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Dr Claus Christophersen

Senior Lecturer

Contact Information Telephone: +61 8 6304 5278, Mobile: 0409119169, Email: c.christophersen@ecu.edu.au, Campus: Joondalup, Room: JO8.503
Staff Member Details
Telephone: +61 8 6304 5278
Mobile: 0409119169
Email: c.christophersen@ecu.edu.au
Campus: Joondalup  
Room: JO8.503  

 

Claus is a Lecturer in Nutrition in the School of Medical & Health Sciences. He is also Post-Graduate Coordinator for Public Heath, Occupational Health & Safety and Allied Health (Paramedical, Occupational Therapies, Nutrition & Dietetics, Speech Pathology).  

Current Teaching

  • NUT1121 Human Nutrition
  • NUT1111 Food & Nutrients

Background

Dr Christophersen has a MSc from the University of Copenhagen (2003) and a PhD from the University of Western Australia (2008). He undertook a Post-Doctoral appointment at the CSIRO Preventative Health Flagship (Adelaide) before becoming a research scientist in CSIRO Food & Nutrition. He returned to Perth in September 2015 to take up a lecturing/research position in the School of Medical and Health Sciences at Edith Cowan University.

Professional Associations

  • Australian Society for Microbiology

Research Areas and Interests

Dr Christophersen is a microbiologist specialising in the role of the gut microbiome in health and disease. As team leader at CSIRO Dr Christophersen led the molecular gut microbiology capability, which he developed over recent years to close the gap and further the understanding of the complex interaction between the gut microbiome, diet and/or disease, and the host response. To accomplish this he utilizes in vitro and animal models and human intervention studies, and an integration of bacterial 16S rRNA sequencing, biochemical and physiological data using multivariate statistical analysis. Dr Christophersen has published in highly esteemed journals (e.g. GUT) in many areas of gut microbiome research, i.e. obesity, effects of high protein diet, ulcerative colitis (UC), irritable bowel syndrome (IBS), Gut-Brain Axis (Autism), athletes and other healthy cohorts. Through these studies he has an in-depth knowledge of microbial changes and the resulting changes of the gut environment and microbial fermentation following diet changes, diet supplementation or disease.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2008.

Research

Recent Research Grants

  • Regular fat versus reduced fat dairy consumption: a pilot study of effects on cardiometabolic and gut health in young children,  Department of Health WA,  Telethon - New Children's Hospital Research Fund,  2016 - 2018,  $216,907.
  • An exploratory study to determine if exercise can impact the gut microbiota composition of men receiving androgen suppression therapy for prostate cancer,  Prostate Cancer Foundation of Australia,  Grant,  2018,  $98,875.
  • Food and Nutrition Postgraduate Scholarship ,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  CSIRO - Scholarship,  2016 - 2018,  $14,882.
  • Clostridium difficile infection in Western Australian (WA) adults with cystic fibrosis ? disease burden, molecular epidemiology, clinical impact and the potential correlation with the gut microbiome,  Sir Charles Gairdner Hospital,  Research Advisory Committee Funding Grant 2017/18,  2017 - 2018,  $40,000.
  • Monash University collaboration,  Edith Cowan University,  School of Medical and Health Sciences Research Collaboration Travel Grant Scheme 2016,  2016 - 2018,  $9,975.
  • Fibre alternative for IBS (Irritable Bowel Syndrome) sufferers on a low FODMAP diet,  Edith Cowan University,  ECU Collaboration Enhancement Scheme - 2017 Round 1,  2017 - 2018,  $10,000.
  • Effects of butyrylated resistant starch on active ulcerative colitis - a randomised controlled trial: microbial, biological, immune and clinical outcomes,  Crohn's & Colitis Foundation of America,  Broad Medical Research Program at CCFA,  2016 - 2017,  $192,806.
  • Regular vs. reduced fat dairy: a pilot study of effects on cardiometabolic and gut health in children,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $10,000.
  • Can periodontal disease change the gut environment and its microbiome?,  Edith Cowan University,  ECU Capability Enhancement Scheme - 2015 or earlier,  2016,  $10,000.

Recent Publications (within the last five years)

Book Chapters

  • Lockett, T., Bird, A., Christophersen, C., Clarke, J., Conlon, M., Topping, D., (2016), Microbes, Metabolites and Health. Microbial Metabolomics: Applications in Clinical, Environmental, and Industrial Microbiology, 13-48, Switzerland, Springer, DOI: 10.1007/978-3-319-46326-1_2.

