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  • Dr Aaron Beasley

    Dr Aaron Beasley

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Dr Aaron Beasley

Post Doctoral Research Fellow

Staff Member Details
Telephone: +61 8 6304 2334
Email: a.beasley@ecu.edu.au
Campus: Joondalup  
ORCID iD: https://orcid.org/0000-0001-5727-7463

Aaron is a post-doctoral researcher in the Cancer research program within the Centre for Precision Health.

Research Areas and Interests

  • Uveal Melanoma
  • Melanoma
  • High Grade Serous Ovarian Carcinoma
  • Small Cell Lung Cancer
  • Non-Small Cell Lung Cancer
  • Next Generation Sequencing
  • Liquid Biopsy

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2021.
  • Master of Science (Human Biology), Edith Cowan University, 2017.
  • Bachelor of Science Biomedical Science, Edith Cowan University, 2014.

Research Outputs

2024

Journal Articles

  • Denisenko, E., De Kock, L., Tan, A., Beasley, A., Beilin, M., Jones, M., Hou, R., Muirí, D., Bilic, S., Mohan, G., Salfinger, S., Fox, S., Hmon, K., Yeow, Y., Kim, Y., John, R., Gilderman, T., Killingbeck, E., Gray, E., Cohen, P., Yu, Y., Forrest, A. (2024). Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones. Nature Communications, 15(1), Article number 2860. https://doi.org/10.1038/s41467-024-47271-y.
  • Acheampong, E., Allsopp, R., Page, K., Wadsley, M., Beasley, A., Coombes, RC., Shaw, J., Gray, E. (2024). Meta-Analysis of Circulating Tumor Cell PD-L1 Expression and the Association with Clinical Outcomes in Non-Small Cell Lung Cancer. Clinical Chemistry (Washington, DC): international journal of molecular diagnostics and laboratory medicine, 70(1), 234-249. https://doi.org/10.1093/clinchem/hvad187.

2023

Journal Articles

  • Acheampong, E., Morici, M., Abed, A., Bowyer, S., Asante, D., Lin, W., Millward, M., Gray, E., Beasley, A. (2023). Powering single-cell genomics to unravel circulating tumour cell subpopulations in non-small cell lung cancer patients. Journal of Cancer Research and Clinical Oncology, 149(5), 1941-1950. https://doi.org/10.1007/s00432-022-04202-y.
  • Beasley, A., Preen, D., McLenachan, S., Gray, E., Chen, F. (2023). Incidence and Mortality of Conjunctival Melanoma in Australia (1982 to 2014). Investigative Ophthalmology and Visual Science, 64(14), Article number 2. https://doi.org/https://doi.org/10.1167/iovs.64.14.2.
  • Cohen, R., Beasley, A., McCoy, M., Platell, C., Meehan, K., Gray, E., Fuller, K. (2023). Locally performed postoperative circulating tumour DNA testing performed during routine clinical care to predict recurrence of colorectal cancer. ANZ Journal of Surgery, 2023(Article in press), 8 pages. https://doi.org/10.1111/ans.18385.
  • Carlessi, R., Denisenko, E., Boslem, E., Köhn-Gaone, J., Main, N., Abu Bakar, ND., Shirolkar, G., Jones, M., Beasley, A., Poppe, D., Dwyer, B., Jackaman, C., Tjiam, M., Lister, R., Karin, M., Fallowfield, J., Kendall, T., Forbes, S., Gray, E., Olynyk, J., Yeoh, G., Forrest, A., Ramm, G., Febbraio, M., Tirnitz-Parker, J. (2023). Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genomics, 3(5), Article number 100301. https://doi.org/10.1016/j.xgen.2023.100301.
  • Medhin, L., Beasley, A., Warburton, L., Amanuel, B., Gray, E. (2023). Extracellular vesicles as a liquid biopsy for melanoma: Are we there yet?. Seminars in Cancer Biology, 89(February 2023), 92-98. https://doi.org/10.1016/j.semcancer.2023.01.008.
  • Asante, D., Mohan, G., Acheampong, E., Ziman, M., Calapre, L., Meniawy, T., Gray, E., Beasley, A. (2023). Genetic analysis of heterogeneous subsets of circulating tumour cells from high grade serous ovarian carcinoma patients. Scientific Reports, 13(1), Article number 2552. https://doi.org/10.1038/s41598-023-29416-z.
  • Calapre, L., Giardina, T., Beasley, A., Reid, A., Stewart, C., Amanuel, B., Meniawy, T., Gray, E. (2023). Identiication of TP53 mutations in circulating tumour DNA in high grade serous ovarian carcinoma using next generation sequencing technologies. Scientific Reports, 13(1), Article number 278. https://doi.org/10.1038/s41598-023-27445-2.
  • Beasley, A., De Bruyn, D., Beasley, L., Al-Ogaili, Z., Isaacs, T., Bentel, J., Reid, A., Dwarkasing, R., Pereira, M., Khattak, A., Meniawy, T., Millward, M., Brosens, E., De Klein, A., Chen, F., Kiliҫ, E., Gray, E. (2023). Detection of metastases using circulating tumour DNA in uveal melanoma. Journal of Cancer Research and Clinical Oncology, 2023(Article in press), 11 pages. https://doi.org/10.1007/s00432-023-05271-3.
  • Abed, A., Beasley, A., Reid, A., Law, N., Beasley, L., Millward, M., Lo, J., Gray, E. (2023). Circulating pre-treatment T-cell receptor repertoire as a predictive biomarker in advanced or metastatic non-small-cell lung cancer patients treated with pembrolizumab alone or in combination with chemotherapy. ESMO Open, 8(6), Article number 102066. https://doi.org/10.1016/j.esmoop.2023.102066.

