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Mr Steve Pedrini

Research Associate

Contact Information Email: s.pedrini@ecu.edu.au, Campus: Joondalup,
Staff Member Details
Email: s.pedrini@ecu.edu.au
Campus: Joondalup  

 

Steve is currently involved in projects involving biomarkers in Alzheimer’s Disease.

Research Areas and Interests

  • Alzheimer, Dementia, Biomarkers

Qualifications

  • Master of Science in Biology, Italy, 1997.

Research

Recent Research Grants

  • Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease.,  Hollywood Private Hospital Research Foundation,  Grant,  2015,  $15,000.
  • Continuation of the 15M S.A work & In vitro testing of the Phylomers,  Alzhyme Pty Ltd,  Grant,  2015,  $111,674.

Recent Publications (within the last five years)

Journal Articles

  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O?bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R., (2017), A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(1), Article number 14057, DOI: 10.1038/s41598-017-14020-9.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R., (2017), Altered levels of blood proteins in Alzheimer?s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 8(2017), 60-72, United States, Elsevier Science Inc., DOI: 10.1016/j.dadm.2017.04.003.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R., (2016), Validation and characterization of a novel peptide that binds monomeric and aggregated ?-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559, Bethesda, USA, American Society for Biochemistry and Molecular Biology, Inc., DOI: 10.1074/jbc.M115.679993.
  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R., (2016), Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers and Dementia: Diagnosis, Assessment & Disease Monitoring, 3(2016), 18-26, Elsevier Inc., DOI: 10.1016/j.dadm.2015.12.001.
  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R., (2015), Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16, United Kingdom, BioMed Central Ltd., DOI: 10.1186/s13195-015-0105-6.
  • Tan, W., Naniche, N., Bogush, A., Pedrini, S., Trotti, D., Pasinelli, P., (2013), Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. Journal of Neuroscience, 33(28), 11588-11598, Washington, DC, USA, Society for Neuroscience, DOI: 10.1523/JNEUROSCI.5385-12.2013.
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