma Cells as Predictive Biomarkers of Treatment Response and Disease Status,  Cancer Council of WA Inc,  Grant,  2015 - 2017,  $111,519.
  • HEROs Huntington's disease Exercise Rehabilitation Optimisation Study,  Lotterywest,  Grant,  2014 - 2017,  $780,974.
  • Using a Functional Protein Array to Identify Autoantibody Biomarkers with Diagnostic Potential for Melanoma,  National Health and Medical Research Council,  Development Grants,  2014 - 2017,  $778,368.
  • Medical and Health Research Infrastructure Fund (MHRIF) 2015 (Round 19),  Department of Health WA,  Medical and Health Research Infrastructure,  2016 - 2017,  $18,590.
  • A Single-Molecule Super-Resolution Microscopy Facility in Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2016,  $2,094,000.
  • 2015 NHMRC Equipment Grant,  National Health and Medical Research Council,  Equipment Grant 2015,  2015 - 2016,  $6,798.
  • Circulating Tumour Cells (CTCs) as a diagnostic tool to monitor disease progression in melanoma patients,  Edith Cowan University,  ECU Industry Collaboration Grant - 2015 (Round 1),  2015 - 2016,  $137,227.
  • Melanoma Mutation Profiling For Personalised Treatment,  National Health and Medical Research Council,  Project Grants,  2013 - 2016,  $765,359.
  • PAX3 dysregulation in glioblastoma.,  Edith Cowan University,  ECU Early Career Researcher Grant - 2015,  2015 - 2016,  $22,800.
  • Mass Cytometry: A breakthrough in multidimensional systems biology,  Australian Research Council,  Grant - Linkage (Infrastructure),  2015 - 2016,  $1,081,489.
  • Transcriptomic profiling of Circulating Tumour Cells (CTCs) isolated from metastatic melanoma patients,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $10,000.
  • In-Vivo Multispectral and X-Ray Micro-CT Imaging: Founding a Western Australian Small Animal Imaging Core Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2010 - 2015,  $1,484,000.
  • The role of DACH1 and the mir-200 family in medulloblastoma pathogenesis,  Cancer Council of WA Inc,  Cancer Council, Scholarship,  2014 - 2015,  $2,000.
  • 2014 NHMRC Equipment Grant Rob Newton and Mel Ziman,  National Health and Medical Research Council,  Equipment Grant 2014,  2014 - 2015,  $9,336.
  • The Transcriptional profile of a metastatic circulation melanoma cell,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $264,182.
  • The role of DACH1 and the mir-200 family in medulloblastoma pathogenesis,  Telethon Kids Institute,  Honours Telethon Adventurers Children's Brain Cancer Training Award,  2014,  $4,000.
  • Standard Equipment Grant 2012,  National Health and Medical Research Council,  Equipment Grant 2012,  2012 - 2014,  $5,744.
  • Genetic Analysis of Melanoma Cells in Blood For Personalised Treatment Management,  Edith Cowan University,  ECU Early Career Researcher Grant - 2013,  2013 - 2014,  $24,083.
  • Detection of Vemurafenib Resistance in Circulating Tumour Cells for Personalised Treatment of Melanoma,  Harry Perkins Institute of Medical Research,  Scott Kirkbride Melanoma Research Centre - Discovery Research Priming Grant,  2013 - 2014,  $68,182.
  • PAX3-mediated melanocytic response to environmental factors,  Edith Cowan University,  ECU Early Career Researcher Grant - 2013,  2013 - 2014,  $25,000.
  • Expanding Capacity and Capability in Western Australian Flow Cytometry for Earth, Oceans, Environmental and Biomedical Science: State-of-the-Art Four Laser and 12 Colour Analysis,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012 - 2013,  $598,000.
  • The Effects of Environmental Enrichment on Clinical Measures of Disease Progression and Quality of Life for Patients with Huntington's Disease,  Huntington's WA (Inc),  Lotterywest Grant,  2010 - 2013,  $530,317.
