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Professor John Olynyk

Research Theme Leader (Health)

Staff Member Details
Mobile: 0404 890 060
Email: j.olynyk@ecu.edu.au
Campus: Joondalup  
Room: JO21.456  
ORCID iD: https://orcid.org/0000-0003-0417-3411

Professor John Olynyk is a consultant Hepatologist in the Department of Gastroenterology at Fiona Stanley Hospital Group and Dean of Clinical Research, Edith Cowan University.

He is also the Honorary Director of Research, Spinnaker Health Research Foundation.

He is a medical advisor to the Haemochromatosis Australia and a consultant for the Lifeblood Australia.  He has established internationally recognized research programs in Hereditary Haemochromatosis and disorders of iron metabolism, chronic liver injury, hepatocellular carcinoma and non-alcoholic fatty liver disease.  He has published over 230 original articles and has a H index of 60.

Professional Associations

  • Fellow of the Royal Australasian College of Physicians.
  • Member, Gastroenterological Society of Australia.
  • Member, Section of Hepatology, Gastroenterological Society of Australia.
  • Member, New York Academy of Sciences.
  • Member, American Association for the Study of Liver Diseases.
  • Member, Australian-Pacific Association for the Study of Liver Diseases.
  • Member, International Association for the Study of Liver Diseases.

Awards and Recognition

  • 2016 - Distinguished Research Prize, Gastroenterological Society of Australia.
  • 2015 - OzApp Award Top 20 Finalist for High Ferritin App, Perth.
  • 2014 - AASLD Fellow.  American Association for the Study of Liver Diseases.
  • 2013 - Nominated for John Rowe Award for Consultant Teacher of 2012, Postgraduate Medical Education, Fremantle Hospital.
  • 2011 - Highest RPI Points for Publications, Faculty of Health Sciences Prize, Office of Research and Development, Curtin University.
  • 1995 - Gastroenterological Society of Australia, Senior Travel Award.
  • 1991 - Wellcome Research Prize, Department of Medicine, Flinders Medical Centre, Adelaide.
  • 1989 - Best Scientific Paper, South Australian College of Physicians Scientific Meeting.
  • 1984 - Helen Jane Lamard Prize in Medicine.

Qualifications

  • Doctor of Medicine, The Flinders University of South Australia, 1995.

Research Outputs

Journal Articles

  • Gratte, F., Pasic, S., Bakar, ND., Gogoi-Tiwari, J., Liu, X., Carlessi, R., Kisseleva, T., Brenner, D., Ramm, G., Olynyk, J., Tirnitz-Parker, J. (2021). Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury. The International Journal of Biochemistry and Cell Biology, 134(2021), Article 105933. https://doi.org/10.1016/j.biocel.2021.105933.
  • Dwyer, B., Jarman, E., Gogoi-Tiwari, J., Ferreira-Gonzalez, S., Boulter, L., Guest, R., Kendall, T., Kurian, D., Kilpatrick, A., Robson, A., O’duibhir, E., Man, TY., Campana, L., Starkey Lewis, P., Wigmore, S., Olynyk, J., Ramm, G., Tirnitz-Parker, J., Forbes, S. (2021). TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression. Journal of Hepatology, 74(4), 860-872. https://doi.org/https://doi.org/10.1016/j.jhep.2020.11.018.

