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Professor John Olynyk

Dean of Clinical Research

Contact Information Telephone: +61 8 9335 3411, Mobile: 0404890060, Email:, Campus: ,
Staff Member Details
Telephone: +61 8 9335 3411
Mobile: 0404890060


John Olynyk is the Professor of Translational Medicine in the School of Medical and Health Sciences. John is also Director of Research Development in Fiona Stanley Hospital and Director of Gastroenterology in Fremantle Hospital and Health Service and Fiona Stanley Hospital.

Professional Associations

  • Fellow of the Royal Australasian College of Physicians.
  • Member, Gastroenterological Society of Australia.
  • Member, Section of Hepatology, Gastroenterological Society of Australia.
  • Member, New York Academy of Sciences.
  • Member, American Association for the Study of Liver Diseases.
  • Member, Australian-Pacific Association for the Study of Liver Diseases.
  • Member, International Association for the Study of Liver Diseases.

Awards and Recognition

  • 2016 - Distinguished Research Prize, Gastroenterological Society of Australia.
  • 2015 - OzApp Award Top 20 Finalist for High Ferritin App, Perth.
  • 2014 - AASLD Fellow.  American Association for the Study of Liver Diseases.
  • 2013 - Nominated for John Rowe Award for Consultant Teacher of 2012, Postgraduate Medical Education, Fremantle Hospital.
  • 2011 - Highest RPI Points for Publications, Faculty of Health Sciences Prize, Office of Research and Development, Curtin University.
  • 1995 - Gastroenterological Society of Australia, Senior Travel Award.
  • 1991 - Wellcome Research Prize, Department of Medicine, Flinders Medical Centre, Adelaide.
  • 1989 - Best Scientific Paper, South Australian College of Physicians Scientific Meeting.
  • 1984 - Helen Jane Lamard Prize in Medicine.


  • Doctor of Medicine, The Flinders University of South Australia, 1995.


Recent Research Grants

  • Targeting the TWEAK/Fn14 signalling pathway as a novel therapeutic strategy to prevent chronic liver disease progression,  National Health and Medical Research Council,  Project Grants,  2019 - 2022,  $997,486.
  • Single nuclei sequencing of matched chronically injured liver tissue - A ground-breaking new opportunity for biomarker discovery in liver cancer research,  Gastroenterological Society of Australia,  2019 GESA Project Grant,  2019 - 2020,  $22,727.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22),  Department of Health WA,  Medical and Health Research Infrastructure,  2019 - 2020,  $17,923.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20),  Department of Health WA,  Medical and Health Research Infrastructure,  2017 - 2018,  $18,270.
  • Translating disordered iron metabolism and liver injury research into clinical practice,  National Health and Medical Research Council,  Practitioner Fellowships,  2017 - 2018,  $72,174.

Recent Publications (within the last five years)