  • The effects of environmental enrichment on physiological markers of disease progression in patients with Huntington’s disease.,  Edith Cowan University,  ECU Early Career Researcher Grant - 2012 (Round 1),  2012 - 2013,  $24,568.
  • Detection of stem cell markers expression in circulating melanoma cells using multiparameter flow cytometry as a prognosis tool,  Edith Cowan University,  ECU Early Career Researcher Grant - 2012 (Round 1),  2012 - 2013,  $19,480.
  • The association between environmental stresses (UV, heat and chemicals) and melanoma incidence amongst staff at Telfer Gold Mine,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2011 - 2012,  $158,456.
  • A high-throughput protein production and structure facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012,  $470,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.
  • Nano mechanical analysis of metastactic melanoma cancer cells using atomic force microscopy,  Cancer Council of WA Inc,  Cancer Council, Scholarship,  2012,  $7,500.
  • The Use of Circulating Melanoma Cells to monitor Treatment Efficacy in Patients with Cutaneous Malignant Melanoma,  University of Western Australia,  Grant - CaPCREU,  2010 - 2011,  $17,240.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant,  2010 - 2011,  $10,881.
  • Evaluation of Paramedic Treatment Techniques to Assess Contributing Factors to Mortality in the Pre Hospital Management of Traumatic Brain Injury,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2009 - 2011,  $54,800.
  • Nature's Wonder,  Cocky Smart,  Grant,  2010 - 2011,  $125,023.
  • Patient outcome affected by paramedic pre hospital treatment of patients with severe brain injuries,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2007 - 2011,  $174,837.
  • Detection and Characterisation of Circulating Cutaneous Malignant Melanoma Cells,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2009 - 2010,  $288,403.
  • A Western Australian Core Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations,  Australian Research Council,  Grant - Linkage (Infrastructure),  2009 - 2010,  $524,000.
  • Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area. ,  Australian Research Council,  Grant - Discovery Projects,  2007 - 2010,  $118,176.
  • Isolation and Characterisation of Melanoma Cancer Stem Cells,  Edith Cowan University,  ECU Early Career Researcher - Grant,  2008 - 2010,  $24,975.
  • Characterisation and Quantification of Circulating Melanoma Cells,  Cancer Council of WA Inc,  Cancer Council, Scholarship,  2010,  $3,000.
  • Quantification and Characterisation of Circulating Cutaneous Malignant Melanoma Cells,  Cancer Council of WA Inc,  Grant,  2009,  $70,000.
  • Development of a Blood Test for Cutaneous Malignant Melanoma,  Edith Cowan University Foundation,  Donation,  2007 - 2008,  $34,485.
  • A cryopreparation facility for Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2008,  $485,000.
  • Development of a blood test for Cutaneous Malignant Melanoma,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2007 - 2008,  $115,019.
  • Developmental genes and Melanoma detection,  Edith Cowan University,  ECU Industry Collaboration - Grant,  2005 - 2008,  $69,400.
  • Detection of Migrating Melanoma Cells in Peripheral Blood of Patients with Metastatic Melanoma,  Cancer Council of WA Inc,  Grant,  2007 - 2008,  $2,000.
  • Matching the developmental transcription factor profiles of transplanted cells and host injured brain regions is crucial for successful cell transplant therapies,  Harry Perkins Institute of Medical Research,  Grant,  2005 - 2006,  $60,000.
  • Corbett Research 'RotorGene' 2 channel real-time DNA multiplexing system,  Ramaciotti Foundation,  Grant,  2004 - 2005,  $49,000.

Recent Publications (within the last five years)

Book Chapters

  • Freeman, J., Gray, E., Ziman, M., (2015), Circulating Tumor Cells as Biomarkers in Cancer. Biomarkers in Cancer, 31-51, London, UK, Springer, DOI: 10.1007/978-94-007-7681-4_21.

