Top of page
Global Site Navigation

School of Medical and Health Sciences

Local Section Navigation
You are here: Main Content

Dr Prashant Bharadwaj

Post Doctoral Fellow

Staff Member Details
Telephone: +61 8 6304 2234
Mobile: 0433 579 575
Email: p.bharadwaj@ecu.edu.au
Campus: Joondalup  
Room: JO17.108  

Prashant is a Post Doctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.

Background

  • April 2016-present: NHMRC-ARC Dementia Research Development Fellow, Edith Cowan University, WA, Australia
  • April 2016-present: Adjunct Research Fellow, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • April 2015- Mar 2016: Research Associate, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • Dec 2011- present: Postdoctoral Research Fellow, School of Medical Sciences, Edith Cowan University, WA, Australia

Professional Associations

  • 2010-2011: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)
  • 2009-2010: Australian Society for Medical Research
  • 2007-2008: The Australian Society of Microbiology
  • 2007- present: Australasian Yeast Group:

Awards and Recognition

Other

  • 2008-2011: Full time PhD Scholarship and Tuition Fee Waiver: Centre of Excellence for Alzheimer’s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Faculty of Computing Health Sciences, Edith Cowan University
  • 2009-2011: PhD Top-up Scholarship: CSIRO, Material Science and Engineering, Parkville, Victoria, Preventive Health Flagship
  • 2010: CSIRO Preventive Health Flagship Travel Award (International Conference on Alzheimer’s Disease, Hawaii)

Research Areas and Interests

  • Alzheimer’s disease
  • Beta amyloid protein
  • Autophagy
  • Neuroprotective genes

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2011.
  • Master of Biotechnology, Royal Melbourne Institute of Technology, 2007.
  • Bachelor of Engineering, India, 2004.

Research Outputs

Journal Articles

  • Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
  • Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.
  • Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R. (2020). Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733. https://doi.org/10.3233/JAD-191033.
  • Krishnan, S., Shrestha, Y., Jayatunga, P., Rea, S., Martins, R., Bharadwaj, P. (2020). Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease. International Journal of Molecular Sciences, 21(18), Article number 6739. https://doi.org/10.3390/ijms21186739.
  • Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P. (2020). Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356. https://doi.org/10.1038/s41598-020-66602-9.
  • Bharadwaj, P., Martins, R. (2020). A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast. Neural Regeneration Research, 15(10), 1931-1936. https://doi.org/10.4103/1673-5374.280318.
  • Bharadwaj, P., Martins, R. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-B Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease, 74(2), 441-448. https://doi.org/10.3233/JAD-190948.
  • Bharadwaj, P., Martins, R. (2020). Autophagy modulates Aβ accumulation and formation of aggregates in yeast. Molecular and Cellular Neuroscience, 104(April 2020), Article 103466. https://doi.org/10.1016/j.mcn.2020.103466.

Journal Articles

Journal Articles

  • Moore, S., Sonar, K., Bharadwaj, P., Deplazes, E., Mancera, R. (2018). Characterisation of the structure and oligomerisation of islet amyloid polypeptides (IAPP). Molecules, 23(9), article no.2142. https://doi.org/10.3390/molecules23092142.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.
  • Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R. (2018). Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651. https://doi.org/10.1016/j.bbamem.2018.03.015.

Journal Articles

  • Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L., Fraser, P., Verdile, G. (2017). The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-B, Amylin, and Tau Proteins. Journal of Alzheimer's Disease, 59(2), 421-432. https://doi.org/10.3233/JAD-161192.

Journal Articles

  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.

Journal Articles

  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G. (2013). Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332. https://doi.org/10.1038/tp.2013.97.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0. (2013). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897. https://doi.org/10.1038/mp.2012.106.
  • Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L. (2013). Modulation of amyloid-β 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103. https://doi.org/10.1039/c2fo30111c.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S. (2013). Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888. https://doi.org/10.1038/mp.2012.115.

Journal Articles

  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R. (2012). Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967. https://doi.org/10.3233/JAD-2012-120178.

Journal Articles

  • Caine, JM., Bharadwaj, P., Sankovich, SE., Ciccotosto, GD., Streltsov, VA., Varghese, J. (2011). Oligomerization and toxicity of Aβ fusion proteins. Biochemical and Biophysical Research Communications, 409(3), 477-482. https://doi.org/10.1016/j.bbrc.2011.05.029.

Research Projects

  • Neuroprotective functions of autophagy regulators in Alzheimer's disease, National Health and Medical Research Council, Dementia Research Development Fellowship, 2016 ‑ 2022, $640,220.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. , Hollywood Private Hospital Research Foundation, Grant, 2013 ‑ 2016, $20,000.
  • Targeting chaperone mediated autophagy to alleviate Aβ accumulation and toxicity in AD , Dementia Australia Research Foundation, AADRF - Dementia Grants Program, 2015 ‑ 2016, $50,000.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2014 ‑ 2015, $12,555.
  • Protective role of autophagy genes in Alzheimer’s disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014, $10,000.

Research Student Supervision

Associate Supervisor

  • Master of Medical and Health Science by Research, Investigating protective effects of grape seed extract (GSE) on amyloid beta induced mitochondrial and neuronal toxicity in an Alzheime's disease (AD) cell model

Associate Supervisor

  • Doctor of Philosophy, Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing alzheimer's risk
Skip to top of page