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Professor Dylan Edwards

Professor Dylan Edwards is a human clinical neuroscientist who has spent the past decade in New York and Boston at Burke-Cornell and Harvard University respectively. His group studies motor recovery after neurological damage including adult stroke, spinal cord injury, and cerebral palsy. The work incorporates emerging technologies of transcranial magnetic stimulation, and rehabilitation robotics. Professor Edwards is advancing these therapies, examining efficacy and biomarkers of recovery, as well as investigating novel combinatorial therapies such as with new drugs or dietary modification. Edith Cowan University is young and vibrant, rapidly rising to serious research productivity status on the International stage, and is well positioned geographically and economically for success in clinical research. Forging great connections between ECU and world leading universities in the United States is a strategic move, whereby new ideas can be shared and tested. The vision for Professor Edwards and his team is to have ECU as a leader in clinical neuroscience research, by partnering with Western Australian, Interstate and International hospitals.

Current Teaching

  • Intensive Course in Transcranial Magnetic Stimulation (at Harvard Medical School, Boston, USA)
  • Transcranial Current Stimulation (at Harvard Medical School, Boston, USA)

Background

Dylan Edwards holds multiple positions in national and international universities. He is the Professor of Neuroscience in the School of Medical and Health Sciences at Edith Cowan University and the Associate Professor of Clinical Neurophysiology at Weill Cornell Medicine, Cornell University, USA. He is also the Director of the Brain Stimulation and Robotics Laboratory, the Director of Restorative Neurology Clinic at Burke Medical Research Institute, as well as the Co-Director of Intensive Course in Transcranial Magnetic Stimulation in Harvard Medical School, USA. Further he is a scientific consultant for Neurology/Neurorehabilitation Departments in Australia, Spain and Brazil.

Professor Dylan Edwards’ main research interests focus on understanding and promoting neuroplasticity following brain lesion, and in particular, using controlled physical rehabilitation (robotics) combined with non-invasive brain stimulation of motor areas. He has extensive experience using non-invasive brain stimulation (NIBS) as an investigative and therapeutic tool in human subjects, initially at The University of Western Australia Medical Faculty, then BIDMC/Harvard and MIT in Boston, and Burke-Cornell in New York.

Edwards’ extensive clinical experience in motor rehabilitation has involved working with traumatic brain injury, stroke, Parkinson’s disease, inclusion body myositis, polymyositis, spinal cord injury, multiple sclerosis, chronic pain, peripheral neuropathy, developmental coordination disorder and cerebral palsy. Over the past eight years through foundation, industry, National Institute of Health, USA, and funding many participants in his program have experienced clinically meaningful gains in function. His clinical research expertise has been recognized through invitations to review and comment on some of the largest recent Neurorehabilitation Mulitcenter Clinical Trials in the United States, via the American Physical Medicine and Rehabilitation Society, and the American Society for Neurorehabilitation.

Professor Edwards has more than 12 years experience lecturing at tertiary level in the areas of human motor rehabilitation, motor control and skill acquisition, and clinical neuroscience. He has trained and supervised a number of clinicians and researchers in the use of TMS and tDCS in clinical studies. Two of his students have received formal accolades for this work, including Australian government awards for science and innovation, and the work has been presented internationally.

Professional Associations

  • American Society for Neurorehabilitation - Board of Directors
  • Harvard Medical School - Data and Safety Monitoring Board Member
  • International Society for Restorative Neurology - Charter Member
  • Journal of Neuroengineering and Rehabilitation - Editorial Board Member
  • Neurorehabilitation and Neural Repair - Editorial Board Member
  • New York Academy of Sciences - Member
  • The Burke Medical Research Institute, Burke Rehabilitation Hospital - Clinical Research Administrator

Awards and Recognition

  • 2016 FCN Committee for International Brain Stimulation Training Guidelines.
  • 2016 NIH/NINDS, NSD-A Translational Program, Invited Reviewer, Chicago, June.
  • 2016 NIH/NIMH, Obama- White House, Brain Initiative, Invited Expert Reviewer, Washington DC.
  • 2016 International Federation for Clinical Neurophysiology (IFCN) Invited Committee Member for Training Guidelines in Noninvasive Brain Stimulation.
  • 2015 NIH/NICHD Special Emphasis Panel: Interventions for Stroke.
  • 2013 ‘State of the Science’ Address on Transcranial Brain Stimulation, by invitation, The United States Institute of Medicine, The National Academy of Sciences.
  • 2013 New York Science Leaders' discussion by invitation, Aust Governor General, New York Academy of Sciences.
  • 2013 Clinical Award, Advancement of Neuromodulation Clinical Trials. New York City Neuromodulation International Meeting.
  • 2012 Appointed to the Board of Directors, American Society of Neurorehabilitation.
  • 2007 Science and Innovation Awards, Neuromuscular Research, Dept. Ind. & Res., Govt Western Australia.
  • 2007 Science and Innovation Awards, Neuromuscular Research, Dept. Ind. & Res., Govt Western Australia.
  • 2006 Science and Innovation Award, Neuromuscular Research, Dept. Ind. & Res., Govt. Western Australia.
  • 2004 Clinical Research Fellowship, Studies of Non-invasive Brain Stimulation, The Fac.Med.Dent, The University of Western Australia.
  • 2004 Whitfield Fellowship Award, Studies of Non-invasive Brain Stimulation, The Faculty of Medicine and Dentistry, The University of Western Australia.

