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Dr Giuseppe Verdile

Qualifications

  • Doctor of Philosophy with Distinction, The University of Western Australia, 2002.

Research

Recent Research Grants

  • The role of a presenilin 2 truncation (PS2V) in Alzheimer's Disease,  National Health and Medical Research Council,  Project Grants,  2013 - 2016,  $536,949.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease,  Australian Alzheimer's Research Foundation,  Australian Alzheimer's Research Foundation - Sponsorship,  2014 - 2015,  $12,555.
  • Protective role of autophagy genes in Alzheimer’s disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014,  $10,000.
  • Effects Latrepirdine on Beta Amyloid Clearance, Aggregation and Neurodegeneration in Alzheimers Disease,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $494,615.
  • Western Australian Zebrafish Facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $682,000.
  • Nuclear magnetic resonance spectroscopy facilities – Advancing cutting-edge chemical, biological, energy and materials research in Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $1,666,000.
  • Developing a Zebrafish Model for Alzheimer's Disease,  The McCusker Foundation For Alzheimer`s Disease Research,  Scholarship,  2009 - 2013,  $75,000.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.
  • A high-throughput protein production and structure facility,  Australian Research Council,  Grant - Linkage (Infrastructure),  2012,  $470,000.
  • Multiphoton Confocal Microscope for High Speed, Deep Tissue Imaging and Multimodal Nanoscale Characterization,  Australian Research Council,  Grant - Linkage (Infrastructure),  2011,  $849,590.
  • Study of the Toxicity of Alzheimer's Ab, Both as a Peptide and a Fusion Protein, in Neuronal Cells and Yeast-Investigation Both the Cause of Toxicity and Means of Preventing It, Including Cellular Pro,  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2011,  $22,750.
  • CCD Camera for Inverted Fluorescent Microscope in Alzheimer's and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant,  2010 - 2011,  $10,881.
  • The Role of CD147 in the Clearance and Metabolism of Alzheimer's Beta Amyloid (AB),  Centre of Excellence for Alzheimers Disease Research and Care,  Grant,  2008 - 2010,  $75,000.
  • The role of gonadotropins in regulating the production of Alzheimer's beta amyloid,  National Health and Medical Research Council,  Project Grants,  2007 - 2010,  $400,278.
  • McCusker Therapeutic Research - Clinical trial,  The McCusker Foundation For Alzheimer`s Disease Research,  Grant,  2000 - 2010,  $322,262.
  • Identifying domains within the candidate proteins (PSI, nicastrin, APH-1 and PEN-2) that are critical for gamma-secretase cleavage of the amyloid,  Centre of Excellence for Alzheimers Disease Research and Care,  Scholarship,  2006 - 2010,  $135,000.
  • New Independent Researcher Infrastructure Support (NIRIS) Award 2009,  Department of Health WA,  Grant,  2009 - 2010,  $10,000.
  • Investigating beta amyloid clearance in vivo,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $207,655.
  • Developing and validating a transgenic zebrafish model for Alzheimer's Disease,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $193,372.
  • Using gonadotropin lowering agents to reduce levels of beta amyloid in an alzheimer's disease mouse model,  J.O. and J.R. Wicking Trust,  Grant,  2005 - 2008,  $25,000.
  • MALDI Imaging and Protein Analysis Facility for WA,  Australian Research Council,  Grant - Linkage (Infrastructure),  2007 - 2008,  $915,000.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory,  Edith Cowan University,  Grant,  2007 - 2008,  $12,266.

