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Dr Veer Gupta

Adjunct Associate Professor

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Staff Member Details


Veer is an Adjunct Associate Professor within the School of Medical and Health Sciences.


  • Doctor of Philosophy in Bio-Chemistry, India, 2009.
  • Master of Science Biochemistry, India, 2002.
  • Bachelor of Science, India, 2001.


Recent Research Grants

  • Establishing a blood-based biomarker panel for pre-clinical Alzheimer's disease,  National Health and Medical Research Council,  Boosting Dementia Research Leadership Fellowship Scheme,  2018 - 2022,  $716,778.
  • Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort,  National Health and Medical Research Council,  Project Grants,  2017 - 2021,  $1,125,804.
  • Developing a blood-based biomarker panel for Alzheimer's disease,  BrightFocus Foundation,  Alzheimer's Disease Research - Postdoctoral Fellowship Awards,  2015 - 2018,  $126,876.
  • 4.4B1 Novel Therapeutics for AD Testosterone Trial,  CRC For Mental Health,  CRC Grant,  2011 - 2018,  $1,068,045.
  • Infrastructure Award,  Department of Health WA,  SHRAC - New Independent Researcher Infrastructure Support Award,  2015 - 2017,  $10,000.
  • Investigating peripheral biochemical changes during familial Alzheimer s disease progression.,  Dementia Australia Research Foundation,  AADRF - Dementia Grants Program,  2016 - 2017,  $50,000.
  • Establishing a combined ocular and blood biomarker panel for Alzheimer’s disease.,  Australian National University,  ANU - Dementia CRC - Grant,  2014 - 2015,  $517,977.
  • Discovery and Validation of Alzheimer's disease biomarkers in human plasma,  National Health and Medical Research Council,  Project Grants,  2011 - 2014,  $352,524.
  • An innovative approach to identify specific biomarkers for early diagnosis of Alzheimer's disease,  Australian National University,  ANU - Dementia CRC - Grant,  2013 - 2014,  $115,000.
  • Nuclear magnetic resonance spectroscopy facilities – Advancing cutting-edge chemical, biological, energy and materials research in Western Australia,  Australian Research Council,  Grant - Linkage (Infrastructure),  2014,  $1,666,000.
  • Initiating an Indo-Australian cooperation for early diagnosis and prediction in the aged population: Partnering the universities for a tactical approach to Alzheimer's disease and other neurodegenerative conditions,  Department of Foreign Affairs and Trade,  Australia-India Council,  2011 - 2013,  $4,000.
  • The Australian Imaging, Biomarker and Lifestyle Study of Ageing - Round 2,  Commonwealth Scientific and Industrial Research Organisation (CSIRO),  Science Industry Endowment Fund Agreement,  2010 - 2013,  $5,341,586.
  • Investigating the Association Between APOE Promoter Polymorphisms and Plasma APOE levels: A Blood Test for Alzheimer’s Disease.,  Edith Cowan University,  ECU Early Career Researcher - Grant,  2009 - 2010,  $24,830.

Recent Publications (within the last five years)

