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Dr Giuseppe Verdile

Adjunct Associate Professor

Staff Member Details
Email: g.verdile@ecu.edu.au

Qualifications

  • Doctor of Philosophy with Distinction, The University of Western Australia, 2002.

Research Outputs

Journal Articles

  • Jaynes, P., Iyengar, P., Lui, S., Tan, T., Vasilevski, N., Wright, S., Verdile, G., Jeyasekharan, A., Eichhorn, P. (2020). OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex. Scientific Reports, 10(1), Article number 15725. https://doi.org/10.1038/s41598-020-72791-0.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.
  • Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P. (2020). Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356. https://doi.org/10.1038/s41598-020-66602-9.
  • Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
  • Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R. (2020). Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733. https://doi.org/10.3233/JAD-191033.
  • Rowles, J., Keane, K., Heck, T., Cruzat, V., Verdile, G., Newsholme, P. (2020). Are heat shock proteins an important link between type 2 diabetes and alzheimer disease?. International Journal of Molecular Sciences, 21(21), Article number 8204. https://doi.org/10.3390/ijms21218204.

Journal Articles

  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.

Journal Articles

  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211. https://doi.org/10.3233/JAD-180713.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
  • Elaskalani, O., Khan, I., Morici, M., Matthysen, C., Sabale, M., Martins, R., Verdile, G., Metharom, P. (2018). Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. Platelets (London), 29(4), 415-420. https://doi.org/10.1080/09537104.2017.1401057.
  • Khan, I., Krishnaswamy, S., Sabale, M., Groth, D., Wijaya, L., Morici, M., Berger, I., Schaffitzel, C., Fraser, P., Martins, R., Verdile, G. (2018). Efficient production of a mature and functional gamma secretase protease. Scientific Reports, 8(1), Article no. 12834. https://doi.org/10.1038/s41598-018-30788-w.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

Journal Articles

  • Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R. (2017). Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80. https://doi.org/10.1007/s11065-016-9338-9.
  • Kirby, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R. (2017). Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201. https://doi.org/10.3233/JAD-161158.
  • Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R. (2017). Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466. https://doi.org/10.3233/JAD-161259.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L., Fraser, P., Verdile, G. (2017). The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-B, Amylin, and Tau Proteins. Journal of Alzheimer's Disease, 59(2), 421-432. https://doi.org/10.3233/JAD-161192.

Journal Articles

  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R. (2016). Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465. https://doi.org/10.1017/S0007114515004687.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R. (2016). Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228. https://doi.org/10.1016/j.neubiorev.2016.01.004.
  • Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R. (2016). The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343. https://doi.org/10.2174/1871527315666151110125704.
  • Kirby, S., Sohrabi, H., Shen, K., Rainey-Smith, S., Weinborn, M., Bates, K., Shah, T., Foster, J., Lenzo, N., Salvado, O., Laske, C., Laws, S., Taddei, K., Verdile, G., Martins, R. (2016). Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults. Journal of Alzheimer's Disease, 52(2), 661-672. https://doi.org/10.3233/JAD-151084.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R. (2016). Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559. https://doi.org/10.1074/jbc.M115.679993.

Journal Articles

  • Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P. (2015). Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation, 6(2015), Article No. 105828. https://doi.org/10.1155/2015/105828.
  • Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M. (2015). Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678. https://doi.org/10.1093/hmg/ddv110.
  • Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R. (2015). The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90. https://doi.org/10.1016/j.yhbeh.2015.05.020.
  • Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R. (2015). Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586.
  • Verdile, G., Fuller, SJ., Martins, R. (2015). The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38. https://doi.org/10.1016/j.nbd.2015.04.008.

Journal Articles

  • Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M. (2014). Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767. https://doi.org/10.1186/1756-0500-7-767.
  • Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R. (2014). A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487. https://doi.org/10.1038/tp.2014.122.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R. (2014). Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75. https://doi.org/10.1038/mp.2012.147.
  • Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M. (2014). Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617. https://doi.org/10.1093/hmg/ddt448.
  • Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S. (2014). Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546. https://doi.org/10.3233/JAD-131442.
  • Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R. (2014). Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378. https://doi.org/10.2217/nmt.14.29.