Journal Articles

  • Nurdin, S., Le Leu, R., Young, G., Stangoulis, J., Christophersen, C., Abbott, C., (2017), Analysis of the Anti-Cancer Effects of Cincau Extract (Premna oblongifolia Merr) and Other Types of Non-Digestible Fibre using Faecal Fermentation Supernatants and Caco-2 Cells as a Model of the Human Colon. Nutrients, 9(4), article no.355, DOI: 10.3390/nu9040355.
  • Hu, Y., Le Leu, RK., Christophersen, C., Somashekar, R., Conlon, MA., Meng, XQ., Winter, JM., Woodman, RJ., McKinnon, R., Young, GP., (2016), Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats. Carcinogenesis, 37(4), 366-375, Oxford University Press, DOI: 10.1093/carcin/bgw019.
  • Halmos, EP., Christophersen, C., Bird, A., Shepherd, SJ., Muir, JG., Gibson, PR., (2016), Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn?s Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets. Clinical and Translational Gastroenterology, 7(2016), Article e164, Nature Publishing Group, DOI: 10.1038/ctg.2016.22.
  • James, S., Christophersen, C., Bird, A., Conlon, M., Rosella, O., Gibson, P., Muir, J., (2015), Abnormal fibre usage in UC in remission. Gut, 64(4), 562-570, London, UK, BMJ Publishing Group, DOI: 10.1136/gutjnl-2014-307198.
  • Halmos, E., Christophersen, C., Bird, A., Shepherd, S., Gibson, P., Muir, J., (2015), Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut, 64(1), 93-100, London, UK, BMJ Publishing Group, DOI: 10.1136/gutjnl-2014-307264.
  • Le Leu, R., Winter, J., Christophersen, C., Young , G., Humphreys, K., Hu, Y., Gratz, S., Miller, R., Topping , D., Bird, A., Conlon, M., (2015), Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue:a randomised clinical trial. British Journal of Nutrition, 114(2), 220-230, Cambridge, UK, Cambridge University Press, DOI: 10.1017/S0007114515001750.
  • Wang, L., Conlon, M., Christophersen, C., Sorich, M., Angley, M., (2014), Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomarkers in Medicine, 8(3), 331-344, London, UK, Future Medicine Ltd., DOI: 10.2217/bmm.14.12.
  • West, N., Christophersen, C., Pyne, D., Cripps, A., Conlon, M., Topping, D., Kang, S., McSweeney, C., Fricker, P., Aguirre, D., Clarke, J., (2013), Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals. Exercise Immunology Review, 19(2013), 102-119, Giessen, Germany, Association for the Advancement of Sports Medicine.
  • Christophersen, C., Petersen, A., Licht, T., Conlon, M., (2013), Xylo-oligosaccharides and inulin affect genotoxicity and bacterial populations differently in a human colonic simulator challenged with soy protein. Nutrients, 5(9), 3740-3756, Basel, Switzerland, M D P I AG, DOI: 10.3390/nu5093740.
  • Wang, L., Christophersen, C., Sorich, M., Gerber, J., Angley, M., Conlon, M., (2013), Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder. Molecular Autism, 4(1), Article no. 42, London, UK, BioMed Central Ltd, DOI: 10.1186/2040-2392-4-42.
  • Conlon, M., Bird, A., Christophersen, C., (2012), Human gut microbiota and future prebiotics. Microbiology Australia, 33(3), 100-103, CSIRO.
  • Belobrajdic, D., King, R., Christophersen, C., Bird, A., (2012), Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats. Nutrition and Metabolism, 9(2012), Article no. 93, London, UK, BioMed Central Ltd, DOI: 10.1186/1743-7075-9-93.
  • Wang, L., Christophersen, C., Sorich, M., Gerber, J., Angley, M., Conlon, M., (2012), Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in Children with Autism Spectrum Disorder. Digestive Diseases and Sciences, 57(8), 2096-2102, New York, USA, Springer, DOI: 10.1007/s10620-012-2167-7.
  • West, N., Pyne, D., Cripps, A., Christophersen, C., Conlon, M., Fricker, P., (2012), Gut balance, a synbiotic supplement, increases fecal Lactobacillus paracasei but has little effect on immunity in healthy physically active individuals. Gut Microbes, 3(3), 221-227, Landes Bioscience, DOI: 10.4161/gmic.19579.

Research Student Supervision

Associate Supervisor

  • Doctor Of Philosophy: Diarrhoea In Children; Zinc Therapy And Homeostasis
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