Recent Publications (within the last five years)

Journal Articles

  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2019), Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2018.12.014.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S., (2018), Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20, United States, Elsevier, DOI: 10.1016/j.pmip.2018.03.001.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-20513-y.
  • Elaskalani, O., Khan, I., Morici, M., Matthysen, C., Sabale, M., Martins, R., Verdile, G., Metharom, P., (2018), Oligomeric and fibrillar amyloid beta 42 induce platelet aggregation partially through GPVI. Platelets (London), 29(4), 415-420, London, Taylor & Francis Group, DOI: 10.1080/09537104.2017.1401057.
  • Khan, I., Krishnaswamy, S., Sabale, M., Groth, D., Wijaya, L., Morici, M., Berger, I., Schaffitzel, C., Fraser, P., Martins, R., Verdile, G., (2018), Efficient production of a mature and functional gamma secretase protease. Scientific Reports, 8(1), Article no. 12834, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-018-30788-w.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211, Netherlands, IOS Press, DOI: 10.3233/JAD-180713.
  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S., (2018), A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2018.00423.
  • Gardener, S., Rainey-Smith, S., Sohrabi, H., Weinborn, M., Verdile, G., Fernando, B., Lim, YY., Harrington, K., Burnham, S., Taddei, K., Masters, C., Macaulay, S., Rowe, C., Ames, D., Maruff, P., Martins, R., (2017), Increased carbohydrate intake is associated with poorer performance in verbal memory and attention in an APOE genotype-dependent manner. Journal of Alzheimer's Disease, 58(1), 193-201, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161158.
  • Shah, T., Weinborn, M., Verdile, G., Sohrabi, H., Martins, R., (2017), Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline. Neuropsychology Review, 27(1), 62-80, Springer, DOI: 10.1007/s11065-016-9338-9.
  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G., (2017), Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766, London, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-09577-4.
  • Asih, P., Tegg, M., Sohrabi, H., Carruthers, M., Gandy, S., Saad, F., Verdile, G., Ittner, L., Martins, R., (2017), Multiple mechanisms linking Type 2 Diabetes and Alzheimer's disease: Testosterone as a modifier. Journal of Alzheimer's Disease, 59(2), 445-466, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-161259.
  • Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L., Fraser, P., Verdile, G., (2017), The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-B, Amylin, and Tau Proteins. Journal of Alzheimer's Disease, 59(2), 421-432, Netherlands, IOS Press, DOI: 10.3233/JAD-161192.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R., (2016), Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559, Bethesda, USA, American Society for Biochemistry and Molecular Biology, Inc., DOI: 10.1074/jbc.M115.679993.
  • Wahjoepramono, EJ., Asih, P., Aniwiyanti, V., Taddei, K., Dhaliwal, S., Fuller, S., Foster, J., Carruthers, M., Verdile, G., Sohrabi, H., Martins, R., (2016), The effects of testosterone supplementation on cognitive functioning in older men. CNS and Neurological Disorders, 15(3), 337-343, Bentham Science Publishers B.V., DOI: 10.2174/1871527315666151110125704.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G., (2016), The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905, Netherlands, IOS Press, DOI: 10.3233/JAD-150790.
  • Goozee, K., Shah, T., Sohrabi, H., Rainey-Smith, S., Brown, B., Verdile, G., Martins, R., (2016), Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. British Journal of Nutrition, 115(3), 449-465, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515004687.
  • Asih, P., Wahjoepramono, EJ., Aniwiyanti, V., Wijaya, L., De Ruyck, K., Taddei, K., Fuller, SJ., Sohrabi, H., Dhaliwal, SS., Verdile, G., Carruthers, M., Martins, R., (2015), Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety. CNS and Neurological Disorders, 14(5), 576-586, Bussum, Netherlands, Bentham Science Publishers B.V..
  • Verdile, G., Keane, KN., Cruzat, VF., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R., Fraser, PE., Newsholme, P., (2015), Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation, 6(2015), Article No. 105828, New York, USA, Hindawi Publishing Corporation, DOI: 10.1155/2015/105828.
  • Nik, SH., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R., Lardelli, M., (2015), Alzheimer’s disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human Molecular Genetics, 24(13), 3662-3678, United Kingdom, Oxford University Press, DOI: 10.1093/hmg/ddv110.
  • Verdile, G., Asih, PR., Barron, AM., Wahjoepramono, EJ., Ittner, LM., Martins, R., (2015), The impact of luteinizing hormone and testosterone on beta amyloid (Aβ) accumulation: Animal and human clinical studies. Hormones and Behaviour, 76(November 01), 81-90, Elsevier, DOI: 10.1016/j.yhbeh.2015.05.020.
  • Verdile, G., Fuller, SJ., Martins, R., (2015), The role of type 2 diabetes in neurodegeneration. Neurobiology of Disease, 84(2015), 22-38, Maryland Heights, USA, Academic Press Inc., DOI: 10.1016/j.nbd.2015.04.008.
  • Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R., (2014), Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378, London, United Kingdom, Future Medicine Ltd, DOI: 10.2217/nmt.14.29.
  • Moussavi Nik, SH., Newman, M., Ganesan, S., Chen, M., Martins, R., Verdile, G., Lardelli, M., (2014), Hypoxia alters expression of Zebrafish Microtubule-associated protein Tau (mapta, maptb) gene transcripts. BMC Research Notes, 7(2014), Article 767, London, United Kingdom, BioMed Central, DOI: 10.1186/1756-0500-7-767.
  • Kanyenda, L., Verdile, G., Martins, R., Meloni, B., Chieng, J., Mastaglia, F., Laws, S., Anderton, R., Boulos, S., (2014), Is cholesterol and amyloid-β stress induced CD147 expression a protective response? Evidence that extracellular cyclophilin a mediated neuroprotection is reliant on CD147. Journal of Alzheimer's Disease, 39(3), 545-546, Netherlands, IOS Press, DOI: 10.3233/JAD-131442.
  • Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S., Pursglove, S., Chapman, G., Martins, R., Lardelli, M., (2014), Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits. Human Molecular Genetics, 23(3), 602-617, Oxford University Press, DOI: 10.1093/hmg/ddt448.
  • Shah, T., Verdile, G., Sohrabi, H., Campbell, A., Putland, E., Cheetham, C., Dhaliwal, S., Weinborn, M., Maruff, P., Darby, D., Martins, R., (2014), A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly. Translational Psychiatry, 4(12), Article no. e487, United Kingdom, Nature Publishing Group, DOI: 10.1038/tp.2014.122.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2014), Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.147.

