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Investigating the vascular and metabolic effects associated with the consumption of plant foods using a metabolomics approach

Project Outline

The metabolome consists of endogenous metabolites, products from the microbiome, and exogenous chemicals arising from exposure (pharmaceuticals, toxins, etc.) and provides a highly sensitive measure of health and disease. Food-derived metabolites interact with genes, proteins, enzymes, and microbiota. This interaction modifies the function of cells, acts as a signal messenger, and regulates metabolic or energy pathways. The changes in metabolites induced by specific ingredients or foods along with the analysis of the corresponding metabolic fingerprint have great value, not only as a useful tool to evaluate their functionality in vivo, but also to establish a cause-effect link between the apparition of risk factors in diseases. This research project aims to understand the vascular health and corresponding metabolic impacts of particular plant foods and their bioactive components using a metabolomics approach.

Essential Skills

Ability to work in a team or independently and manage time across multiple demands whilst maintaining a high level of accuracy and productivity.

Project Area: Applied Chemistry

Research Centre: Centre for Integrative Metabolomics and Computational Biology (CiMCB)

Supervisor(s): Dr Armaghan Shafaei Darestani (SSCI), Prof David Broadhurst (SSCI), Dr Lauren Blekkenhorst (SMHS)

Project level: Masters / PhD

Funding: No external funding

Start date: Any

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