Journal Articles

  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S. (2013). Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888. https://doi.org/10.1038/mp.2012.115.
  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G. (2013). Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332. https://doi.org/10.1038/tp.2013.97.
  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R. (2013). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224. https://doi.org/10.1016/j.neurobiolaging.2013.03.012.
  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G. (2013). The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235. https://doi.org/10.1371/journal.pone.0066235.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0. (2013). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897. https://doi.org/10.1038/mp.2012.106.

Journal Articles

  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R. (2012). Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967. https://doi.org/10.3233/JAD-2012-120178.
  • Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R. (2012). Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469. https://doi.org/10.3233/JAD-2011-110704.

Journal Articles

  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Bates, K., Howard, M., Martins, G., De Ruyck, K., Matthews, P., Verdile, G., Martins, R. (2011). Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels.. Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 94(4), 313-322. https://doi.org/10.1159/000330812.
  • Newman, M., Verdile, G., Martins, R., Lardelli, M. (2011). Zebrafish as a tool in Alzheimer's disease research. BBA: Molecular Basis of Disease, 1812(3), 346-352. https://doi.org/10.1016/j.bbadis.2010.09.012.
  • Pike, K., Ellis, KA., Villemagne, VL., Good, N., Chetelat, G., Ames, D., Szoeke, C., Laws, S., Verdile, G., Martins, R., Masters, CL., Rowe, CC. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia, 49(9), 2384-2390. https://doi.org/10.1016/j.neuropsychologia.2011.04.012.
  • Kanyenda, L., Verdile, G., Boulos, S., Krishnaswamy, S., Taddei, K., Meloni, BP., Mastaglia, FL., Martins, R. (2011). The dynamics of CD147 in Alzheimer's disease development and pathology. Journal of Alzheimer's Disease, 26(4), 593-605. https://doi.org/10.3233/JAD-2011-110584.

Journal Articles

  • Barron, A., Verdile, G., Taddei, K., Bates, K., Martins, R. (2010). Effect of Chronic hCG Administration on Alzheimer's-Related Cognition and Aβ accumulation in PS1KI mice. Endocrinology, 151(11), 5380–5388.
  • Rodrigues, M., Foster, J., Verdile, G., Joesbury, K., Prince, R., Devine, A., Mehta, P., Beilby, J., Martins, R. (2010). Predicting memory decline as a risk factor for Alzheimer's disease in older post-menopausal women: Quod erat demonstrandum?. International Psychogeriatrics, 22(2), 332-335. https://doi.org/10.1017/S1041610209991190.
  • Newman, M., Wilson, L., Camp, E., Verdile, G., Martins, R., Lardelli, M. (2010). A Zebrafish melanophore model of Amyloid β toxicity. Zebrafish, 7(2), 155-159.

Book Chapters

  • Verdile, G., Martins, R. (2009). Molecular Genetics of Alzheimer's Disease. Molecular Biology of Neuropsychiatric Disorders (229-276). Springer Verlag. https://doi.org/10.1007/978-3-540-85383-1_8.
  • Verdile, G., Martins, R. (2009). The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism.. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies (259-268). Cambridge University Press.

Journal Articles

  • Foster, J., Verdile, G., Bates, K., Martins, R. (2009). Immunization in Alzheimer's disease: naive hope or realistic clinical potential. Molecular Psychiatry, 14(3), 239-251.
  • Barron, A., Cake, M., Verdile, G., Martins, R. (2009). Ovariectomy and 17β-Estradiol Replacement Do Not Alter beta-Amyloid Levels in Sheep Brain. Endocrinology, 150(7), 3228-3236.
  • Nornes, S., Newman, M., Wells, S., Verdile, G., Martins, R., Lardelli, M. (2009). Independent an cooperative action of Psen2 with Psen1 in zebrafish embryos. Experimental Cell Research, 315(16), 2791-2801.
  • Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R. (2009). Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308.
  • Krishnaswamy, S., Verdile, G., Groth, D., Kanyenda, L., Martins, R. (2009). The structure and function of Alzheimer's gamma secretase enzyme complex. Critical Reviews in Clinical Laboratory Science, 46(5-6), 282-301.
  • Bates, K., Verdile, G., Li, Q., Ames, D., Hudson, P., Masters, C., Martins, R. (2009). Clearance mechanisms of Alzheimer’s amyloid-β peptide: implications for therapeutic design and diagnostic tests. Molecular Psychiatry, 14(5), 469-486.