Journal Articles

  • Mitchell, T., McKinnon, E., Ayonrinde, O., Adams, L., Trinder, D., Chua, A., Newton, R., Straker, L., Olynyk, J. (2020). Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability. Clinical Gastroenterology and Hepatology, 18(7), 1584-1591. https://doi.org/10.1016/j.cgh.2019.10.017.
  • Chin, J., Powell, L., Ramm, L., Hartel, G., Olynyk, J., Ramm, G. (2020). Utility of Serum Biomarker Indices for Staging of Hepatic Fibrosis Before and After Venesection in Patients With Hemochromatosis Caused by Variants in HFE. Clinical Gastroenterology and Hepatology, 2020(Article in press), 1-15. https://doi.org/10.1016/j.cgh.2020.07.052.
  • Adikari, P., Makanyanga, J., Olynyk, J. (2020). Clinical and Demographic Characteristics of Older Inflammatory Bowel Disease Patients. Recent Advances in Biology and Medicine, 6(2), Article 1111504. https://doi.org/10.18639/RABM.2020.1111504.
  • Rehman, A., Carroll, G., Powell, L., Ramm, L., Ramm, G., Olynyk, J. (2020). Arthropathy in hereditary haemochromatosis segregates with elevated erythrocyte mean corpuscular volume. Scandinavian Journal of Rheumatology, 2020(Article in press), 1-4. https://doi.org/10.1080/03009742.2020.1800081.
  • Pearen, M., Lim, H., Gratte, F., Fernandez-Rojo, M., Nawaratna, S., Gobert, G., Olynyk, J., Tirnitz-Parker, J., Ramm, G. (2020). Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology. Journal of Visualized Experiments, 2020(157), Article number e60992. https://doi.org/10.3791/60992.
  • Wan, F., Pan, F., Ayonrinde, O., Adams, L., Mori, T., Beilin, L., O'Sullivan, T., Olynyk, J., Oddy, W. (2020). Validation of fatty liver disease scoring systems for ultrasound diagnosed non-alcoholic fatty liver disease in adolescents. Digestive and Liver Disease, 2020(Article in press), 1-7. https://doi.org/10.1016/j.dld.2020.11.037.
  • Adikari, P., Olynyk, J. (2020). Impact of Implementation of Additional Endoscopy List on Hospital Inpatient Length of Stay. Recent Advances in Biology and Medicine, 6(2), Article number 1109565. https://doi.org/10.18639/RABM.2020.1109565.
  • Chin, J., Mori, T., Adams, L., Beilin, L., Huang, R., Olynyk, J., Ayonrinde, O. (2020). Association between remnant lipoprotein cholesterol levels and non-alcoholic fatty liver disease in adolescents. JHEP Reports, 2(6), Article number 100150. https://doi.org/10.1016/j.jhepr.2020.100150.
  • Lim, Z., Bentley, P., Olynyk, J. (2020). Ensuring donor safety: is venesecting therapeutic donors to haemoglobin levels below Blood Service guidelines safe?. Vox Sanguinis: international journal of transfusion medicine, 115(4), 288-292. https://doi.org/10.1111/vox.12900.
  • Ayonrinde, O., Ayonrinde, OA., Adams, L., Sanfilippo, F., O'Sullivan, T., Robinson, M., Oddy, W., Olynyk, J. (2020). The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study. Scientific Reports, 10(1), Article number 1646. https://doi.org/10.1038/s41598-020-58543-0.
  • Olsson-White, D., Olynyk, J., Ayonrinde, O., Paramalingam, S., Keen, H. (2020). Assessment of Liver Fibrosis Markers in People with Rheumatoid Arthritis on Methotrexate. Internal Medicine Journal, 2020(Article in press), 34p.. https://doi.org/10.1111/imj.15125.

