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Dr Ian Martins

Research Fellow

Staff Member Details
Email: i.martins@ecu.edu.au
ORCID iD: https://orcid.org/0000-0002-2390-1501

Mr Ian Martins is a Research Fellow in the School of Medical and Health Sciences.

Qualifications

  • Doctor of Philosophy (Biochemistry), The University of Western Australia, 1987.

Research Outputs

Journal Articles

  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.
  • Huynh, K., Lim, F., Giles, C., Jayawardana, K., Salim, A., Mellett, N., Smith, A., Olshansky, G., Drew, B., Chatterjee, P., Martins, I., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Arnold, M., Nho, K., Saykin, A., Baillie, R., Han, X., Kaddurah-Daouk, R., Martins, R., Meikle, P. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease. Nature Communications, 11(1), Article number 5698. https://doi.org/https://doi.org/10.1038/s41467-020-19473-7.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2020). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 2020(Article in press), 14p.. https://doi.org/10.1111/jnc.15128.
  • Lim, F., Huynh, K., Chatterjee, P., Martins, I., Jayawardana, K., Giles, C., Mellett, N., Laws, S., Bush, A., Rowe, C., Villemagne, V., Ames, D., Drew, B., Masters, C., Meikle, P., Martins, R. (2020). Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease. Journal of Alzheimer's Disease, 76(1), 303-315. https://doi.org/10.3233/JAD-191304.
  • Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.

Book Chapters

  • Hone, E., Lim, F., Martins, I. (2019). Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease. Neurodegeneration and Alzheimer's Disease The role of diabetes, Genetics, Hormones and Lifestyle (189-230). John Wiley & Sons. https://doi.org/10.1002/9781119356752.ch7.

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

Journal Articles

  • Bates, K., Sohrabi, H., Rainey-Smith, S., Weinborn, M., Bucks, R., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, L., Gandy, S., Martins, R. (2017). Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252. https://doi.org/10.1080/00207454.2016.1182527.

Journal Articles

  • Fernando, B., Martins, I., Goozee, K., Brennan, C., Jayasena, V., Martins, R. (2015). The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. The British Journal of Nutrition, 114(1), 1-14. https://doi.org/10.1017/S0007114515001452.
  • Sohrabi, H., Bates, K., Weinborn, M., Bucks, R., Rainey-Smith, S., Rodrigues, M., Bird, S., Brown, B., Beilby, J., Howard, M., Criddle, A., Wraith, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S., Mehta, P., Foster, J., Martins, I., Lautenschlager, N., Mastaglia, F., Laws, S., Martins, R. (2015). Bone mineral density, adiposity, and cognitive functions. Frontiers in Aging Neuroscience, 7(FEB), Article no. 16. https://doi.org/10.3389/fnagi.2015.00016.
  • Xu, H., Gupta, V., Martins, I., Martins, R., Fowler, CJ., Bush, AI., Finkelstein, DI., Adlard, PA. (2015). Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiology of Disease, 81(September 2015), 38-48. https://doi.org/10.1016/j.nbd.2015.06.016.

Journal Articles

  • Martins, I., Gupta, V., Wilson, A., Fuller, SJ., Martins, R. (2014). Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics: the journal for current and in-depth reviews on proteomics, 11(3), 171-183.
  • Lim, F., Martins, I., Martins, R. (2014). The Involvement of Lipids in Alzheimer's Disease. Journal of Genetics and Genomics, 41(5), 261-274. https://doi.org/10.1016/j.jgg.2014.04.003.

Books

  • Martins, I. (2013). Appetite dysregulation and Obesity in Western Countries. Lambert Academic Publishing.

Journal Articles

  • Martins, I., Lim, F., Wilson, A., Laws, S., Martins, R. (2013). The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity and type II diabetes. Health, 5(5), 913-920. https://doi.org/10.4236/health.2013.55121.
  • Martins, I. (2013). Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Journal of Molecular and Genetic Medicine: an international journal of biomedical research, S1(001), 8p.. https://doi.org/10.4172/1747-0862.S1-001.
  • Martins, I., Creegan, R., Lim, F., Martins, R. (2013). Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Open Journal of Endocrine and Metabolic Diseases, 3(5A), 11-33. https://doi.org/10.4236/ojemd.2013.35A002.
  • Lim, F., Lam, SM., Shui, G., Mondal, A., Ong, D., Duan, X., Creegan, R., Martins, I., Sharman, M., Taddei, K., Verdile, G., Wenk, M., Martins, R. (2013). Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E E3 and E4 knock-in mice. Neurobiology of Aging, 34(9), 2217-2224. https://doi.org/10.1016/j.neurobiolaging.2013.03.012.

