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Dr Prashant Bharadwaj

Post Doctoral Fellow

Contact Information Telephone: +61 8 6304 2234, Mobile: 0433579575, Email: p.bharadwaj@ecu.edu.au, Campus: Joondalup, Room: JO17.108
Staff Member Details
Telephone: +61 8 6304 2234
Mobile: 0433579575
Email: p.bharadwaj@ecu.edu.au
Campus: Joondalup  
Room: JO17.108  

 

Prashant is a Post Doctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.

Background

  • April 2016-present: NHMRC-ARC Dementia Research Development Fellow, Edith Cowan University, WA, Australia
  • April 2016-present: Adjunct Research Fellow, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • April 2015- Mar 2016: Research Associate, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • Dec 2011- present: Postdoctoral Research Fellow, School of Medical Sciences, Edith Cowan University, WA, Australia

Professional Associations

  • 2010-2011: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)
  • 2009-2010: Australian Society for Medical Research
  • 2007-2008: The Australian Society of Microbiology
  • 2007- present: Australasian Yeast Group:

Awards and Recognition

Other

  • 2008-2011: Full time PhD Scholarship and Tuition Fee Waiver: Centre of Excellence for Alzheimer’s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Faculty of Computing Health Sciences, Edith Cowan University
  • 2009-2011: PhD Top-up Scholarship: CSIRO, Material Science and Engineering, Parkville, Victoria, Preventive Health Flagship
  • 2010: CSIRO Preventive Health Flagship Travel Award (International Conference on Alzheimer’s Disease, Hawaii)

Research Areas and Interests

  • Alzheimer’s disease
  • Beta amyloid protein
  • Autophagy
  • Neuroprotective genes

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2011.
  • Master of Biotechnology, Royal Melbourne Institute of Technology, 2007.
  • Bachelor of Engineering, India, 2004.

Research

Recent Research Grants

  • Neuroprotective functions of autophagy regulators in Alzheimer's disease,  National Health and Medical Research Council,  Dementia Research Development Fellowship,  2016 - 2020,  $640,220.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. ,  Hollywood Private Hospital Research Foundation,  Grant,  2013 - 2016,  $20,000.
  • Targeting chaperone mediated autophagy to alleviate Aβ accumulation and toxicity in AD ,  Dementia Australia Research Foundation,  AADRF - Dementia Grants Program,  2015 - 2016,  $50,000.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease,  Australian Alzheimer's Research Foundation,  McCusker Alzheimer's Research Foundation - Sponsorship,  2014 - 2015,  $12,555.
  • Protective role of autophagy genes in Alzheimer’s disease,  Edith Cowan University,  ECU Early Career Researcher Grant - 2014,  2014,  $10,000.

Recent Publications (within the last five years)

Journal Articles

  • Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R., (2018), Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651, Netherlands, Elsevier, DOI: 10.1016/j.bbamem.2018.03.015.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Gardener, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C., (2018), Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992, Netherlands, IOS Press, DOI: 10.3233/JAD-171145.
  • Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L., Fraser, P., Verdile, G., (2017), The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-B, Amylin, and Tau Proteins. Journal of Alzheimer's Disease, 59(2), 421-432, Netherlands, IOS Press, DOI: 10.3233/JAD-161192.
  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G., (2016), The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905, Netherlands, IOS Press, DOI: 10.3233/JAD-150790.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S., (2013), Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.115.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0., (2013), Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2012.106.
  • Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L., (2013), Modulation of amyloid-β 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103, United Kingdom, R S C Publications, DOI: 10.1039/c2fo30111c.
  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G., (2013), Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332, London, UK, Nature Publishing Group, DOI: 10.1038/tp.2013.97.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy,  INVESTIGATION OF THE ROLE OF AMLA IN MODULATING CHOLESTEROL METABOLISM, AND UNDERSTANDING ITS MECHANISM OF ACTION IN REDUCING ALZHEIMER'S RISK
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