Book Chapters

Journal Articles

  • Adris, N., Hazeldine, S., Bentley, P., Trinder, D., Chua, A., Powell, LW., Ramm, L., Ramm, GA., Olynyk, J. (2019). Detection of HFE Haemochromatosis in the clinic and community using standard erthyrocyte tests. Blood Cells, Molecules and Diseases, 74(February 2019), 18-24. https://doi.org/10.1016/j.bcmd.2018.10.003.
  • Bazerbachi, F., Haffar, S., Wang, Z., Cabezas, J., Arias-Loste, MT., Crespo, J., Darwish-Murad, S., Ikram, MA., Olynyk, J., Gan, E., Petta, S., Berzuini, A., Prati, D., De Ledinghen, V., Wong, VW., Del Poggio, P., Chavez-Tapia, NC., Chen, Y., Cheng, P., Yuen, M., Das, K., Chowdhury, A., Caballeria, L., Fabrellas, N., Gines, P., Kumar, M., Sarin, SK., Conti, F., Andreone, P., Sirli, R., Cortez-Pinto, H., Carvalhana, S., Sugihara, T., Kim, SU., Parikh, P., Chayama, K., Corpechet, C., Kim, KM., Papatheodoridis, G., Alsebaey, A., Kamath, PS., Murad, MH., Watt, KD. (2019). Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals. Clinical Gastroenterology and Hepatology, 17(1), 54-64. https://doi.org/10.1016/j.cgh.2018.08.069.
  • Chin, J., Powell, L., Ramm, L., Ayonrinde, O., Ramm, G., Olynyk, J. (2019). Utility of hepatic or total body iron burden in the assessment of advanced hepatic fibrosis in HFE hemochromatosis. Scientific Reports, 9(1), Article number 20234. https://doi.org/10.1038/s41598-019-56732-0.
  • Tirnitz-Parker, J., Forbes, SJ., Olynyk, J., Ramm, GA. (2019). Cellular plasticity in liver regeneration - spotlight on cholangiocytes. Hepatology, 69(5), 2286-2289. https://doi.org/10.1002/hep.30340.
  • Ayonrinde, O., Sanfilippo, FM., O'Sullivan, T., Adams, L., Ayonrinde, O., Robinson, M., Oddy, W., Olynyk, J. (2019). Bowel patterns, gastrointestinal symptoms and emotional well-being in adolescents: A cohort study. Journal of Gastroenterology and Hepatology, 34(11), 1946-1954. https://doi.org/10.1111/jgh.14699.
  • Genz, B., Coleman, M., Irvine, K., Kutasovic, JR., Miranda, M., Gratte, FD., Tirnitz-Parker, JE., Olynyk, J., Calvopina, DA., Weis, A., Cloonan, N., Robinson, H., Hill, MM., Al-Ejeh, F., Ramm, GA. (2019). Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-B-induced collagen expression in hepatic stellate cells. Scientific Reports, 9(1), Article number 8541. https://doi.org/10.1038/s41598-019-44865-1.
  • Hart, RJ., Doherty, DA., Mori, TA., Adams, LA., Huang, RC., Minaee, N., Handelsman, DJ., McLachlan, R., Norman, RJ., Dickinson, JE., Olynyk, J., Beilin, LJ. (2019). Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age. Human Reproduction, 34(3), 389-402. https://doi.org/10.1093/humrep/dey371.

Journal Articles

  • Britton, L., Bridle, K., Reiling, J., Santrampurwala, N., Wockner, L., Ching, H., Stuart, K., Subramaniam, VN., Jeffrey, G., St Pierre, T., House, M., Gummer, J., Trengove, R., Olynyk, J., Crawford, D., Adams, L. (2018). Hepatic iron concentration correlates with insulin sensitivity in non-alcoholic fatty liver disease. Hepatology Communications, 2(6), 644-653. https://doi.org/10.1002/hep4.1190.
  • Gratte, F., Pasic, S., Olynyk, J., Yeoh, G., Tosh, D., Coombe, D., Tirnitz-Parker, J. (2018). Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins. Scientific Reports, 8(1), article no.4385. https://doi.org/10.1038/s41598-018-22596-z.
  • Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S. (2018). Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study. Journal of Intensive Care, 6(1), Article no.60. https://doi.org/10.1186/s40560-018-0328-2.
  • Ayonrinde, O., Adams, L., Mori, T., Beilin, L., De Klerk, N., Pennell, C., White, S., Olynyk, J. (2018). Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents. Hepatology, 67(1), 108-122. https://doi.org/10.1002/hep.29347.
  • Adris, N., Chua, AC., Knuiman, M., Divitini, ML., Trinder, D., Olynyk, J. (2018). A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study. BMC Cancer, 18(1), Article number 863. https://doi.org/10.1186/s12885-018-4775-x.