Journal Articles

  • Martins, I., Wilson, A., Lim, F., Laws, S., Fuller, S., Martins, R. (2012). Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Health, 4(12A), 1448-1456. https://doi.org/10.4236/health.2012.412A209.
  • Lau, S., Bates, K., Sohrabi, H., Rodrigues, M., Martins, G., Dhaliwal, S., Taddei, K., Laws, S., Martins, I., Mastaglia, F., Foster, J., Phillips, J., Martins, R. (2012). Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33(6), 1054-1056. https://doi.org/10.1016/j.neurobiolaging.2010.09.003.

Journal Articles

  • Sharman, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R. (2010). APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-ß42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409. https://doi.org/10.3233/JAD-2010-100141.
  • Sharman, M., Shui, G., Fernandis, A., Lim, WL., Berger, T., Hone, E., Taddei, K., Martins, I., Ghiso, J., Buxbaum, JD., Gandy, S., Wenk, M., Martins, R. (2010). Profiling brain and plasma lipids in human APOE ε2, ε3 and ε4 knock-in mice using electrospray ionization mass spectrometry.. Journal of Alzheimer's Disease, 20(1), 105-111.

Journal Articles

  • Martins, I., Berger, T., Sharman, M., Verdile, G., Fuller, S., Martins, R. (2009). Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. Journal of Neurochemsitry, 111(6), 1275-1308.
  • Bates, K., Sohrabi, H., Rodrigues, M., Beilby, J., Dhaliwal, S., Taddei, K., Criddle, A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J., Martins, I., Launtenschlager, N., Mastaglia, F., Laws, S., Gandy, S., Martins, R. (2009). Association of Cardiovascular Factors and Alzhemer's Disease Plasma Amyloid-β Protein in subjective memory Complainers. Journal of Alzheimer's Disease, 17(2), 305-318.

Journal Articles

  • Taddei, K., Laws, S., Verdile, G., Munns, S., D'costa, K., Harvey, A., Martins, I., Hill, F., Levy, E., Shaw, J., Martins, R. (2008). Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging, n/a(n/a), 12 pages.

Journal Articles

  • Martins, I., Hone, E., Foster, J., Sunram-Lea, S., Gnjec, A., Fuller, S., Nolan, DA., Gandy, S., Martins, R. (2006). Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry, 11(8), 721-736.

Journal Articles

  • Hone, E., Martins, I., Jeoung, M., Ji, T., Gandy, S., Martins, R. (2005). Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. Journal of Alzheimer's disease, 7(4), 303-314.

Journal Articles

  • Hone, E., Martins, I., Fonte, J., Martins, R. (2003). Apolipoprotein E influences amyloid-beta clearance from the murine periphery. Journal of Alzheimer's Disease, 5(1), 1-8.

Research Projects

  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. , Hollywood Private Hospital Research Foundation, Grant, 2013 ‑ 2016, $20,000.
  • Use of coconut oil as a novel neuro protective agent for Alzheimer’s disease, Edith Cowan University, School of Medical and Health Sciences Research Grant Scheme 2016, 2016, $9,203.
  • The Effect of Human apoE Isoforms and apoE Receptors on the Clearance of Oligomeric A 42 by Hepatocytes In Vitro, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $409,650.
  • Enhancing Peripheral Clearance of Beta Amyloid as a Treatment of Alzheimer's Disease, National Health and Medical Research Council, Grant, 2010 ‑ 2013, $529,125.
  • Neon Transfection System and Biomedical Research Grade -30oC Freezer for Alzheimer’s and Melanoma Research, National Health and Medical Research Council, Equipment Grant 2011, 2011 ‑ 2012, $10,927.
  • Investigating beta amyloid clearance in vivo, Centre of Excellence for Alzheimers Disease Research and Care, Fellowship, 2006 ‑ 2009, $207,655.
  • -30C Freezer for Increased Tissue/Blood Storage Capacity in the Alzheimer's Disease Research Laboratory, Edith Cowan University, Grant, 2007 ‑ 2008, $12,266.
  • Cholesterol, high fat diets, exercise and cholesterol lowering drugs on beta-amyloid clearance and deposition in brains on Alzheimer's disease transgenic mice, Hollywood Private Hospital, Grant, 2006 ‑ 2007, $9,455.
  • Molecular & neuropsychological predictive markers of cognitive decline, National Health and Medical Research Council, Grant, 2005 ‑ 2007, $423,750.

Research Student Supervision

Associate Supervisor

  • Doctor of Philosophy, Identification of plasma lipid biomarkers in alzheimer's disease.
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