Journal Articles

  • Dhiman, K., Blennow, K., Zetterberg, H., Martins, R., Gupta, V., (2019), Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis. Cellular and Molecular Life Sciences, 76(10), 1833-1863, DOI: 10.1007/s00018-019-03040-5.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A., (2019), A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220, DOI: 10.1126/sciadv.aau7220.
  • Fernando, B., Rainey-Smith, S., Gardener, S., Villemagne, V., Burnham, S., Macaulay, SL., Brown, B., Gupta, V., Sohrabi, H., Weinborn, M., Taddei, K., Laws, S., Goozee, K., Ames, D., Fowler, C., Maruff, P., Masters, C., Salvado, O., Rowe, C., Martins, R., (2018), Associations of dietary protein and fiber intake with brain and blood amyloid-B. Journal of Alzheimer's Disease, 61(2018), 1589-1598, Netherlands, IOS Press, DOI: 10.3233/JAD-170742.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R., (2017), Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 8(2017), 60-72, United States, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.04.003.
  • Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK., (2017), Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685, Lonon, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-12858-7.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P., (2017), BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S1041610217001284.
  • Chitranshi, N., Dheer, Y., Vander Wall, R., Gupta, V., Abbasi, M., Graham, S., Gupta, V., (2017), Computational analysis unravels novel destructive single nucleotide polymorphisms in the non-synonymous region of human caveolin gene. Gene Reports, 6(1 March), 142-157, Elsevier, DOI: 10.1016/j.genrep.2016.08.008.
  • O'Bryan, S., Mielke, M., Rissman, R., Lista, S., Vanderstichele, H., Zetterberg, H., Lewczuk, P., Posner, H., Hall, J., Johnson, L., Fong, Y., Luthman, J., Jeromin, A., Batrla-Utermann, R., Villarreal, A., Britton, G., Snyder, P., Henriksen, K., Grammas, P., Gupta, V., Martins, R., Hampel, H., (2017), Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimer's and Dementia, 13(1), 45-58, United States, Elsevier Science Inc., DOI: 10.1016/j.jalz.2016.09.014.
  • Chitranshi, N., Dheer, Y., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S., Gupta, V., (2017), PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells. Neuroscience, 364(2017), 175-189, DOI: 10.1016/j.neuroscience.2017.09.028.
  • Gupta, V., Mirzaei, M., Gupta, V., Chitranshi, N., Dheer, Y., Vanderwall, R., Abbasi, M., You, Y., Chung, R., Graham, S., (2017), Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin. Scientific Reports, 7(8412), 18p., United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-08688-2.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R., (2017), A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057, DOI: 10.1038/s41598-017-14020-9.
  • Muenchhoff, J., Poljak, A., Thalamuthu, A., Gupta, V., Chatterjee, P., Raffery, M., Masters, C., Morris, J., Bateman, J., Fagan, A., Martins, R., Sachdev, P., (2016), Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease. Science Reports, 6(2016), Article no. 29078, Nature Publishing Group, DOI: 10.1038/srep29078.
  • Gupta, V., Chitranshi, N., Gupta, V., Golzan, M., Dheer, Y., Vander Wall, R., Georgevsky, D., King, A., Vickers, JC., Chung, R., Graham, S., (2016), Amyloid β accumulation and Inner retinal degenerative changes in Alzheimer’s disease transgenic mouse. Neuroscience Letters, 623(2016), 52-56, Elsevier, DOI: 10.1016/j.neulet.2016.04.059.
  • Rainey-Smith, S., Brown, B., Sohrabi, H., Shah, T., Goozee, K., Gupta, V., Martins, R., (2016), Curcumin and cognition: a randomized, placebo-controlled, double-blind study of community-dwelling older adults. British Journal of Nutrition, 115(2), 2106-2113, Cambridge University Press, DOI: 10.1017/S0007114516001203.
  • Chatterjee, P., Lim, F., Shui, G., Gupta, V., James, I., Fagan, A., Xiong, C., Sohrabi, H., Taddei, K., Brown, B., Benzinger, T., Masters, C., Snowden, S., Wenk, M., Bateman, R., Morris, J., Martins, R., (2016), Plasma Phospholipid and Sphingolipid Alterations in Presnilin1 Mutation Carriers: A Pilot Study. Journal of Alzheimer's disease, 50(3), 887-894, Netherlands, IOS Press, DOI: 10.3233/JAD-150948.
