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Dr Giuseppe Verdile

Qualifications

  • Doctor of Philosophy with Distinction, The University of Western Australia, 2002.

Research

Recent Research Grants

  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease,  National Health and Medical Research Council,  Project Grants,  2013 - 2016,  $536,949.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer?s disease,  Australian Alzheimer's Research Foundation,  McCusker Alzheimer's Research Foundation - Sponsorship,  2014 - 2015,  $12,555.
  • Protective role of autophagy genes in Alzheimer?s disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014,  $10,000.
  • Western Australian Zebrafish Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $682,000.
  • Nuclear magnetic resonance spectroscopy facilities ? Advancing cutting-edge chemical, biological, energy and materials research in Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $1,666,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $494,615.
  • Developing a Zebrafish Model for Alzheimer's Disease,  The McCusker Foundation For Alzheimer`s Disease Research,  Scholarship,  2009 - 2013,  $75,000.
  • A high-throughput protein production and structure facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012,  $470,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization,  Australian Research Council,  Grant - Linkage (Infrastructure),  2011,  $849,590.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant,  2010 - 2011,  $10,881.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2011,  $22,750.
  • New Independent Researcher Infrastructure Support (NIRIS) Award 2009,  Department of Health WA,  Grant,  2009 - 2010,  $10,000.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2010,  $75,000.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2000 - 2010,  $322,262.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $400,278.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid,  Centre of Excellence for Alzheimers Disease Research and Care,  Scholarship,  2006 - 2010,  $135,000.
  • Investigating beta amyloid clearance in vivo,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $207,655.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $193,372.
  • MALDI Imaging and Protein Analysis Facility for WA,  Australian Research Council,  Grant - Linkage (Infrastructure),  2007 - 2008,  $915,000.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory,  Edith Cowan University,  Grant,  2007 - 2008,  $12,266.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2008,  $25,000.

Recent Publications (within the last five years)

Journal Articles

  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G., (2017), Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article 9766, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-09577-4.
  • Gardener, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, Y., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R., (2017), Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201, Netherlands, IOS Press, DOI: 10.3233/JAD-161158.
  • Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R., (2017), Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466, Netherlands, IOS Press, DOI: 10.3233/JAD-161259.
  • Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R., (2017), Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80, Springer, DOI: 10.1007/s11065-016-9338-9.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-? accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G., (2016), The Effects of Latrepirdine on Amyloid-? Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905, Netherlands, IOS Press, DOI: 10.3233/JAD-150790.
  • Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R., (2016), The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343, Bentham Science Publishers B.V., DOI: 10.2174/1871527315666151110125704.
  • Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P., (2015), Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer?s Disease. Mediators of Inflammation, 6(2015), Article No. 105828, New York, USA, Hindawi Publishing Corporation, DOI: 10.1155/2015/105828.
  • Verdile, G., Fuller, SJ., Martins, R., (2015), The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38, Maryland Heights, USA, Academic Press Inc., DOI: 10.1016/j.nbd.2015.04.008.
  • Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R., (2015), The impact of luteinizing hormone and testosterone on beta amyloid (A?) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90, Elsevier, DOI: 10.1016/j.yhbeh.2015.05.020.
  • Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R., (2015), Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586, Bussum, Netherlands, Bentham Science Publishers B.V..
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2015), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515004687.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R., (2015), Validation and characterization of a novel peptide that binds monomeric and aggregated ?-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559, Bethesda, USA, American Society for Biochemistry and Molecular Biology, Inc., DOI: 10.1074/jbc.M115.679993.
  • Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M., (2015), Alzheimer?s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of ?-secretase activity. Human Molecular Genetics, 24(13), 3662-3678, United Kingdom, Oxford University Press, DOI: 10.1093/hmg/ddv110.
  • Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R., (2014), A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487, United Kingdom, Nature Publishing Group, DOI: 10.1038/tp.2014.122.
  • Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R., (2014), Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378, London, United Kingdom, Future Medicine Ltd, DOI: 10.2217/nmt.14.29.
  • Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S., (2014), Is cholesterol and amyloid-? stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546, Netherlands, IOS Press, DOI: 10.3233/JAD-131442.
  • Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M., (2014), Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617, Oxford University Press, DOI: 10.1093/hmg/ddt448.
  • Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M., (2014), Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767, London, United Kingdom, BioMed Central, DOI: 10.1186/1756-0500-7-767.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0., (2013), Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.106.
  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R., (2013), Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224, United States, Elsevier.
  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G., (2013), Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer?s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332, London, UK, Nature Publishing Group, DOI: 10.1038/tp.2013.97.
  • Sharman, M., Moussavi Nik, S., Chen, M., Ong, D., Wijaya, L., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., Verdile, G., (2013), The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes. PLoS One, 8(6), e66235.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S., (2012), Latrepirdine stimulates autophagy and reduces accumulation of ?-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.115.
  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R., (2012), Latrepirdine (Dimebon?) enhances autophagy and reduces intracellular GFP-A?42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967, Netherlands, IOS Press, DOI: 10.3233/JAD-2012-120178.
  • Avdesh, ., Martin-Iverson, MT., Mondal, A., Chen, M., Askraba, S., Morgan, N., Lardelli, M., Groth, DM., Verdile, G., Martins, R., (2012), Evaluation of Color Preference in Zebrafish for Learning and Memory. Journal of Alzheimer's Disease, 28(2), 459-469, USA, IOS Press, DOI: 10.3233/JAD-2011-110704.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2012), Associations between gonadotropins, testosterone and ? amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.147.

Research Student Supervision

Co-principal Supervisor

  • Doctor of Philosophy,  Identifying Gamma Secretase Enzyme Domains Responsible For The Generation Of Alzheimer's Beta Amyloid Protein.
  • Doctor of Philosophy,  Yeast As A Model For Studying Ab Aggregation, Toxicity And Clearance
  • Doctor of Philosophy,  Investigating The Impact Of Cd147 And Its Expression On Neuordegeneration And Alzheimer's Disease Ad
  • Master of Science (Human Biology),  The Role Of Luteninizing Hormone (lh) And Human Chorionic Gonadotropin (hcg) In The Aetiology Of Alzheimer's Disease.

Associate Supervisor

  • Doctor of Philosophy,  Role Of Testosterone In Prevention Of Alzheimer's Disease.
  • Master of Science (Human Biology),  Plasma Insulin-degrading Enzyme: Characterisation And Evaluation As A Potential Biomarker For Alzheimer's Disease.
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