2022

Journal Articles

  • De Bruyn, D., Beasley, A., Verdijk, R., Van Poppelen, N., Paridaens, D., De Keizer, R., Naus, N., Gray, E., De Klein, A., Brosens, E., Kilic, E. (2022). Is tissue still the issue? The promise of liquid biopsy in Uveal Melanoma. Biomedicines, 10(2), Article Number 506. https://doi.org/10.3390/biomedicines10020506.
  • Dyke, J., Beasley, L., Beasley, A., Gray, E., Allcock, R., Bentel, J. (2022). Application of multiplex ligation-dependent probe amplification (MLPA) and low pass whole genome sequencing (LP-WGS) to the classification / characterisation of low grade glioneuronal tumours. Pathology, Research and Practice, 229(January 2022), Article number 153724. https://doi.org/10.1016/j.prp.2021.153724.
  • Beasley, A., Chen, F., Isaacs, T., Gray, E. (2022). Future perspectives of uveal melanoma blood based biomarkers. British Journal of Cancer, 126(11), 1511-1528. https://doi.org/10.1038/s41416-022-01723-8.
  • Acheampong, E., Abed, A., Morici, M., Spencer, I., Beasley, A., Bowyer, S., Asante, D., Lomma, C., Lin, W., Millward, M., Gray, E. (2022). Evaluation of PD-L1 expression on circulating tumour cells in small-cell lung cancer. Translational Lung Cancer Research, 11(5), 440-451. https://doi.org/10.21037/tlcr-21-819.

2021

Book Chapters

  • Beasley, A., Acheampong, E., Lin, W., Gray, E. (2021). Multi-marker immunomagnetic enrichment of circulating melanoma cells. Melanoma. Methods and Protocols (213-222). Humana Press. https://doi.org/10.1007/978-1-0716-1205-7_16.

Journal Articles

  • Lin, W., Beasley, A., Ardakani, N., Denisenko, E., Beasley, L., Jones, M., Wood, B., Warburton, L., Forrest, A., Gray, E. (2021). Intra- and inter-tumoral heterogeneity of liver metastases in a patient with uveal melanoma revealed by single-cell RNA sequencing. Cold Spring Harbor Molecular Case Studies, 7(5), article number a006111. https://doi.org/10.1101/mcs.a006111.
  • Beasley, A., Isaacs, T., Vermeulen, T., Freeman, J., Desousa, J., Bhikoo, R., Hennessy, D., Reid, A., Chen, F., Bentel, J., McKay, D., Conway, R., Pereira, M., Mirzai, B., Beasley, L., Erber, W., Ziman, M., Gray, E. (2021). Analysis of Circulating Tumour Cells in Early-Stage Uveal Melanoma: Evaluation of Tumour Marker Expression to Increase Capture. Cancers, 13(23), Article 5990. https://doi.org/10.3390/cancers13235990.
  • Asante, D., Morici, M., Mohan, G., Acheampong, E., Spencer, I., Lin, W., Van Miert, P., Gibson, S., Beasley, A., Ziman, M., Beasley, L., Meniawy, T., Gray, E. (2021). Multi-Marker Immunofluorescent Staining and PD-L1 Detection on Circulating Tumour Cells from Ovarian Cancer Patients. Cancers, 13(24), Article number 6225. https://doi.org/10.3390/cancers13246225.
  • Beasley, A., Preen, DB., McLenachan, S., Gray, E., Chen, FK. (2021). Incidence and mortality of uveal melanoma in Australia (1982–2014). British Journal of Ophthalmology, 2021(Article in press), 1-6. https://doi.org/10.1136/bjophthalmol-2021-319700.