Journal Articles

  • Asante, D., Calapre, L., Ziman, M., Meniawy, T., Gray, E., (2020), Liquid biopsy in ovarian cancer using circulating tumor DNA and cells: Ready for prime time?. Cancer Letters, epub ahead of Print(October 11), In Press, DOI: 10.1016/j.canlet.2019.10.014.
  • Bartlett, D., Dominguez D, JF., Lazar, A., Kordsachia, C., Rankin, T., Lo, J., Govus, A., Power, B., Lampit, A., Eastwood, P., Ziman, M., Cruickshank, T., (2020), Multidisciplinary Rehabilitation Reduces Hypothalamic Grey Matter Volume Loss in Individuals with Preclinical Huntington's Disease: A Nine-Month Pilot Study. Journal of the Neurological Sciences, 408(2020), 116522, DOI: https://doi.org/10.1016/j.jns.2019.116522.
  • Khattak, M., Reid, A., Freeman, J., Pereira, M., McEvoy, A., Lo, J., Frank, M., Meniawy, T., Didan, A., Spencer, I., Amanuel, B., Millward, M., Ziman, M., Gray, E., (2020), PD-L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study. The Oncologist, 25(3), e520-e527, DOI: 10.1634/theoncologist.2019-0557.
  • Aya-Bonilla, C., Morici, M., Hong, X., McEvoy, A., Sullivan, R., Freeman, J., Calapre, L., Khattak, M., Meniawy, T., Millward, M., Ziman, M., Gray, E., (2020), Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells. British Journal of Cancer, 122(Feb), 1059-1067, DOI: 10.1038/s41416-020-0750-9.
  • Beasley, A., Bentel, J., Allcock, R., Vermeulen, T., Calapre, L., Isaacs, T., Ziman, M., Chen, F., Gray, E., (2020), Low-Pass Whole-Genome Sequencing as a Method of Determining Copy Number Variations in Uveal Melanoma Tissue Samples. The Journal of Molecular Diagnostics, 22(3), 429-434, DOI: 10.1016/j.jmoldx.2019.12.005.
  • Turner, M., Reyes, A., Bartlett, D., Culpin, S., Hart, N., Hardt, L., Feindel, K., Poudel, G., Ziman, M., Cruickshank, T., (2020), Exploring the brain-body composition relationship in Huntington’s disease. The Journal of Musculoskeletal and Neuronal Interactions, x(x), xx-xx.
  • Dejong, H., Abbott, S., Zelesco, M., Spilsbury, K., Martin, L., Sanderson, R., Ziman, M., Kennedy, B., Wood, F., (2020), A novel, reliable protocol to objectively assess scar stiffness using shear wave elastography. Ultrasound in Medicine and Biology, In Press(In Press), 1-16, DOI: 10.1016/j.ultrasmedbio.2020.03.003.
  • Stark, M., Gray, E., Isaacs, T., Chen, F., Millward, M., McEvoy, A., Zaenker, P., Ziman, M., Soyer, H., Glasson, W., Warrier, S., Stark, A., Rolfe, O., Palmer, J., Hayward, N., (2019), A Panel of Circulating MicroRNAs Detects Uveal Melanoma With High Precision. Translational Vision Science and Technology, 8(6), Article 12, DOI: 10.1167/tvst.8.6.12.
  • Calapre, L., Giardina, T., Robinson, C., Reid, A., Al-Ogaili, Z., Pereira, M., McEvoy, A., Warburton, L., Hayward, N., Khattak, M., Meniawy, T., Millward, M., Amanuel, B., Ziman, M., Gray, E., (2019), Locus-specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma. Molecular Oncology, 13(2), 171-184, United Kingdom, John Wiley & Sons Ltd, DOI: 10.1002/1878-0261.12391.
