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Dr Weitao Lin

Adjunct Lecturer

Staff Member Details
Email: w.lin@ecu.edu.au
ORCID iD: https://orcid.org/0000-0003-4385-9897

Dr Weitao Lin is an ECU adjunct within the Melanoma and blood-based biomarkers research group, and the Centre for Precision Health. He focuses on characterising the genetic profiles of circulating tumour cells of melanoma by using single-cell RNA sequencing.

Background

  • 2017-2018: Research Associate, University of Hong Kong
  • 2009-2012: Laboratory Technician, Joint Shantou International Eye Centre of Shantou University and the Chinese University of Hong Kong

Qualifications

  • Doctor of Philosophy, Hong Kong (SAR of China), 2017.

Research Outputs

Journal Articles

  • Acheampong, E., Morici, M., Abed, A., Bowyer, S., Asante, D., Lin, W., Millward, M., Gray, E., Beasley, A. (2023). Powering single-cell genomics to unravel circulating tumour cell subpopulations in non-small cell lung cancer patients. Journal of Cancer Research and Clinical Oncology, 149(5), 1941-1950. https://doi.org/10.1007/s00432-022-04202-y.

Journal Articles

  • Acheampong, E., Abed, A., Morici, M., Spencer, I., Beasley, A., Bowyer, S., Asante, D., Lomma, C., Lin, W., Millward, M., Gray, E. (2022). Evaluation of PD-L1 expression on circulating tumour cells in small-cell lung cancer. Translational Lung Cancer Research, 11(5), 440-451. https://doi.org/10.21037/tlcr-21-819.

Book Chapters

Journal Articles

  • Asante, D., Morici, M., Mohan, G., Acheampong, E., Spencer, I., Lin, W., Van Miert, P., Gibson, S., Beasley, A., Ziman, M., Beasley, L., Meniawy, T., Gray, E. (2021). Multi-Marker Immunofluorescent Staining and PD-L1 Detection on Circulating Tumour Cells from Ovarian Cancer Patients. Cancers, 13(24), Article number 6225. https://doi.org/10.3390/cancers13246225.
  • Lin, W., Beasley, A., Ardakani, N., Denisenko, E., Beasley, L., Jones, M., Wood, B., Warburton, L., Forrest, A., Gray, E. (2021). Intra- and inter-tumoral heterogeneity of liver metastases in a patient with uveal melanoma revealed by single-cell RNA sequencing. Cold Spring Harbor Molecular Case Studies, 7(5), article number a006111. https://doi.org/10.1101/mcs.a006111.

Journal Articles

  • Acheampong, E., Abed, A., Morici, M., Bowyer, S., Amanuel, B., Lin, W., Millward, M., Gray, E. (2020). Tumour PD-L1 Expression in Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Cells, 9(11), Article Number 2393. https://doi.org/10.3390/cells9112393.

Book Chapters

  • Yip, YL., Lin, W., Deng, W., Tsang, CM., Tsao, SW. (2019). Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelial Cell Lines for Nasopharyngeal Carcinoma and Epstein–Barr Virus Infection Studies. Nasopharyngeal Carcinoma: From Aetiology to Clinical Practice (85-107). Academic Press. https://doi.org/10.1016/B978-0-12-814936-2.00005-5.

Journal Articles

  • Acheampong, E., Spencer, I., Lin, W., Ziman, M., Millward, M., Gray, E. (2019). Is the Blood an Alternative for Programmed Cell Death Ligand 1 Assessment in Non-Small Cell Lung Cancer?. Cancers, 11(7), article no. 920. https://doi.org/10.3390/cancers11070920.
  • Jun, Z., Lin, J., Liu, T., Yip, YL., Tang, WC., Lin, W., Deng, W., Lo, KW., You, C., Lung, ML., Lung, HL., Cheung, AL., Tsao, SW., Tsang, CM. (2019). mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma. Oncogene, 38(24), 4669–4684. https://doi.org/10.1038/s41388-019-0749-y.
  • Pang, PS., Liu, T., Lin, W., Tsang, C., Yip, Y., Zhou, Y., Guan, X., Chan, RC., Tsao, SW., Deng, W. (2019). Defining early events of Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection. Journal of General Virology, 100(6), 999-1012. https://doi.org/10.1099/jgv.0.001243.

Journal Articles

  • Lin, W., Yip, YL., Jia, L., Deng, W., Zheng, H., Dai, W., Ko, J., Lo, KW., Chung, G., Yip, K., Lee, S., Kwan, J., Zhang, J., Liu, T., Chan, J., Kwong, D., Lee, V., Nicholls, J., Busson, P., Liu, X., Chiang, A., Hui, K., Kwok, H., Cheung, S., Cheung, Y., Chan, C., Li, B., Cheung, A., Hau, P., Zhou, Y., Tsang, C., Middledorp, J., Chen, H., Lung, M., Tsao, S. (2018). Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma. Nature Communications, 9(1), Article no.4663. https://doi.org/10.1038/s41467-018-06889-5.
  • Yip, Y., Lin, W., Deng, W., Jia, L., Lo, K., Busson, P., Verillaud, B., Liu, X., Tsang, C., Lung, M., Tsao, S. (2018). Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein-Barr virus reactivation. Laboratory Investigation, 98(8), 1093-1104. https://doi.org/10.1038/s41374-018-0034-7.

Journal Articles

  • Zhang, J., Jia, L., Lin, W., Yip, Y., Lo, K., Lau, V., Zhu, D., Tsang, C., Zhou, Y., Deng, W., Lung, H., Lung, M., Cheung, L., Tsao, S. (2017). Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-kB Signaling Pathways. Journal of Virology, 91(6), Article no. e02168-16. https://doi.org/10.1128/JVI.02168-16.

Journal Articles

  • Tsang, C., Cheung, Y., Lui, V., Yip, Y., Zhang, G., Lin, W., Cheung, K., Feng, Y., Tsao, S. (2013). Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. BMC Cancer, 13(December), Article number 619. https://doi.org/10.1186/1471-2407-13-619.

Journal Articles

  • Chen, J., Lin, W., Sun, G., Huang, C., Huang, Y., Chen, H., Pang, CP., Zhang, M. (2012). A novel PAX6 deletion in a Chinese family with congenital aniridia. Molecular Vision, 18(12 April 2012), 989-995. https://doi.org/10.1080/13816810.2018.1466336.

Research Projects

  • Multimodal Liquid biopsy to Predict Response of Melanoma to Immuno-Oncology, Spinnaker Health Research Foundation, Janine Chalwell Gift Grant, 2022 ‑ 2024, $102,459.
  • Developing a blood test for predicting the response to treatment with immunotherapies in melanoma patients, Cancer Council of WA Inc, Grant, 2022 ‑ 2023, $96,453.
  • Circulating Melanoma Cells as Predictive Biomarkers of Response to Immune Checkpoint Blockade , Cancer Council of WA Inc, Grant, 2020 ‑ 2022, $100,000.
  • Exploring therapeutic targets for the treatment of metastatic uveal melanoma, Cancer Council of WA Inc, Collaborative Cancer Grant Scheme, 2021 ‑ 2022, $64,718.
  • Establishment of cell lines from melanoma circulating tumour cells , Edith Cowan University, ECU Early Career Researcher Grant - 2019, 2019 ‑ 2020, $29,959.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy, Role of CD44 in metastatic Uveal Melanoma

Associate Supervisor

  • Doctor of Philosophy, Development of Novel Tests to Improve the Management of Uveal Melanoma
  • Doctor of Philosophy, Assessment of circulating tumour cells in lung cancer patients
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