Journal Articles

  • Elsegood, CL., Tirnitz-Parker, JE., Olynyk, J., Yeoh, GC. (2017). Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma. Clinical and Translational Immunology, 6(2017), e161. https://doi.org/10.1038/cti.2017.47.
  • Warne, CD., Zaloumis, S., Bertalli, N., Delatycki, MB., Nicoll, A., McLaren, CE., Hopper, JL., Giles, GG., Anderson, GJ., Olynyk, J., Powell, LW., Allen, KJ., Gurrin, LC. (2017). HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women. Journal of Gastroenterology and Hepatology, 32(4), 797-802. https://doi.org/10.1111/jgh.13621.
  • Holman, R., Olynyk, J., Kulkami, H., Ferrari, P. (2017). Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis. Nephrology, 22(2), 114-117. https://doi.org/10.1111/nep.12735.
  • Gummer, J., Trengove, R., Pascoe, EM., Badve, SV., Cass, A., Clarke, P., McDonald, SP., Morrish, AT., Pedagogos, E., Perkovic, V., Reidlinger, D., Scaria, A., Walker, R., Vergara, LA., Hawley, CM., Johnson, DW., Olynyk, J., Ferrari, P. (2017). Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. Nephrology, 22(7), 548-554. https://doi.org/10.1111/nep.12815.
  • Ramanathan, G., Olynyk, J., Ferrari, P. (2017). Diagnosing and preventing iron overload. Hemodialysis International, 21(July 2017), S58-S67. https://doi.org/10.1111/hdi.12555.
  • Ong, S., Gurrin, L., Dolling, L., Dixon, J., Nicoll, A., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, J., Crawford, D., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M. (2017). Reduction of body iron in HFE-related haemochromatosis and moderate iron overload (Mi-Iron): a multicentre, participant-blinded, randomised controlled trial. The Lancet Haematology, 4(12), e607-e614. https://doi.org/10.1016/S2352-3026(17)30214-4.
  • Ayonrinde, O., Oddy, W., Adams, L., Mori, T., Beilin, L., De Klerk, N., Olynyk, J. (2017). Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents. Journal of Hepatology, 67(3), 568-576. https://doi.org/10.1016/j.jhep.2017.03.029.
  • Pozniak, KN., Pearen, MA., Pereira, TN., Kramer, CS., Kalita-De Croft, P., Nawaratna, SN., Fernandez-Rojo, MA., Gobert, GN., Tirnitz-Parker, JE., Olynyk, J., Shepherd, RW., Lewindon, PJ., Ramm, GA. (2017). Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in paediatric cystic fibrosis liver disease. American Journal of Pathology, 187(12), 2744-2757. https://doi.org/10.1016/j.ajpath.2017.08.024.
  • O'Hara, S., Hodson, S., Hernaman, C., Wambeek, N., Olynyk, J. (2017). Concordance of transient elastography and shear wave elastography for measurement of liver stiffness. Sonography, 4(141), 141-145. https://doi.org/10.1002/sono.12122.
  • Gogoi-Tiwari, J., Köhn-Gaone, J., Giles, C., Schmidt-Arras, D., Gratte, F., Elsegood, C., McCaughan, G., Ramm, G., Olynyk, J., Tirnitz-Parker, J. (2017). The murine choline-deficient, ethionine-supplemented (CDE) diet model of chronic liver injury. Journal of Visualized Experiments, 2017(128), Article Number e56138. https://doi.org/10.3791/56138.