  • Phan, T., Carter, O., Waterer, G., Chung, LP., Hawkins, M., Rudd, C., Ziman, M., Strobel, N., (2019), Determinants for concomitant anxiety and depression in people living with chronic obstructive pulmonary disease. Journal of Psychosomatic Research, 120(May 2019), 60-65, DOI: 10.1016/j.jpsychores.2019.03.004.
  • Acheampong, E., Spencer, I., Lin, W., Ziman, M., Millward, M., Gray, E., (2019), Is the Blood an Alternative for Programmed Cell Death Ligand 1 Assessment in Non-Small Cell Lung Cancer?. Cancers, 11(7), article no. 920, DOI: 10.3390/cancers11070920.
  • Osborne, D., Domenico, J., Luo, Y., Reid, A., Amato, C., Zhai, Z., Gao, D., Ziman, M., Dinarello, C., Robinson, W., Fujita, M., (2019), Interleukin‐37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome. Molecular Carcinogenesis, 58(9), 1670-1679, DOI: 10.1002/mc.23044.
  • Bartlett, D., Dominguez D, JF., Reyes, A., Zaenker, P., Feindel, K., Newton, R., Hannan, A., Slater, J., Eastwood, P., Lazar, A., Ziman, M., Cruickshank, T., (2019), Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease. Neurobiology of Sleep and Circadian Rhythms, 6(January 2019), p. 1-8, DOI: https://doi.org/10.1016/j.nbscr.2018.07.001.
  • Gray, E., Witkowski, T., Pereira, M., Calapre, L., Herron, K., Irwin, D., Chapman, B., Khattak, M., Raleigh, J., Hatzimihalis, A., Cebon, J., Sandhu, S., McArthur, G., Millward, M., Ziman, M., Dubrovic, A., Wong, S., (2019), Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel. The Journal of Molecular Diagnostics, 21(3), 418-426, DOI: 10.1016/j.jmoldx.2018.12.001.
  • Aya-Bonilla, C., Gray, E., Manikandan, J., Freeman, J., Zaenker, P., Reid, A., Khattak, M., Frank, M., Millward, M., Ziman, M., (2019), Immunomagnetic-Enriched Subpopulations of Melanoma Circulating Tumour Cells (CTCs) Exhibit Distinct Transcriptome Profiles. Cancers, 11(2), Article number 157, DOI: 10.3390/cancers11020157.
  • McEvoy, A., Pereira, M., Reid, A., Pearce, R., Cowell, L., Al-Ogaili, Z., Khattak, M., Millward, M., Meniawy, T., Gray, E., Ziman, M., (2019), Monitoring melanoma recurrence with circulating tumor DNA: a proof of concept from three case studies. Oncotarget, 10(2), 113-122, DOI: 10.18632/oncotarget.26451.
  • McEvoy, A., Wood, B., Ardakani, N., Pereira, M., Pearce, R., Cowell, L., Robinson, C., Grieu-Iacopetta, F., Spicer, A., Amanuel, B., Ziman, M., Gray, E., (2018), Droplet Digital PCR for Mutation Detection in Formalin-Fixed, Paraffin-Embedded Melanoma Tissues: A Comparison with Sanger Sequencing and Pyrosequencing. The Journal of Molecular Diagnostics, 20(2), 240-252, United States, Elsevier, DOI: 10.1016/j.jmoldx.2017.11.009.
  • Dunkel, Y., Reid, A., Ear, J., Aznar, N., Millward, M., Gray, E., Pearce, R., Ziman, M., Ghosh, P., (2018), Prognostic relevance of CCDC88C (Daple) transcripts in the peripheral blood of patients with cutaneous melanoma. Scientific Reports, 8(1), Article number 18036, DOI: 10.1038/s41598-018-36173-x.
  • McEvoy, A., Warburton, L., Al-Ogaili, Z., Celliers, L., Calapre, L., Pereira, M., Khattak, M., Meniawy, T., Millward, M., Ziman, M., Gray, E., (2018), Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients. BMC Cancer, 18(1), Article no. 726, United Kingdom, BioMed Central Ltd, DOI: 10.1186/s12885-018-4637-6.
