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Dr Claus Christophersen

Senior Lecturer

Contact Information Telephone: +61 8 6304 5278, Mobile: 0409119169, Email: c.christophersen@ecu.edu.au, Campus: Joondalup, Room: JO8.503
Staff Member Details
Telephone: +61 8 6304 5278
Mobile: 0409119169
Email: c.christophersen@ecu.edu.au
Campus: Joondalup  
Room: JO8.503  

 

Claus is a Lecturer in Nutrition in the School of Medical & Health Sciences. He is also Post-Graduate Coordinator for Public Heath, Occupational Health & Safety and Allied Health (Paramedical, Occupational Therapies, Nutrition & Dietetics, Speech Pathology).  

Current Teaching

  • NUT1121 Human Nutrition
  • NUT1111 Food & Nutrients

Background

Dr Christophersen has a MSc from the University of Copenhagen (2003) and a PhD from the University of Western Australia (2008). He undertook a Post-Doctoral appointment at the CSIRO Preventative Health Flagship (Adelaide) before becoming a research scientist in CSIRO Food & Nutrition. He returned to Perth in September 2015 to take up a lecturing/research position in the School of Medical and Health Sciences at Edith Cowan University.

Professional Associations

  • Australian Society for Microbiology

Research Areas and Interests

Dr Christophersen is a microbiologist specialising in the role of the gut microbiome in health and disease. As team leader at CSIRO Dr Christophersen led the molecular gut microbiology capability, which he developed over recent years to close the gap and further the understanding of the complex interaction between the gut microbiome, diet and/or disease, and the host response. To accomplish this he utilizes in vitro and animal models and human intervention studies, and an integration of bacterial 16S rRNA sequencing, biochemical and physiological data using multivariate statistical analysis. Dr Christophersen has published in highly esteemed journals (e.g. GUT) in many areas of gut microbiome research, i.e. obesity, effects of high protein diet, ulcerative colitis (UC), irritable bowel syndrome (IBS), Gut-Brain Axis (Autism), athletes and other healthy cohorts. Through these studies he has an in-depth knowledge of microbial changes and the resulting changes of the gut environment and microbial fermentation following diet changes, diet supplementation or disease.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2008.

Research

Recent Research Grants

  • Abnormalities in the gut health of athletes is a contributing factor to illness incidence,  WA Institute of Sport,  Industry Engagement Scholarship to support PhD projects,  2019 - 2025,  $23,750.
  • Application of a plant based diet in active Ulcerative Colitis (UC),  St John of God Health Care,  Scholarships to support Industry Engagement PhD Projects,  2018 - 2024,  $40,000.
  • Gateway to allergy prevention: Promoting an immunomodulatory breastmilk profile with maternal prebiotic supplementation,  Department of Health WA,  WA Child Research Fund,  2019 - 2021,  $700,648.
  • An exploratory study to determine if exercise can impact the gut microbiota composition of men receiving androgen suppression therapy for prostate cancer,  Prostate Cancer Foundation of Australia,  Grant,  2018 - 2021,  $98,875.
  • Effects of butyrylated resistant starch on active ulcerative colitis - a randomised controlled trial: microbial, biological, immune, clinical outcomes,  Crohn's & Colitis Foundation of America,  Broad Medical Research Program at CCFA,  2018 - 2019,  $7,951.
  • Is the dysbiosis of the gut microbiome and subsequent inflammation caused by changes in the gut metabolome of pregnant mice with periodontitis?,  Australian Dental Research Foundation Inc.,  ADRF - Grant,  2018,  $9,360.
  • IBS Intervention Study,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  CSIRO - Grant,  2018,  $10,000.
  • Clostridium difficile infection in Western Australian (WA) adults with cystic fibrosis – disease burden, molecular epidemiology, clinical impact and the potential correlation with the gut microbiome,  Sir Charles Gairdner Hospital,  Research Advisory Committee Funding Grant 2017/18,  2017 - 2018,  $40,000.
  • Monash University collaboration,  Edith Cowan University,  School of Medical and Health Sciences Research Collaboration Travel Grant Scheme 2016,  2016 - 2018,  $9,975.
  • Effect of probiotic treatment in an experimental model of periodontitis,  Australian Dental Research Foundation Inc.,  ADRF - Grant,  2018,  $10,012.
  • Food and Nutrition Postgraduate Scholarship ,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  CSIRO - Scholarship,  2016 - 2018,  $18,382.
  • Fibre alternative for IBS (Irritable Bowel Syndrome) sufferers on a low FODMAP diet,  Edith Cowan University,  ECU Collaboration Enhancement Scheme - 2017 Round 1,  2017 - 2018,  $10,000.
  • Regular fat versus reduced fat dairy consumption: a pilot study of effects on cardiometabolic and gut health in young children,  Department of Health WA,  WA Child Research Fund,  2016 - 2018,  $216,907.
  • Effects of butyrylated resistant starch on active ulcerative colitis - a randomised controlled trial: microbial, biological, immune and clinical outcomes,  Crohn's & Colitis Foundation of America,  Broad Medical Research Program at CCFA,  2016 - 2017,  $192,806.
  • Can periodontal disease change the gut environment and its microbiome?,  Edith Cowan University,  ECU Capability Enhancement Scheme - 2015 or earlier,  2016,  $10,000.
  • Regular vs. reduced fat dairy: a pilot study of effects on cardiometabolic and gut health in children,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $10,000.