Journal Articles

  • Ironman Investigators, T., Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S., Anzics Clinical Trials Group, T. (2016). Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial: A randomized trial of IV iron in critical illness. Intensive Care Medicine, 42(11), 1715-1722. https://doi.org/10.1007/s00134-016-4465-6.
  • St. Pierre, TG., House, MJ., Bangma, SJ., Pang, W., Bathgate, A., Gan, EK., Ayonrinde, OT., Bhathal, PS., Clouston, A., Olynyk, J., Adams, LA. (2016). Stereological analysis of liver biopsy histology sections as a reference standard for validating non-invasive liver fat fraction measurements by MRI. PLoS One, 11(8), Article number e01060789. https://doi.org/10.1371/journal.pone.0160789.
  • Ayonrinde, O., Adams, L., Doherty, D., Mori, T., Beilin, L., Oddy, W., Hickey, M., Sloboda, D., Olynyk, J., Hart, R. (2016). Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. Journal of Gastroenterology and Hepatology, 31(5), 980-987. https://doi.org/10.1111/jgh.13241.
  • Kohn-Gaone, J., Dwyer, B., Grzelak, C., Miller, G., Shackel, N., Ramm, G., McCaughan, G., Elsegood, C., Olynyk, J., Tirnitz-Parker, JE. (2016). Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury. American Journal of Pathology, 186(7), 1762-1774. https://doi.org/10.1016/j.ajpath.2016.03.005.
  • Van Rijnsoever, M., Galhenage, S., Mollison, L., Gummer, J., Trengove, R., Olynyk, J. (2016). Dysregulated erythropoietin, hepcidin, and bone marrow iron metabolism contribute to interferon-induced anemia in hepatitis C. Journal of Interferon and Cytokine Research, 36(11), 630-634. https://doi.org/10.1089/jir.2016.0043.
  • Subramaniam, K., Spilsbury, K., Ayonrinde, O., Latchmiah, F., Mukhtar, S., Semmens, J., Leahy, M., Olynyk, J. (2016). Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding. Transfusion, 56(4), 816-826. https://doi.org/10.1111/trf.13446.
  • Kohn-Gaone, J., Gogoi-Tiwari, J., Ramm, G., Olynyk, J., Tirnits-Parker, JE. (2016). The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 310(3), G143-G154. https://doi.org/10.1152/ajpgi.00215.2015.
  • Heidari, M., Johnstone, D., Bassett, B., Graham , R., Chua, A., House, MJ., Collingwood, JF., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Milward, EA. (2016). Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features. Molecular Psychiatry, 21(11), 1599-1607. https://doi.org/10.1038/mp.2015.192.
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Soon Lee, C., Richardson, D. (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 727-748. https://doi.org/10.1016/j.bbamcr.2016.01.026.
  • Woo, K., Stewart, SG., Kong, GS., Finch-Edmonson, ML., Dwyer, BJ., Yeung, SY., Abraham, LJ., Kampmann, SS., Diepeveen, LA., Passman, AM., Elsegood, CL., Tirnitz-Parker, JE., Callus, BA., Olynyk, J., Yeoh, GC. (2016). Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European Journal of Medicinal Chemistry, 120(2016), 275-283. https://doi.org/10.1016/j.ejmech.2016.03.015.
  • Chua, A., Knuiman, M., Trinder, D., Divitini, M., Olynyk, J. (2016). Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes. American Journal of Clinical Nutrition, 104(3), 736-742. https://doi.org/10.3945/ajcn.115.129411.
  • Heidari, M., Gerami, S., Bassett, B., Graham, R., Chua, A., Aryal, R., House, M., Collingwood, J., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Johnstone, D., Milward, E. (2016). Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare Diseases, 4(1), 11p.. https://doi.org/10.1080/21675511.2016.1198458.