Journal Articles

  • Genz, B., Coleman, M., Irvine, K., Kutasovic, JR., Miranda, M., Gratte, FD., Tirnitz-Parker, JE., Olynyk, J., Calvopina, DA., Weis, A., Cloonan, N., Robinson, H., Hill, MM., Al-Ejeh, F., Ramm, GA., (2019), Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-B-induced collagen expression in hepatic stellate cells. Scientific Reports, 1-18, DOI: 10.1038/s41598-019-44865-1.
  • Bazerbachi, F., Haffar, S., Wang, Z., Gonzalez, JC., Arias-Loste, MT., Crespo, J., Darwish-Murad, S., Ikram, MA., Olynyk, J., Gan, E., Petta, S., Berzuini, A., Prati, D., De Ledinghen, V., Wong, VW., Del Poggio, P., Chavez-Tapia, NC., Chen, Y., Cheng, P., Yuen, M., Das, K., Chowdhury, A., Caballeria, L., Fabrellas, N., Gines, P., Kumar, M., Sarin, SK., Conti, F., Andreone, P., Sirli, R., Cortez-Pinto, H., Carvalhana, S., Sugihara, T., Kim, SU., Parikh, P., Chayama, K., Corpechet, C., Kim, KM., Papatheodoridis, G., Alsebaey, A., Kamath, PS., Murad, MH., Watt, KD., (2019), Range of normal liver stiffness and predictors of suspected advanced fibrosis in apparently healthy individuals. Clinical Gastroenterology and Hepatology, 17(1), 54-64, DOI: 10.1016/j.cgh.2018.08.069.
  • Adris, N., Hazeldine, S., Bentley, P., Trinder, D., Chua, A., Powell, LW., Ramm, L., Ramm, GA., Olynyk, J., (2019), Detection of HFE Haemochromatosis in the clinic and community using standard erthyrocyte tests. Blood Cells, Molecules and Diseases, 74(n/a), 18-24, DOI: 10.1016/j.bcmd.2018.10.003.
  • Hart, RJ., Doherty, DA., Mori, TA., Adams, LA., Huang, RC., Minaee, N., Handelsman, DJ., McLachlan, R., Norman, RJ., Dickinson, JE., Olynyk, J., Beilin, LJ., (2019), Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age. Human Reproduction, epub ahead of print(Dec 2018), 14p., United Kingdom, Oxford University Press, DOI: 10.1093/humrep/dey371.
  • Tirnitz-Parker, J., Forbes, SJ., Olynyk, J., Ramm, GA., (2019), Cellular plasticity in liver regeneration - spotlight on cholangiocytes. Hepatology, 65(5), 2286-2289.
  • Ayonrinde, O., Adams, L., Mori, T., Beilin, L., De Klerk, N., Pennell, C., White, S., Olynyk, J., (2018), Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents. Hepatology, 67(1), 108-122, Netherlands, Elsevier, DOI: 10.1002/hep.29347.
  • Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Stuart, K., Subramaniam, VN., Jeffrey, G., St Pierre, T., House, M., Gummer, J., Trengove, R., Olynyk, J., Crawford, D., Adams, L., (2018), Hepatic iron concentration correlates with insulin sensitivity in non-alcoholic fatty liver disease. Hepatology Communications, 2(6), 644-653, DOI: 10.1002/hep4.1190.
  • Gratte, F., Pasic, S., Olynyk, J., Yeoh, G., Tosh, D., Coombe, D., Tirnitz-Parker, J., (2018), Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins. Scientific Reports, 8(1), article no.4385, DOI: 10.1038/s41598-018-22596-z.
  • Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S., (2018), Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study. Journal of Intensive Care, 6(1), Article no.60, DOI: 10.1186/s40560-018-0328-2.
  • Adris, N., Chua, AC., Knuiman, M., Divitini, ML., Trinder, D., Olynyk, J., (2018), A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study. BMC Cancer, 18(1), Article number 863, United Kingdom, BioMed Central Ltd, DOI: 10.1186/s12885-018-4775-x.
  • Gummer, J., Trengove, R., Pascoe, EM., Badve, SV., Cass, A., Clarke, P., McDonald, SP., Morrish, AT., Pedagogos, E., Perkovic, V., Reidlinger, D., Scaria, A., Walker, R., Vergara, LA., Hawley, CM., Johnson, DW., Olynyk, J., Ferrari, P., (2017), Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. Nephrology, 22(7), 548-554, Australia, Wiley-Blackwell Publishing Asia, DOI: 10.1111/nep.12815.
  • Ramanathan, G., Olynyk, J., Ferrari, P., (2017), Diagnosing and preventing iron overload. Hemodialysis International, 21(July 2017), S58-S67, DOI: 10.1111/hdi.12555.
  • Holman, R., Olynyk, J., Kulkami, H., Ferrari, P., (2017), Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis. Nephrology, 22(2), 114-117, DOI: 10.1111/nep.12735.
  • Ayonrinde, O., Oddy, W., Adams, L., Mori, T., Beilin, L., De Klerk, N., Olynyk, J., (2017), Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents. Journal of Hepatology, 67(3), 568-576, Netherlands, Elsevier.
  • Pozniak, KN., Pearen, MA., Pereira, TN., Kramer, CS., Kalita-De Croft, P., Nawaratna, SN., Fernandez-Rojo, MA., Gobert, GN., Tirnitz-Parker, JE., Olynyk, J., Shepherd, RW., Lewindon, PJ., Ramm, GA., (2017), Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in paediatric cystic fibrosis liver disease. American Journal of Pathology, 187(12), 2744-2757, United States, Elsevier, DOI: 10.1016/j.ajpath.2017.08.024.