  • Bird, S., Sohrabi, H., Sutton, T., Weinborn, M., Rainey-Smith, S., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R., Verdile, G., Martins, R., (2016), Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies. Neuroscience & Biobehavioural Reviews, 64(2016), 215-228, Elsevier Ltd, DOI: 10.1016/j.neubiorev.2016.01.004.
  • O'Bryant, S., Lista, S., Rissman, R., Edwards, M., Zhang, F., Hall, J., Zetterberg, H., Lovestone, S., Gupta, V., Graff-Radford, N., Martins, R., Jeromin, A., Waring, S., Oh, E., Kling, M., Baker, L., Hampel, H., (2016), Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 27-34, Elsevier, DOI: 10.1016/j.dadm.2015.12.003.
  • Chitranshi, N., Gupta, V., Dheer, Y., Gupta, V., Vander Wall, R., Graham, S., (2016), Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor. Data in Brief, 6(March 2016), 776-782, Elsevier, DOI: 10.1016/j.dib.2016.01.016.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.12.001.
  • Gupta, V., Gupta, V., Chitranshi, N., Gangoda, S., Vander Wall, R., Abbasi, M., Golzan, M., Dheer, Y., Shah, T., Avolio, A., Chung, R., Martins, R., Graham, S., (2016), One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina. Cellular and Molecular Life Sciences, 73(22), 4279-4297, Birkhauser Verlag AG, DOI: 10.1007/s00018-016-2295-x.
  • Gupta, V., Gupta, V., (2016), Using Technology, Bioinformatics and Health Informatics Approaches to Improve Learning Experiences in Optometry Education, Research and Practice. Healthcare, 4(86), 12p., Switzerland, MDPI, DOI: 10.3390/healthcare4040086.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R., (2016), Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559, Bethesda, USA, American Society for Biochemistry and Molecular Biology, Inc., DOI: 10.1074/jbc.M115.679993.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0105-6.
  • O'Bryant, SE., Gupta, V., Henriksen, K., Edwards, M., Jeromin, A., Lista, S., Bazenet, C., Soares, H., Lovestone, S., Hampel, H., Montine, T., Blennow, K., Foroud, T., Carrillo, M., Graff-Radford, N., Laske, C., Breteler, M., Shaw, L., Trojanowski, J., Schupf, N., Rissman, R., Fagan, A., Oberoi, P., Umek, R., Weiner, M., Grammas, P., Posner, H., Martins, R., (2015), Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimer's and Dementia, 11(5), 549-560, United States, Elsevier Inc., DOI: 10.1016/j.jalz.2014.08.099.
  • Chatterjee, P., Gupta, V., Fagan, A., Jasielec, M., Xiong, C., Sohrabi, H., Dhaliwal, S., Taddei, K., Bourgeat, P., Brown, B., Benzinger, T., Bateman, R., Morris, J., Martins, R., (2015), Decreased Platelet APP Isoform Ratios in Autosomal Dominant Alzheimer's Disease: Baseline Data from a DIAN Cohort Subset. Current Alzheimer Research, 12(2), 157-164, Bussum, Netherlands, Bentham Science Publishers, DOI: 10.2174/1567205012666150204125732.
  • Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA., (2015), Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48, Elsevier, DOI: 10.1016/j.nbd.2015.06.016.
  • Asih, P., Chatterjee, P., Verdile, G., Gupta, V., Trengove, RD., Martins, R., (2014), Clearing the amyloid in Alzheimers: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management, 4(5), 363-378, London, United Kingdom, Future Medicine Ltd, DOI: 10.2217/nmt.14.29.
  • Gupta, V., Chitranshi, N., You, Y., Gupta, V., Klistorner, A., Graham, S., (2014), Brain derived neurotrophic factor is involved in the regulation of glycogen synthase kinase 3β (GSK3β) signalling. Biochemical and Biophysical Research Communications, 454(3), 381-386, Academic Press Inc., DOI: 10.1016/j.bbrc.2014.10.087.
  • Gupta, V., You, Y., Li, J., Gupta, V., Golzan, M., Klistorner, A., Van Den Buuse, M., Graham, S., (2014), BDNF impairment is associated with age-related changes in the inner retina and exacerbates experimental glaucoma. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1842(9), 1567-1578, Elsevier, DOI: 10.1016/j.bbadis.2014.05.026.
  • Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R., (2014), Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183, Netherlands, Bentham Science Publishers.
  • Verdile, G., Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R., (2014), Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry, 19(1), 69-75, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.147.

Research Student Supervision

Associate Supervisor

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