Research Student Supervision

Co-principal Supervisor

  • Doctor of Philosophy,  IDENTIFYING GAMMA SECRETASE ENZYME DOMAINS RESPONSIBLE FOR THE GENERATION OF ALZHEIMER'S BETA AMYLOID PROTEIN.
  • Doctor of Philosophy,  YEAST AS A MODEL FOR STUDYING AB AGGREGATION, TOXICITY AND CLEARANCE
  • Doctor of Philosophy,  GENETIC DETERMINANTS OF RATES OF COGNITIVE DECLINE IN PRECLINICAL ALZHEIMER'S DISEASE
  • Doctor of Philosophy,  INVESTIGATING THE IMPACT OF CD147 AND ITS EXPRESSION ON NEUORDEGENERATION AND ALZHEIMER'S DISEASE AD
  • Master of Science (Human Biology),  THE ROLE OF LUTENINIZING HORMONE (LH) AND HUMAN CHORIONIC GONADOTROPIN (HCG) IN THE AETIOLOGY OF ALZHEIMER'S DISEASE.

Associate Supervisor

  • Doctor of Philosophy,  ROLE OF TESTOSTERONE IN PREVENTION OF ALZHEIMER'S DISEASE.
  • Doctor of Philosophy,  INVESTIGATION OF THE ROLE OF AMLA IN MODULATING CHOLESTEROL METABOLISM, AND UNDERSTANDING ITS MECHANISM OF ACTION IN REDUCING ALZHEIMER'S RISK
  • Master of Science (Human Biology),  PLASMA INSULIN-DEGRADING ENZYME: CHARACTERISATION AND EVALUATION AS A POTENTIAL BIOMARKER FOR ALZHEIMER'S DISEASE.
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