  • Warne, CD., Zaloumis, S., Bertalli, N., Delatycki, MB., Nicoll, A., McLaren, CE., Hopper, JL., Giles, GG., Anderson, GJ., Olynyk, J., Powell, LW., Allen, KJ., Gurrin, LC., (2017), HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women. Journal of Gastroenterology and Hepatology, 32(4), 797-802, DOI: 10.1111/jgh.13621.
  • Elsegood, CL., Tirnitz-Parker, JE., Olynyk, J., Yeoh, GC., (2017), Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma. Clinical and Translational Immunology, 6(2017), e161, Nature Publishing, DOI: 10.1038/cti.2017.47.
  • O'Hara, S., Hodson, S., Hernaman, C., Wambeek, N., Olynyk, J., (2017), Concordance of transient elastography and shear wave elastography for measurement of liver stiffness. Sonography, 4(141), 141-145, Australia, Wiley-Blackwell Publishing Asia, DOI: 10.1002/sono.12122.
  • Ong, S., Gurrin, L., Dolling, L., Dixon, J., Nicoll, A., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, J., Crawford, D., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M., (2017), Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial. The Lancet Haematology, 4(12), e607-e614, United Kingdom, The Lancet Publishing Group, DOI: 10.1016/S2352-3026(17)30214-4.
  • Gogoi-Tiwari, J., Köhn-Gaone, J., Giles, C., Schmidt-Arras, D., Gratte, F., Elsegood, C., McCaughan, G., Ramm, G., Olynyk, J., Tirnitz-Parker, J., (2017), The murine choline-deficient, ethionine-supplemented (CDE) diet model of chronic liver injury. Journal of Visualized Experiments, 2017(128), Article Number e56138, DOI: 10.3791/56138.
  • Heidari, M., Gerami, S., Bassett, B., Graham, R., Chua, A., Aryal, R., House, M., Collingwood, J., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Johnstone, D., Milward, E., (2016), Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare Diseases, 4(1), 11p., DOI: 10.1080/21675511.2016.1198458.
  • Chua, A., Knuiman, M., Trinder, D., Divitini, M., Olynyk, J., (2016), Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes. American Journal of Clinical Nutrition, 104(3), 736-742, American Society for Nutrition, DOI: 10.3945/ajcn.115.129411.
  • Heidari, M., Johnstone, D., Bassett, B., Graham , R., Chua, A., House, MJ., Collingwood, JF., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Milward, EA., (2016), Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features. Molecular Psychiatry, 21(11), 1599-1607, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2015.192.
  • Van Rijnsoever, M., Galhenage, S., Mollison, L., Gummer, J., Trengove, R., Olynyk, J., (2016), Dysregulated erythropoietin, hepcidin, and bone marrow iron metabolism contribute to interferon-induced anemia in hepatitis C. Journal of Interferon and Cytokine Research, 36(11), 630-634, Mary Ann Liebert, DOI: 10.1089/jir.2016.0043.
  • Ironman Investigators, T., Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S., Anzics Clinical Trials Group, T., (2016), Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial: A randomized trial of IV iron in critical illness. Intensive Care Medicine, 42(11), 1715-1722, DOI: 10.1007/s00134-016-4465-6.
  • Subramaniam, K., Spilsbury, K., Ayonrinde, O., Latchmiah, F., Mukhtar, S., Semmens, J., Leahy, M., Olynyk, J., (2016), Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding. Transfusion, 56(4), 816-826, Blackwell, DOI: 10.1111/trf.13446.
  • Ayonrinde, O., Adams, L., Doherty, D., Mori, T., Beilin, L., Oddy, W., Hickey, M., Sloboda, D., Olynyk, J., Hart, R., (2016), Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. Journal of Gastroenterology and Hepatology, 31(5), 980-987, Wiley-Blackwell Publishing Asia, DOI: 10.1111/jgh.13241.
  • St. Pierre, TG., House, MJ., Bangma, SJ., Pang, W., Bathgate, A., Gan, EK., Ayonrinde, OT., Bhathal, PS., Clouston, A., Olynyk, J., Adams, LA., (2016), Stereological analysis of liver biopsy histology sections as a reference standard for validating non-invasive liver fat fraction measurements by MRI. PLoS One, 11(8), Article number e01060789, DOI: 10.1371/journal.pone.0160789.
  • Kohn-Gaone, J., Dwyer, B., Grzelak, C., Miller, G., Shackel, N., Ramm, G., McCaughan, G., Elsegood, C., Olynyk, J., Tirnitz-Parker, JE., (2016), Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury. American Journal of Pathology, 186(7), 1762-1774, Elsevier, DOI: 10.1016/j.ajpath.2016.03.005.
  • Woo, K., Stewart, SG., Kong, GS., Finch-Edmonson, ML., Dwyer, BJ., Yeung, SY., Abraham, LJ., Kampmann, SS., Diepeveen, LA., Passman, AM., Elsegood, CL., Tirnitz-Parker, JE., Callus, BA., Olynyk, J., Yeoh, GC., (2016), Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European Journal of Medicinal Chemistry, 120(2016), 275-283, Elsevier, DOI: 10.1016/j.ejmech.2016.03.015.
