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Dr Leslie Calapre

Adjunct Lecturer

Staff Member Details
Email: l.calapre@ecu.edu.au

Dr Leslie Calapre is a Research Fellow in the School of Medical and Health Sciences.

Research Areas and Interests

  • Liquid Biopsy for Melanoma
  • Circulating Tumour DNA
  • Environmental stressors and skin cancers

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2015.
  • Bachelor of Science Human Biology (Honours), Edith Cowan University, 2011.
  • Bachelor of Science (Biomedical Science), Edith Cowan University, 2010.

Research Outputs

Journal Articles

  • Mavropalias, G., Calapre, L., Morici, M., Koeda, T., Poon, W., Barley, O., Gray, E., Blazevich, T., Nosaka, K. (2021). Changes in plasma hydroxyproline and plasma cell‑free DNA concentrations after higher‑ versus lower‑intensity eccentric cycling. European Journal of Applied Physiology, epub ahead of print(Jan), 11p.. https://doi.org/10.1007/s00421-020-04593-1.
  • Shyam, S., Eccles, M., Rodger, E., Pattison, S., McCall, J., Gray, E., Calapre, L., Chatterjee, A. (2021). The epigenetic landscape of circulating tumour cells. Biochimica et Biophysica Acta: Reviews on Cancer, epub ahead of print(2021), 188514. https://doi.org/10.1016/j.bbcan.2021.188514.

Journal Articles

  • Warburton, L., Meniawy, T., Calapre, L., Pereira, M., McEvoy, A., Ziman, M., Gray, E., Millward, M. (2020). Stopping targeted therapy for complete responders in advanced BRAF mutant melanoma. Scientific Reports, 10(1), Article number 18878. https://doi.org/10.1038/s41598-020-75837-5.
  • Aya-Bonilla, C., Morici, M., Hong, X., McEvoy, A., Sullivan, R., Freeman, J., Calapre, L., Khattak, M., Meniawy, T., Millward, M., Ziman, M., Gray, E. (2020). Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells. British Journal of Cancer, 122(7), 1059-1067. https://doi.org/10.1038/s41416-020-0750-9.
  • Marsavela, G., Johansson, P., Pereira, M., McEvoy, A., Reid, A., Robinson, C., Warburton, L., Khattak, M., Meniawy, T., Amanuel, B., Millward, M., Hayward, N., Ziman, M., Gray, E., Calapre, L. (2020). The Prognostic Impact of Circulating Tumour DNA in Melanoma Patients Treated with Systemic Therapies-Beyond BRAF Mutant Detection. Cancers, 12(12), Article number 3793. https://doi.org/10.3390/cancers12123793.
  • Abed, A., Calapre, L., Lo, J., Correia, S., Bowyer, S., Chopra, A., Watson, M., Khattak, M., Millward, M., Gray, E. (2020). Prognostic value of HLA-I homozygosity in patients with non-small cell lung cancer treated with single agent immunotherapy. Journal for Immunotherapy of Cancer, 8(2), Article number e001620. https://doi.org/10.1136/jitc-2020-001620.
  • Marsavela, G., Lee, J., Calapre, L., Wong, S., Pereira, M., McEvoy, A., Reid, A., Robinson, C., Warburton, L., Abed, A., Khattak, M., Meniawy, T., Dawson, S., Sandhu, S., Carlino, M., Menzies, A., Scolyer, R., Long, G., Amanuel, B., Millward, M., Ziman, M., Rizos, H., Gray, E. (2020). Circulating Tumor DNA Predicts Outcome from First-, but not Second-line Treatment and Identifies Melanoma Patients Who May Benefit from Combination Immunotherapy. Clinical Cancer Research, 26(22), 5926-5933. https://doi.org/10.1158/1078-0432.CCR-20-2251.
  • Clark, M., Rizos, H., Pereira, M., McEvoy, A., Marsavela, G., Calapre, L., Meehan, K., Ruhen, O., Khattak, M., Meniawy, T., Long, G., Carlino, M., Menzies, A., Millward, M., Ziman, M., Gray, E. (2020). Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies. Oncotarget, 11(44), 4016-4027. https://doi.org/https://doi.org/10.18632/oncotarget.27790.
  • Warburton, L., Calapre, L., Pereira, M., Reid, A., Robinson, C., Amanuel, B., Ziman, M., Millward, M., Gray, E. (2020). Circulating Tumour DNA in Advanced Melanoma Patients Ceasing PD1 Inhibition in the Absence of Disease Progression. Cancers, 12(11), Article number 3486. https://doi.org/10.3390/cancers12113486.
  • Beasley, A., Bentel, J., Allcock, R., Vermeulen, T., Calapre, L., Isaacs, T., Ziman, M., Chen, F., Gray, E. (2020). Low-Pass Whole-Genome Sequencing as a Method of Determining Copy Number Variations in Uveal Melanoma Tissue Samples. The Journal of Molecular Diagnostics, 22(3), 429-434. https://doi.org/10.1016/j.jmoldx.2019.12.005.
  • Asante, D., Calapre, L., Ziman, M., Meniawy, T., Gray, E. (2020). Liquid biopsy in ovarian cancer using circulating tumor DNA and cells: Ready for prime time?. Cancer Letters, 468(1 January 2020), 59-71. https://doi.org/10.1016/j.canlet.2019.10.014.

