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  • Dr Liang Wang

    Dr Liang Wang

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Dr Liang Wang

Adjunct Academic

Staff Member Details
Email: liang.wang@ecu.edu.au

Professor and Group Leader:  Dr Wang is a principal investigator.  He currently leads a theoretical and experimental microbiology team at the Department of Laboratory Medicine, Southern Medical University affiliated Guangdong Provincial Children's Hospital in China.

Research Areas and Interests

  • Bioinformatics with focuses on microbial informatics;
  • Microbial metabolism and physiology;
  • Rapid diagnosis of bacterial infection and antibiotic resistance;
  • Bacterial transmission and evolution;
  • Environmental survival of bacterial pathogens;
  • Glycogen structure, metabolism and functions;
  • Raman spectroscopy and its applications in clinical settings; and
  • Traditional Chinese medicine.

Research Outputs

2026

Journal Articles

  • Luan, L., Tang, JW., Luo, Y., Ru, X., Luo, Y., Yao, Y., Liu, S., Gu, B., Wang, L. (2026). Influences of growth media and culture time on the SERS spectral patterns of three common pathogenic bacteria: a comparative analysis. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 348(2026), article number 127078. https://doi.org/10.1016/j.saa.2025.127078.

2025

Journal Articles

  • Wen, X., Tang, J., Chen, J., Chen, H., Usman, M., Yuan, Q., Tang, Y., Zhang, Y., Chen, H., Wang, L. (2025). Rapid Diagnosis Of Bacterial Vaginosis Using Machine-Learning-Assisted Surface-Enhanced Raman Spectroscopy Of Human Vaginal Fluids. Msystems, 10(1), article number e01058-24. https://doi.org/10.1128/msystems.01058-24.
  • Yuan, Q., Tang, J., Chen, J., Liao, Y., Zhang, W., Wen, X., Liu, X., Chen, H., Wang, L. (2025). SERS-ATB: A comprehensive database server for antibiotic SERS spectral visualization and deep-learning identification. Environmental Pollution, 373(2025), article number 126083. https://doi.org/10.1016/j.envpol.2025.126083.
  • Wang, L., Li, Z., Lai, J., Si, Y., Chen, J., Chua, EG., Dai, L., Dai, Q., Dai, X., Deng, Z., Du, H., Fang, Q., Feng, C., He, M., Hu, G., Hu, Y., Huang, H., Huang, Y., Li, F., Li, J., Li, Q., Lin, Z., Liu, H., Liu, M., Luo, J., Ma, J., Man, B., Ru, X., Tang, B., Tang, J., Tang, S., Tian, Y., Umar, Z., Wang, H., Wang, J., Wang, S., Wang, X., Wu, T., Xia, D., Xie, Q., Xie, R., Xu, J., Xu, J., Ye, Y., Yuan, G., Yuan, Q., Zhang, L., Zhang, X., Zhao, S., Zhou, B., Zhu, X., Zou, W., Marshall, BJ., Tay, AC., Hou, Z., Gu, B. (2025). Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study. International Journal of Infectious Diseases, 154(2025), article number 107890. https://doi.org/10.1016/j.ijid.2025.107890.
  • Tang, J., Wen, X., Liao, Y., Wang, L. (2025). How can surface-enhanced Raman spectroscopy improve diagnostics for bacterial infections?. Nanomedicine, 20(7), 701-706. https://doi.org/10.1080/17435889.2025.2466419.
  • Tang, J., Tay, AC., Wang, L. (2025). Interpretive prediction of hyperuricemia and gout patients via machine learning analysis of human gut microbiome. BMC Microbiology, 25(1), article number 429. https://doi.org/10.1186/s12866-025-04125-x.
