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Dr Eugene Hone

Post Doctoral Research Fellow

Contact Information Telephone: +61 8 6304 5076, Email:, Campus: Joondalup, Room: JO17.109
Staff Member Details
Telephone: +61 8 6304 5076
Campus: Joondalup  
Room: JO17.109  


Eugene is a Post Doctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.


  • Doctor of Philosophy, The University of Western Australia, 2010.


Recent Research Grants

  • In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease (AD),  CWEK Pty Ltd,  Industry Engagement Scholarship to support PhD projects,  2018 - 2023,  $32,500.
  • The studies on rheological properties of activated sludge in wastewater treatment plants project - phase 2,  Water Corporation,  Grant,  2019 - 2020,  $87,128.
  • Sponsorship Agreement Post-Doctoral Research Fellow,  Australian Alzheimer's Research Foundation,  Neuroscience Research Institute - Sponsorship,  2018 - 2019,  $94,922.
  • Targeting chaperone mediated autophagy to alleviate Aβ accumulation and toxicity in AD ,  Dementia Australia Research Foundation,  AADRF - Dementia Grants Program,  2015 - 2016,  $50,000.

Recent Publications (within the last five years)

Journal Articles

  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A., (2019), A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220, DOI: 10.1126/sciadv.aau7220.
  • Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., Bharadwaj, P., (2019), Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24(2019), Article 3372, DOI: 10.3390/molecules24183372.
  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T., (2019), Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(2019), 740-750, DOI:
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK., (2017), Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685, Lonon, United Kingdom, Nature Publishing Group, DOI: 10.1038/s41598-017-12858-7.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R., (2017), A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057, DOI: 10.1038/s41598-017-14020-9.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R., (2017), Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 8(2017), 60-72, United States, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.04.003.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.12.001.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0105-6.
  • Ortiz-Virumbrales, M., Ruiz, M., Hone, E., Dolios, G., Wang, R., Morant, A., Kottwitz, J., Ozelius, LJ., Gandy, S., Ehrlich, M., (2014), Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions. Acta Neuropathologica Communications, 18(2), 139, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s40478-014-0139-1.
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