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Professor John Olynyk

Professor of Translational Medicine

Contact Information Telephone: +61 8 9335 3411, Mobile: 0404890060, Email: j.olynyk@ecu.edu.au, Campus: ,
Staff Member Details
Telephone: +61 8 9335 3411
Mobile: 0404890060
Email: j.olynyk@ecu.edu.au
Campus:  

 

John Olynyk is the Professor of Translational Medicine in the School of Medical and Health Sciences. John is also Director of Research Development in Fiona Stanley Hospital and Director of Gastroenterology in Fremantle Hospital and Health Service and Fiona Stanley Hospital.

Professional Associations

  • Fellow of the Royal Australasian College of Physicians.
  • Member, Gastroenterological Society of Australia.
  • Member, Section of Hepatology, Gastroenterological Society of Australia.
  • Member, New York Academy of Sciences.
  • Member, American Association for the Study of Liver Diseases.
  • Member, Australian-Pacific Association for the Study of Liver Diseases.
  • Member, International Association for the Study of Liver Diseases.

Awards and Recognition

  • 2016 - Distinguished Research Prize, Gastroenterological Society of Australia.
  • 2015 - OzApp Award Top 20 Finalist for High Ferritin App, Perth.
  • 2014 - AASLD Fellow.  American Association for the Study of Liver Diseases.
  • 2013 - Nominated for John Rowe Award for Consultant Teacher of 2012, Postgraduate Medical Education, Fremantle Hospital.
  • 2011 - Highest RPI Points for Publications, Faculty of Health Sciences Prize, Office of Research and Development, Curtin University.
  • 1995 - Gastroenterological Society of Australia, Senior Travel Award.
  • 1991 - Wellcome Research Prize, Department of Medicine, Flinders Medical Centre, Adelaide.
  • 1989 - Best Scientific Paper, South Australian College of Physicians Scientific Meeting.
  • 1984 - Helen Jane Lamard Prize in Medicine.

Qualifications

  • Doctor of Medicine, The Flinders University of South Australia, 1995.

Research

Recent Research Grants

  • Translating disordered iron metabolism and liver injury research into clinical practice,  National Health and Medical Research Council,  Practitioner Fellowships,  2017 - 2018,  $72,174.
  • Medical and Health Research Infrastructure Fund 2016 (Round 20),  Department of Health WA,  Medical and Health Research Infrastructure,  2017 - 2018,  $18,270.

Recent Publications (within the last five years)

Book Chapters

  • Millward, E., Acikyol, B., Bassett, B., Williams, E., Graham, R., Delima, R., Trinder, D., Olynyk, J., Johnstone, D., (2012), Brain changes in iron loading disorders. Metal Ions in Neurological Systems, 17-29, Heidelberg, Germany, Springer, DOI: 10.1007/978-3-7091-1001-0_2.