Journal Articles

  • Gray, E., Witkowski, T., Pereira, M., Calapre, L., Herron, K., Irwin, D., Chapman, B., Khattak, M., Raleigh, J., Hatzimihalis, A., Cebon, J., Sandhu, S., McArthur, G., Millward, M., Ziman, M., Dubrovic, A., Wong, S. (2019). Genomic Analysis of Circulating Tumor DNA Using a Melanoma-Specific UltraSEEK Oncogene Panel. The Journal of Molecular Diagnostics, 21(3), 418-426. https://doi.org/10.1016/j.jmoldx.2018.12.001.
  • Calapre, L., Giardina, T., Robinson, C., Reid, A., Al-Ogaili, Z., Pereira, M., McEvoy, A., Warburton, L., Hayward, N., Khattak, M., Meniawy, T., Millward, M., Amanuel, B., Ziman, M., Gray, E. (2019). Locus-specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma. Molecular Oncology, 13(2), 171-184. https://doi.org/10.1002/1878-0261.12391.
  • Calapre, L., Warburton, L., Millward, M., Gray, E. (2019). Circulating tumour DNA (ctDNA) as a biomarker in metachronous melanoma and colorectal cancer- a case report. BMC Cancer, 19(1), Article number 1109. https://doi.org/10.1186/s12885-019-6336-3.

Journal Articles

  • Beasley, A., Isaacs, T., Khattak, M., Freeman, J., Allcock, R., Chen, F., Pereira, M., Yau, K., Bentel, J., Vermeulen, T., Calapre, L., Millward, M., Ziman, M., Gray, E. (2018). Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma. JCO Precision Oncology, 2(May 17, 2018), 12p.. https://doi.org/10.1200/PO.17.00279.
  • McEvoy, A., Warburton, L., Al-Ogaili, Z., Celliers, L., Calapre, L., Pereira, M., Khattak, M., Meniawy, T., Millward, M., Ziman, M., Gray, E. (2018). Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients. BMC Cancer, 18(1), Article no. 726. https://doi.org/10.1186/s12885-018-4637-6.

Journal Articles

  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Descargues, P., Ziman, M. (2017). SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes. BMC Dermatology, 17(June 2017), Article No. 8. https://doi.org/10.1186/s12895-017-0060-y.
  • McEvoy, A., Calapre, L., Pereira, M., Giardina, T., Robinson, C., Khattak, M., Meniawy, T., Pritchard, A., Hayward, N., Amanuel, B., Millward, M., Ziman, M., Gray, E. (2017). Sensitive droplet digital PCR method for detection of TERT promoter mutations in cell free DNA from patients with metastatic melanoma. Oncotarget, 8(45), 78890-78900. https://doi.org/10.18632/oncotarget.20354.
  • Calapre, L., Warburton, L., Millward, M., Ziman, M., Gray, E. (2017). Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma. Cancer Letters, 404(28 Sept, 2017), 62-69. https://doi.org/10.1016/j.canlet.2017.06.030.

Journal Articles

  • Calapre, L., Gray, E., Kurdykowski, S., David, A., Hart, P., Descargues, P., Ziman, M. (2016). Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo. BMC Dermatology, 16(1), Article no. 6. https://doi.org/10.1186/s12895-016-0043-4.

Journal Articles

  • Gray, E., Reid, A., Bowyer, S., Calapre, L., Siew, K., Pearce, R., Cowell, L., Frank, M., Millward, M., Ziman, M. (2015). Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment. Journal of Investigative Dermatology, 135(8), 2040-2048. https://doi.org/10.1038/jid.2015.127.

Journal Articles

Research Projects

  • Identification of melanoma-specific signature that can predict response to immunotherapies., Cancer Council of WA Inc, Suzanne Cavanagh Early Career Investigator Grants, 2021 ‑ 2023, $34,960.
  • Genomic HLA heterozygosity, T-cell receptor (TCR) – repertoire diversity and tumor PD-L1 expression as predictive biomarkers of response to immunotherapy in lung cancer patients, Lung Foundation Australia, Ellen Yates Memorial Grant in Aid, 2020 ‑ 2021, $20,000.
  • Enhancing Methodologies for Circulating Tumour DNA (ctDNA) Analysis, Edith Cowan University, ECU Early Career Researcher Grant - 2017, 2017 ‑ 2018, $30,000.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy, The use of ctcs and ctdna for the prediction and monitoring of response to combined chemotherapy and immunotherapy in high grade serous ovarian carcinoma (hgsoc)
  • Doctor of Philosophy, Blood based biomarkers of response in advanced melanoma
  • Doctor of Philosophy, Blood based biomarkers of response in advanced melanoma
  • Doctor of Philosophy, Understanding the potential roles of exosomes in intercellular communication

Associate Supervisor

  • Doctor of Philosophy, Assessment of the clinical utility of ctDNA analysis for melanoma management
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