Research Areas and Interests

  • Motor rehabilitation following neurological injury (stroke, spinal cord injury, and traumatic brain injury)

Qualifications

  • Bachelor of Applied Science Honours, Curtin University of Technology.
  • Bachelor of Science (Physiotherapy), Curtin University of Technology.
  • Doctor Of Philosophy, The University of Western Australia, 2005.

Research

Recent Research Grants

  • Development of Methods to Assess Standing Fatigue,  Taisho Pharmaceutical Co Ltd,  Grant,  2006 - 2007,  $106,569.
  • Is therapeutic brain stimulation during exercise therapy effective for enhancing functional agonist / antagonist muscle coordination in the treatment of spasticity? ,  Edith Cowan University,  ECU Early Career Researcher - Grant,  2005 - 2007,  $14,941.

Recent Publications (within the last five years)

Book Chapters

  • Krebs, HI., Edwards, D., Hogan, N., (2016), Forging Mens et Manus: The MIT Experience in Upper Extremity Robotic Therapy. Neurorehabilitation Technology, 333-350, London, England, Springer, DOI: 10.1007/978-3-319-28603-7_16.

Journal Articles

  • Putrino, D., Zanders, H., Hamilton, T., Rykman, A., Lee, P., Edwards, D., (2017), Patient engagement is related to impairment reduction during digital game-based therapy in Stroke. Games for Health Journal, 6(5), 295-302, United States, Mary Ann Liebert Inc. Publishers, DOI: 10.1089/g4h.2016.0108.
  • Friel, K., Lee, P., Soles, L., Smorenburg, A., Kuo, H., Gupta, D., Edwards, D., (2017), Combined transcranial direct current stimulation and robotic upper limb therapy improves upper limb function in an adult with cerebral palsy. NeuroRehabilitation: an interdisciplinary journal, 41(1), 41-50, Netherlands, IOS Press, DOI: 10.3233/NRE-171455.
  • Cortes, M., Medeiros, A., Gandhi, A., Lee, P., Krebs, H., Thickbroom, G., Edwards, D., (2017), Improved grasp function with transcranial direct current stimulation in chronic spinal cord injury. NeuroRehabilitation: an interdisciplinary journal, 41(1), 51-59, Netherlands, IOS Press.
  • Cortes, M., Thickbroom, G., Elder, J., Rykman, A., Valls-Sole, J., Pascual-Leone, A., Edwards, D., (2017), The corticomotor projection to liminally-contractable forearm muscles in chronic spinal cord injury: a transcranial magnetic stimulation study. Spinal Cord, 55(4), 362-366, DOI: 10.1038/sc.2016.161.
  • Labar, D., Labar, A., Edwards, D., (2016), Long-Term Distributed Repetitive Transcranial Magnetic Stimulation for Tinnitus: A Feasibility Study. Neuromodulation, 19(3), 249-253, Blackwell Publishing Inc, DOI: 10.1111/ner.12390.
  • Bolognini, N., Russo, C., Edwards, D., (2016), The sensory side of post-stroke motor rehabilitation. Restorative Neurology and Neuroscience, 34(4), 571-586, IOS Press, DOI: 10.3233/RNN-150606.
  • Tsagaris, Z., Labar, D., Edwards, D., (2016), A Framework for Combining rTMS with Behavioral Therapy. Frontiers in Systems Neuroscience, 10(Nov), article no. 82, DOI: 10.3389/fnsys.2016.00082.
  • Grimaldi, G., Argyropoulos, G., Bastian, A., Cortes, M., Davis, N., Edwards, D., Ferrucci, R., Fregni, F., Galea, J., Hamada, M., Manto, M., Miall, R., Morales-Quezada, L., Pope, P., Priori, A., Rothwell, J., Tomlinson, S., Celnik, P., (2016), Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease. The Neuroscientist: reviews at the interface of basic and clinical neurosciences , 22(1), 83-97, Sage, DOI: 10.1177/1073858414559409.
  • Otal, B., Dutta, A., Foerster, A., Ripolles, O., Kuceyeski, A., Miranda, P., Edwards, D., Illic, T., Nitsche, M., Ruffini, G., (2016), Opportunities for guided multichannel non-invasive transcranial current stimulation in poststroke rehabilitation. Frontiers in Neurology, 7(Article 21), 11p., Frontiers Research Foundation, DOI: 10.3389/fneur.2016.00021.