Journal Articles

  • Warne, CD., Zaloumis, S., Bertalli, N., Delatycki, MB., Nicoll, A., McLaren, CE., Hopper, JL., Giles, GG., Anderson, GJ., Olynyk, J., Powell, LW., Allen, KJ., Gurrin, LC., (2017), HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype-stratified cohort study of hemochromatosis in Australian women. Journal of Gastroenterology and Hepatology, 32(4), 797-802, DOI: 10.1111/jgh.13621.
  • Holman, R., Olynyk, J., Kulkami, H., Ferrari, P., (2017), Characterization of hepatic and cardiac iron deposition during standard treatment of anaemia in haemodialysis. Nephrology, 22(2), 114-117, DOI: 10.1111/nep.12735.
  • Ramanathan, G., Olynyk, J., Ferrari, P., (2017), Diagnosing and preventing iron overload. Hemodialysis International, 21(July 2017), S58-S67, DOI: 10.1111/hdi.12555.
  • Ayonrinde, O., Oddy, W., Adams, L., Mori, T., Beilin, L., De Klerk, N., Olynyk, J., (2017), Infant Nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents. Journal of Hepatology, 67(3), 568-576, Netherlands, Elsevier.
  • Gummer, J., Trengove, R., Pascoe, EM., Badve, SV., Cass, A., Clarke, P., McDonald, SP., Morrish, AT., Pedagogos, E., Perkovic, V., Reidlinger, D., Scaria, A., Walker, R., Vergara, LA., Hawley, CM., Johnson, DW., Olynyk, J., Ferrari, P., (2017), Association between serum hepcidin-25 and primary resistance to erythropoiesis-stimulating agents in chronic kidney disease: a secondary analysis of the HERO trial. Nephrology, 22(7), 548-554, Australia, Wiley-Blackwell Publishing Asia, DOI: 10.1111/nep.12815.
  • Elsegood, CL., Tirnitz-Parker, JE., Olynyk, J., Yeoh, GC., (2017), Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma. Clinical and Translational Immunology, 6(2017), e161, Nature Publishing, DOI: 10.1038/cti.2017.47.
  • Kohn-Gaone, J., Dwyer, B., Grzelak, C., Miller, G., Shackel, N., Ramm, G., McCaughan, G., Elsegood, C., Olynyk, J., Tirnitz-Parker, JE., (2016), Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury. American Journal of Pathology, 186(7), 1762-1774, Elsevier, DOI: 10.1016/j.ajpath.2016.03.005.
  • Woo, K., Stewart, SG., Kong, GS., Finch-Edmonson, ML., Dwyer, BJ., Yeung, SY., Abraham, LJ., Kampmann, SS., Diepeveen, LA., Passman, AM., Elsegood, CL., Tirnitz-Parker, JE., Callus, BA., Olynyk, J., Yeoh, GC., (2016), Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European Journal of Medicinal Chemistry, 120(2016), 275-283, Elsevier, DOI: 10.1016/j.ejmech.2016.03.015.
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Soon Lee, C., Richardson, D., (2016), Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta - Molecular Cell Research, 1863(4), 727-748, Elsevier, DOI: 10.1016/j.bbamcr.2016.01.026.
  • Kohn-Gaone, J., Gogoi-Tiwari, J., Ramm, G., Olynyk, J., Tirnits-Parker, JE., (2016), The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 310(3), G143-G154, American Physiological Society, DOI: 10.1152/ajpgi.00215.2015.
  • Heidari, M., Gerami, S., Bassett, B., Graham, R., Chua, A., Aryal, R., House, M., Collingwood, J., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Johnstone, D., Milward, E., (2016), Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare Diseases, 4(1), 11p., DOI: 10.1080/21675511.2016.1198458.
  • Chua, A., Knuiman, M., Trinder, D., Divitini, M., Olynyk, J., (2016), Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes. American Journal of Clinical Nutrition, 104(3), 736-742, American Society for Nutrition, DOI: 10.3945/ajcn.115.129411.