Journal Articles

  • Adams, L., Crawford, D., Stuart, K., House, M., St Pierre, T., Webb, M., Ching, H., Kava, J., Bynevelt, M., Macquillan, G., Garas, G., Ayonrinde, O., Mori, T., Croft, K., Niu, X., Jeffrey, G., Olynyk, J. (2015). The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology, 61(5), 1555-1564. https://doi.org/10.1002/hep.27662.
  • Bentley, P., Bell, B., Olynyk, J. (2015). Therapeutic venesection at the Australian Red Cross Blood Service: Impact of the High Ferritin Application on management of hereditary haemochromatosis. Australian Family Physician, 44(8), 589-592.
  • Ayonrinde, O., Olynyk, J., Marsh, J., Beilin, L., Mori, T., Oddy, W., Adams, L. (2015). Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. Journal of Gastroenterology and Hepatology, 30(1), 163-171. https://doi.org/10.1111/jgh.12666.
  • Ong, S., Dolling, L., Dixon, J., Nicoll, A., Gurrin, L., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, J., Crawford, D., Kava, J., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M. (2015). Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron). BMJ Open, 5(8), e008938. https://doi.org/10.1136/bmjopen-2015-008938.
  • Yeap, B., Divitini, M., Gunton, J., Olynyk, J., Beilby, J., McQuillan, B., Hung, J., Knuiman, M. (2015). Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis. Clinical Endocrinology, 82(4), 525-532. https://doi.org/10.1111/cen.12529.
  • Zaloumis, S., Allen, K., Bertalli, N., Turkovic, L., Delatycki, M., Nicoll, A., McLaren, C., English, D., Hopper, J., Giles, G., Anderson, G., Olynyk, J., Powell, L., Gurrin, L. (2015). Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study. Journal of Gastroenterology and Hepatology, 30(4), 719-725. https://doi.org/10.1111/jgh.12804.
  • House, M., Bangma, S., Thomas, M., Gan, E., Ayonrinde, O., Adams, L., Olynyk, J., St. Pierre, T. (2015). Texture-based classification of liver fibrosis using MRI. Journal of Magnetic Resonance Imaging, 41(2), 322-328. https://doi.org/10.1002/jmri.24536.
  • Elsegood, C., Chan, CW., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J., Yeoh, GC. (2015). Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology, 62(4), 1272-1284. https://doi.org/10.1002/hep.27977.

Journal Articles

  • Thin, L., Lawrance, I., Spilsbury, K., Kava, J., Olynyk, J. (2014). Detection of liver injury in IBD using transient elastography. Journal of Crohn's and Colitis, 8(7), 671-677. https://doi.org/10.1016/j.crohns.2013.12.006.
  • Black, L., Jacoby, P., Chan She Ping-Delfos, W., Mori, T., Beilin, L., Olynyk, J., Ayonrinde, O., Chi Huang, R., Holt, P., Hart, P., Oddy, W., Adams, L. (2014). Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology, 29(6), 1215-1222. https://doi.org/10.1111/jgh.12541.
  • Dwyer, B., Olynyk, J., Ramm, G., Tirnitz-Parker, J. (2014). TWEAK and LTß signaling during chronic liver disease. Frontiers in Immunology, 5(Feb), art 39. https://doi.org/10.3389/fimmu.2014.00039.
  • McKinnon, E., Rossi, E., Beilby, J., Trinder, D., Olynyk, J. (2014). Factors that affect serum levels of ferritin in australian adults and implications for follow-up. Clinical Gastroenterology and Hepatology, 12(1), 101-108. https://doi.org/10.1016/j.cgh.2013.07.019.
  • Tirnitz-Parker, J., Olynyk, J., Ramm, G. (2014). Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses. Hepatology, 59(3), 1198-1201. https://doi.org/10.1002/hep.26701.
  • Litton, E., Baker, S., Erber, W., French, C., Ferrier, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., Farmer, S., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Webb, S. (2014). The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Critical Care and Resuscitation, 16(4), 285-290.
  • Prakoso, E., Tirnitz-Parker, J., Clouston, A., Kayali, Z., Lee, A., Gan, E., Ramm, G., Kench, J., Bowen, D., Olynyk, J., McCaughan, G., Shackel, N. (2014). Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver Transplantation, 20(12), 1508-1519. https://doi.org/10.1002/lt.24007.