  • Wang, L., Ma, Z., Tang, J., Mou, J., Liu, Q., Wang, Z., Liu, X., Zhang, M., Tang, D. (2025). Identification of structural stability and fragility of mouse liver glycogen via label-free Raman spectroscopy coupled with convolutional neural network algorithm. International Journal of Biological Macromolecules, 286(2025), article number 138340. https://doi.org/10.1016/j.ijbiomac.2024.138340.
  • Xian, L., Si, Y., Luan, L., Lai, J., Tang, J., Wang, L. (2025). Epidemiological characteristics of Helicobacter pylori infection and antibiotic resistance in urban areas of Guangdong Province, China: a multi-center, cross-sectional surveillance. European Journal of Clinical Microbiology and Infectious Diseases, 44(6), 1305-1312. https://doi.org/10.1007/s10096-025-05105-9.
  • Si, Y., Xiong, X., Zhang, S., Lai, J., Li, Y., Umar, Z., Luan, L., Tang, J., Li, Z., Li, F., Gu, B., Wang, L. (2025). Detection of Helicobacter pylori Infection and Antibiotic Resistance via String Test Coupled With qPCR Method: A Comparative Methodological Study. Journal of Gastroenterology and Hepatology, 40(7), 1763-1771. https://doi.org/10.1111/jgh.16962.
  • Tang, J., Yuan, Q., Zhang, L., Marshall, BJ., Yen Tay, AC., Wang, L. (2025). Application of machine learning-assisted surface-enhanced Raman spectroscopy in medical laboratories: Principles, opportunities, and challenges. Trends in Analytical Chemistry, 184(2025), article number 118135. https://doi.org/10.1016/j.trac.2025.118135.
  • Lai, J., Tang, JW., Gong, SS., Qin, M., Zhang, Y., Liang, Q., Li, L., Cai, Z., Wang, L. (2025). Development and validation of an interpretable risk prediction model for the early classification of thalassemia. npj Digital Medicine, 8(1), article number 346. https://doi.org/10.1038/s41746-025-01766-0.
  • Umar, Z., Tang, J., Marshall, BJ., Tay, AC., Wang, L. (2025). Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings. Critical Reviews in Microbiology, 51(2), 369-398. https://doi.org/10.1080/1040841X.2024.2364194.
  • Tang, JW., Hong, Y., Chen, J., Xie, Y., Ma, Z., Liu, Q., Wang, L. (2025). Ratio Quantification of Geranium and Rose Essential Oil Mixtures via Deep Learning Analysis of Complex Raman Spectra. ACS Measurement Science Au, 5(6), 823-832. https://doi.org/10.1021/acsmeasuresciau.5c00088.
  • Tang, JW., Xiong, X., Huang, T., Zhang, Y., Yao, L., Zhang, W., Xie, Y., Liang, Q., Tan, Z., Jiang, K., Liu, X., Wang, L. (2025). Rapid discrimination of Mycobacterium tuberculosis and non-tuberculous mycobacteria disease via interpretive machine learning analysis of routine laboratory tests. BMJ Health and Care Informatics, 32(1), article number e101575. https://doi.org/10.1136/bmjhci-2025-101575.
  • Tang, J., Mou, J., Chen, J., Yuan, Q., Wen, X., Liu, Q., Liu, Z., Wang, L. (2025). Discrimination of Benign and Malignant Thyroid Nodules through Comparative Analyses of Human Saliva Samples via Metabolomics and Deep-Learning-Guided Label-free SERS. ACS Applied Materials and Interfaces, 17(3), 5538-5549. https://doi.org/10.1021/acsami.4c20503.
  • Yuan, Q., Wen, X., Liu, W., Ma, Z., Tang, J., Liu, Q., Usman, M., Tang, Y., Wu, X., Wang, L. (2025). Simultaneous detection and quantification of ciprofloxacin, doxycycline, and levofloxacin in municipal lake water via deep learning analysis of complex Raman spectra. Environmental Technology and Innovation, 37(2025), article number 103987. https://doi.org/10.1016/j.eti.2024.103987.