  • Heidari, M., Johnstone, D., Bassett, B., Graham , R., Chua, A., House, MJ., Collingwood, JF., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J., Trinder, D., Milward, EA., (2016), Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features. Molecular Psychiatry, 21(11), 1599-1607, United Kingdom, Nature Publishing Group, DOI: 10.1038/mp.2015.192.
  • Van Rijnsoever, M., Galhenage, S., Mollison, L., Gummer, J., Trengove, R., Olynyk, J., (2016), Dysregulated erythropoietin, hepcidin, and bone marrow iron metabolism contribute to interferon-induced anemia in hepatitis C. Journal of Interferon and Cytokine Research, 36(11), 630-634, Mary Ann Liebert, DOI: 10.1089/jir.2016.0043.
  • Ironman Investigators, T., Litton, E., Baker, S., Erber, W., Farmer, S., Ferrier, J., French, C., Gummer, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Trengove, R., Webb, S., Anzics Clinical Trials Group, T., (2016), Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial: A randomized trial of IV iron in critical illness. Intensive Care Medicine, 42(11), 1715-1722, DOI: 10.1007/s00134-016-4465-6.
  • Subramaniam, K., Spilsbury, K., Ayonrinde, O., Latchmiah, F., Mukhtar, S., Semmens, J., Leahy, M., Olynyk, J., (2016), Red blood cell transfusion is associated with further bleeding and fresh-frozen plasma with mortality in nonvariceal upper gastrointestinal bleeding. Transfusion, 56(4), 816-826, Blackwell, DOI: 10.1111/trf.13446.
  • Ayonrinde, O., Adams, L., Doherty, D., Mori, T., Beilin, L., Oddy, W., Hickey, M., Sloboda, D., Olynyk, J., Hart, R., (2016), Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys. Journal of Gastroenterology and Hepatology, 31(5), 980-987, Wiley-Blackwell Publishing Asia, DOI: 10.1111/jgh.13241.
  • St. Pierre, TG., House, MJ., Bangma, SJ., Pang, W., Bathgate, A., Gan, EK., Ayonrinde, OT., Bhathal, PS., Clouston, A., Olynyk, J., Adams, LA., (2016), Stereological analysis of liver biopsy histology sections as a reference standard for validating non-invasive liver fat fraction measurements by MRI. PLoS One, 11(8), Article number e01060789, DOI: 10.1371/journal.pone.0160789.
  • Elsegood, C., Chan, CW., Degli-Esposti, M., Wikstrom, M., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J., Yeoh, GC., (2015), Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology, 62(4), 1272-1284, DOI: 10.1002/hep.27977.
  • Ong, S., Dolling, L., Dixon, J., Nicoll, A., Gurrin, L., Wolthuizen, M., Wood, E., Anderson, G., Ramm, G., Allen, K., Olynyk, J., Crawford, D., Kava, J., Ramm, L., Gow, P., Durrant, S., Powell, L., Delatycki, M., (2015), Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron). BMJ Open, 5(8), e008938, DOI: 10.1136/bmjopen-2015-008938.
  • Bentley, P., Bell, B., Olynyk, J., (2015), Therapeutic venesection at the Australian Red Cross Blood Service: Impact of the High Ferritin Application on management of hereditary haemochromatosis. Australian Family Physician, 44(8), 589-592, South Melbourne, Victoria, The Royal Australian College of General Practitioners.
  • Zaloumis, S., Allen, K., Bertalli, N., Turkovic, L., Delatycki, M., Nicoll, A., McLaren, C., English, D., Hopper, J., Giles, G., Anderson, G., Olynyk, J., Powell, L., Gurrin, L., (2015), Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study. Journal of Gastroenterology and Hepatology, 30(4), 719-725, DOI: 10.1111/jgh.12804.
  • House, M., Bangma, S., Thomas, M., Gan, E., Ayonrinde, O., Adams, L., Olynyk, J., St. Pierre, T., (2015), Texture-based classification of liver fibrosis using MRI. Journal of Magnetic Resonance Imaging, 41(2), 322-328, DOI: 10.1002/jmri.24536.
  • Ayonrinde, O., Olynyk, J., Marsh, J., Beilin, L., Mori, T., Oddy, W., Adams, L., (2015), Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. Journal of Gastroenterology and Hepatology, 30(1), 163-171, DOI: 10.1111/jgh.12666.