Journal Articles

  • Tirnitz-Parker, J., Glanfield, A., Olynyk, J., Ramm, G. (2013). Iron and Hepatic Carcinogenesis. Critical Reviews in Oncogenesis, 18(5), 391-407. https://doi.org/10.1615/CritRevOncog.2013007759.
  • Chua, A., Klopcic, B., Ho, D., Fu, K., Forrest, C., Croft, K., Olynyk, J., Lawrance, I., Trinder, D. (2013). Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in Mice. PLoS One, 8(11), e78850. https://doi.org/10.1371/journal.pone.0078850.
  • Acikyol, B., Graham, R., Trinder, D., House, M., Olynyk, J., Scott, R., Millward, E., Johnstone, D. (2013). Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience, 235(3 April 2013), 119-128. https://doi.org/10.1016/j.neuroscience.2013.01.014.
  • Maker, G., Siva, B., Batty, K., Trengove, R., Ferrari, P., Olynyk, J. (2013). Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis. Nephrology, 18(3), 188-193. https://doi.org/10.1111/nep.12035.
  • Hazeldine, S., Trinder, D., Olynyk, J. (2013). Non-HFE iron overload: Is phlebotomy the answer?. Current Hepatitis Reports, 12(1), 20-27. https://doi.org/10.1007/s11901-012-0153-3.
  • Adams, L., White, S., Marsh, J., Lye, S., Connor, K., Maganga , R., Ayonrinde, O., Olynyk, J., Mori, T., Beilin, L., Palmer, L., Hamdorf, J., Pennell, C. (2013). Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. Hepatology, 57(2), 590-600. https://doi.org/10.1002/hep.26184.
  • Huang, R., Beilin, L., Ayonrinde, O., Mori, T., Olynyk, J., Burrows, S., Hands, B., Adams, L. (2013). Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents. Hepatology, 58(4), 1306-1314. https://doi.org/10.1002/hep.26495.
  • House, M., Gan, E., Adams, L., Ayonrinde, O., Bangma, S., Bhathal, P., Olynyk, J., St Pierre, T. (2013). Diagnostic Performance of a Rapid Magnetic Resonance Imaging Method of Measuring Hepatic Steatosis. PLoS One, 8(3), e59287. https://doi.org/10.1371/journal.pone.0059287.

Book Chapters

  • Millward, E., Acikyol, B., Bassett, B., Williams, E., Graham, R., Delima, R., Trinder, D., Olynyk, J., Johnstone, D. (2012). Brain changes in iron loading disorders. Metal Ions in Neurological Systems (17-29). Springer. https://doi.org/10.1007/978-3-7091-1001-0_2.

Journal Articles

  • Carroll, G., Breidahl, W., Olynyk, J. (2012). Characteristics of the arthropathy described in hereditary hemochromatosis. Arthritis Care and Research, 64(1), 9-14. https://doi.org/10.1002/acr.20501.
  • Nadakkavukaran, I., Gan, E., Olynyk, J. (2012). Screening for hereditary haemochromatosis. Pathology, 44(2), 148-152. https://doi.org/10.1097/PAT.0b013e32834e8453.
  • Chalmers, K., Knuiman, M., Divitini, M., Bruce, D., Olynyk, J., Milward, E. (2012). Long-term mortality risks associated with mild anaemia in older persons: The Busselton Health Study. Age and Ageing, 41(6), 759-764. https://doi.org/10.1093/ageing/afs150.
  • Johnstone, D., Graham, R., Trinder, D., Delima, R., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Brain transcriptome perturbations in the Hfe −/− mouse model of genetic iron loading. Brain Research, 1448(11 April 2012), 144-152. https://doi.org/10.1016/j.brainres.2012.02.006.
  • Adams, L., Marsh, J., Ayonrinde, O., Olynyk, J., Ang, W., Beilin, L., Mori, T., Palmer, L., Oddy, W., Lye, S., Pennell, C. (2012). Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. Journal of Gastroenterology and Hepatology, 27(9), 1520-1527. https://doi.org/10.1111/j.1440-1746.2012.07120.x.
  • Delima, R., Chua, A., Tirnitz-Parker, J., Gan, E., Croft, K., Graham, R., Olynyk, J., Trinder, D. (2012). Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice. Hepatology, 56(2), 585-593. https://doi.org/10.1002/hep.25689.
  • Johnstone, DM., Graham, R., Trinder, D., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E. (2012). Changes in brain transcripts related to alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased alzheimer's disease risk. Journal of Alzheimer's Disease, 30(4), 791-803. https://doi.org/10.3233/JAD-2012-112183.
  • Raftopoulus, S., Kumarasinghe, P., De Boer, B., Iacobelli, J., Kontorinis, N., Fermoyle, S., Olynyk, J., Forrest, C., Ee, H., Yusoff, I. (2012). Gastric intraepithelial neoplasia in a Western population. European Journal of Gastroenterology and Hepatology, 24(1), 48-54. https://doi.org/10.1097/MEG.0b013e32834dc1bb.
  • Goot, K., Hazeldine, S., Bentley, P., Olynyk, J., Crawford, D. (2012). Elevated serum ferritin: what should GPs know?. Australian Family Physician, 41(12), 945-949.