Journal Articles

  • Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R. (2008). Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274.
  • Nornes, S., Newman, M., Verdile, G., Wells, S., Stoick-Cooper, C., Tucker, B., Sleptsova - Fredrich, I., Martins, R., Lardelli, M. (2008). Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity. Human Molecular Genetics, 17(3), 402-412. https://doi.org/10.1093/hmg/ddm317.
  • Foster, J., Sohrabi, H., Verdile, G., Martins, R. (2008). Research Criteria for the Diagnosis of Alzheimer'S Disease: Genetic Risk Factors, Blood Biomarkers and Olfactory Dysfunction. International Psychogeriatrics, 20(4), 853-855.
  • Gnjec, A., D'costa, K., Laws, S., Hedley, R., Balakrishnan, K., Taddei, K., Martins, G., Paton, A., Verdile, G., Gandy, S., Broe, A., Brooks, W., Bennett, H., Piguet, O., Price, P., Miklossy, J., Hallmayer, J., McGeer, P., Martins, R. (2008). Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation, 5(36), 1-10. https://doi.org/10.1186/1742-2094-5-36.
  • Wahjoepramono, EJ., Wijaya, L., Taddei, K., Martins, G., Howard, M., De Ruyck, K., Bates, K., Dhaliwal, S., Verdile, G., Carruthers, M., Martins, R. (2008). Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137.
  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R. (2008). Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages.
  • Verdile, G., Yeap, B., Clarnette, R., Dhaliwal, S., Burkhart, M., Chubb, SA., De Ruyck, K., Rodrigues, M., Mehta, PD., Foster, J., Bruce, D., Martins, R. (2008). Luteinizing Hormone Levels are Positively Correlated with Plasma Amyloid-beta Protein Levels in Elderly Men. Journal of Alzheimer's Disease, 14(2), 201-208.

Journal Articles

  • Verdile, G., Gandy, S., Martins, R. (2007). The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer's Beta Amyloid. Neurochemical Research, 32(4-5), 609-623.

Journal Articles

  • Barron, A., Verdile, G., Martins, R. (2006). The Role of Gonadotropins in Alzheimer's Disease. Endocrine, 9(2), 257-269.
  • Barron, A., Fuller, S., Verdile, G., Martins, R. (2006). Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease. Antioxidants & redox signaling, 8(11), 2047-2059.
  • Barron, A., Verdile, G., Martins, R. (2006). Gonadotropins: potential targets for preventative and therapeutic interventions in Alzheimer's Disease. Future Neurology, 1(2), 189-202.

Journal Articles

  • Balakrishnan, K., Verdile, G., Mehta, P., Beilby, J., Nolan, DA., Galvao, D., Newton, R., Gandy, S., Martins, R. (2005). Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's disease, 8(3), 269-282.