  • Santos-Pontelli, T., Rimoli, B., Favoretto, D., Mazin, S., Truong, D., Leite, J., Pontes-Neto, O., Babyar, S., Reding, M., Bikson, M., Edwards, D., (2016), Polarity-dependent misperception of subjective visual vertical during and after transcranial direct current stimulation (tDCS). PLoS One, 11(3), Article number e0152331, Public Library of Science, DOI: 10.1371/journal.pone.0152331.
  • Grecco, L., Oliveira, C., Galli, M., Cosmo, C., Duarte, N., Zanon, N., Edwards, D., Fregni, F., (2016), Spared primary motor cortex and the presence of MEP in Cerebral Palsy dictate the responsiveness to tDCS during gait training. Frontiers in Human Neuroscience, 10(Article 361), 11p., Frontiers Media S.A, DOI: 10.3389/fnhum.2016.00361.
  • Peters, H., Edwards, D., Wortman-Jutt, S., Page, S., (2016), Moving forward by stimulating the brain: Transcranial direct current stimulation in post-stroke Hemiparesis. Frontiers in Human Neuroscience, 10(Article 394), 8p., Frontiers Media S.A, DOI: 10.3389/fnhum.2016.00394.
  • Bashir, S., Vernet, M., Najib, U., Perez, J., Alonso-Alonso, M., Knobel, M., Yoo, W., Edwards, D., Pascual-Leone, A., (2016), Enhanced motor function and its neurophysiological correlates after navigated low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in stroke. Restorative Neurology and Neuroscience, 34(4), 677-689, IOS Press, DOI: 10.3233/RNN-140460.
  • Caparelli-Daquer, E., Valente, A., Nigri, F., Edwards, D., Medeiros, A., (2016), A Halo-Shaped Electrode Holder System for HD-tDCS is a Practical and Flexible Alternative to the EEG Cap 4?1-Ring Montage. Brain Stimulation, 9(1), 153-155, Elsevier, DOI: 10.1016/j.brs.2015.11.001.
  • Babyar, S., Santos-Pontelli, T., Will-Lemos, T., Mazin, S., Bikson, M., Truong, D., Edwards, D., Reding, M., (2016), Center of Pressure Speed Changes with tDCS Versus GVS in Patients with Lateropulsion after Stroke. Brain Stimulation, 9(5), 796-798, Elsevier, DOI: 10.1016/j.brs.2016.06.053.
  • Murray, L., Edwards, D., Ruffini, G., Labar, D., Stampas, A., Pascual-Leone, A., Cortes, M., (2015), Intensity dependent effects of transcranial direct current stimulation on corticospinal excitability in chronic spinal cord injury. Archives of Physical Medicine and Rehabilitation, 96(4), S114-S121, Philadelphia, United States, W.B. Saunders, DOI: 10.1016/j.apmr.2014.11.004.
  • Schambra, H., Ogden, R., Martinez-Hernandez, I., Lin, X., Chang, Y., Rahman, A., Edwards, D., Krakauer, J., (2015), The reliability of repeated TMS measures in older adults and in patients with subacute and chronic stroke. Frontiers in Cellular Neuroscience, 9(1), Article no. 335, Frontiers Research Foundation, DOI: 10.3389/fncel.2015.00335.
  • Thickbroom, G., Cortes, M., Rykman, A., Volpe, B., Fregni, F., Krebs, H., Pascual-Leone, A., Edwards, D., (2015), Stroke subtype and motor impairment influence contralesional excitability. Neurology, 85(6), 517-520, DOI: 10.1212/WNL.0000000000001828.
  • Edwards, D., Dipietro, L., Demirtas-Tatlidede, A., Medeiros, A., Thickbroom, G., Mastaglia, F., Krebs, H., Pascual-Leone, A., (2014), Movement-generated afference paired with transcranial magnetic stimulation: An associative stimulation paradigm. Journal of NeuroEngineering and Rehabilitation, 11(1), Article No. 31, BioMed Central Ltd., DOI: 10.1186/1743-0003-11-31.
  • Hopper, D., Grisbook, T., Newnham, P., Edwards, D., (2014), The effects of vestibular stimulation and fatigue on postural control in classical ballet dancers. Journal of Dance Medicine and Science, 18(2), 67-73, DOI: 10.12678/1089-313X.18.2.67.