2020

Journal Articles

  • Beasley, A., Bentel, J., Allcock, R., Vermeulen, T., Beasley, L., Isaacs, T., Ziman, M., Chen, F., Gray, E. (2020). Low-Pass Whole-Genome Sequencing as a Method of Determining Copy Number Variations in Uveal Melanoma Tissue Samples. The Journal of Molecular Diagnostics, 22(3), 429-434. https://doi.org/10.1016/j.jmoldx.2019.12.005.
  • Johansson, P., Brooks, K., Newell, F., Palmer, J., Wilmott, J., Pritchard, A., Broit, N., Wood, S., Carlino, M., Leonard, C., Koufariotis, L., Nathan, V., Beasley, A., Howlie, M., Dawson, R., Rizos, H., Schmidt, C., Long, G., Hamilton, H., Kiilgaard, J., Isaacs, T., Gray, E., Rolfe, O., Park, J., Stark, A., Mann, G., Scolyer, R., Pearson, J., Van Baren, N., Waddell, N., Wadt, K., McGrath, L., Warrier, S., Glasson, W., Hayward, N. (2020). Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours. Nature Communications, 11(1), Article number 2408. https://doi.org/10.1038/s41467-020-16276-8.

2018

Journal Articles

  • Beasley, A., Isaacs, T., Khattak, A., Freeman, J., Allcock, R., Chen, F., Pereira, M., Yau, K., Bentel, J., Vermeulen, T., Beasley, L., Millward, M., Ziman, M., Gray, E. (2018). Clinical Application of Circulating Tumor Cells and Circulating Tumor DNA in Uveal Melanoma. JCO Precision Oncology, 2(May 17, 2018), 12p.. https://doi.org/10.1200/PO.17.00279.

Research Projects

  • Western Australia Melanoma Initiative (WAMI): developing novel treatments for immunotherapy-resistant melanoma, Cancer Research Trust, The Grant, 2024 ‑ 2028, $2,068,757.
  • Using circulating tumour cells in novel uveal melanoma PDX to discover new therapies, Department of Health WA, WA Near-miss Awards: Emerging Leaders Program, 2024 ‑ 2025, $100,000.
  • Predicting prognosis using circulating tumour DNA in uveal melanoma, Cancer Council of WA Inc, Suzanne Cavanagh Early Career Investigator Grants, 2023 ‑ 2024, $35,000.
  • Predicting prognosis using circulating tumour DNA in uveal melanoma, Edith Cowan University, Early-Mid Career Researcher Grant Scheme 2022 (Stream 1), 2023 ‑ 2024, $36,312.
  • TCR repertoire in combination with HLA and TMB as predictor of response to immune checkpoint blockade in melanoma and lung cancer, Thermo Fisher Scientific Australia Pty Ltd, Grant, 2022 ‑ 2023, $200,000.
  • Little Vesicles in blood could reveal what patients will respond to immunotherapy, Spinnaker Health Research Foundation, Janine Chalwell Innovation Grant, 2022 ‑ 2023, $24,800.
  • Early detection of uveal melanoma, Australian Melanoma Research Foundation, 2020 Research Grant, 2020, $8,500.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Master of Medical and Health Science by Research, TCR Repertoire and HLA Genotype as Response Biomarkers to Immune Checkpoint Blockade in Advanced Melanoma Patients
  • Doctor of Philosophy, A multi-omic approach for the detection of melanoma brain metastasis

Co-principal Supervisor

  • Doctor of Philosophy, Role of CD44 in metastatic Uveal Melanoma

Associate Supervisor

  • Doctor of Philosophy, Exploring the Molecular Mechanism of Ferroptosis in Bladder Cancer
  • Doctor of Philosophy, Investigating the mechanism of release of circulating tumour DNA by melanoma cells

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
  • Doctor of Philosophy, Assessment of circulating tumour cells in lung cancer patients
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