  • Zaenker, P., Lo, J., Pearce, R., Cantwell, P., Cowell, L., Lee, M., Quirk, C., Law, H., Gray, E., Ziman, M., (2018), A diagnostic autoantibody signature for primary cutaneous melanoma. Oncotarget, 9(55), 30539-30551, United States, Impact Journals LLC, DOI: 10.18632/oncotarget.25669.
  • Beasley, A., Isaacs, T., Khattak, M., Freeman, J., Allcock, R., Chen, F., Pereira, M., Yau, K., Bentel, J., Vermeulen, T., Calapre, L., Millward, M., Ziman, M., Gray, E., (2018), Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma. JCO Precision Oncology, 2(May 17, 2018), 12p., United States, American Society of Clinical Oncology, DOI: 10.1200/PO.17.00279.
  • Marsavela, G., Aya-Bonilla, C., Warkiani, M., Gray, E., Ziman, M., (2018), Melanoma circulating tumor cells: Benefits and challenges required for clinical application. Cancer Letters, 424(Jun 2018), 1-8, Ireland, Elsevier, DOI: 10.1016/j.canlet.2018.03.013.
  • Cruickshank, T., Reyes, A., Penailillo, L., Pulverenti, T., Bartlett, D., Zaenker, P., Blazevich, T., Newton, R., Thompson, J., Lo, J., Ziman, M., (2018), Effects of multidisciplinary therapy on physical function in Huntington’s disease. Acta Neurologica Scandinavica, 138(6), 500-507, United States, Wiley-Blackwell Publishing, Inc., DOI: 10.1111/ane.13002.
  • Reyes, A., Salomonczyk, D., Teo, W., Medina, L., Bartlett, D., Pirogovsky-Turk, E., Zaenker, P., Bloom, J., Simmons, R., Ziman, M., Gilbert, P., Cruickshank, T., (2018), Computerised dynamic posturography in premanifest and manifest individuals with Huntington's disease. Scientific Reports, 8(1), Article number 14615, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-32924-y.
  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Descargues, P., Ziman, M., (2017), SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes. BMC Dermatology, 17(June 2017), Article No. 8, London, United Kingdom, BioMed Central, DOI: 10.1186/s12895-017-0060-y.
  • Calapre, L., Warburton, L., Millward, M., Ziman, M., Gray, E., (2017), Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma. Cancer Letters, 404(28 Sept, 2017), 62-69, Shannon, Ireland, Elsevier, DOI: 10.1016/j.canlet.2017.06.030.
  • Dejong, H., Abbott, S., Zelesco, M., Kennedy, B., Ziman, M., Wood, F., (2017), The validity and reliability of using ultrasound elastography to measure cutaneous stiffness, a systematic review. International Journal of Burns and Trauma, 7(7), 124-141, United States, E-Century Publications.
  • McEvoy, A., Calapre, L., Pereira, M., Giardina, T., Robinson, C., Khattak, M., Meniawy, T., Pritchard, A., Hayward, N., Amanuel, B., Millward, M., Ziman, M., Gray, E., (2017), Sensitive droplet digital PCR method for detection of TERT promoter mutations in cell free DNA from patients with metastatic melanoma. Oncotarget, 8(45), 78890-78900, Albany, United States, Impact Journals LLC, DOI: 10.18632/oncotarget.20354.
  • Aya-Bonilla, C., Marsavela, G., Freeman, J., Lomma, C., Frank, M., Khattak, M., Tarek, M., Millward, M., Warkiani, M., Gray, E., Ziman, M., (2017), Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device. Oncotarget, 8(40), 67355-67368, New York, USA, Impact Journals LLC, DOI: 10.18632/oncotarget.18641.