  • Yeap, B., Divitini, M., Gunton, J., Olynyk, J., Beilby, J., McQuillan, B., Hung, J., Knuiman, M., (2015), Higher ferritin levels, but not serum iron or transferrin saturation, are associated with Type 2 diabetes mellitus in adult men and women free of genetic haemochromatosis. Clinical Endocrinology, 82(4), 525-532, DOI: 10.1111/cen.12529.
  • Adams, L., Crawford, D., Stuart, K., House, M., St Pierre, T., Webb, M., Ching, H., Kava, J., Bynevelt, M., Macquillan, G., Garas, G., Ayonrinde, O., Mori, T., Croft, K., Niu, X., Jeffrey, G., Olynyk, J., (2015), The impact of phlebotomy in nonalcoholic fatty liver disease: A prospective, randomized, controlled trial. Hepatology, 61(5), 1555-1564, DOI: 10.1002/hep.27662.
  • Tirnitz-Parker, J., Olynyk, J., Ramm, G., (2014), Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses. Hepatology, 59(3), 1198-1201, American Association for the Study of Liver Diseases, DOI: 10.1002/hep.26701.
  • Thin, L., Lawrance, I., Spilsbury, K., Kava, J., Olynyk, J., (2014), Detection of liver injury in IBD using transient elastography. Journal of Crohn's and Colitis, 8(7), 671-677, Elsevier, DOI: 10.1016/j.crohns.2013.12.006.
  • Prakoso, E., Tirnitz-Parker, J., Clouston, A., Kayali, Z., Lee, A., Gan, E., Ramm, G., Kench, J., Bowen, D., Olynyk, J., McCaughan, G., Shackel, N., (2014), Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver Transplantation, 20(12), 1508-1519, John Wiley & Sons Ltd, DOI: 10.1002/lt.24007.
  • McKinnon, E., Rossi, E., Beilby, J., Trinder, D., Olynyk, J., (2014), Factors that affect serum levels of ferritin in australian adults and implications for follow-up. Clinical Gastroenterology and Hepatology, 12(1), 101-108, The AGA Institute, DOI: 10.1016/j.cgh.2013.07.019.
  • Dwyer, B., Olynyk, J., Ramm, G., Tirnitz-Parker, J., (2014), TWEAK and LT? signaling during chronic liver disease. Frontiers in Immunology, 5(Feb), art 39, Frontiers Research Foundation, DOI: 10.3389/fimmu.2014.00039.
  • Litton, E., Baker, S., Erber, W., French, C., Ferrier, J., Hawkins, D., Higgins, A., Hofmann, A., De Keulenaer, B., Farmer, S., McMorrow, J., Olynyk, J., Richards, T., Towler, S., Webb, S., (2014), The IRONMAN trial: a protocol for a multicentre randomised placebo-controlled trial of intravenous iron in intensive care unit patients with anaemia. Critical Care and Resuscitation, 16(4), 285-290, Australasian Medical Publishing Co..
  • Black, L., Jacoby, P., Chan She Ping-Delfos, W., Mori, T., Beilin, L., Olynyk, J., Ayonrinde, O., Chi Huang, R., Holt, P., Hart, P., Oddy, W., Adams, L., (2014), Low serum 25-hydroxyvitamin D concentrations associate with non-alcoholic fatty liver disease in adolescents independent of adiposity. Journal of Gastroenterology and Hepatology, 29(6), 1215-1222, Blackwell Publishing, DOI: 10.1111/jgh.12541.
  • Adams, L., White, S., Marsh, J., Lye, S., Connor, K., Maganga , R., Ayonrinde, O., Olynyk, J., Mori, T., Beilin, L., Palmer, L., Hamdorf, J., Pennell, C., (2013), Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease. Hepatology, 57(2), 590-600, DOI: 10.1002/hep.26184.
  • Maker, G., Siva, B., Batty, K., Trengove, R., Ferrari, P., Olynyk, J., (2013), Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis. Nephrology, 18(3), 188-193, DOI: 10.1111/nep.12035.
  • Hazeldine, S., Trinder, D., Olynyk, J., (2013), Non-HFE iron overload: Is phlebotomy the answer?. Current Hepatitis Reports, 12(1), 20-27, DOI: 10.1007/s11901-012-0153-3.
