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Dr Ian Martins

Mr Ian Martins is a Research Fellow in the School of Medical and Health Sciences.

Qualifications

  • Doctor of Philosophy (Biochemistry), The University of Western Australia, 1987.

Research

Recent Research Grants

  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. ,  Hollywood Private Hospital Research Foundation,  Grant,  2013 - 2016,  $20,000.
  • Use of coconut oil as a novel neuro protective agent for Alzheimer?s disease,  Edith Cowan University,  School of Medical and Health Sciences Research Grant Scheme 2016,  2016,  $9,203.
  • The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro,  National Health and Medical Research Council,  Grant,  2010 - 2013,  $409,650.
  • Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease,  National Health and Medical Research Council,  Grant,  2010 - 2013,  $529,125.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer?s and Melanoma Research,  National Health and Medical Research Council,  Equipment Grant 2011,  2011 - 2012,  $10,927.
  • Investigating beta amyloid clearance in vivo,  Centre of Excellence for Alzheimers Disease Research and Care,  Fellowship,  2006 - 2009,  $207,655.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory,  Edith Cowan University,  Grant,  2007 - 2008,  $12,266.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice,  Hollywood Private Hospital,  Grant,  2006 - 2007,  $9,455.
  • Molecular & neuropsychological predictive markers of cognitive decline,  National Health and Medical Research Council,  Grant,  2005 - 2007,  $423,750.

Recent Publications (within the last five years)

Books

  • Martins, I., (2015), Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer?s disease. Photon ebooks UBN: 015-A94510112017, 48, online, Photon.
  • Martins, I., (2015), Nutrition increases Survival and Reverses NAFLD and Alzheimer's disease., 168, Germany, Lambert Academic Publishing.
  • Martins, I., (2013), Appetite dysregulation and Obesity in Western Countries., 88, Germany, Lambert Academic Publishing.

Book Chapters

  • Martins, I., (2015), Nutritional and Genotoxic Stress Contributes to Diabetes and Neurodegenerative Diseases such as Parkinson's and Alzheimer's Diseases. Frontiers in Clinical Drug Research -CNS and Neurological Disorders, 3(7), 158-192, Bentham eBooks, Bentham Science Publishers, DOI: 10.2174/97816080592631140301.