  • Phan, T., Carter, O., Adams, C., Waterer, G., Chung, LP., Hawkins, M., Rudd, C., Ziman, M., Strobel, N., (2016), Discriminant validity of the Hospital Anxiety and Depression Scale, Beck Depression Inventory (II) and Beck Anxiety Inventory to confirmed clinical diagnosis of depression and anxiety in patients with chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13(3), 220-228, DOI: 10.1177/1479972316634604.
  • Phan, T., Carter, O., Adams, C., Waterer, G., Chung, L., Hawkins, M., Rudd, C., Ziman, M., Strobel, N., (2016), Discriminant validity of the Hospital Anxiety and Depression Scale, Beck Depression Inventory (II) and Beck Anxiety Inventory to confirmed clinical diagnosis of depression and anxiety in patients with chronic obstructive pulmonary disease. Chronic Respiratory Disease, 13(3), 220-228, London, UK, Sage Publications Ltd., DOI: 10.1177/1479972316634604.
  • Zaenker, P., Gray, E., Ziman, M., (2016), Autoantibody Production in Cancer—The Humoral Immune Response toward Autologous Antigens in Cancer Patients. Autoimmunity Reviews, 15(5), 477-483, Elsevier, DOI: 10.1016/j.autrev.2016.01.017.
  • Bartlett, D., Cruickshank, T., Hannan, A., Eastwood, P., Lazar, A., Ziman, M., (2016), Neuroendocrine and neurotrophic signaling in Huntington's Disease: Implications for pathogenic mechanisms and treatment strategies. Neuroscience and Biobehavioral Reviews, 71(2016), 444-454, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.09.006.
  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Hart, P., Descargues, P., Ziman, M., (2016), Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo. BMC Dermatology, 16(1), Article no. 6, London, UK, BioMed Central Ltd., DOI: 10.1186/s12895-016-0043-4.
  • Collins, L., Begeti, F., Panin, F., Lazar, A., Cruickshank, T., Ziman, M., Mason, S., Barker, R., (2015), Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease. PLoS Currents, 7(Huntington Disease), online, San Francisco, USA, Public Library of Science, DOI: 10.1371/currents.hd.ded251617ae62a1364506b0521bd3761.
  • Reid, A., Freeman, J., Millward, M., Ziman, M., Gray, E., (2015), Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR. Clinical Biochemistry, 48(15), 999-1002, Philadelphia, USA, Elsevier, DOI: 10.1016/j.clinbiochem.2014.12.007.
  • Bartlett, D., Boyle, GM., Ziman, M., Medic, S., (2015), Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells. PLoS One, 10(4), Article no. e0124154, San Francisco, USA, Public Library of Science, DOI: 10.1371/journal.pone.0124154.
  • Cruickshank, T., Reyes, A., Ziman, M., (2015), A systematic review and meta-analysis of strength training in individuals with Multiple Sclerosis or Parkinson disease. Medicine, 94(4), e411, Wolters Kluwer Health, DOI: 10.1097/MD.0000000000000411.
  • Gray, E., Reid, A., Bowyer, S., Calapre, L., Siew, K., Pearce, R., Cowell, L., Frank, M., Millward, M., Ziman, M., (2015), Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment. Journal of Investigative Dermatology, 135(8), 2040-2048, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/jid.2015.127.
  • Gray, E., Rizos, H., Reid, A., Boyd, S., Pereira, M., Lo, J., Tembe, V., Freeman, J., Lee, J., Scolyer, R., Siew, K., Lomma, C., Cooper, A., Khattak, M., Meniawy, T., Long, G., Carlino, M., Millward, M., Ziman, M., (2015), Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget, 6(39), 42008-42018, New York, USA, Impact Journals LLC, DOI: 10.18632/oncotarget.5788.
  • Reyes, A., Cruickshank, T., Nosaka, K., Ziman, M., (2015), Respiratory muscle training on pulmonary and swallowing function in patients with Huntington's disease: A pilot randomised controlled trial. Clinical Rehabilitation, 29(10), 961-973, SAGE Publications Ltd, DOI: 10.1177/0269215514564087.