Recent Publications (within the last five years)

Book Chapters

  • Lockett, T., Bird, A., Christophersen, C., Clarke, J., Conlon, M., Topping, D., (2016), Microbes, Metabolites and Health. Microbial Metabolomics: Applications in Clinical, Environmental, and Industrial Microbiology, 13-48, Switzerland, Springer, DOI: 10.1007/978-3-319-46326-1_2.

Journal Articles

  • Wang, Y., Mortimer, E., Katundu, K., Kalanga, N., Leong, L., Gopalsamy, G., Christophersen, C., Richard, A., Shivasami, A., Abell, G., Young, G., Rogers, G., (2019), The capacity of the fecal microbiota from Malawian infants to ferment resistant starch. Frontiers in Microbiology, 10(June 2019), Article 1459, DOI: 10.3389/fmicb.2019.01459.
  • Genoni, A., Lo, J., Lyons-Wall, P., Boyce, M., Christophersen, C., Bird, A., Devine, A., (2019), A Paleolithic diet lowers resistant starch intake but does not affect serum trimethylamine-N-oxide concentrations in healthy women. The British Journal of Nutrition: an international journal of nutritional science, 121(3), 322-329, Cambridge University Press, DOI: 10.1017/S000711451800329X.
  • Belobrajdic, D., Jenkins, C., Christophersen, C., Bird, A., (2019), Cereal fructan extracts alter intestinal fermentation to reduce adiposity and increase mineral retention compared to oligofructose. European Journal of Nutrition, 58(October 2019), 2811–2821, DOI: 10.1007/s00394-018-1830-y.
  • Newton, R., Christophersen, C., Fairman, C., Hart, N., Taaffe, D., Broadhurst, D., Devine, A., Chee, R., Tang, C., Spry, N., Galvao, D., (2019), Does exercise impact gut microbiota composition in men receiving androgen deprivation therapy for prostate cancer? A single-blinded, two-armed, randomised controlled trial. BMJ Open, 9(4), article no. e024872, DOI: 10.1136/bmjopen-2018-024872.
  • Genoni, A., Christophersen, C., Lo, J., Coghlan, M., Boyce, M., Bird, A., Lyons-Wall, P., Devine, A., (2019), Long‑term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations. European Journal of Nutrition, epub ahead of Print(July 2019), 14p., DOI: 10.1007/s00394-019-02036-y.
  • Le, TT., Shafaei Darestani, A., Genoni, A., Christophersen, C., Devine, A., Lo, J., Lyons-Wall, P., Boyce, M., (2019), Development and validation of a simple LC-MS/MS method for the simultaneous quantitative determination of trimethylamine-N-oxide and branched chain amino acids in human serum. Analytical and Bioanalytical Chemistry, 411(5), 1019–1028, DOI: 10.1007/s00216-018-1522-8.
  • Gopalsamy, G., Mortimer, E., Greenfield, P., Bird, A., Young, G., Christophersen, C., (2019), Resistant Starch Is Actively Fermented by Infant Faecal Microbiota and Increases Microbial Diversity. Nutrients, 11(6), Article number 1345, DOI: 10.3390/nu11061345.