Journal Articles

  • Martins, I., (2016), Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 5(2016), 9-26, United States of America, Scientific Research Publishing, DOI: 10.4236/aar.2016.51002.
  • Martins, I., (2016), Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research, 16(2), 1-8, Global Academic Research Journals .
  • Martins, I., (2016), Appetite Control with Relevance to Mitochondrial Biogenesis and Activation of Post- Prandial Lipid Metabolism in Obesity Linked Diabetes. Annals of Obesity and Disorders , 1(3), 1-3, USA, Austin Publishing .
  • Martins, I., (2016), The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer?s Disease. Proteomes, 4(14), 1-19, Switzerland, MDPI , DOI: 10.3390/proteomes4020014.
  • Martins, I., (2016), Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer?s Disease. Health, 8(2016), 694-710, United States of America, Scientific Research Publishing, DOI: 10.4236/health.2016.87073.
  • Martins, I., (2016), Diet and Nutrition Reverse Type 3 Diabetes and Accelerated Aging Linked to Global Chronic Diseases. Journal of Diabetes Research and Therapy, 2(2), 1-6, Germany, SciForschen, DOI: 10.16966/2380-5544.117.
  • Martins, I., (2016), Type 3 diabetes with links to NAFLD and other chronic diseases in the Western World. International Journal of Diabetes and Metabolic disorders, 1(1), 1-5, USA, Opast online publishing .
  • Martins, I., (2016), Food quality induces a miscible disease with relevance to Alzheimer?s disease and Neurological diseases. Journal of Food Research, 5(6), 45-52, Canada, Canadian Center of Science and Education, DOI: 10.5539/ jfr. v5n6p 45.
  • Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., (2016), Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, Article in press(Article in press), 10p., Taylor and Francis Ltd, DOI: 10.1080/00207454.2016.1182527.
  • Martins, I., (2016), Food Intake and Caffeine Determine Amyloid Beta Metabolism with Relevance to Mitophagy in Brain Aging and Chronic Disease. European Journal of Food Science and Technology, 4(5), 11-17, European Center for Research Training and Development .
  • Martins, I., (2016), Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer?s Disease. Journal of Microbial Biochemical Technology, 8(4), 322-324, USA, OMICS publishing, DOI: 10.4172/1948-5948.1000304.
  • Martins, I., (2015), Diabetes and organ dysfunction in the developing and developed world. Global Journal of Medical Research, 15(1), 1-6, United States of America, Global Journals Inc..
  • Martins, I., (2015), Unhealthy nutrigenomic diets accelerate NAFLD and adiposity in global communities. Journal of Molecular and Genetic Medicine: an international journal of biomedical research, 9(1), 1-11, United States of America, Omics Publishing Group, DOI: 10.4172/1747-0862.1000162.
  • Martins, I., (2015), Diabetes and cholesterol dyshomeostasis involve abnormal ?-synuclein and amyloid beta transport in neurodegenerative diseases. Austin Alzheimer's and Parkinsons Disease, 2(1), 1-8, United States of America, Austin Publishing Group.
  • Martins, I., (2015), Unhealthy diets determine benign or toxic amyloid beta states and promote brain amyloid beta aggregation. Austin Journal of Clinical Neurology, 2(7), 1-6, United States of America, Austin Publishing Group.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R., (2015), Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16, Lausanne, Switzerland, Frontiers Research Foundation, DOI: 10.3389/fnagi.2015.00016.
  • Martins, I., (2015), LPS regulates apolipoprotein E and A? interactions with effects on acute phase proteins and amyloidosis. Advances in Aging Research, 4(2015), 69-77, Scientific Research Publishing, DOI: 10.4236/aar.2015.42009.
  • Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA., (2015), Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48, Elsevier, DOI: 10.1016/j.nbd.2015.06.016.
  • Martins, I., (2015), Overnutrition determines LPS regulation of mycotoxin induced neurotoxicity in neurodegenerative diseases. International Journal of Molecular Sciences, 16(12), 29554-29573, Basel, Switzerland, MDPI AG, DOI: 10.3390/ijms161226190.
  • Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R., (2015), The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14, Cambridge, United Kingdom, Cambridge University Press, DOI: 10.1017/S0007114515001452.
  • Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R., (2014), Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183, Netherlands, Bentham Science Publishers .
  • Martins, I., (2014), Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries. Open Journal of Endocrine and Metabolic Diseases, 2014(4), 90-110, United States of America, Scientific Research Publishing, Inc., DOI: 10.4236/ojemd.2014.44011.
  • Martins, I., Fernando, B., (2014), High Fibre Diets and Alzheimer?s Disease. Food and Nutrition Sciences , 5(4), 410-424, United States of America.
  • Martins, I., (2014), The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer?s disease. JSM Alzheimer?s Disease and Related Dementia , 1(2), 1010-1018, USA.
  • Lim, F., Martins, I., Martins, R., (2014), The Involvement of Lipids in Alzheimer's Disease. Journal of Genetics and Genomics, 41(5), 261-274, Elsevier, DOI: 10.1016/j.jgg.2014.04.003.
  • Martins, I., Creegan, R., (2014), Links between Insulin Resistance, Lipoprotein Metabolism and Amyloidosis in Alzheimer?s Disease. Health , 6(10), 1549-1579, USA, DOI: 10.4236/health.2014.612190.
  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R., (2013), The acceleration of aging and Alzheimer?s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920, United States of America, Scientific Research Publishing, Inc., DOI: 10.4236/health.2013.55121.
  • Martins, I., (2013), Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Journal of Molecular and Genetic Medicine: an international journal of biomedical research, S1(001), 8p., United States of America, OMICS, DOI: 10.4172/1747-0862.S1-001.
  • Martins, I., Creegan, R., Lim, F., Martins, R., (2013), Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33, United States of America, Scientific Research, DOI: 10.4236/ojemd.2013.35A002.
  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R., (2013), Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224, United States, Elsevier.
  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R., (2012), Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer?s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456, United States, Scientific Research Publishing, Inc., DOI: 10.4236/health.2012.412A209.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R., (2012), Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056, United States, Elsevier, DOI: 10.1016/j.neurobiolaging.2010.09.003.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy,  Identification Of Plasma Lipid Biomarkers In Alzheimer's Disease.
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