  • Cruickshank, T., Thompson, J., DomĂ­nguez , J., Reyes, A., Bynevelt, M., Georgiou-Karistianis, N., Barker, R., Ziman, M., (2015), The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study. Brain and Behavior, 5(2), 1-10, West Sussex, UK, John Wiley and Sons Ltd, DOI: 10.1002/brb3.312.

Conference Publications

  • Maurya, D., Fooladvand, M., Gray, E., Ziman, M., Alameh, K., (2015), Lab-on-chip platform for circulating tumor cells isolation. Micro+Nano Materials, Devices, and Systems, 9668(6-9 Dec, 2015), 9668-34, Sydney, Australia, SPIE, DOI: 10.1117/12.2201127.

Research Student Supervision

Principal Supervisor

  • Master of Science (Human Biology),  The efficacy of inhaled methoxyflurance and intranasal fentanyl for the pre hospital management of cardiac or visceral pain.
  • Doctor of Philosophy,  Pulmonary and swallowing function in patients with huntington's disease.
  • Doctor of Philosophy,  Breathing new life: Investigating ways to improve the mental health of people living with chronic obstructive pulmonary disease in wester Australia
  • Doctor of Philosophy: The role of PAX3 and PAX7 in alveolar rhabdomyosarcoma focusing on DNA binding domains, alternative splicing and target gene analysis by microarray
  • Doctor of Philosophy: A possible role for PAX7 in initiating differentiation of neuronal cells in the optic tectum during normal development and after injury
  • Doctor of Philosophy,  New perspectives on melanoma: The role of PAX3
  • Doctor of Philosophy,  New perspectives on melanoma: The role of PAX3
  • Doctor of Philosophy,  The role of PAX7 in the formation of the superior colliculus and the vertebrate visual system.
  • Master of Science (Human Biology),  Pax3 and cutaneous malignant melanoma
  • Master of Science (Human Biology),  Pax3 and cutaneous malignant melanoma
  • Doctor of Philosophy,  The clinical utility of multidisciplinary rehabilitation in individuals with huntington's disease
  • Master of Science (Human Biology),  Pax3 expression, protein modifications and downstream target gene profiling in melanocytes and melanoma cells
  • Master of Science (Human Biology),  The effectiveness of airway management in the pre hospital treatment of traumatic brain injury
  • Doctor of Philosophy,  The characterisation of PAX3 expressant cells in adult peripheral nerve
  • Doctor of Philosophy,  Heat stress: A risk factor for skin carcinogenesis
  • Master of Science (Human Biology),  Molecular genetic investigation of autosomal dominant hemifacial microsomia.
  • Master of Science (Human Biology),  Optimisation of the isolation and identification of circulating melanoma cells
  • Doctor of Philosophy,  Circulating tumour DNA: A non-invasive biomarker for melanoma
  • Doctor of Philosophy,  The utility of multidisciplinary rehabilitation as a treatment strategy for circadian rhythm and sleep disturbances in premanifest huntington's disease
  • Doctor of Philosophy,  The developmental function of pax 7: Chromatin-immunoprecipitation discovery of PAX7 target genes
  • Master of Science (Human Biology),  The role of PAX3 in the metastasis of cutaneous malignant melanoma.
  • Master of Science (Human Biology),  The identification of diagnostic serological autoantibodies for cutaneous melanoma.
  • Doctor of Philosophy,  The role of PAX3/PAX7-fkhr in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis.
  • Doctor of Philosophy,  The identification and validation of a diagnostic signature of tumour-associated autoantibodies for the early diagnosis of cutaneous melanoma
  • Doctor of Philosophy,  An investigation of the mechanism of PAX7 mediated oncogenesis via in silico biology.

Co-principal Supervisor

  • Master of Science (Human Biology),  The evaluation of Midazolam on head injured patients in the prehospital setting
  • Master of Science (Human Biology),  Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
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