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Ms Melissa Eccles

Post Doctoral Research Fellow

Staff Member Details
Email: m.eccles@ecu.edu.au

Qualifications

  • Bachelor of Science (Biomedical Science), Curtin University of Technology, 2018.
  • Bachelor of Science (Molecular Genetics and Biotechnology), Curtin University of Technology, 2017.
  • Bachelor of Engineering Mining Engineering, Curtin University of Technology, 2000.

Research Outputs

2025

Journal Articles

  • Kumari, N., Wright, SC., Witham, CM., Monserrat, L., Palafox, M., Richard, JL., Costa, C., Elkabets, M., Agostino, M., Klemm, T., Eccles, M., Garnham, A., Wu, T., Nilsson, JA., Walz, N., Venugopal, V., Cerra, A., Vasilevski, N., Bridgeman, S., Bassi, S., Saei, A., Helal, M., Neundorf, P., Riedel, A., Rosenfeldt, M., Gill, J., Pahor, N., Hartmann, O., Chung, J., Sidhu, SS., Moderau, N., Jha, S., Rodon, J., Diefenbacher, ME., Komander, D., Serra, V., Eichhorn, PJ. (2025). USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer. Journal of Clinical Investigation, 135(22), article number e180927. https://doi.org/10.1172/JCI180927.

2024

Book Chapters

  • Milligan Armstrong, A., Woodfield, A., Eccles, M., Groth, D., Verdile, G. (2024). The role of stress in mediating inflammation in the context of neurodegeneration. Stress: Immunology and Inflammation: Handbook of Stress Series Volume 5 (325-337). Elsevier. https://doi.org/10.1016/B978-0-12-817558-3.00005-6.

Journal Articles

  • Eccles, M., Main, N., Carlessi, R., Armstrong, AM., Sabale, M., Roberts-Mok, B., Tirnitz-Parker, JE., Agostino, M., Groth, D., Fraser, PE., Verdile, G. (2024). Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase. The FASEB Journal, 38(1), article number e23396. https://doi.org/10.1096/fj.202300954RR.

2023

Book Chapters

  • Vasantharajan, SS., Barnett, E., Gray, E., Rodger, E., Eccles, M., Pattison, S., Munro, F., Chatterjee, A. (2023). Size-Based Method for Enrichment of Circulating Tumor Cells from Blood of Colorectal Cancer Patients. Oral Biology: Molecular Techniques and Applications (231-248). Humana Press. https://doi.org/10.1007/978-1-0716-2780-8_15.

2022

Journal Articles

  • Ioppolo, A., Eccles, M., Groth, D., Verdile, G., Agostino, M. (2022). Evaluation of virtual screening strategies for the identification of γ-secretase inhibitors and modulators. Molecules, 27(1), article number 176. https://doi.org/10.3390/molecules27010176.
  • Vasantharajan, S., Barnett, E., Gray, E., McCall, J., Rodger, E., Eccles, M., Munro, F., Pattison, S., Chatterjee, A. (2022). Assessment of a Size-Based Method for Enriching Circulating Tumour Cells in Colorectal Cancer. Cancers, 14(14), Article number 3446. https://doi.org/10.3390/cancers14143446.

2021

Journal Articles

  • Vasantharajan, S., Eccles, M., Rodger, E., Pattison, S., McCall, J., Gray, E., Calapre, L., Chatterjee, A. (2021). The epigenetic landscape of circulating tumour cells. Biochimica et Biophysica Acta: Reviews on Cancer, 1875(2), Article number 188514. https://doi.org/10.1016/j.bbcan.2021.188514.
  • Moussavi Nik, S., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., Eccles, M., Woodfield, A., Groth, D., Dore, V., Villemagne, V., Masters, C., Martins, R., Laws, S., Lardelli, M., Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 Transcript to Alzheimer's disease and neurodegeneration. Journal of Alzheimer's Disease, 80(4), 1479-1489. https://doi.org/10.3233/jad-201133.
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