  • House, M., Gan, E., Adams, L., Ayonrinde, O., Bangma, S., Bhathal, P., Olynyk, J., St Pierre, T., (2013), Diagnostic Performance of a Rapid Magnetic Resonance Imaging Method of Measuring Hepatic Steatosis. PLoS One, 8(3), e59287, DOI: 10.1371/journal.pone.0059287.
  • Acikyol, B., Graham, R., Trinder, D., House, M., Olynyk, J., Scott, R., Millward, E., Johnstone, D., (2013), Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience, 235(3 April 2013), 119-128, DOI: 10.1016/j.neuroscience.2013.01.014.
  • Huang, R., Beilin, L., Ayonrinde, O., Mori, T., Olynyk, J., Burrows, S., Hands, B., Adams, L., (2013), Importance of cardiometabolic risk factors in the association between nonalcoholic fatty liver disease and arterial stiffness in adolescents. Hepatology, 58(4), 1306-1314, DOI: 10.1002/hep.26495.
  • Tirnitz-Parker, J., Glanfield, A., Olynyk, J., Ramm, G., (2013), Iron and Hepatic Carcinogenesis. Critical Reviews in Oncogenesis, 18(5), 391-407, DOI: 10.1615/CritRevOncog.2013007759.
  • Chua, A., Klopcic, B., Ho, D., Fu, K., Forrest, C., Croft, K., Olynyk, J., Lawrance, I., Trinder, D., (2013), Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in Mice. PLoS One, 8(11), e78850, DOI: 10.1371/journal.pone.0078850.
  • Adams, L., Marsh, J., Ayonrinde, O., Olynyk, J., Ang, W., Beilin, L., Mori, T., Palmer, L., Oddy, W., Lye, S., Pennell, C., (2012), Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. Journal of Gastroenterology and Hepatology, 27(9), 1520-1527, DOI: 10.1111/j.1440-1746.2012.07120.x.
  • Johnstone, D., Graham, R., Trinder, D., Delima, R., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E., (2012), Brain transcriptome perturbations in the Hfe ?/? mouse model of genetic iron loading. Brain Research, 1448(11 April 2012), 144-152, Netherlands, Elsevier, DOI: 10.1016/j.brainres.2012.02.006.
  • Goot, K., Hazeldine, S., Bentley, P., Olynyk, J., Crawford, D., (2012), Elevated serum ferritin: what should GPs know?. Australian Family Physician, 41(12), 945-949, Melbourne, Victoria, Royal Australian College of General Practitioners.
  • Carroll, G., Breidahl, W., Olynyk, J., (2012), Characteristics of the arthropathy described in hereditary hemochromatosis. Arthritis Care and Research, 64(1), 9-14, DOI: 10.1002/acr.20501.
  • Chalmers, K., Knuiman, M., Divitini, M., Bruce, D., Olynyk, J., Milward, E., (2012), Long-term mortality risks associated with mild anaemia in older persons: The Busselton Health Study. Age and Ageing, 41(6), 759-764, DOI: 10.1093/ageing/afs150.
  • Delima, R., Chua, A., Tirnitz-Parker, J., Gan, E., Croft, K., Graham, R., Olynyk, J., Trinder, D., (2012), Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice. Hepatology, 56(2), 585-593, New Jersey, USA, John Wiley & Sons, DOI: 10.1002/hep.25689.
  • Johnstone, DM., Graham, R., Trinder, D., Riveros, C., Olynyk, J., Scott, R., Moscato, P., Milward, E., (2012), Changes in brain transcripts related to alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased alzheimer's disease risk. Journal of Alzheimer's Disease, 30(4), 791-803, Amsterdam, Netherlands, IOS Press, DOI: 10.3233/JAD-2012-112183.
  • Raftopoulus, S., Kumarasinghe, P., De Boer, B., Iacobelli, J., Kontorinis, N., Fermoyle, S., Olynyk, J., Forrest, C., Ee, H., Yusoff, I., (2012), Gastric intraepithelial neoplasia in a Western population. European Journal of Gastroenterology and Hepatology, 24(1), 48-54, United Kingdom, Lippincott Williams & Wilkins Ltd, DOI: 10.1097/MEG.0b013e32834dc1bb.
  • Nadakkavukaran, I., Gan, E., Olynyk, J., (2012), Screening for hereditary haemochromatosis. Pathology, 44(2), 148-152, DOI: 10.1097/PAT.0b013e32834e8453.
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