Journal Articles

  • Ferrari, P., Kulkarni, H., Dheda, S., Betti, S., Harrison, C., St Pierre, T., Olynyk, J. (2011). Serum iron markers are inadequate for guiding iron repletion in chronic kidney disease. Clinical Journal of the American Society of Nephrology, 6(1), 77-83. https://doi.org/10.2215/CJN.04190510.
  • Bremner , A., Feddema, P., Joske, D., Leedman, P., O'Leary, P., Olynyk, J., Walsh, J. (2011). Significant association between thyroid hormones and erythrocyte indices in euthyroid subjects. Clinical Endocrinology, 76(2), 304-311. https://doi.org/10.1111/j.1365-2265.2011.04228.x.
  • Bertalli, N., Allen, K., McLaren, C., Turkovic, L., Osborne, N., Constantine, C., Delatycki, M., English, D., Giles, G., Hopper, J., Anderson, G., Olynyk, J., Powell, L., Gurrin, L. (2011). A comparison of self-reported and record-linked blood donation history in an Australian cohort. Transfusion, 51(10), 2189-2198. https://doi.org/10.1111/j.1537-2995.2011.03141.x.
  • Carroll, G., Breidahl, W., Bulsara, M., Olynyk, J. (2011). Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load. Arthritis and Rheumatism, 63(1), 286-294. https://doi.org/10.1002/art.30094.
  • Chua, A., Trinder, D., Olynyk, J. (2011). Liver and serum iron: Discrete regulators of hepatic hepcidin expression. Hepatology, 54(1), 16-19. https://doi.org/10.1002/hep.24449.
  • Gan, E., Powell, L., Olynyk, J. (2011). Natural History and Management of HFE-Hemochromatosis. Seminars in Liver Disease, 31(3), 293-301. https://doi.org/10.1055/s-0031-1286060.
  • Ayonrinde, O., Olynyk, J., Beilin, L., Mori, T., Pennell, C., De Klerk, N., Oddy, W., Shipman, P., Adams, L. (2011). Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease. Hepatology, 53(3), 800-809. https://doi.org/10.1002/hep.24097.

Research Projects

  • Targeting the TWEAK/Fn14 signalling pathway as a novel therapeutic strategy to prevent chronic liver disease progression, National Health and Medical Research Council, Project Grants, 2019 ‑ 2022, $997,486.
  • Optimal Care Pathways Research Initiatives, WA Cancer and Palliative Care Network, Grant, 2020 ‑ 2021, $68,725.
  • Single nuclei sequencing of matched chronically injured liver tissue - A ground-breaking new opportunity for biomarker discovery in liver cancer research, Gastroenterological Society of Australia, 2019 GESA Project Grant, 2019 ‑ 2020, $22,727.
  • Medical and Health Research Infrastructure Fund 2018 (Round 22), Department of Health WA, Medical and Health Research Infrastructure, 2019 ‑ 2020, $17,923.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20), Department of Health WA, Medical and Health Research Infrastructure, 2017 ‑ 2018, $18,270.
  • Translating disordered iron metabolism and liver injury research into clinical practice, National Health and Medical Research Council, Practitioner Fellowships, 2017 ‑ 2018, $72,174.

Research Student Supervision

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