Journal Articles

  • Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: Still a cause of everything or the only one who got caught?. Pharmacological research, 50(4), 397-409.
  • Liu, T., Perry, G., Chan, H., Verdile, G., Martins, R., Smith, M., Atwood, C. (2004). Amyloid-b-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. Journal of Neurochemistry, 88(3), 554-563.
  • Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K., Kakulas, B., Mehta, P., Milward, E., Tan, N., Lareu, R., Lim, D., Dharmarajan, A., Martins, R. (2004). Protein markers for alzheimer disease in the frontal cortex and cerebellum. Neurology, 63(8), 1385-1392.
  • Verdile, G., Groth, D., Matthews, P., St Geroge Hyslop, P., Fraser, P., Ramabhadran, T., Kwok, J., Schofeild, P., Carter, T., Gandy, S., Martins, R. (2004). Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells. Molecular psychiatry, 9(6), 594-602.
  • Verdile, G., Fuller, S., Atwood, C., Laws, S., Gandy, S., Martins, R. (2004). The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?. Pharmacological Research, 50(4), 397-409.
  • Carter, T., Verdile, G., Groth, D., Bogush, A., Thomas, S., Shen, P., Fraser, P., Matthews, P., Nixon, R., Ehrlich, M., Kwok, J., St-George Hyslop, P., Schofeild, P., Li, Y., Yang, A., Martins, R., Gandy, S. (2004). Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Alzheimer disease and associated disorders, 18(4), 261-263.
  • Bowen, R., Verdile, G., Liu, T., Parlow, A., Perry, G., Smith, M., Martins, R., Atwood, C. (2004). Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-Beta precursor protein and amyloid-Beta deposition. The journal of biological chemistry, 279(19), 20539-20545.

Book Chapters

  • Verdile, G., Gandy, S., Fraser, P., Atwood, C., Martins, R. (2003). The Presenilins and their Role in Amyloid-β Generation Production. Focus on Alzheimer’s Disease Research (167-210). Nova Science Publishers.

Journal Articles

  • Miklossy, J., Taddei, K., Suva, D., Verdile, G., Fonte, J., Fisher, C., Gnjec, A., Ghika, J., Suard, F., Mehta, P., McLean, C., Masters, C., Brooks, W., Martins, R. (2003). Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease. Neurobiol Aging, 24(5), 655-662.

Research Projects

  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease, National Health and Medical Research Council, Project Grants, 2013 ‑ 2016, $536,949.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2014 ‑ 2015, $12,555.
  • Nuclear magnetic resonance spectroscopy facilities – Advancing cutting-edge chemical, biological, energy and materials research in Western Australia, Australian Research Council, Grant - Linkage (Infrastructure), 2014, $1,316,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease, National Health and Medical Research Council, Project Grants, 2011 ‑ 2014, $494,615.
  • Protective role of autophagy genes in Alzheimer’s disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014, $10,000.
  • Western Australian Zebrafish Facility, Australian Research Council, Grant - Linkage (Infrastructure), 2014, $620,000.
  • Developing a Zebrafish Model for Alzheimer's Disease, The McCusker Foundation For Alzheimer`s Disease Research, Scholarship, 2009 ‑ 2013, $75,000.
  • A high-throughput protein production and structure facility, Australian Research Council, Grant - Linkage (Infrastructure), 2012, $470,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research, National Health and Medical Research Council, Equipment Grant 2011, 2011 ‑ 2012, $10,927.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research, National Health and Medical Research Council, Equipment Grant, 2010 ‑ 2011, $10,881.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization, Australian Research Council, Grant - Linkage (Infrastructure), 2011, $849,590.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro, Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2011, $22,750.
  • New Independent Researcher Infrastructure Support (NIRIS) Award 2009, Department of Health WA, Grant, 2009 ‑ 2010, $10,000.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB), Centre of Excellence for Alzheimers Disease Research and Care, Grant, 2008 ‑ 2010, $75,000.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid, Centre of Excellence for Alzheimers Disease Research and Care, Scholarship, 2006 ‑ 2010, $135,000.
  • McCusker Therapeutic Research - Clinical trial, The McCusker Foundation For Alzheimer`s Disease Research, Grant, 2000 ‑ 2010, $322,262.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid, National Health and Medical Research Council, Project Grants, 2007 ‑ 2010, $400,278.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $193,372.
  • Investigating beta amyloid clearance in vivo, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $207,655.
  • MALDI Imaging and Protein Analysis Facility for WA, Australian Research Council, Grant - Linkage (Infrastructure), 2007 ‑ 2008, $915,000.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model, J.O. and J.R. Wicking Trust, Grant, 2005 ‑ 2008, $25,000.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory, Edith Cowan University, Grant, 2007 ‑ 2008, $12,266.
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