  • Cortes, M., Elder, J., Rykman, A., Murray, L., Avedissian, M., Stampa, A., Thickbroom, G., Pascual-Leone, A., Krebs, H., Valls-Sole, J., Edwards, D., (2013), Improved motor performance in chronic spinal cord injury following upper-limb robotic training. NeuroRehabilitation: an interdisciplinary journal, 33(1), 57-65, DOI: 10.3233/NRE-130928.
  • Giacobbe, V., Krebs, H., Volpe, B., Pascual-Leone, A., Rykman, A., Zeiarati, G., Fregni, F., Dipietro, L., Thickbroom, G., Edwards, D., (2013), Transcranial direct current stimulation (tDCS) and robotic practice in chronic stroke: Thedimension of timing. NeuroRehabilitation: an interdisciplinary journal, 33(1), 49-56, DOI: 10.3233/NRE-130927.
  • Elder, J., Cortes, M., Rykman, A., Hill, J., Karuppagounder, S., Edwards, D., Ratan, R., (2013), The Epigenetics of Stroke Recovery and Rehabilitation: From Polycomb to Histone Deacetylases. Neurotherapeutics, 10(4), 808-816, Springer, DOI: 10.1007/s13311-013-0224-3.
  • Guleyupoglu, B., Schestatsky, P., Edwards, D., Fregni, F., Bikson, M., (2013), Classification of methods in transcranial Electrical Stimulation (tES) and evolving strategy from historical approaches to contemporary innovations. Journal of Neuroscience Methods, 219(2), 297-311, DOI: 10.1016/j.jneumeth.2013.07.016.
  • Edwards, D., Cortes, M., Thickbroom, G., Rykman, A., Pascual-Leone, A., Volpe, B., (2013), Preserved corticospinal conduction without voluntary movement after spinal cord injury. Spinal Cord, 51(10), 765-767, DOI: 10.1038/sc.2013.74.
  • Edwards, D., Cortes, M., Datta, A., Minhas, P., Wassermann, E., Bikson, M., (2013), Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS. NeuroImage, 74(N/A), 266-275, DOI: 10.1016/j.neuroimage.2013.01.042.
  • Cortes, M., Black-Schaffer, RM., Edwards, D., (2012), Transcranial magnetic stimulation as an investigative tool for motor dysfunction and recovery in stroke: an overview for neurorehabilitation clinicians. Neuromodulation, 15(4), 316-325, DOI: 10.1111/j.1525-1403.2012.00459.x.
  • Benito-Penalva, J., Edwards, D., Opisso, E., Cortes, M., Lopez-Blazquez, R., Murillo, N., Costa, U., Tormos, J., Vidal-Samso, J., Valls-Sole, J., Medina, J., (2012), Gait Training in Human Spinal Cord Injury Using Electromechanical Systems: Effect of Device Type and PatientCharacteristics. Archives of Physical Medicine and Rehabilitation, 93(3), 404-412, Philadelphia, United States, W.B. Saunders Co, DOI: 10.1016/j.apmr.2011.08.028.
  • Brunoni, AR., Nitsche, MA., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., Edwards, D., Valero-Cabre, A., Rotenberg, A., Pascual-Leone, A., Ferucci, R., Priori, A., Boggio, PS., Fregni, F., (2012), Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions. Brain Stimulation, 5(3), 175-195, Philadelphia, USA, Elsevier, DOI: 10.1016/j.brs.2011.03.002.
  • Conesa, L., Costa, U., Morales, E., Edwards, D., Cortes, M., Lean, D., Bernabeu, M., Medina, J., (2012), An observational report of intensive robotic and manual gait training in sub-acute stroke. Journal of NeuroEngineering and Rehabilitation, 9(1), article no. 13, DOI: 10.1186/1743-0003-9-13.

Conference Publications

  • Kreb, H., Peltz, A., Berkowe, J., Angacian, G., Cortes, M., Edwards, D., (2016), Robotic Biomarkers in RETT Syndrome: Evaluating Stiffness. 2016 6th IEEE International Conference on Biomedical Robotics and Biomechatronics (BioRob) Proceedings, 680-684, Piscataway, USA, Institute of Electrical and Electronics Engineers Inc., DOI: 10.1109/BIOROB.2016.7523704.
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