2024

Journal Articles

  • Li, F., Si, Y., Tang, J., Umar, Z., Xiong, X., Wang, J., Yuan, Q., Tay, AC., Chua, EG., Zhang, L., Marshall, BJ., Yang, W., Gu, B., Wang, L. (2024). Rapid profiling of carcinogenic types of Helicobacter pylori infection via deep learning analysis of label-free SERS spectra of human serum. Computational and Structural Biotechnology Journal, 23(2024), 3379-3390. https://doi.org/10.1016/j.csbj.2024.09.008.
  • Zhang, M., Wu, Y., Mou, J., Yao, Y., Wen, P., Liu, X., Shang, S., Kang, X., Tian, J., Liu, Y., Lv, E., Wang, L. (2024). The global landscape of immune-derived lncRNA signature in colorectal cancer. Heliyon, 10(4), Article e25568. https://doi.org/10.1016/j.heliyon.2024.e25568.
  • Si, Y., Xiong, X., Wang, J., Yuan, Q., Li, Y., Tang, J., Li, Y., Zhang, X., Li, Z., Lai, J., Umar, Z., Yang, W., Li, F., Wang, L., Gu, B. (2024). Identification of chronic non-atrophic gastritis and intestinal metaplasia stages in the Correa's cascade through machine learning analyses of SERS spectral signature of non-invasively-collected human gastric fluid samples. Biosensors and Bioelectronics, 262(2024), article number 116530. https://doi.org/10.1016/j.bios.2024.116530.
  • Zhang, L., Wang, L., Umar, Z., Huang, Y., Gu, B. (2024). Weathering the storm: diagnosis and treatment of a life-threatening disseminated Nocardia otitidiscaviarum infection. Frontiers in Cellular and Infection Microbiology, 14(2024), article number 1397847. https://doi.org/10.3389/fcimb.2024.1397847.
  • Usman, M., Tang, Y., Du, Y., Yuan, Q., Wen, X., Tang, J., Wang, J., Zhang, X., Wang, L. (2024). Overview of nanoparticles for the rapid diagnosis and effective treatment of bacterial pathogens in clinical settings. Physica Scripta: an international journal for experimental and theoretical physics, 99(6), article number 62009. https://doi.org/10.1088/1402-4896/ad4b66.
  • Mou, J., Usman, M., Tang, J., Yuan, Q., Ma, Z., Wen, X., Liu, Z., Wang, L. (2024). Pseudo-Siamese network combined with label-free Raman spectroscopy for the quantification of mixed trace amounts of antibiotics in human milk: A feasibility study. Food Chemistry: X, 22(2024), article number 101507. https://doi.org/10.1016/j.fochx.2024.101507.
  • Yuan, Q., Gu, B., Liu, W., Wen, X., Wang, J., Tang, J., Usman, M., Liu, S., Tang, Y., Wang, L. (2024). Rapid discrimination of four Salmonella enterica serovars: A performance comparison between benchtop and handheld Raman spectrometers. Journal of Cellular and Molecular Medicine, 28(8), article number e18292. https://doi.org/10.1111/jcmm.18292.
  • Zhang, L., Tang, J., Tian, B., Huang, Y., Liu, X., Zhao, Y., Cui, X., Zhang, X., Qin, Y., Li, G., Wang, L. (2024). Identification of hypermucoviscous Klebsiella pneumoniae strains via untargeted surface-enhanced Raman spectroscopy. Analytical Methods: advancing methods and applications, 16(42), 7105-7113. https://doi.org/10.1039/d4ay01137f.
  • Liu, Q., Tang, J., Ma, Z., Hong, Y., Yuan, Q., Chen, J., Wen, X., Tang, Y., Wang, L. (2024). Rapid discrimination between wild and cultivated Ophiocordyceps sinensis through comparative analysis of label-free SERS technique and mass spectrometry. Current Research in Food Science, 9(2024), article number 100820. https://doi.org/10.1016/j.crfs.2024.100820.
  • Tang, J., Wen, X., Chen, H., Chen, J., Hong, K., Yuan, Q., Usman, M., Wang, L. (2024). Classification of Vaginal Cleanliness Grades through Surface-Enhanced Raman Spectral Analysis via The Deep-Learning Variational Autoencoder–Long Short-Term Memory Model. Advanced Intelligent Systems, 6(12), article number 2400587. https://doi.org/10.1002/aisy.202400587.
  • Tang, J., Yuan, Q., Wen, X., Usman, M., Tay, AC., Wang, L. (2024). Label-free surface-enhanced Raman spectroscopy coupled with machine learning algorithms in pathogenic microbial identification: Current trends, challenges, and perspectives. Interdisciplinary Medicine, 2(3), article number e20230060. https://doi.org/10.1002/INMD.20230060.
  • Ma, Z., Mou, J., Yuan, Q., Wang, Z., Liu, Q., Deng, B., Zhang, Y., Tang, D., Wang, L. (2024). Molecular exploration of the diurnal alteration of glycogen structural fragility and stability in time-restricted-feeding mouse liver. International Journal of Biological Macromolecules, 277(2), Article number 134225. https://doi.org/10.1016/j.ijbiomac.2024.134225.

2023

Journal Articles

  • Hong, R., Luo, L., Wang, L., Hu, Z., Yin, Q., Li, M., Gu, B., Wang, B., Zhuang, T., Zhang, X., Zhou, Y., Wang, W., Huang, L., Gu, B., Qi, S. (2023). Lepidium meyenii Walp (Maca)-derived extracellular vesicles ameliorate depression by promoting 5-HT synthesis via the modulation of gut–brain axis. iMeta, 2(3), Article number e116. https://doi.org/10.1002/imt2.116.
  • Tang, J., Lyu, J., Lai, J., Zhang, X., Du, Y., Zhang, X., Zhang, Y., Gu, B., Zhang, X., Gu, B., Wang, L. (2023). Determination Of Shigella Spp. Via Label-Free Sers Spectra Coupled With Deep Learning. Microchemical Journal, 189(2023), article number 108539. https://doi.org/10.1016/j.microc.2023.108539.
  • Lyu, J., Zhang, XD., Tang, J., Zhao, Y., Liu, S., Zhao, Y., Zhang, N., Wang, D., Ye, L., Chen, X., Wang, L., Gu, B. (2023). Rapid Prediction Of Multidrug-Resistant Klebsiella Pneumoniae Through Deep Learning Analysis Of Sers Spectra. Microbiology Spectrum, 11(2), e04126-22. https://doi.org/10.1128/spectrum.04126-22.
  • Luk, CY., Lee, SA., Naidovski, N., Liu, F., Tay, AC., Wang, L., Riordan, S., Zhang, L. (2023). Investigation of Campylobacter concisus gastric epithelial pathogenicity using AGS cells. Frontiers in Microbiology, 14(2023), article number 1289549. https://doi.org/10.3389/fmicb.2023.1289549.
  • Li, Y., Xu, S., Wang, L., Shi, H., Wang, H., Fang, Z., Hu, Y., Jin, J., Du, Y., Deng, M., Wang, L., Zhu, Z. (2023). Gut microbial genetic variation modulates host lifespan, sleep, and motor performance. The ISME Journal, 17(10), 1733-1740. https://doi.org/10.1038/s41396-023-01478-x.
  • Wang, L., Lai, J., Si, Y., Cui, X., Umar, Z., Ru, X., Zhang, X., Li, Z., Tay, A., Marshall, B., Li, G., Gu, B. (2023). Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance. Journal of Visualized Experiments, 2023(197), article number e65689. https://doi.org/10.3791/65689.
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