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Mr Steve Pedrini

Research Associate

Staff Member Details
Email: s.pedrini@ecu.edu.au
Campus: Joondalup  

Steve is currently involved in projects involving biomarkers in Alzheimer’s Disease.

Research Areas and Interests

  • Alzheimer, Dementia, Biomarkers

Qualifications

  • Master of Science in Biology, Italy, 1997.

Research Outputs

Journal Articles

  • Chatterjee, P., Pedrini, S., Stoops, E., Goozee, K., Villemagne, V., Asih, P., Verberk, I., Dave, P., Taddei, K., Sohrabi, H., Zetterberg, H., Blennow, K., Teunissen, C., Vanderstichele, H., Martins, R. (2021). Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease. Translational Psychiatry, 11(2021), Article 27. https://doi.org/10.1038/s41398-020-01137-1.

Journal Articles

  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2020). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 2020(Article in press), 14p.. https://doi.org/10.1111/jnc.15128.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.
  • Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Shen, K., Asih, P., Dave, P., Pedrini, S., Ashton, N., Hye, A., Taddei, K., Lovejoy, D., Zetterberg, H., Blennow, K., Martins, R. (2020). Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(2020), 291-301. https://doi.org/10.3233/JAD-200162.
  • Pedrini, S., Chatterjee, P., Hone, E., Martins, R. (2020). High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease. Journal of Neurochemistry, 2020(Article in press), 1-35. https://doi.org/10.1111/jnc.15170.
  • Chatterjee, P., Fernando, M., Fernando, B., Dias, C., Shah, T., Silva, R., Williams, S., Pedrini, S., Hillebrandt, H., Goozee, K., Barin, E., Sohrabi, H., Garg, M., Cunnane, S., Martins, R. (2020). Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development, 186(March 2020), Article number 111209. https://doi.org/10.1016/j.mad.2020.111209.

Journal Articles

  • Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C., Jacobs, K., Ashton, N., Hye, A., Pedrini, S., Sohrabi, H., Shah, T., Asih, P., Dave, P., Shen, K., Taddei, K., Lovejoy, D., Guillemin, G., Blennow, K., Martins, R. (2019). Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease. Journal of Neuroinflammation, 16(2019), Article number 186. https://doi.org/10.1186/s12974-019-1567-4.
  • Chatterjee, P., Elmi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Pedrini, S., Shen, K., Asih, P., Dave, P., Taddei, K., Vanderstichele, H., Zetterberg, H., Blennow, K., Martins, R. (2019). Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 71(3), 775-783. https://doi.org/10.3233/JAD-190533.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A. (2019). A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220. https://doi.org/10.1126/sciadv.aau7220.
  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T. (2019). Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(2019), 740-750. https://doi.org/https://doi.org/10.1016/j.trci.2019.09.015.

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

Journal Articles

  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R. (2017). Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72. https://doi.org/10.1016/j.dadm.2017.04.003.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057. https://doi.org/10.1038/s41598-017-14020-9.

Journal Articles

  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R. (2016). Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559. https://doi.org/10.1074/jbc.M115.679993.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.

Journal Articles

  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.

Journal Articles

  • Tan, W., Naniche, N., Bogush, A., Pedrini, S., Trotti, D., Pasinelli, P. (2013). Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. Journal of Neuroscience, 33(28), 11588-11598. https://doi.org/10.1523/JNEUROSCI.5385-12.2013.

Research Projects

  • In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease, National Foundation for Medical Research and Innovation, NFMRI - Grant, 2020 ‑ 2023, $170,000.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease., Hollywood Private Hospital Research Foundation, Grant, 2015, $15,000.
  • Continuation of the 15M S.A work & In vitro testing of the Phylomers, Alzhyme Pty Ltd, Grant, 2015, $103,875.
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