  • Nurdin, S., Le Leu, R., Young, G., Stangoulis, J., Christophersen, C., Abbott, C., (2017), Analysis of the Anti-Cancer Effects of Cincau Extract (Premna oblongifolia Merr) and Other Types of Non-Digestible Fibre using Faecal Fermentation Supernatants and Caco-2 Cells as a Model of the Human Colon. Nutrients, 9(4), article no.355, DOI: 10.3390/nu9040355.
  • Halmos, EP., Christophersen, C., Bird, A., Shepherd, SJ., Muir, JG., Gibson, PR., (2016), Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn’s Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets. Clinical and Translational Gastroenterology, 7(2016), Article e164, Nature Publishing Group, DOI: 10.1038/ctg.2016.22.
  • Hu, Y., Le Leu, RK., Christophersen, C., Somashekar, R., Conlon, MA., Meng, XQ., Winter, JM., Woodman, RJ., McKinnon, R., Young, GP., (2016), Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats. Carcinogenesis, 37(4), 366-375, Oxford University Press, DOI: 10.1093/carcin/bgw019.
  • Le Leu, R., Winter, J., Christophersen, C., Young , G., Humphreys, K., Hu, Y., Gratz, S., Miller, R., Topping , D., Bird, A., Conlon, M., (2015), Butyrylated starch intake can prevent red meat-induced O6-methyl-2-deoxyguanosine adducts in human rectal tissue:a randomised clinical trial. British Journal of Nutrition, 114(2), 220-230, Cambridge, UK, Cambridge University Press, DOI: 10.1017/S0007114515001750.
  • Conlon, MA., Bird, A., Clarke, J., Le Leu, R., Christophersen, C., Lockett, T., Topping, D., (2015), Lowering of Large Bowel Butyrate Levels in Healthy Populations is Unlikely to be Beneficial. The Journal of Nutrition, 145(5), 1030–1031, Journal of Nutrition, Oxford Academic, DOI: https://doi.org/10.3945/jn.114.209460.
  • James, S., Christophersen, C., Bird, A., Conlon, M., Rosella, O., Gibson, P., Muir, J., (2015), Abnormal fibre usage in UC in remission. Gut, 64(4), 562-570, London, UK, BMJ Publishing Group, DOI: 10.1136/gutjnl-2014-307198.
  • Halmos, E., Christophersen, C., Bird, A., Shepherd, S., Gibson, P., Muir, J., (2015), Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut, 64(1), 93-100, London, UK, BMJ Publishing Group, DOI: 10.1136/gutjnl-2014-307264.
  • Wang, L., Conlon, M., Christophersen, C., Sorich, M., Angley, M., (2014), Gastrointestinal microbiota and metabolite biomarkers in children with autism spectrum disorders. Biomarkers in Medicine, 8(3), 331-344, London, UK, Future Medicine Ltd., DOI: 10.2217/bmm.14.12.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy: Diarrhoea in children; zinc therapy and homeostasis
  • Doctor of Philosophy,  HEALTH IMPACTS AND DIETARY COMPOSITION OF THE PALEOLITHIC AND AUSTRALIAN GUIDE TO HEALTHY EATING DIETS IN AUSTRALIA
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