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Soon Lee, C., Richardson, D., (2016), Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 727-748, Elsevier, DOI: 10.1016/j.bbamcr.2016.01.026.
  • Kohn-Gaone, J., Gogoi-Tiwari, J., Ramm, G., Olynyk, J., Tirnits-Parker, JE., (2016), The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 310(3), G143-G154, American Physiological Society, DOI: 10.1152/ajpgi.00215.2015.
  • Adams, L., Crawford, D., Stuart, K., House, M., St Pierre, T., Webb, M., Ching, H., Kava, J., Bynevelt, M., Macquillan, G., Garas, G., Ayonrinde, O., Mori, T., Croft, K., Niu, X., Jeffrey, G., Olynyk, J., (2015), The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology, 61(5), 1555-1564, DOI: 10.1002/hep.27662.
  • Elsegood, C., Chan, CW., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J., Yeoh, GC., (2015), Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology, 62(4), 1272-1284, DOI: 10.1002/hep.27977.
  • Yeap, B., Divitini, M., Gunton, J., Olynyk, J., Beilby, J., McQuillan, B., Hung, J., Knuiman, M., (2015), Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis. Clinical Endocrinology, 82(4), 525-532, DOI: 10.1111/cen.12529.
  • Zaloumis, S., Allen, K., Bertalli, N., Turkovic, L., Delatycki, M., Nicoll, A., McLaren, C., English, D., Hopper, J., Giles, G., Anderson, G., Olynyk, J., Powell, L., Gurrin, L., (2015), Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study. Journal of Gastroenterology and Hepatology, 30(4), 719-725, DOI: 10.1111/jgh.12804.
  • Bentley, P., Bell, B., Olynyk, J., (2015), Therapeutic venesection at the Australian Red Cross Blood Service: Impact of the High Ferritin Application on management of hereditary haemochromatosis. Australian Family Physician, 44(8), 589-592, South Melbourne, Victoria, The Royal Australian College of General Practitioners.
  • Ayonrinde, O., Olynyk, J., Marsh, J., Beilin, L., Mori, T., Oddy, W., Adams, L., (2015), Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. Journal of Gastroenterology and Hepatology, 30(1), 163-171, DOI: 10.1111/jgh.12666.
  • House, M., Bangma, S., Thomas, M., Gan, E., Ayonrinde, O., Adams, L., Olynyk, J., St. Pierre, T., (2015), Texture-based classification of liver fibrosis using MRI. Journal of Magnetic Resonance Imaging, 41(2), 322-328, DOI: 10.1002/jmri.24536.
  • Ong, S., Dolling, L., Dixon, J., Nicoll, A., Gurrin, L., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, J., Crawford, D., Kava, J., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M., (2015), Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron). BMJ Open, 5(8), e008938, DOI: 10.1136/bmjopen-2015-008938.
  • Litton, E., Baker, S., Erber, W., French, C., Ferrier, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., Farmer, S., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Webb, S., (2014), The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Critical Care and Resuscitation, 16(4), 285-290, Australasian Medical Publishing Co..
  • Thin, L., Lawrance, I., Spilsbury, K., Kava, J., Olynyk, J., (2014), Detection of liver injury in IBD using transient elastography. Journal of Crohn's and Colitis, 8(7), 671-677, Elsevier, DOI: 10.1016/j.crohns.2013.12.006.
  • Tirnitz-Parker, J., Olynyk, J., Ramm, G., (2014), Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses. Hepatology, 59(3), 1198-1201, American Association for the Study of Liver Diseases, DOI: 10.1002/hep.26701.
  • Dwyer, B., Olynyk, J., Ramm, G., Tirnitz-Parker, J., (2014), TWEAK and LTß signaling during chronic liver disease. Frontiers in Immunology, 5(Feb), art 39, Frontiers Research Foundation, DOI: 10.3389/fimmu.2014.00039.
  • McKinnon, E., Rossi, E., Beilby, J., Trinder, D., Olynyk, J., (2014), Factors that affect serum levels of ferritin in australian adults and implications for follow-up. Clinical Gastroenterology and Hepatology, 12(1), 101-108, The AGA Institute, DOI: 10.1016/j.cgh.2013.07.019.
  • Black, L., Jacoby, P., Chan She Ping-Delfos, W., Mori, T., Beilin, L., Olynyk, J., Ayonrinde, O., Chi Huang, R., Holt, P., Hart, P., Oddy, W., Adams, L., (2014), Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology, 29(6), 1215-1222, Blackwell Publishing, DOI: 10.1111/jgh.12541.
  • Prakoso, E., Tirnitz-Parker, J., Clouston, A., Kayali, Z., Lee, A., Gan, E., Ramm, G., Kench, J., Bowen, D., Olynyk, J., McCaughan, G., Shackel, N., (2014), Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver Transplantation, 20(12), 1508-1519, John Wiley & Sons Ltd, DOI: 10.1002/lt.24007.
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